Published in Thromb Res on August 15, 1989
Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature (2000) 7.66
The mechanism of Z alpha 1-antitrypsin accumulation in the liver. Nature (1992) 5.71
The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature. J Biol Chem (2001) 4.81
The outline structure of the T-cell alpha beta receptor. EMBO J (1988) 4.37
Structure and variation of human alpha 1-antitrypsin. Nature (1982) 4.13
Structure of a serpin-protease complex shows inhibition by deformation. Nature (2000) 4.02
Increased fetal loss in women with heritable thrombophilia. Lancet (1996) 3.34
Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm. Development (1993) 3.25
Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins. Biochemistry (1989) 3.18
The anticoagulant activation of antithrombin by heparin. Proc Natl Acad Sci U S A (1997) 3.09
The estimation of red cell superoxide dismutase activity. J Lab Clin Med (1975) 2.75
A method for measuring the non-random bias of a codon usage table. Nucleic Acids Res (1984) 2.57
Sequence comparison by exponentially-damped alignment. Nucleic Acids Res (1984) 2.50
Mutation of antitrypsin to antithrombin. alpha 1-antitrypsin Pittsburgh (358 Met leads to Arg), a fatal bleeding disorder. N Engl J Med (1983) 2.36
What do dysfunctional serpins tell us about molecular mobility and disease? Nat Struct Biol (1995) 2.30
Risk of a first venous thrombotic event in carriers of a familial thrombophilic defect. The European Prospective Cohort on Thrombophilia (EPCOT). J Thromb Haemost (2005) 2.13
Variations in the structure of human haemoglobin. With particular reference to the unstable haemoglobins. Br Med Bull (1969) 2.07
Smoking, lung function, and alpha 1-antitrypsin deficiency. Lancet (1985) 1.99
Oral surgery in anticoagulated patients without reducing the dose of oral anticoagulant: a prospective randomized study. J Oral Maxillofac Surg (1996) 1.89
Familial dementia caused by polymerization of mutant neuroserpin. Nature (1999) 1.88
A simple method for the detection of unstable haemoglobins. Br J Haematol (1972) 1.87
Genetic susceptibility to thrombosis and its relationship to physiological risk factors: the GAIT study. Genetic Analysis of Idiopathic Thrombophilia. Am J Hum Genet (2000) 1.69
Reactions involving superoxide and normal and unstable haemoglobins. Biochem J (1976) 1.66
Inhibitory conformation of the reactive loop of alpha 1-antitrypsin. Nat Struct Biol (1996) 1.66
Electric-field control of exchange bias in multiferroic epitaxial heterostructures. Phys Rev Lett (2006) 1.65
Genetic determinants of hemostasis phenotypes in Spanish families. Circulation (2000) 1.63
alpha 1-Antitrypsin: molecular pathology, leukocytes, and tissue damage. J Clin Invest (1986) 1.61
Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient mice. Mol Cell Neurosci (2001) 1.58
D-Dimer is an early diagnostic marker of coronary ischemia in patients with chest pain. Am Heart J (2000) 1.57
Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease. Proc Natl Acad Sci U S A (2000) 1.54
Hyponatremia in ultradistance triathletes. Med Sci Sports Exerc (1999) 1.53
A circulating variant of human proalbumin. Nature (1978) 1.52
Crystal structure of uncleaved ovalbumin at 1.95 A resolution. J Mol Biol (1991) 1.52
Evolution of leukotriene B4, peptide leukotrienes, and interleukin-8 plasma concentrations in patients at risk of acute respiratory distress syndrome and with acute respiratory distress syndrome: mortality prognostic study. Crit Care Med (2000) 1.50
The mouse homolog of the orphan nuclear receptor tailless is expressed in the developing forebrain. Development (1995) 1.49
Effect of the Z mutation on the physical and inhibitory properties of alpha 1-antitrypsin. Biochemistry (1993) 1.49
