Published in Biochem J on June 01, 1976
Pyocycanin, a contributory factor in haem acquisition and virulence enhancement of Porphyromonas gingivalis in the lung. PLoS One (2015) 1.39
Hydroxyl radical production in body fluids. Roles of metal ions, ascorbate and superoxide. Biochem J (1981) 1.32
Oxidation of human haemoglobin by copper. Mechanism and suggested role of the thiol group of residue beta-93. Biochem J (1977) 1.22
Irreversible inactivation of glutathione peroxidase 1 and reversible inactivation of peroxiredoxin II by H2O2 in red blood cells. Antioxid Redox Signal (2010) 1.15
Free-radical production and oxidative reactions of hemoglobin. Environ Health Perspect (1985) 1.12
The rate of reaction of superoxide radical ion with oxyhaemoglobin and methaemoglobin. Biochem J (1976) 1.11
Hemoglobin-induced oxidative stress contributes to matrix metalloproteinase activation and blood-brain barrier dysfunction in vivo. J Cereb Blood Flow Metab (2010) 1.11
Mechanism of oxyhaemoglobin breakdown on reaction with acetylphenylhydrazine. Biochem J (1978) 1.06
A stopped-flow study of the cupric ion oxidation of adult-human haemoglobin. Biochem J (1980) 1.03
Ligands and oxidants in ferrihemochrome formation and oxidative hemolysis. Proc Natl Acad Sci U S A (1977) 0.98
The effects of disruption of genes for peroxiredoxin-2, glutathione peroxidase-1, and catalase on erythrocyte oxidative metabolism. Free Radic Biol Med (2009) 0.96
A combination of both arginine- and lysine-specific gingipain activity of Porphyromonas gingivalis is necessary for the generation of the micro-oxo bishaem-containing pigment from haemoglobin. Biochem J (2004) 0.93
Increased erythrocyte superoxide dismutase activities in beta 0-thalassaemia/haemoglobin E and in haemoglobin H diseases. J Clin Pathol (1983) 0.93
Recurrent acute respiratory tract infections in areas with high nitrate concentrations in drinking water. Environ Health Perspect (2000) 0.92
Changes in dry state hemoglobin over time do not increase the potential for oxidative DNA damage in dried blood. PLoS One (2009) 0.88
Haemichrome formation from haemoglobin subunits by hydrogen peroxide. Biochem J (1978) 0.85
Kinetic analysis of myoglobin autoxidation by isoelectric-focusing electrophoresis. Biochem J (1981) 0.85
Oxidative interactions between haemoglobin and membrane lipid. A liposome model. Biochem J (1984) 0.83
Significance of an in vitro phenomenon in which murine erythrocytes are lysed by autologous spleen cells and spherules of Coccidioides immitis. Infect Immun (1979) 0.81
Atherogenesis may involve the prooxidant and proinflammatory effects of ferryl hemoglobin. Oxid Med Cell Longev (2013) 0.81
Changes in intermediate haemoglobins during autoxidation of haemoglobin. Biochem J (1981) 0.78
An Origin of Cooperative Oxygen Binding of Human Adult Hemoglobin: Different Roles of the α and β Subunits in the α2β2 Tetramer. PLoS One (2015) 0.77
Growth promotion of the opportunistic human pathogen, Staphylococcus lugdunensis, by heme, hemoglobin, and coculture with Staphylococcus aureus. Microbiologyopen (2014) 0.77
Autoxidation and oxygen binding properties of recombinant hemoglobins with substitutions at the αVal-62 or βVal-67 position of the distal heme pocket. J Biol Chem (2013) 0.76
Protection by plasma proteins of the isolated lamb heart perfused with stroma-free hemoglobin at 38 degrees. Ann Surg (1979) 0.75
Studies with primaquine in vitro: superoxide radical formation and oxidation of haemoglobin. Br J Clin Pharmacol (1978) 0.75
Tissue sulfhydryl groups. Arch Biochem Biophys (1959) 61.89
Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Anal Biochem (1971) 28.59
Studies on the heterogeneity of hemoglobin. IX. The use of Tris(hydroxymethyl)aminomethanehcl buffers in the anion-exchange chromatography of hemoglobins. J Chromatogr (1965) 4.17
The generation of superoxide radical during the autoxidation of hemoglobin. J Biol Chem (1972) 2.83
The estimation of red cell superoxide dismutase activity. J Lab Clin Med (1975) 2.75
Preparation and properties of alpha- and beta-chains from human hemoglobin. J Biol Chem (1969) 2.37
