Published in Proc Jpn Acad Ser B Phys Biol Sci on January 01, 2016
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem (1979) 41.65
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science (1995) 17.76
Hydroperoxide metabolism in mammalian organs. Physiol Rev (1979) 14.13
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun (1997) 14.09
The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem (1972) 12.87
Cell signaling. H2O2, a necessary evil for cell signaling. Science (2006) 7.53
CXCL12 (SDF-1)/CXCR4 pathway in cancer. Clin Cancer Res (2010) 5.42
Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes Cells (2003) 4.47
Transcriptional regulation via the NF-kappaB signaling module. Oncogene (2006) 3.92
Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic Biol Med (1996) 3.35
Reactive oxygen species as a signal in glucose-stimulated insulin secretion. Diabetes (2007) 2.59
Activation of the JAK-STAT pathway by reactive oxygen species. Am J Physiol (1998) 2.37
Regulation of superoxide dismutase genes: implications in disease. Free Radic Biol Med (2009) 2.35
Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB. Free Radic Biol Med (2000) 2.28
Non-classical p38 map kinase functions: cell cycle checkpoints and survival. Int J Biol Sci (2008) 2.18
An intronic NF-kappaB element is essential for induction of the human manganese superoxide dismutase gene by tumor necrosis factor-alpha and interleukin-1beta. DNA Cell Biol (1999) 2.06
Oxidative stress: the vulnerable beta-cell. Biochem Soc Trans (2008) 1.98
Coordinated binding of NF-kappaB family members in the response of human cells to lipopolysaccharide. Proc Natl Acad Sci U S A (2006) 1.96
Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway. Proc Natl Acad Sci U S A (2004) 1.88
Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress through the upregulation of manganese superoxide dismutase. Circulation (2001) 1.79
Phosphatidylinositol 3-kinase, not extracellular signal-regulated kinase, regulates activation of the antioxidant-responsive element in IMR-32 human neuroblastoma cells. J Biol Chem (2001) 1.74
Signal transduction by CXC chemokine receptor 4. Stromal cell-derived factor 1 stimulates prolonged protein kinase B and extracellular signal-regulated kinase 2 activation in T lymphocytes. J Exp Med (2000) 1.67
ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function. Toxicol Appl Pharmacol (2009) 1.63
Inhibition of ERK and p38 MAP kinases inhibits binding of Nrf2 and induction of GCS genes. Biochem Biophys Res Commun (2000) 1.57
p38alpha: a suppressor of cell proliferation and tumorigenesis. Cell Cycle (2007) 1.57
Rapid insulinotropic effect of 17beta-estradiol via a plasma membrane receptor. FASEB J (1998) 1.54
Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: protection against reactive oxygen and nitrogen species-induced cell injury. FEBS Lett (2005) 1.53
Suppressor of cytokine signaling-3 is a biomechanical stress-inducible gene that suppresses gp130-mediated cardiac myocyte hypertrophy and survival pathways. J Clin Invest (2001) 1.51
Chronic oxidative stress as a mechanism for glucose toxicity of the beta cell in type 2 diabetes. Cell Biochem Biophys (2007) 1.49
Regulation of Mn-superoxide dismutase activity and neuroprotection by STAT3 in mice after cerebral ischemia. J Neurosci (2009) 1.33
The Keap1-Nrf2 system prevents onset of diabetes mellitus. Mol Cell Biol (2013) 1.30
Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway. Cell Signal (2011) 1.28
Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for proteasome inhibitor-mediated cardioprotection. Cardiovasc Res (2009) 1.26
Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway. Toxicol Appl Pharmacol (2008) 1.26
GSK-3beta down-regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress. J Neurochem (2007) 1.24
Stromal cell derived factor-1 (SDF-1)/CXCL12 attenuates diabetes in mice and promotes pancreatic beta-cell survival by activation of the prosurvival kinase Akt. Diabetes (2007) 1.23
Signal transduction pathways involved in oxidative stress-induced intestinal epithelial cell apoptosis. Pediatr Res (2005) 1.23
MnSOD and catalase transgenes demonstrate that protection of islets from oxidative stress does not alter cytokine toxicity. Diabetes (2005) 1.17
