Published in Science on January 16, 1987
Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins. Biochem J (1997) 4.31
Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo. J Cell Biol (1990) 3.03
Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site. Proc Natl Acad Sci U S A (1990) 2.48
Sequence requirements for proteolytic processing of glycoprotein B of human cytomegalovirus strain Towne. J Virol (1990) 1.33
Structural changes and metal binding by proalbumins and other amino-terminal genetic variants of human serum albumin. Proc Natl Acad Sci U S A (1987) 1.20
Birnavirus precursor polyprotein is processed in Escherichia coli by its own virus-encoded polypeptide. J Virol (1988) 1.08
Albumin Redhill (-1 Arg, 320 Ala----Thr): a glycoprotein variant of human serum albumin whose precursor has an aberrant signal peptidase cleavage site. Proc Natl Acad Sci U S A (1990) 1.02
Novel glycosylation pathways of retroviral envelope proteins identified with avian reticuloendotheliosis virus. J Virol (1988) 0.93
Processing and trafficking of clotting factor X in the secretory pathway. Effects of warfarin. Biochem J (1992) 0.87
Identification of an enzyme in human kidney that correctly processes prorenin. Proc Natl Acad Sci U S A (1990) 0.85
Processing of proopiomelanocortin by insulin secretory granule proinsulin processing endopeptidases. J Biol Chem (1993) 0.82
Purification and characterization of recombinant human interleukin 4. Biological activities, receptor binding and the generation of monoclonal antibodies. Biochem J (1989) 0.78
Endoproteolytic processing of recombinant proalbumin variants by the yeast Kex2 protease. Biochem J (1995) 0.77
Genetic organization and diversity of the hepatitis C virus. Proc Natl Acad Sci U S A (1991) 14.05
Nucleotide sequence and expression of an AIDS-associated retrovirus (ARV-2). Science (1985) 10.97
Characterization of ribosomal frameshifting in HIV-1 gag-pol expression. Nature (1988) 10.69
Cell-specific expression of the rat insulin gene: evidence for role of two distinct 5' flanking elements. Science (1985) 8.44
Elevated levels of mRNA can account for the trans-activation of human immunodeficiency virus. Proc Natl Acad Sci U S A (1986) 6.57
A capsaicin-receptor homologue with a high threshold for noxious heat. Nature (1999) 5.85
The mechanism of Z alpha 1-antitrypsin accumulation in the liver. Nature (1992) 5.71
(E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent. Proc Natl Acad Sci U S A (1979) 5.28
The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature. J Biol Chem (2001) 4.81
Structure and variation of human alpha 1-antitrypsin. Nature (1982) 4.13
Structure of a serpin-protease complex shows inhibition by deformation. Nature (2000) 4.02
Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule. Science (1994) 3.98
Purification and complementary DNA cloning of a receptor for basic fibroblast growth factor. Science (1989) 3.83
Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel. Science (1991) 3.73
Redesigning trypsin: alteration of substrate specificity. Science (1985) 3.70
Expression cloning of an ATP receptor from mouse neuroblastoma cells. Proc Natl Acad Sci U S A (1993) 3.68
Intracellular targeting and structural conservation of a prohormone-processing endoprotease. Science (1989) 3.61
On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs. Cell (1983) 3.56
Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins. Biochemistry (1989) 3.18
Nucleotide sequence of SRV-1, a type D simian acquired immune deficiency syndrome retrovirus. Science (1986) 3.11
The anticoagulant activation of antithrombin by heparin. Proc Natl Acad Sci U S A (1997) 3.09
Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo. J Cell Biol (1990) 3.03
Anti-inflammatory properties of a platelet-activating factor acetylhydrolase. Nature (1995) 2.79
The estimation of red cell superoxide dismutase activity. J Lab Clin Med (1975) 2.75
