Published in Mol Cell on February 02, 2017
Dynamic chromatin technologies: from individual molecules to epigenomic regulation in cells. Nat Rev Genet (2017) 0.84
SET1A/COMPASS and shadow enhancers in the regulation of homeotic gene expression. Genes Dev (2017) 0.76
Bivalent Epigenetic Control of Oncofetal Gene Expression in Cancer. Mol Cell Biol (2017) 0.75
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol (2009) 235.12
TopHat: discovering splice junctions with RNA-Seq. Bioinformatics (2009) 81.13
edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics (2009) 67.17
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature (2007) 65.18
Multiplex genome engineering using CRISPR/Cas systems. Science (2013) 55.53
Model-based analysis of ChIP-Seq (MACS). Genome Biol (2008) 51.63
A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 48.80
Capturing chromosome conformation. Science (2002) 23.93
A chromatin landmark and transcription initiation at most promoters in human cells. Cell (2007) 23.41
Active genes are tri-methylated at K4 of histone H3. Nature (2002) 15.68
Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci U S A (2010) 15.13
A unique chromatin signature uncovers early developmental enhancers in humans. Nature (2010) 14.02
Chromatin signatures of pluripotent cell lines. Nat Cell Biol (2006) 12.88
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature (2007) 11.14
A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. Nature (2006) 10.73
ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature (2006) 9.30
A clustering approach for identification of enriched domains from histone modification ChIP-Seq data. Bioinformatics (2009) 8.33
Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature (2006) 7.70
Chromatin immunoprecipitation and microarray-based analysis of protein location. Nat Protoc (2006) 7.29
Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4. Cell (2007) 6.62
Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells. Cell (2011) 6.22
Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. Mol Cell (2007) 5.78
Blimp1 is a critical determinant of the germ cell lineage in mice. Nature (2005) 5.49
The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. EMBO J (2001) 5.34
Enhancer function: new insights into the regulation of tissue-specific gene expression. Nat Rev Genet (2011) 5.27
COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc Natl Acad Sci U S A (2001) 5.19
Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression. Nature (2007) 4.49
RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature (2007) 4.35
Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. Cell (2010) 4.31
Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains. J Biol Chem (2005) 4.20
COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem (2002) 4.05
The SET-domain protein superfamily: protein lysine methyltransferases. Genome Biol (2005) 3.93
The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis. Cell (2005) 3.70
The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis. Annu Rev Biochem (2012) 3.61
Critical function of Prdm14 for the establishment of the germ cell lineage in mice. Nat Genet (2008) 3.52
Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1. Mol Cell Biol (2000) 3.44
Orphan CpG islands identify numerous conserved promoters in the mammalian genome. PLoS Genet (2010) 3.38
Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development. Development (2006) 3.28
Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II. Mol Cell Biol (2009) 3.26
Isolation of a DEAD-family protein gene that encodes a murine homolog of Drosophila vasa and its specific expression in germ cell lineage. Proc Natl Acad Sci U S A (1994) 3.25
Molecular regulation of histone H3 trimethylation by COMPASS and the regulation of gene expression. Mol Cell (2005) 2.89
A role for Lin28 in primordial germ-cell development and germ-cell malignancy. Nature (2009) 2.88
The human VASA gene is specifically expressed in the germ cell lineage. Proc Natl Acad Sci U S A (2000) 2.56
Robust 4C-seq data analysis to screen for regulatory DNA interactions. Nat Methods (2012) 2.42
Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. Mol Cell Biol (2008) 2.34
NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression. EMBO J (2011) 2.09
Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4. Genes Dev (2012) 2.04
Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia. Nat Struct Mol Biol (2009) 1.98
Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein. Mol Cell Biol (2004) 1.94
Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding. Cell Host Microbe (2015) 1.83
Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein. J Biol Chem (2011) 1.79
Vasa homolog genes in mammalian germ cell development. Cell Struct Funct (2001) 1.69
MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing. PLoS Biol (2010) 1.68
Cfp1 integrates both CpG content and gene activity for accurate H3K4me3 deposition in embryonic stem cells. Genes Dev (2012) 1.55
The COMPASS family of H3K4 methylases in Drosophila. Mol Cell Biol (2011) 1.54
4C technology: protocols and data analysis. Methods Enzymol (2012) 1.52
Jarid1b targets genes regulating development and is involved in neural differentiation. EMBO J (2011) 1.50
Increased apoptosis and skewed differentiation in mouse embryonic stem cells lacking the histone methyltransferase Mll2. Mol Biol Cell (2007) 1.48
The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers. Mol Cell Biol (2013) 1.35
Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant. Development (2014) 1.27
GAT: a simulation framework for testing the association of genomic intervals. Bioinformatics (2013) 1.27
Structural insight into autoinhibition and histone H3-induced activation of DNMT3A. Nature (2014) 1.27
The Mll2 branch of the COMPASS family regulates bivalent promoters in mouse embryonic stem cells. Nat Struct Mol Biol (2013) 1.21
Chromatin signatures of cancer. Genes Dev (2015) 1.20
Enhancer malfunction in cancer. Mol Cell (2014) 1.19
Synthetic CpG islands reveal DNA sequence determinants of chromatin structure. Elife (2014) 1.13
Generation of eggs from mouse embryonic stem cells and induced pluripotent stem cells. Nat Protoc (2013) 1.09
Epigenetic balance of gene expression by Polycomb and COMPASS families. Science (2016) 1.06
NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers. Nature (2016) 0.88
Cfp1 is required for gene expression-dependent H3K4 trimethylation and H3K9 acetylation in embryonic stem cells. Genome Biol (2014) 0.87
The little elongation complex functions at initiation and elongation phases of snRNA gene transcription. Mol Cell (2013) 0.86
Poised chromatin in the mammalian germ line. Development (2014) 0.82
An Evolutionary Conserved Epigenetic Mark of Polycomb Response Elements Implemented by Trx/MLL/COMPASS. Mol Cell (2016) 0.81