Approaches to modernize the combination drug development paradigm.

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🔗 View Article (PMID 27793177)

Published in Genome Med on October 28, 2016

Authors

Daphne Day1,2,3, Lillian L Siu4,5

Author Affiliations

1: Drug Development Program, Division of Medical Oncology & Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, M5G 2M9, Canada.
2: Department of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.
3: OICR Research Fellow, Ontario Institute for Cancer Research, Toronto, Ontario, M5G 0A3, Canada.
4: Drug Development Program, Division of Medical Oncology & Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, M5G 2M9, Canada. lillian.siu@uhn.ca.
5: Department of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. lillian.siu@uhn.ca.

Associated clinical trials:

I-SPY 2 TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer (I-SPY 2) | NCT01042379

Lung-MAP: Biomarker-Targeted Second-Line Therapy in Treating Patients With Recurrent Stage IV Squamous Cell Lung Cancer | NCT02154490

BATTLE Program: Umbrella Protocol for Patients With Non-Small Cell Lung Cancer (NSCLC) | NCT00409968

NCI-MATCH: Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors or Lymphomas | NCT02465060

A Study Evaluating Safety and Efficacy of the Addition of ABT-888 Plus Carboplatin Versus the Addition of Carboplatin to Standard Chemotherapy Versus Standard Chemotherapy in Subjects With Early Stage Triple Negative Breast Cancer | NCT02032277

A Study Evaluating Herceptin/Perjeta, Tarceva, Zelboraf/Cotellic, and Erivedge Treatment Targeted Against Certain Mutations in Cancer Patients | NCT02091141

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