Alpha-factor-directed synthesis and secretion of mature foreign proteins in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1984) 2.74
Macrophage inflammatory protein 1 modulates macrophage function. J Immunol (1992) 2.66
A recombinant baculovirus 42-kilodalton C-terminal fragment of Plasmodium falciparum merozoite surface protein 1 protects Aotus monkeys against malaria. Infect Immun (1996) 2.60
Sequences homologous to the variant antigen mRNA spliced leader are located in tandem repeats and variable orphons in trypanosoma brucei. Cell (1983) 2.53
Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site. Proc Natl Acad Sci U S A (1990) 2.48
Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. Nature (1995) 2.48
Mutation of antitrypsin to antithrombin. alpha 1-antitrypsin Pittsburgh (358 Met leads to Arg), a fatal bleeding disorder. N Engl J Med (1983) 2.36
A carboxyl-terminal fragment of Plasmodium falciparum gp195 expressed by a recombinant baculovirus induces antibodies that completely inhibit parasite growth. J Immunol (1992) 2.32
Complete murine cDNA sequence, genomic structure, and tissue expression of the high mobility group protein HMG-I(Y). J Biol Chem (1988) 2.30
What do dysfunctional serpins tell us about molecular mobility and disease? Nat Struct Biol (1995) 2.30
Cloning of three human multifunctional de novo purine biosynthetic genes by functional complementation of yeast mutations. Proc Natl Acad Sci U S A (1990) 2.16
Recombinant Pfs25 protein of Plasmodium falciparum elicits malaria transmission-blocking immunity in experimental animals. J Exp Med (1991) 2.15
Variations in the structure of human haemoglobin. With particular reference to the unstable haemoglobins. Br Med Bull (1969) 2.07
Sequence relationships of type D retroviruses which cause simian acquired immunodeficiency syndrome. Virology (1987) 2.04
Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15. DNA Cell Biol (1991) 2.02
Smoking, lung function, and alpha 1-antitrypsin deficiency. Lancet (1985) 1.99
Molecular cloning and structural characterization of the Arg-gingipain proteinase of Porphyromonas gingivalis. Biosynthesis as a proteinase-adhesin polyprotein. J Biol Chem (1995) 1.98
Three-dimensional structure of human basic fibroblast growth factor. Proc Natl Acad Sci U S A (1991) 1.94
Mammalian subtilisin-related proteinases in cleavage activation of the paramyxovirus fusion glycoprotein: superiority of furin/PACE to PC2 or PC1/PC3. J Virol (1992) 1.91
Familial dementia caused by polymerization of mutant neuroserpin. Nature (1999) 1.88
Saccharomyces cerevisiae recombinant Pfs25 adsorbed to alum elicits antibodies that block transmission of Plasmodium falciparum. Infect Immun (1994) 1.87
A simple method for the detection of unstable haemoglobins. Br J Haematol (1972) 1.87
Chemical synthesis of a gene for human epidermal growth factor urogastrone and its expression in yeast. Proc Natl Acad Sci U S A (1983) 1.81
Differential antibody responses of individuals infected with AIDS-associated retroviruses surveyed using the viral core antigen p25gag expressed in bacteria. Virology (1986) 1.81
Different accessibilities in chromatin to histone acetylase. J Biol Chem (1979) 1.79
Three-dimensional structure of human basic fibroblast growth factor, a structural homolog of interleukin 1 beta. Proc Natl Acad Sci U S A (1991) 1.73
Acidic and basic fibroblast growth factors stimulate tyrosine kinase activity in vivo. J Biol Chem (1988) 1.70
Reactions involving superoxide and normal and unstable haemoglobins. Biochem J (1976) 1.66
Inhibitory conformation of the reactive loop of alpha 1-antitrypsin. Nat Struct Biol (1996) 1.66
The ompA signal peptide directed secretion of Staphylococcal nuclease A by Escherichia coli. J Biol Chem (1985) 1.65
Ligand-affinity cloning and structure of a cell surface heparan sulfate proteoglycan that binds basic fibroblast growth factor. Proc Natl Acad Sci U S A (1990) 1.62
alpha 1-Antitrypsin: molecular pathology, leukocytes, and tissue damage. J Clin Invest (1986) 1.61
