Published in BMC Biol on December 23, 2016
Biological function in the twilight zone of sequence conservation. BMC Biol (2017) 0.76
Population and clinical genetics of human transposable elements in the (post) genomic era. Mob Genet Elements (2017) 0.75
Gene Duplication and Protein Evolution in Tick-Host Interactions. Front Cell Infect Microbiol (2017) 0.75
An integrated encyclopedia of DNA elements in the human genome. Nature (2012) 64.73
The evolutionary fate and consequences of duplicate genes. Science (2000) 24.22
Long non-coding RNAs: insights into functions. Nat Rev Genet (2009) 19.61
The spandrels of San Marco and the Panglossian paradigm: a critique of the adaptationist programme. Proc R Soc Lond B Biol Sci (1979) 14.03
The origins of genome complexity. Science (2003) 12.25
The probability of duplicate gene preservation by subfunctionalization. Genetics (2000) 10.27
Selfish DNA: the ultimate parasite. Nature (1980) 9.85
Selfish genes, the phenotype paradigm and genome evolution. Nature (1980) 9.66
Evolution and tinkering. Science (1977) 9.07
Functionality or transcriptional noise? Evidence for selection within long noncoding RNAs. Genome Res (2007) 7.34
lincRNAs: genomics, evolution, and mechanisms. Cell (2013) 6.50
The evolution of gene duplications: classifying and distinguishing between models. Nat Rev Genet (2010) 5.75
Selection in the evolution of gene duplications. Genome Biol (2002) 5.58
The eukaryotic genome as an RNA machine. Science (2008) 5.29
The frailty of adaptive hypotheses for the origins of organismal complexity. Proc Natl Acad Sci U S A (2007) 4.96
The probability of preservation of a newly arisen gene duplicate. Genetics (2001) 4.42
Origin of a substantial fraction of human regulatory sequences from transposable elements. Trends Genet (2003) 4.39
The complex eukaryotic transcriptome: unexpected pervasive transcription and novel small RNAs. Nat Rev Genet (2009) 4.19
The origins of eukaryotic gene structure. Mol Biol Evol (2005) 4.11
Life, hierarchy, and the thermodynamic machinery of planet Earth. Phys Life Rev (2010) 4.06
The evolution of spliceosomal introns: patterns, puzzles and progress. Nat Rev Genet (2006) 3.64
On the possibility of constructive neutral evolution. J Mol Evol (1999) 3.51
RAG1 core and V(D)J recombination signal sequences were derived from Transib transposons. PLoS Biol (2005) 3.50
Introns and the origin of nucleus-cytosol compartmentalization. Nature (2006) 3.16
The rise of regulatory RNA. Nat Rev Genet (2014) 3.02
On the immortality of television sets: "function" in the human genome according to the evolution-free gospel of ENCODE. Genome Biol Evol (2013) 3.00
Genomics: ENCODE explained. Nature (2012) 2.62
Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs. PLoS Genet (2013) 2.46
What fraction of the human genome is functional? Genome Res (2011) 2.46
Is junk DNA bunk? A critique of ENCODE. Proc Natl Acad Sci U S A (2013) 2.37
Pervasive transcription constitutes a new level of eukaryotic genome regulation. EMBO Rep (2009) 2.22
So much "junk" DNA in our genome. Brookhaven Symp Biol (1972) 2.09
Drift-barrier hypothesis and mutation-rate evolution. Proc Natl Acad Sci U S A (2012) 2.08
Genomics. ENCODE project writes eulogy for junk DNA. Science (2012) 2.05
Non-coding RNAs: Meet thy masters. Bioessays (2010) 1.90
The origin of introns and their role in eukaryogenesis: a compromise solution to the introns-early versus introns-late debate? Biol Direct (2006) 1.88
ENCODE: The human encyclopaedia. Nature (2012) 1.87
Cell biology. Irremediable complexity? Science (2010) 1.85
