Hippocampal CysLT1R knockdown or blockade represses LPS-induced depressive behaviors and neuroinflammatory response in mice.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28112182)

Published in Acta Pharmacol Sin on January 23, 2017

Authors

Jing-Ran Lin1, Shun-Chang Fang1, Su-Su Tang1, Mei Hu1, Yan Long1, Arijit Ghosh1, Hong-Bin Sun1, Ling-Yi Kong1, Hao Hong1

Author Affiliations

1: Department of Pharmacology, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.

Articles cited by this

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science (2003) 16.14

From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci (2008) 15.90

Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther (1977) 8.46

Grand challenges in global mental health. Nature (2011) 8.40

Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia (2007) 5.67

Biological basis of the behavior of sick animals. Neurosci Biobehav Rev (1988) 5.03

The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. Neurosci Biobehav Rev (2005) 4.64

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice. Mol Psychiatry (2008) 3.28

Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus. Neuron (2013) 2.74

Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia. J Neuroinflammation (2008) 2.53

Microglia: biology and pathology. Acta Neuropathol (2009) 2.51

Research and treatment approaches to depression. Nat Rev Neurosci (2001) 2.24

Nuclear factor-kappaB activation: from bench to bedside. Exp Biol Med (Maywood) (2008) 2.19

The effect of antidepressant medication treatment on serum levels of inflammatory cytokines: a meta-analysis. Neuropsychopharmacology (2011) 2.15

Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: a meta-analysis and meta-regression. J Affect Disord (2011) 1.58

Depression: an inflammatory illness? J Neurol Neurosurg Psychiatry (2012) 1.50

Baseline mood and psychosocial characteristics of patients developing depressive symptoms during interleukin-2 and/or interferon-alpha cancer therapy. Brain Behav Immun (2004) 1.43

Transcriptional activation of indoleamine dioxygenase by interleukin 1 and tumor necrosis factor alpha in interferon-treated epithelial cells. Cytokine (2000) 1.41

Effects of interleukin-1 and endotoxin in the forced swim and tail suspension tests in mice. Pharmacol Biochem Behav (2005) 1.40

Therapeutic options for treatment-resistant depression. CNS Drugs (2010) 1.30

Cysteinyl leukotrienes and their receptors: molecular and functional characteristics. Pharmacology (2010) 1.20

Antidepressant effects of TrkB ligands on depression-like behavior and dendritic changes in mice after inflammation. Int J Neuropsychopharmacol (2014) 1.18

Regulation of interleukin-6 gene expression in brain of aged mice by nuclear factor kappaB. J Neuroimmunol (2001) 1.12

Antiasthmatic drugs targeting the cysteinyl leukotriene receptor 1 alleviate central nervous system inflammatory cell infiltration and pathogenesis of experimental autoimmune encephalomyelitis. J Immunol (2011) 1.11

Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug. Nat Commun (2015) 1.10

Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton. J Pharmacol Exp Ther (2007) 1.04

Depressive-like behavior induced by tumor necrosis factor-α in mice. Neuropharmacology (2011) 1.03

NF-kappaB downregulation may be involved the depression of tumor cell proliferation mediated by human mesenchymal stem cells. Acta Pharmacol Sin (2008) 0.99

Rho kinase inhibitor fasudil protects against β-amyloid-induced hippocampal neurodegeneration in rats. CNS Neurosci Ther (2013) 0.94

Prostaglandins mediate depressive-like behaviour induced by endotoxin in mice. Behav Brain Res (2010) 0.90

Cysteinyl leukotrienes induce nuclear factor kappa b activation and RANTES production in a murine model of asthma. J Allergy Clin Immunol (2003) 0.89

Expression of cysteinyl leukotriene receptor 1 in human traumatic brain injury and brain tumors. Neurosci Lett (2004) 0.89

Protective effect of pranlukast on Aβ₁₋₄₂-induced cognitive deficits associated with downregulation of cysteinyl leukotriene receptor 1. Int J Neuropsychopharmacol (2013) 0.89

Efficacy and tolerability of antidepressants for treatment of depression in coronary artery disease: a meta-analysis. Can J Psychiatry (2010) 0.88

Antidepressant-like effect of nitric oxide synthase inhibitors and sildenafil against lipopolysaccharide-induced depressive-like behavior in mice. Neuroscience (2014) 0.87

Effects of doxycycline on depressive-like behavior in mice after lipopolysaccharide (LPS) administration. J Psychiatr Res (2013) 0.86

CysLT1 receptor engagement induces activator protein-1- and NF-kappaB-dependent IL-8 expression. Am J Respir Cell Mol Biol (2006) 0.86

Cysteinyl leukotriene receptors CysLT1 and CysLT2 are upregulated in acute neuronal injury after focal cerebral ischemia in mice. Acta Pharmacol Sin (2006) 0.85

Effects of bupropion augmentation on pro-inflammatory cytokines in escitalopram-resistant patients with major depressive disorder. J Psychopharmacol (2008) 0.84

Cysteinyl leukotrienes induce monocyte chemoattractant protein-1 in human monocyte/macrophages via mitogen-activated protein kinase and nuclear factor-kappaB pathways. Int Arch Allergy Immunol (2009) 0.84

Leukotriene D4 upregulates MUC2 gene transcription in human epithelial cells. Pharmacology (2008) 0.82

Leukotriene D4 induces amyloid-β generation via CysLT(1)R-mediated NF-κB pathways in primary neurons. Neurochem Int (2013) 0.79

Doxycycline Suppresses Microglial Activation by Inhibiting the p38 MAPK and NF-kB Signaling Pathways. Neurotox Res (2016) 0.78

Protective effect of pranlukast, a cysteinyl-leukotriene receptor 1 antagonist, on indomethacin-induced small intestinal damage in rats. Inflammopharmacology (2007) 0.77

Knockdown of hippocampal cysteinyl leukotriene receptor 1 prevents depressive behavior and neuroinflammation induced by chronic mild stress in mice. Psychopharmacology (Berl) (2015) 0.77

Salvianolic acid B ameliorates depressive-like behaviors in chronic mild stress-treated mice: involvement of the neuroinflammatory pathway. Acta Pharmacol Sin (2016) 0.77

The effect of the leukotriene receptor antagonist zafirlukast on neurokinin A-induced bronchoconstriction in patients with asthma--A comparison with leukotriene D4 induced broncoconstriction. Pulm Pharmacol Ther (2007) 0.76

Cysteinyl Leukotrienes and Their Receptors: Emerging Therapeutic Targets in Central Nervous System Disorders. CNS Neurosci Ther (2016) 0.76