Published in Nat Immunol on January 16, 2017
Macrophages: mTORC1 drives granulomas. Nat Rev Immunol (2017) 0.75
TORmented macrophages spontaneously form granulomas. Nat Immunol (2017) 0.75
Lymphangioleiomyomatosis, multifocal micronodular pneumocyte hyperplasia, and sarcoidosis: more pathological findings in the same chest CT, or a single pathological pathway? BMC Pulm Med (2017) 0.75
Mass Cytometry Identifies Distinct Lung CD4(+) T Cell Patterns in Löfgren's Syndrome and Non-Löfgren's Syndrome Sarcoidosis. Front Immunol (2017) 0.75
mTOR signaling in growth control and disease. Cell (2012) 29.21
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol (2002) 17.41
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene (2004) 7.92
Module map of stem cell genes guides creation of epithelial cancer stem cells. Cell Stem Cell (2008) 7.69
Immunity to tuberculosis. Annu Rev Immunol (2004) 5.60
Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nat Med (2013) 4.14
Foamy macrophages and the progression of the human tuberculosis granuloma. Nat Immunol (2009) 3.17
Metabolic pathways in immune cell activation and quiescence. Immunity (2013) 3.09
Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation. J Immunol (2010) 2.88
Revisiting the role of the granuloma in tuberculosis. Nat Rev Immunol (2012) 2.86
Regulation and function of mTOR signalling in T cell fate decisions. Nat Rev Immunol (2012) 2.79
Cyclin-dependent kinases and cell-cycle transitions: does one fit all? Nat Rev Mol Cell Biol (2008) 2.48
Sarcoidosis: clinical presentation, immunopathogenesis, and therapeutics. JAMA (2011) 2.39
Beyond stem cells: self-renewal of differentiated macrophages. Science (2013) 2.23
Control of cell cycle transcription during G1 and S phases. Nat Rev Mol Cell Biol (2013) 2.17
Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung. Am J Respir Cell Mol Biol (2013) 1.90
Results of 188 whole-body fluorodeoxyglucose positron emission tomography scans in 137 patients with sarcoidosis. Chest (2007) 1.79
The TSC-mTOR pathway regulates macrophage polarization. Nat Commun (2013) 1.57
The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes. Nat Immunol (2006) 1.49
Genome-wide association analysis reveals 12q13.3-q14.1 as new risk locus for sarcoidosis. Eur Respir J (2012) 1.47
Development of everolimus, a novel oral mTOR inhibitor, across a spectrum of diseases. Ann N Y Acad Sci (2013) 1.41
A growing role for mTOR in promoting anabolic metabolism. Biochem Soc Trans (2013) 1.37
The schistosoma granuloma: friend or foe? Front Immunol (2013) 1.34
Generation of a conditional disruption of the Tsc2 gene. Genesis (2007) 1.32
Lethal granuloma disintegration in mycobacteria-infected TNFRp55-/- mice is dependent on T cells and IL-12. J Immunol (2000) 1.30
The balance between protective and pathogenic immune responses in the TB-infected lung. Nat Immunol (2015) 1.30
Regulation of innate immune cell function by mTOR. Nat Rev Immunol (2015) 1.27
Targeting CDK4 and CDK6: From Discovery to Therapy. Cancer Discov (2015) 1.27
Host evasion and exploitation schemes of Mycobacterium tuberculosis. Cell (2014) 1.22
The granuloma in tuberculosis: dynamics of a host-pathogen collusion. Front Immunol (2013) 1.15
The role of tuberous sclerosis complex 1 in regulating innate immunity. J Immunol (2012) 1.13
Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells. Proc Natl Acad Sci U S A (2013) 1.08
Transgenic expression of cyclin-dependent kinase 4 results in epidermal hyperplasia, hypertrophy, and severe dermal fibrosis. Am J Pathol (2001) 1.05
M2 polarized macrophages and giant cells contribute to myofibrosis in neuromuscular sarcoidosis. Am J Pathol (2011) 1.05
Local proliferation of macrophages in adipose tissue during obesity-induced inflammation. Diabetologia (2013) 1.05
The formation of the granuloma in tuberculosis infection. Semin Immunol (2014) 1.00
Efficient siRNA-mediated prolonged gene silencing in human amniotic fluid stem cells. Nat Protoc (2010) 1.00
Gene set analysis of lung samples provides insight into pathogenesis of progressive, fibrotic pulmonary sarcoidosis. Am J Respir Crit Care Med (2010) 0.98
Current and emerging pharmacological treatments for sarcoidosis: a review. Drug Des Devel Ther (2013) 0.94
Heme oxygenase-1 promotes granuloma development and protects against dissemination of mycobacteria. Lab Invest (2012) 0.92
Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis. Semin Immunopathol (2015) 0.92
The role of the innate immune system in granulomatous disorders. Front Immunol (2013) 0.89
Local macrophage proliferation in multinucleated giant cell and granuloma formation in experimental Goodpasture's syndrome. Am J Pathol (1995) 0.87
IL-1α induces CD11b(low) alveolar macrophage proliferation and maturation during granuloma formation. J Pathol (2015) 0.84
Proliferating alveolar macrophages in BAL and lung function changes in interstitial lung disease. Eur Respir J (1993) 0.82
Enhanced proliferation and decreased apoptosis in lung lavage cells of sarcoidosis patients. Sarcoidosis Vasc Diffuse Lung Dis (2006) 0.81
Worsening of pulmonary sarcoidosis. Curr Opin Pulm Med (2014) 0.80
Tsc1 is a Critical Regulator of Macrophage Survival and Function. Cell Physiol Biochem (2015) 0.79
Cellular Players in the Immunopathogenesis of Sarcoidosis. Clin Chest Med (2015) 0.79
Successful treatment of systemic de novo sarcoidosis with cyclosporine discontinuation and provision of rapamune after liver transplantation. Transpl Int (2011) 0.79
Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease. Nat Immunol (2016) 1.45
mTORC1 and mTORC2 as regulators of cell metabolism in immunity. FEBS Lett (2017) 0.75
mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review. Gerontology (2017) 0.75
Multiparametric [11C]Acetate positron emission tomography-magnetic resonance imaging in the assessment and staging of prostate cancer. PLoS One (2017) 0.75
STAT5BN642H is a driver mutation for T cell neoplasia. J Clin Invest (2017) 0.75
A New Immunomodulatory Role for Peroxisomes in Macrophages Activated by the TLR4 Ligand Lipopolysaccharide. J Immunol (2017) 0.75