Genomic scrap yard: how genomes utilize all that junk. Gene (2000) 1.84
Gene duplication as a mechanism of genomic adaptation to a changing environment. Proc Biol Sci (2012) 1.83
Pervasive transcription of the eukaryotic genome: functional indices and conceptual implications. Brief Funct Genomic Proteomic (2009) 1.79
Trends in prokaryotic evolution revealed by comparison of closely related bacterial and archaeal genomes. J Bacteriol (2008) 1.79
Ancestral paralogs and pseudoparalogs and their role in the emergence of the eukaryotic cell. Nucleic Acids Res (2005) 1.77
Origin and evolution of spliceosomal introns. Biol Direct (2012) 1.65
Transposable elements as a significant source of transcription regulating signals. Gene (2006) 1.58
The extinction dynamics of bacterial pseudogenes. PLoS Genet (2010) 1.53
What does our genome encode? Genome Res (2012) 1.47
Evidence for turnover of functional noncoding DNA in mammalian genome evolution. Genomics (2004) 1.45
The function of introns. Front Genet (2012) 1.42
Transposable elements in gene regulation and in the evolution of vertebrate genomes. Curr Opin Genet Dev (2009) 1.42
Deletional bias across the three domains of life. Genome Biol Evol (2009) 1.40
The bioenergetic costs of a gene. Proc Natl Acad Sci U S A (2015) 1.30
How a neutral evolutionary ratchet can build cellular complexity. IUBMB Life (2011) 1.28
Evolution of molecular error rates and the consequences for evolvability. Proc Natl Acad Sci U S A (2011) 1.23
Can ENCODE tell us how much junk DNA we carry in our genome? Biochem Biophys Res Commun (2012) 1.16
Prp8, the pivotal protein of the spliceosomal catalytic center, evolved from a retroelement-encoded reverse transcriptase. RNA (2011) 1.13
Selective forces for the origin of the eukaryotic nucleus. Bioessays (2006) 1.11
One Loop to Rule Them All: The Ping-Pong Cycle and piRNA-Guided Silencing. Trends Biochem Sci (2016) 1.08
Intron-dominated genomes of early ancestors of eukaryotes. J Hered (2009) 1.07
The Hedgehog protein family. Genome Biol (2008) 1.05
The exaptive excellence of spandrels as a term and prototype. Proc Natl Acad Sci U S A (1997) 1.02
Evolution of the RAG1-RAG2 locus: both proteins came from the same transposon. Biol Direct (2015) 1.00
A non-adaptationist perspective on evolution of genomic complexity or the continued dethroning of man. Cell Cycle (2004) 0.98
Maintenance and Loss of Duplicated Genes by Dosage Subfunctionalization. Mol Biol Evol (2015) 0.96
Complexity and tinkering. Ann N Y Acad Sci (2001) 0.93
Constructive neutral evolution: exploring evolutionary theory's curious disconnect. Biol Direct (2012) 0.89
An evolutionary classification of genomic function. Genome Biol Evol (2015) 0.87
Genetic drift, selection and the evolution of the mutation rate. Nat Rev Genet (2016) 0.87
Long noncoding RNA (lincRNA), a new paradigm in gene expression control. Funct Integr Genomics (2016) 0.85
Taking the pseudo out of pseudogenes. Curr Opin Microbiol (2014) 0.85
Theory of prokaryotic genome evolution. Proc Natl Acad Sci U S A (2016) 0.84
"Nothing in biology makes sense except in the light of evolution": Theodosius Dobzhansky: 1900-1975. J Hered (1977) 0.80
It is not the entropy you produce, rather, how you produce it. Philos Trans R Soc Lond B Biol Sci (2010) 0.80
Transposable Element Insertions in Long Intergenic Non-Coding RNA Genes. Front Bioeng Biotechnol (2015) 0.79
The meaning of biological information. Philos Trans A Math Phys Eng Sci (2016) 0.78
Drift Barriers to Quality Control when Genes Are Expressed at Different Levels. Genetics (2016) 0.77