Hydrogen peroxide induces DNA single- and double-strand breaks in thyroid cells and is therefore a potential mutagen for this organ. Endocr Relat Cancer (2009) 1.06
Overexpression of catalase provides partial protection to transgenic mouse beta cells. Free Radic Biol Med (1999) 1.06
Stromal cell-derived factor-1 (SDF-1)/chemokine (C-X-C motif) receptor 4 (CXCR4) axis activation induces intra-islet glucagon-like peptide-1 (GLP-1) production and enhances beta cell survival. Diabetologia (2011) 1.05
Role of impaired Nrf2 activation in the pathogenesis of oxidative stress and inflammation in chronic tubulo-interstitial nephropathy. Nephrol Dial Transplant (2013) 1.04
Transcription regulation of human manganese superoxide dismutase gene. Methods Enzymol (2002) 1.04
T lymphocytes on the move: chemokines, PI 3-kinase and beyond. Trends Immunol (2006) 1.03
Nrf2 protects pancreatic β-cells from oxidative and nitrosative stress in diabetic model mice. Diabetes (2013) 1.01
Regulation of the catalase gene promoter by Sp1, CCAAT-recognizing factors, and a WT1/Egr-related factor in hydrogen peroxide-resistant HP100 cells. Cancer Res (2001) 0.98
A role for manganese superoxide dismutase in radioprotection of hematopoietic stem cells by interleukin-1. Blood (1993) 0.96
SOCS3 is required to temporally fine-tune photoreceptor cell differentiation. Dev Biol (2006) 0.92
Isolation and characterization of the rat catalase-encoding gene. Gene (1989) 0.87
CCAAT/enhancer binding protein-beta (C/EBP-beta), a pivotal regulator of the TATA-less promoter in the rat catalase gene. FEBS Lett (2005) 0.85
Walterinnesia aegyptia venom combined with silica nanoparticles enhances the functioning of normal lymphocytes through PI3K/AKT, NFκB and ERK signaling. Lipids Health Dis (2012) 0.83
Differential regulation of rat insulin I and II messenger RNA synthesis: effects of fasting and cyproheptadine. Mol Endocrinol (1991) 0.83
C/EBP alpha and C/EBPbeta play similar roles in the transcription of the human Cu/Zn SOD gene. Gene (1997) 0.80
Treg cells in pancreatic lymph nodes: the possible role in diabetogenesis and β cell regeneration in a T1D model. Cell Mol Immunol (2012) 0.80
Selective expression of the insulin I gene in rat insulinoma-derived cell lines. Mol Endocrinol (1990) 0.80
CXCL12/SDF-1 over-expression in human insulinomas and its biological relevance. Mol Cell Endocrinol (2008) 0.80
Overexpression of the antioxidant enzyme catalase does not interfere with the glucose responsiveness of insulin-secreting INS-1E cells and rat islets. Diabetologia (2013) 0.79
PARP-1 and YY1 are important novel regulators of CXCL12 gene transcription in rat pancreatic beta cells. PLoS One (2013) 0.79
Protective effect of Nrf2 and catalase in maternal diabetes-induced perinatal hypertension and kidney disease. Diabetes (2012) 0.77
Therapeutic potential of pterostilbene against pancreatic beta-cell apoptosis mediated through Nrf2. Br J Pharmacol (2014) 0.77
CXC chemokine ligand 12 protects pancreatic β-cells from necrosis through Akt kinase-mediated modulation of poly(ADP-ribose) polymerase-1 activity. PLoS One (2014) 0.77
Hepatoprotective effects of Gentiana asclepiadea L. extracts against carbon tetrachloride induced liver injury in rats. Food Chem Toxicol (2012) 0.94
Methanol extract from the stem of Cotinus coggygria Scop., and its major bioactive phytochemical constituent myricetin modulate pyrogallol-induced DNA damage and liver injury. Mutat Res (2013) 0.93
The radioprotective effect of alpha2-macroglobulin: a morphological study of rat liver. Med Sci Monit (2009) 0.87
Alpha-lipoic acid upregulates antioxidant enzyme gene expression and enzymatic activity in diabetic rat kidneys through an O-GlcNAc-dependent mechanism. Eur J Nutr (2012) 0.85
Extract of the plant Cotinus coggygria Scop. attenuates pyrogallol-induced hepatic oxidative stress in Wistar rats. Can J Physiol Pharmacol (2011) 0.83
Co-localization of PARP-1 and lamin B in the nuclear architecture: a halo-fluorescence- and confocal-microscopy study. J Cell Biochem (2005) 0.83
STAT3/NFkappaB interplay in the regulation of alpha2-macroglobulin gene expression during rat liver development and the acute phase response. IUBMB Life (2007) 0.83
Poly(ADP-ribose) polymerase-1: association with nuclear lamins in rodent liver cells. J Cell Biochem (2004) 0.83