Equations for the spectrophotometric analysis of hemoglobin mixtures. Anal Biochem (1973) 1.67
Studies on the equilibria and kinetics of the reactions of peroxidase with ligands. II. The reaction of ferroperoxidase with oxygen. J Biol Chem (1967) 1.48
Activated oxygen and haemolysis. Br J Haematol (1975) 1.41
Studies of hemoglobin denaturation and Heinz body formation in the unstable hemoglobins. J Clin Invest (1974) 1.39
Studies on the stability of oxyhemoglobin A and its constituent chains and their derivatives. J Biol Chem (1971) 1.38
Evidence that superoxide dismutase plays a role in protecting red blood cells against peroxidative hemolysis. Biochem Biophys Res Commun (1972) 1.34
The relevance of the superoxide anion radical in biological systems. Curr Top Radiat Res Q (1974) 1.28
The role of hemoglobin heme loss in Heinz body formation: studies with a partially heme-deficient hemoglobin and with genetically unstable hemoglobins. J Clin Invest (1970) 1.22
Denaturation of the normal and abnormal hemoglobin molecule. Semin Hematol (1974) 1.17
Autoxidation of oxymyoglobins. J Biol Chem (1969) 1.12
The rate of reaction of superoxide radical ion with oxyhaemoglobin and methaemoglobin. Biochem J (1976) 1.11
Copper and the autoxidation of hemoglobin. Biochemistry (1974) 1.06
Decay of oxyperoxidase and oxygen radicals; a possible role for myeloperoxidase. Biochem J (1975) 1.01
Mechanisms of Heinz body formation and attachment to red cell membrane. Semin Hematol (1970) 1.00
The mechanism of Z alpha 1-antitrypsin accumulation in the liver. Nature (1992) 5.71
Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing. Blood (1998) 5.02
The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature. J Biol Chem (2001) 4.81
Structure and variation of human alpha 1-antitrypsin. Nature (1982) 4.13
Structure of a serpin-protease complex shows inhibition by deformation. Nature (2000) 4.02
Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins. Biochemistry (1989) 3.18
The anticoagulant activation of antithrombin by heparin. Proc Natl Acad Sci U S A (1997) 3.09
The estimation of red cell superoxide dismutase activity. J Lab Clin Med (1975) 2.75
Mutation of antitrypsin to antithrombin. alpha 1-antitrypsin Pittsburgh (358 Met leads to Arg), a fatal bleeding disorder. N Engl J Med (1983) 2.36
What do dysfunctional serpins tell us about molecular mobility and disease? Nat Struct Biol (1995) 2.30
Comparison of superoxide with other reducing agents in the biological production of hydroxyl radicals. Biochem J (1979) 2.26
Comparative reactivities of various biological compounds with myeloperoxidase-hydrogen peroxide-chloride, and similarity of the oxidant to hypochlorite. Biochim Biophys Acta (1985) 2.15
Protein carbonyl measurement by a sensitive ELISA method. Free Radic Biol Med (1997) 2.14
Variations in the structure of human haemoglobin. With particular reference to the unstable haemoglobins. Br Med Bull (1969) 2.07
Smoking, lung function, and alpha 1-antitrypsin deficiency. Lancet (1985) 1.99
Familial dementia caused by polymerization of mutant neuroserpin. Nature (1999) 1.88
A simple method for the detection of unstable haemoglobins. Br J Haematol (1972) 1.87
Involvement of superoxide and myeloperoxidase in oxygen-dependent killing of Staphylococcus aureus by neutrophils. Infect Immun (1996) 1.83
The ability of scavengers to distinguish OH. production in the iron-catalyzed Haber-Weiss reaction: comparison of four assays for OH. Free Radic Biol Med (1987) 1.73
A microtiter plate assay for superoxide dismutase using a water-soluble tetrazolium salt (WST-1). Clin Chim Acta (2000) 1.73
Thiocyanate and chloride as competing substrates for myeloperoxidase. Biochem J (1997) 1.70
Inhibitory conformation of the reactive loop of alpha 1-antitrypsin. Nat Struct Biol (1996) 1.66
alpha 1-Antitrypsin: molecular pathology, leukocytes, and tissue damage. J Clin Invest (1986) 1.61
Oxidative reactions of hemoglobin. Methods Enzymol (1990) 1.55
Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease. Proc Natl Acad Sci U S A (2000) 1.54