Hormone binding globulins undergo serpin conformational change in inflammation. Nature (1988) 1.47
Abnormal haem binding and globin SH group blockade in unstable haemoglobins. Nature (1968) 1.44
Familial thrombophilia and lifetime risk of venous thrombosis. J Thromb Haemost (2004) 1.44
Plakalbumin, alpha 1-antitrypsin, antithrombin and the mechanism of inflammatory thrombosis. Nature (1985) 1.44
Crystal structure of ovalbumin as a model for the reactive centre of serpins. Nature (1990) 1.42
Alpha 1-antitrypsin Siiyama (Ser53-->Phe). Further evidence for intracellular loop-sheet polymerization. J Biol Chem (1993) 1.41
Activated oxygen and haemolysis. Br J Haematol (1975) 1.41
Massive skin necrosis associated to the prothrombin gene G20210A mutation. Thromb Haemost (2000) 1.40
A new hemoglobin variant resembling hemoglobin E. Hemoglobin E Saskatoon: beta-22 Glu replaced by Lys. Can J Biochem (1967) 1.40
The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion. Structure (1999) 1.40
Activated protein C resistance assay when applied in the general population. Am J Obstet Gynecol (1997) 1.39
A prospective evaluation of cerebral infarction following transcervical carotid stenting with carotid flow reversal. Eur J Vasc Endovasc Surg (2010) 1.39
Studies of hemoglobin denaturation and Heinz body formation in the unstable hemoglobins. J Clin Invest (1974) 1.39
Heparin-induced thrombocytopenia and heart operation: management with tedelparin. Ann Thorac Surg (1995) 1.38
Laboratory evaluation and clinical characteristics of 2,132 consecutive unselected patients with venous thromboembolism--results of the Spanish Multicentric Study on Thrombophilia (EMET-Study). Thromb Haemost (1997) 1.36
Imprisonment of J-P Allain. Lancet (1993) 1.34
Haemoglobin Köln (beta-98 valine--methionine): an unstable protein causing inclusion-body anaemia. Nature (1966) 1.33
alpha 1-Antitrypsin Mmalton (Phe52-deleted) forms loop-sheet polymers in vivo. Evidence for the C sheet mechanism of polymerization. J Biol Chem (1995) 1.33
Differences between alpha- and beta-chain mutants of human haemoglobin and between alpha- and beta-thalassaemia. Possible duplication of the alpha-chain gene. Br Med J (1968) 1.33
The serpins: evolution and adaptation in a family of protease inhibitors. Cold Spring Harb Symp Quant Biol (1987) 1.30
Prothrombotic state and signs of endothelial lesion in plasma of patients with inflammatory bowel disease. Dig Dis Sci (1995) 1.29
Effects of mutations in the hinge region of serpins. Biochemistry (1993) 1.29
The unstable haemoglobin haemolytic anaemias. Semin Hematol (1969) 1.27
The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site. J Mol Biol (1997) 1.27
Functional effects of the ABO locus polymorphism on plasma levels of von Willebrand factor, factor VIII, and activated partial thromboplastin time. Arterioscler Thromb Vasc Biol (2000) 1.27
A 2.6 A structure of a serpin polymer and implications for conformational disease. J Mol Biol (1999) 1.26
Structural and functional characterization of the abnormal Z alpha 1-antitrypsin isolated from human liver. FEBS Lett (1984) 1.24
Comparison of gentamicin dosing regimens using an in-vitro model. J Antimicrob Chemother (1992) 1.23
Oxidation of human haemoglobin by copper. Mechanism and suggested role of the thiol group of residue beta-93. Biochem J (1977) 1.22
The serpin inhibitory mechanism is critically dependent on the length of the reactive center loop. J Biol Chem (2001) 1.22
Spontaneous retroperitoneal hemorrhage during oral anticoagulant therapy. Arch Intern Med (1985) 1.21
Diagnosis and prevention of hyponatremia at an ultradistance triathlon. Clin J Sport Med (2000) 1.17