C/EBP alpha and C/EBP beta regulate haptoglobin gene expression during rat liver development and the acute-phase response. Mol Biol Rep (2005) 0.82
Relationship between genome and epigenome--challenges and requirements for future research. BMC Genomics (2014) 0.82
PARP-1 expression in the mouse is controlled by an autoregulatory loop: PARP-1 binding to an upstream S/MAR element and to a novel recognition motif in its promoter suppresses transcription. J Mol Biol (2009) 0.81
Hepatoprotective effects of melatonin against pronecrotic cellular events in streptozotocin-induced diabetic rats. J Physiol Biochem (2014) 0.81
DNA break repair: refined rules of an already complicated game. Biochem Cell Biol (2005) 0.80
The protective effect of a mix of Lactarius deterrimus and Castanea sativa extracts on streptozotocin-induced oxidative stress and pancreatic β-cell death. Br J Nutr (2011) 0.80
Acute-phase protein expression in DMSO-intoxicated rats. Toxicol Lett (2004) 0.80
In vitro antioxidant activity of selected 4-hydroxy-chromene-2-one derivatives-SAR, QSAR and DFT studies. Int J Mol Sci (2011) 0.80
Hepatoprotective effects of secoiridoid-rich extracts from Gentiana cruciata L. against carbon tetrachloride induced liver damage in rats. Food Funct (2014) 0.79
Identification of transcription factors involved in the transcriptional regulation of the CXCL12 gene in rat pancreatic insulinoma Rin-5F cell line. Biochem Cell Biol (2014) 0.79
STAT3/NF-κB interactions determine the level of haptoglobin expression in male rats exposed to dietary restriction and/or acute phase stimuli. Mol Biol Rep (2011) 0.79
PARP-1 and YY1 are important novel regulators of CXCL12 gene transcription in rat pancreatic beta cells. PLoS One (2013) 0.79
The absence of cardiomyopathy is accompanied by increased activities of CAT, MnSOD and GST in long-term diabetes in rats. J Physiol Sci (2010) 0.78
Association of the glucocorticoid receptor with STAT3, C/EBPbeta, and the hormone-responsive element within the rat haptoglobin gene promoter during the acute phase response. IUBMB Life (2010) 0.78
YY1-binding sites provide central switch functions in the PARP-1 gene expression network. PLoS One (2012) 0.77
The acute-phase protein alpha2-macroglobulin plays an important role in radioprotection in the rat. Shock (2009) 0.77
Proteolytic events in cryonecrotic cell death: Proteolytic activation of endonuclease P23. Cryobiology (2010) 0.77
Administration of rat acute-phase protein α(2)-macroglobulin before total-body irradiation initiates cytoprotective mechanisms in the liver. Radiat Environ Biophys (2010) 0.76
Regulation of rat haptoglobin gene expression is coordinated by the nuclear matrix. J Cell Biochem (2009) 0.76
Nuclear localization and binding affinity of STAT5b for the alpha(2)-macroglobulin gene promoter during rat liver development and the acute-phase response. Acta Biochim Pol (2007) 0.76
Decreased O-GlcNAcylation of the key proteins in kinase and redox signalling pathways is a novel mechanism of the beneficial effect of α-lipoic acid in diabetic liver. Br J Nutr (2013) 0.76
Biochemical and pharmacological evaluation of 4-hydroxychromen-2-ones bearing polar C-3 substituents as anticoagulants. Eur J Med Chem (2012) 0.75
Catalase inhibition in diabetic rats potentiates DNA damage and apoptotic cell death setting the stage for cardiomyopathy. J Physiol Biochem (2014) 0.75
Characterization of an Mg2+-dependent endonucleolytic activity of the rat hepatocyte nuclear matrix. Comp Biochem Physiol B Biochem Mol Biol (2003) 0.75
Establishment of association of an Mg2+-dependent endonuclease with the rat liver nuclear matrix in cryonecrosis. Cell Biochem Funct (2007) 0.75
Solubility partitioning of C/EBPbeta on the rat hepatocyte nuclear matrix by hydrophobic interactions. Cell Biol Int (2002) 0.75
p53-like protein binding affinity to the hormone responsive element of the haptoglobin gene in fetal rat livers. Cell Biol Int (2002) 0.75
Pharmacological interaction between oxcarbazepine and two COX inhibitors in a rat model of inflammatory hyperalgesia. Pharmacol Biochem Behav (2010) 0.75
The organophosphate-induced acute-phase response is characterized by synthesis of alpha 1-acid glycoprotein that exhibits an immunomodulatory effect. J Appl Toxicol (2008) 0.75