A circulating variant of human proalbumin. Nature (1978) 1.52
Crystal structure of uncleaved ovalbumin at 1.95 A resolution. J Mol Biol (1991) 1.52
Production of the superoxide adduct of myeloperoxidase (compound III) by stimulated human neutrophils and its reactivity with hydrogen peroxide and chloride. Biochem J (1985) 1.51
Kinetics of the reactions of hypochlorous acid and amino acid chloramines with thiols, methionine, and ascorbate. Free Radic Biol Med (2001) 1.50
Effect of the Z mutation on the physical and inhibitory properties of alpha 1-antitrypsin. Biochemistry (1993) 1.49
Lactoferrin-catalysed hydroxyl radical production. Additional requirement for a chelating agent. Biochem J (1983) 1.47
Hormone binding globulins undergo serpin conformational change in inflammation. Nature (1988) 1.47
Chlorination of tyrosyl residues in peptides by myeloperoxidase and human neutrophils. J Biol Chem (1995) 1.45
Oxidation of parenteral lipid emulsion by ambient and phototherapy lights: potential toxicity of routine parenteral feeding. J Pediatr (1995) 1.45
Assays for the chlorination activity of myeloperoxidase. Methods Enzymol (1994) 1.45
Abnormal haem binding and globin SH group blockade in unstable haemoglobins. Nature (1968) 1.44
Plakalbumin, alpha 1-antitrypsin, antithrombin and the mechanism of inflammatory thrombosis. Nature (1985) 1.44
Crystal structure of ovalbumin as a model for the reactive centre of serpins. Nature (1990) 1.42
Alpha 1-antitrypsin Siiyama (Ser53-->Phe). Further evidence for intracellular loop-sheet polymerization. J Biol Chem (1993) 1.41
Activated oxygen and haemolysis. Br J Haematol (1975) 1.41
The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion. Structure (1999) 1.40
A new hemoglobin variant resembling hemoglobin E. Hemoglobin E Saskatoon: beta-22 Glu replaced by Lys. Can J Biochem (1967) 1.40
Studies of hemoglobin denaturation and Heinz body formation in the unstable hemoglobins. J Clin Invest (1974) 1.39
Imprisonment of J-P Allain. Lancet (1993) 1.34
Haemoglobin Köln (beta-98 valine--methionine): an unstable protein causing inclusion-body anaemia. Nature (1966) 1.33
Oxidative damage to fibronectin. I. The effects of the neutrophil myeloperoxidase system and HOCl. Arch Biochem Biophys (1991) 1.33
alpha 1-Antitrypsin Mmalton (Phe52-deleted) forms loop-sheet polymers in vivo. Evidence for the C sheet mechanism of polymerization. J Biol Chem (1995) 1.33
Mechanism of inactivation of myeloperoxidase by 4-aminobenzoic acid hydrazide. Biochem J (1997) 1.33
Differences between alpha- and beta-chain mutants of human haemoglobin and between alpha- and beta-thalassaemia. Possible duplication of the alpha-chain gene. Br Med J (1968) 1.33
Hydroxyl radical production in body fluids. Roles of metal ions, ascorbate and superoxide. Biochem J (1981) 1.32
Effects of mutations in the hinge region of serpins. Biochemistry (1993) 1.29
The unstable haemoglobin haemolytic anaemias. Semin Hematol (1969) 1.27
The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site. J Mol Biol (1997) 1.27
Inhibition of myeloperoxidase by benzoic acid hydrazides. Biochem J (1995) 1.26
A 2.6 A structure of a serpin polymer and implications for conformational disease. J Mol Biol (1999) 1.26
A single assay for measuring the rates of phagocytosis and bacterial killing by neutrophils. J Leukoc Biol (1994) 1.24
Structural and functional characterization of the abnormal Z alpha 1-antitrypsin isolated from human liver. FEBS Lett (1984) 1.24
Oxidation of human haemoglobin by copper. Mechanism and suggested role of the thiol group of residue beta-93. Biochem J (1977) 1.22
Superoxide modulates the activity of myeloperoxidase and optimizes the production of hypochlorous acid. Biochem J (1988) 1.22
The serpin inhibitory mechanism is critically dependent on the length of the reactive center loop. J Biol Chem (2001) 1.22
Oxidation of intracellular glutathione after exposure of human red blood cells to hypochlorous acid. Biochem J (1995) 1.18
Living with a killer: the effects of hypochlorous acid on mammalian cells. IUBMB Life (2001) 1.17
