Identification of a tumor-reactive T-cell repertoire in the immune infiltrate of patients with resectable pancreatic ductal adenocarcinoma.

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Published in Oncoimmunology on October 07, 2016

Authors

Isabel Poschke1, Marta Faryna2, Frank Bergmann3, Michael Flossdorf4, Claudia Lauenstein1, Jennifer Hermes1, Ulf Hinz5, Thomas Hank5, Roland Ehrenberg6, Michael Volkmar1, Martin Loewer7, Hanno Glimm8, Thilo Hackert5, Martin R Sprick9, Thomas Höfer4, Andreas Trumpp9, Niels Halama10, Jessica C Hassel11, Oliver Strobel5, Markus Büchler5, Ugur Sahin12, Rienk Offringa13

Author Affiliations

1: Division of Molecular Oncology of Gastrointestinal Tumors, German Cancer Research Center , Heidelberg, Germany.
2: BioNTech Diagnostics GmbH , Mainz, Germany.
3: Department of Pathology, Heidelberg University Hospital , Heidelberg, Germany.
4: Division of Theoretical Systems Biology, German Cancer Research Center and BioQuant Center, University of Heidelberg , Heidelberg, Germany.
5: Department of General, Visceral and Transplantation Surgery , Heidelberg University Hospital, Heidelberg, Germany.
6: Division of Applied Stem Cell Biology, National Center for Tumor Diseases, Heidelberg, Germany; National Center for Tumor Diseases, Department of Medical Oncology, Heidelberg University Hospital, Heidelberg, Germany.
7: TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University , Mainz, Germany.
8: Division of Applied Stem Cell Biology, National Center for Tumor Diseases , Heidelberg, Germany.
9: Division of Stem Cells and Cancer, German Cancer Research Center, Heidelberg , Germany and HI-STEM gGmbH , Heidelberg, Germany.
10: National Center for Tumor Diseases, Department of Medical Oncology, Heidelberg University Hospital , Heidelberg, Germany.
11: Department of Dermatology and National Center for Tumor Diseases, Heidelberg University Hospital , Heidelberg, Germany.
12: TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University, Mainz, Germany; BioNTech AG, Mainz, Germany.
13: Division of Molecular Oncology of Gastrointestinal Tumors, German Cancer Research Center, Heidelberg, Germany; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.

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