The significance of monoclonal gammopathy in a normal population. Aust N Z J Med (1971) 1.16
Basis of the defect in alpha-1-antitrypsin deficiency. Nature (1973) 1.16
A prospective study of exercise-associated hyponatremia in two ultradistance triathletes. Clin J Sport Med (2000) 1.16
Preparation and characterization of latent alpha 1-antitrypsin. J Biol Chem (1995) 1.15
Thromboembolic disease due to thermolabile conformational changes of antithrombin Rouen-VI (187 Asn-->Asp) J Clin Invest (1994) 1.14
Prevalence of antithrombin deficiency in the healthy population. Br J Haematol (1994) 1.13
Yeast KEX2 protease has the properties of a human proalbumin converting enzyme. Science (1987) 1.13
Fluid balance during and after an ironman triathlon. Clin J Sport Med (2001) 1.13
A new doubly substituted sickling haemoglobin: HbS-Oman. Br J Haematol (1989) 1.12
Conformational changes in serpins: II. The mechanism of activation of antithrombin by heparin. J Mol Biol (2000) 1.12
Linkage analysis demonstrates that the prothrombin G20210A mutation jointly influences plasma prothrombin levels and risk of thrombosis. Blood (2000) 1.11
The amino acid sequence of the alpha chain of the major haemoglobin of the rat (Rattus norvegicus). Biochem J (1975) 1.11
The sequence of the major protein stored in ovine ceroid lipofuscinosis is identical with that of the dicyclohexylcarbodiimide-reactive proteolipid of mitochondrial ATP synthase. Biochem J (1990) 1.11
Magnetization reversal by electric-field decoupling of magnetic and ferroelectric domain walls in multiferroic-based heterostructures. Phys Rev Lett (2011) 1.11
LPA1 receptor-deficient mice have phenotypic changes observed in psychiatric disease. Mol Cell Neurosci (2003) 1.11
Surface symmetry-breaking and strain effects on orbital occupancy in transition metal perovskite epitaxial films. Nat Commun (2012) 1.10
alpha 1-Antitrypsin microheterogeneity. Isolation and physiological significance of isoforms. Biochim Biophys Acta (1982) 1.10
Nanoscale multiphase separation at La(2/3)Ca(1/3)MnO3/SrTiO3 interfaces. Phys Rev Lett (2001) 1.10
Exercise-induced hyponatremia in ultradistance triathletes is caused by inappropriate fluid retention. Clin J Sport Med (2000) 1.09
Mechanism of oxyhaemoglobin breakdown on reaction with acetylphenylhydrazine. Biochem J (1978) 1.06
Inhibition of plasmin, urokinase, tissue plasminogen activator, and C1S by a myxoma virus serine proteinase inhibitor. J Biol Chem (1993) 1.06
Dysfunctional C1-inhibitor(At), isolated from a type II hereditary-angio-oedema plasma, contains a P1 'reactive centre' (Arg444----His) mutation. Biochem J (1988) 1.06
Alpha-1-antitrypsin-Pittsburgh. A potent inhibitor of human plasma factor XIa, kallikrein, and factor XIIf. J Clin Invest (1986) 1.05
Structural explanation for the deficiency of S alpha 1-antitrypsin. Nat Struct Biol (1996) 1.04
Antithrombins Wibble and Wobble (T85M/K): archetypal conformational diseases with in vivo latent-transition, thrombosis, and heparin activation. Blood (1998) 1.04
Implications for function and therapy of a 2.9 A structure of binary-complexed antithrombin. J Mol Biol (1998) 1.03
Importance of the release of strand 1C to the polymerization mechanism of inhibitory serpins. Protein Sci (1997) 1.03
The conformational activation of antithrombin. A 2.85-A structure of a fluorescein derivative reveals an electrostatic link between the hinge and heparin binding regions. J Biol Chem (2000) 1.03
Human alpha 1-antitrypsin: carbohydrate attachment and sequence homology. FEBS Lett (1981) 1.02
Heparin-dependent modification of the reactive center arginine of antithrombin and consequent increase in heparin binding affinity. J Biol Chem (1997) 1.00