Mechanism of inhibition of myeloperoxidase by anti-inflammatory drugs. Biochem Pharmacol (1991) 1.16
The significance of monoclonal gammopathy in a normal population. Aust N Z J Med (1971) 1.16
Cytochrome c reduction by semiquinone radicals can be indirectly inhibited by superoxide dismutase. Arch Biochem Biophys (1981) 1.16
Basis of the defect in alpha-1-antitrypsin deficiency. Nature (1973) 1.16
Preparation and characterization of latent alpha 1-antitrypsin. J Biol Chem (1995) 1.15
Thromboembolic disease due to thermolabile conformational changes of antithrombin Rouen-VI (187 Asn-->Asp) J Clin Invest (1994) 1.14
Methods for quantifying phagocytosis and bacterial killing by human neutrophils. J Immunol Methods (1999) 1.14
Prevalence of antithrombin deficiency in the healthy population. Br J Haematol (1994) 1.13
Yeast KEX2 protease has the properties of a human proalbumin converting enzyme. Science (1987) 1.13
A new doubly substituted sickling haemoglobin: HbS-Oman. Br J Haematol (1989) 1.12
Conformational changes in serpins: II. The mechanism of activation of antithrombin by heparin. J Mol Biol (2000) 1.12
Free-radical production and oxidative reactions of hemoglobin. Environ Health Perspect (1985) 1.12
The rate of reaction of superoxide radical ion with oxyhaemoglobin and methaemoglobin. Biochem J (1976) 1.11
The amino acid sequence of the alpha chain of the major haemoglobin of the rat (Rattus norvegicus). Biochem J (1975) 1.11
Myeloperoxidase as an effective inhibitor of hydroxyl radical production. Implications for the oxidative reactions of neutrophils. J Clin Invest (1986) 1.10
alpha 1-Antitrypsin microheterogeneity. Isolation and physiological significance of isoforms. Biochim Biophys Acta (1982) 1.10
On the participation of higher oxidation states of iron and copper in Fenton reactions. Free Radic Biol Med (1989) 1.10
Human neutrophil collagenase cleaves alpha 1-antitrypsin. Biochem J (1990) 1.07
Production of hydroxyl radicals from paraquat radicals and H2O2. FEBS Lett (1981) 1.07
Nitrite as a substrate and inhibitor of myeloperoxidase. Implications for nitration and hypochlorous acid production at sites of inflammation. J Biol Chem (2000) 1.06
Mechanism of oxyhaemoglobin breakdown on reaction with acetylphenylhydrazine. Biochem J (1978) 1.06
Dysfunctional C1-inhibitor(At), isolated from a type II hereditary-angio-oedema plasma, contains a P1 'reactive centre' (Arg444----His) mutation. Biochem J (1988) 1.06
Degradation of glomerular basement membrane by human neutrophils in vitro. Biochim Biophys Acta (1984) 1.06
Inhibition of plasmin, urokinase, tissue plasminogen activator, and C1S by a myxoma virus serine proteinase inhibitor. J Biol Chem (1993) 1.06
Hydroxyl radical production from hydrogen peroxide and enzymatically generated paraquat radicals: catalytic requirements and oxygen dependence. Arch Biochem Biophys (1984) 1.05
Alpha-1-antitrypsin-Pittsburgh. A potent inhibitor of human plasma factor XIa, kallikrein, and factor XIIf. J Clin Invest (1986) 1.05
Antithrombins Wibble and Wobble (T85M/K): archetypal conformational diseases with in vivo latent-transition, thrombosis, and heparin activation. Blood (1998) 1.04
Structural explanation for the deficiency of S alpha 1-antitrypsin. Nat Struct Biol (1996) 1.04
Implications for function and therapy of a 2.9 A structure of binary-complexed antithrombin. J Mol Biol (1998) 1.03
Radical driven Fenton reactions--evidence from paraquat radical studies for production of tetravalent iron in the presence and absence of ethylenediaminetetraacetic acid. Arch Biochem Biophys (1987) 1.03
Importance of the release of strand 1C to the polymerization mechanism of inhibitory serpins. Protein Sci (1997) 1.03
The conformational activation of antithrombin. A 2.85-A structure of a fluorescein derivative reveals an electrostatic link between the hinge and heparin binding regions. J Biol Chem (2000) 1.03
The effect of oxidants on neutrophil-mediated degradation of glomerular basement membrane collagen. Biochim Biophys Acta (1986) 1.03