beta-Galactosidase chimeras: primary structure of a lac repressor-beta-galactosidase protein. Proc Natl Acad Sci U S A (1978) 1.60
Importance of hypervariable regions of HIV-1 gp120 in the generation of virus neutralizing antibodies. AIDS Res Hum Retroviruses (1990) 1.60
Synthetic peptide vaccine confers protection against murine malaria. J Exp Med (1987) 1.58
Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2. Curr Biol (1996) 1.57
Human immunodeficiency virus reverse transcriptase expressed in transformed yeast cells. Biochemical properties and interactions with bovine tRNALys. Eur J Biochem (1989) 1.56
Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease. Proc Natl Acad Sci U S A (2000) 1.54
Role of tyrosine kinase and membrane-spanning domains in signal transduction by the platelet-derived growth factor receptor. Mol Cell Biol (1988) 1.54
A circulating variant of human proalbumin. Nature (1978) 1.52
Crystal structure of uncleaved ovalbumin at 1.95 A resolution. J Mol Biol (1991) 1.52
Effect of the Z mutation on the physical and inhibitory properties of alpha 1-antitrypsin. Biochemistry (1993) 1.49
Hormone binding globulins undergo serpin conformational change in inflammation. Nature (1988) 1.47
Synthesis in yeast of a functional oxidation-resistant mutant of human alpha-antitrypsin. Nature (1984) 1.46
Sequences homologous to variant antigen mRNA spliced leader in Trypanosomatidae which do not undergo antigenic variation. Nature (1984) 1.45
A functional prepro-alpha-factor gene in Saccharomyces yeasts can contain three, four, or five repeats of the mature pheromone sequence. Mol Cell Biol (1983) 1.45
Abnormal haem binding and globin SH group blockade in unstable haemoglobins. Nature (1968) 1.44
Plakalbumin, alpha 1-antitrypsin, antithrombin and the mechanism of inflammatory thrombosis. Nature (1985) 1.44
Molecular cloning of a high-affinity receptor for the growth factor-like lipid mediator lysophosphatidic acid from Xenopus oocytes. Proc Natl Acad Sci U S A (1996) 1.43
Molecular cloning and characterization of Porphyromonas gingivalis lysine-specific gingipain. A new member of an emerging family of pathogenic bacterial cysteine proteinases. J Biol Chem (1997) 1.43
Crystal structure of ovalbumin as a model for the reactive centre of serpins. Nature (1990) 1.42
Alpha 1-antitrypsin Siiyama (Ser53-->Phe). Further evidence for intracellular loop-sheet polymerization. J Biol Chem (1993) 1.41
Activated oxygen and haemolysis. Br J Haematol (1975) 1.41
The cDNA and derived amino acid sequence for human osteopontin. Nucleic Acids Res (1989) 1.41
A new hemoglobin variant resembling hemoglobin E. Hemoglobin E Saskatoon: beta-22 Glu replaced by Lys. Can J Biochem (1967) 1.40
The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion. Structure (1999) 1.40
Apolipoprotein E variation in patients with hyperlipidaemia: DNA and protein phenotyping. N Z Med J (1989) 1.39
Studies of hemoglobin denaturation and Heinz body formation in the unstable hemoglobins. J Clin Invest (1974) 1.39
Kluyveromyces as a host for heterologous gene expression: expression and secretion of prochymosin. Biotechnology (N Y) (1990) 1.38
Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts. Proc Natl Acad Sci U S A (1998) 1.37
Preferential interaction of human immunodeficiency virus reverse transcriptase with two regions of primer tRNA(Lys) as evidenced by footprinting studies and inhibition with synthetic oligoribonucleotides. J Mol Biol (1992) 1.35
Expression in yeast of a Plasmodium vivax antigen of potential use in a human malaria vaccine. J Exp Med (1987) 1.35
Imprisonment of J-P Allain. Lancet (1993) 1.34
Haemoglobin Köln (beta-98 valine--methionine): an unstable protein causing inclusion-body anaemia. Nature (1966) 1.33
alpha 1-Antitrypsin Mmalton (Phe52-deleted) forms loop-sheet polymers in vivo. Evidence for the C sheet mechanism of polymerization. J Biol Chem (1995) 1.33