F901318 represents a novel class of antifungal drug that inhibits dihydroorotate dehydrogenase.

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🔗 View Article (PMID 27791100)

Published in Proc Natl Acad Sci U S A on October 25, 2016

Authors

Jason D Oliver1, Graham E M Sibley2, Nicola Beckmann2, Katharine S Dobb2, Martin J Slater3, Laura McEntee4, Saskia du Pré2, Joanne Livermore4, Michael J Bromley2, Nathan P Wiederhold5, William W Hope4, Anthony J Kennedy2, Derek Law2, Mike Birch2

Author Affiliations

1: F2G Ltd., Manchester M30 0LX, United Kingdom; joliver@f2g.com.
2: F2G Ltd., Manchester M30 0LX, United Kingdom.
3: Cresset, Litlington SG8 0SS, United Kingdom.
4: Antimicrobial Pharmacodynamics and Therapeutics, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L69 3GE, United Kingdom.
5: Fungus Testing Laboratory, Departments of Pathology and Medicine/Infectious Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.

Associated clinical trials:

F901318 Single Ascending Dose Study in Healthy Male Volunteers | NCT02142153

F901318 Multiple Ascending Dose Study | NCT02342574

Single Ascending Oral Dose Study of F901318 | NCT02394483

Multiple Ascending Oral Dose Study of F901318 in Healthy Subjects (ORALMAD) | NCT02737371

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