Published in Genome Biol on August 02, 2005
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat Genet (2010) 10.97
Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth. Mol Cell Biol (2006) 5.74
Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas. Proc Natl Acad Sci U S A (2010) 4.52
Protein methyltransferases as a target class for drug discovery. Nat Rev Drug Discov (2009) 3.50
Histone lysine methylation dynamics: establishment, regulation, and biological impact. Mol Cell (2012) 2.85
Regulation of nucleosome dynamics by histone modifications. Nat Struct Mol Biol (2013) 2.71
The super elongation complex (SEC) and MLL in development and disease. Genes Dev (2011) 2.63
Structural biology of human H3K9 methyltransferases. PLoS One (2010) 2.45
NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming. Mol Cell (2011) 2.27
Targeted metagenomics and ecology of globally important uncultured eukaryotic phytoplankton. Proc Natl Acad Sci U S A (2010) 2.26
Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappaB-dependent inflammatory genes. Relevance to diabetes and inflammation. J Biol Chem (2008) 2.17
Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes. Proc Natl Acad Sci U S A (2007) 2.11
Histone methylation by NUE, a novel nuclear effector of the intracellular pathogen Chlamydia trachomatis. PLoS Pathog (2010) 1.98
Epigenetic analysis of KSHV latent and lytic genomes. PLoS Pathog (2010) 1.94
Uncovering the human methyltransferasome. Mol Cell Proteomics (2010) 1.91
Structural origins for the product specificity of SET domain protein methyltransferases. Proc Natl Acad Sci U S A (2008) 1.72
Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases. Nature (2010) 1.63
Epigenome manipulation as a pathway to new natural product scaffolds and their congeners. Nat Prod Rep (2009) 1.63
On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. J Biol Chem (2009) 1.61
Dominant alleles identify SET domain residues required for histone methyltransferase of Polycomb repressive complex 2. J Biol Chem (2008) 1.58
The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection. Nat Immunol (2014) 1.57
Genetic and epigenetic mechanisms of gene regulation during lens development. Prog Retin Eye Res (2007) 1.56
Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics (2013) 1.53
An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain. PLoS One (2010) 1.52
How do SET-domain protein lysine methyltransferases achieve the methylation state specificity? Revisited by Ab initio QM/MM molecular dynamics simulations. J Am Chem Soc (2008) 1.48
Ab initio quantum mechanical/molecular mechanical molecular dynamics simulation of enzyme catalysis: the case of histone lysine methyltransferase SET7/9. J Phys Chem B (2007) 1.40
Mutation spectrum of MLL2 in a cohort of Kabuki syndrome patients. Orphanet J Rare Dis (2011) 1.32
Lysine methylation of HIV-1 Tat regulates transcriptional activity of the viral LTR. Retrovirology (2008) 1.30
Recognition of enhancer element-specific histone methylation by TIP60 in transcriptional activation. Nat Struct Mol Biol (2011) 1.29
Drosophila SETDB1 is required for chromosome 4 silencing. PLoS Genet (2007) 1.29
Mixed lineage leukemia: a structure-function perspective of the MLL1 protein. FEBS J (2010) 1.28
RNA polymerase II stalling: loading at the start prepares genes for a sprint. Genome Biol (2008) 1.25
The redox basis of epigenetic modifications: from mechanisms to functional consequences. Antioxid Redox Signal (2011) 1.24
Mechanism of histone methylation catalyzed by protein lysine methyltransferase SET7/9 and origin of product specificity. Proc Natl Acad Sci U S A (2007) 1.24
Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas. Nat Genet (2015) 1.24
Histone lysine methyltransferases and demethylases in Plasmodium falciparum. Int J Parasitol (2008) 1.22
A role for Set1/MLL-related components in epigenetic regulation of the Caenorhabditis elegans germ line. PLoS Genet (2011) 1.22
A novel non-SET domain multi-subunit methyltransferase required for sequential nucleosomal histone H3 methylation by the mixed lineage leukemia protein-1 (MLL1) core complex. J Biol Chem (2010) 1.21
Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer. Oncogene (2012) 1.21
How genetically heterogeneous is Kabuki syndrome?: MLL2 testing in 116 patients, review and analyses of mutation and phenotypic spectrum. Eur J Hum Genet (2011) 1.20
Structural Chemistry of Human SET Domain Protein Methyltransferases. Curr Chem Genomics (2011) 1.20
G9a, a multipotent regulator of gene expression. Epigenetics (2012) 1.20
SET8-mediated methylations of histone H4 lysine 20 mark silent heterochromatic domains in apicomplexan genomes. Mol Cell Biol (2007) 1.17
Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation. J Biol Chem (2013) 1.16
Substrate and product specificities of SET domain methyltransferases. Epigenetics (2011) 1.15
Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations. PLoS One (2013) 1.13
Lysyl 5-hydroxylation, a novel histone modification, by Jumonji domain containing 6 (JMJD6). J Biol Chem (2013) 1.12
Genetic syndromes caused by mutations in epigenetic genes. Hum Genet (2013) 1.11
The functional diversity of protein lysine methylation. Mol Syst Biol (2014) 1.11
Chatting histone modifications in mammals. Brief Funct Genomics (2010) 1.10
Di-methyl H4 lysine 20 targets the checkpoint protein Crb2 to sites of DNA damage. J Biol Chem (2008) 1.09
The motility of a human parasite, Toxoplasma gondii, is regulated by a novel lysine methyltransferase. PLoS Pathog (2011) 1.08
Inner workings and regulatory inputs that control Polycomb repressive complex 2. Chromosoma (2012) 1.07
A fine balance: epigenetic control of cellular quiescence by the tumor suppressor PRDM2/RIZ at a bivalent domain in the cyclin a gene. Nucleic Acids Res (2015) 1.07
Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2. Nat Commun (2016) 1.06
Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases. J Biol Chem (2012) 1.04
Zebrafish nephrogenesis is regulated by interactions between retinoic acid, mecom, and Notch signaling. Dev Biol (2013) 1.03
Dietary manipulation of histone structure and function. Annu Rev Nutr (2008) 1.02
CXXC finger protein 1 restricts the Setd1A histone H3K4 methyltransferase complex to euchromatin. FEBS J (2009) 1.01
WRAD: enabler of the SET1-family of H3K4 methyltransferases. Brief Funct Genomics (2012) 1.01
Chromatin dynamics associated with HIV-1 Tat-activated transcription. Biochim Biophys Acta (2009) 1.01
Bioinformatic Identification of Novel Methyltransferases. Epigenomics (2009) 1.01
Selective inhibitors of protein methyltransferases. J Med Chem (2014) 1.01
SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation. J Biol Chem (2010) 1.01
Two SET domain containing genes link epigenetic changes and aging in Caenorhabditis elegans. Aging Cell (2012) 1.00
CXXC finger protein 1 contains redundant functional domains that support embryonic stem cell cytosine methylation, histone methylation, and differentiation. Mol Cell Biol (2009) 1.00
Dietary factors and epigenetic regulation for prostate cancer prevention. Adv Nutr (2011) 1.00
Comprehensive structural and substrate specificity classification of the Saccharomyces cerevisiae methyltransferome. PLoS One (2011) 0.99
Molecular analysis, pathogenic mechanisms, and readthrough therapy on a large cohort of Kabuki syndrome patients. Hum Mutat (2014) 0.99
Direct evidence for methyl group coordination by carbon-oxygen hydrogen bonds in the lysine methyltransferase SET7/9. J Biol Chem (2011) 0.99
UpSET recruits HDAC complexes and restricts chromatin accessibility and acetylation at promoter regions. Cell (2012) 0.96
A medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L. J Med Chem (2013) 0.95
Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy. Clin Epigenetics (2016) 0.95
Methylation of the tumor suppressor protein, BRCA1, influences its transcriptional cofactor function. PLoS One (2010) 0.94
Identification of lysine 37 of histone H2B as a novel site of methylation. PLoS One (2011) 0.94
The promise and failures of epigenetic therapies for cancer treatment. Cancer Treat Rev (2013) 0.93
Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond. Exp Hematol (2015) 0.93
Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation. Proc Natl Acad Sci U S A (2013) 0.92
Histone H3K79 methyltransferase Dot1L is directly activated by thyroid hormone receptor during Xenopus metamorphosis. Cell Biosci (2012) 0.92
Identification of a novel gene, CIA6, required for normal pyrenoid formation in Chlamydomonas reinhardtii. Plant Physiol (2011) 0.91
Set2-dependent K36 methylation is regulated by novel intratail interactions within H3. Mol Cell Biol (2009) 0.91
Autoimmune haematological disorders in two Italian children with Kabuki syndrome. Ital J Pediatr (2014) 0.90
Rubisco in complex with Rubisco large subunit methyltransferase. Proc Natl Acad Sci U S A (2009) 0.90
Dimerization of a viral SET protein endows its function. Proc Natl Acad Sci U S A (2010) 0.89
Analysis of high-identity segmental duplications in the grapevine genome. BMC Genomics (2011) 0.89
Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications. Med Res Rev (2015) 0.88
Dynamics of histone lysine methylation: structures of methyl writers and erasers. Prog Drug Res (2011) 0.88
Genome-wide analysis of the SET DOMAIN GROUP family in grapevine. Plant Cell Rep (2011) 0.88
Chromatin-remodelling proteins of the pea aphid, Acyrthosiphon pisum (Harris). Insect Mol Biol (2010) 0.88
Targeting of host organelles by pathogenic bacteria: a sophisticated subversion strategy. Nat Rev Microbiol (2015) 0.88
Determinants of sensitivity to DZNep induced apoptosis in multiple myeloma cells. PLoS One (2011) 0.87
S-adenosyl-L-homocysteine hydrolase and methylation disorders: yeast as a model system. Biochim Biophys Acta (2012) 0.87
RNA expression microarray analysis in mouse prospermatogonia: identification of candidate epigenetic modifiers. Dev Dyn (2008) 0.86
Horizontal gene transfer of epigenetic machinery and evolution of parasitism in the malaria parasite Plasmodium falciparum and other apicomplexans. BMC Evol Biol (2013) 0.86
Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives. J Hematol Oncol (2016) 0.85
Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas. PLoS One (2010) 0.85
Automethylation activities within the mixed lineage leukemia-1 (MLL1) core complex reveal evidence supporting a "two-active site" model for multiple histone H3 lysine 4 methylation. J Biol Chem (2013) 0.85
EpiFactors: a comprehensive database of human epigenetic factors and complexes. Database (Oxford) (2015) 0.85
Identification of KMT2D and KDM6A mutations by exome sequencing in Korean patients with Kabuki syndrome. J Hum Genet (2014) 0.84
Evolution of SET-domain protein families in the unicellular and multicellular Ascomycota fungi. BMC Evol Biol (2008) 0.84
The Pfam protein families database. Nucleic Acids Res (2004) 56.46
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell (2004) 21.30
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature (2001) 19.67
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature (2001) 19.54
SMART 4.0: towards genomic data integration. Nucleic Acids Res (2004) 19.37
The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature (2002) 18.30
Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature (2000) 18.26
Active genes are tri-methylated at K4 of histone H3. Nature (2002) 15.68
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci U S A (2003) 13.68
Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity. Mol Cell (2003) 11.78
G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes Dev (2002) 10.54
Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase. Nature (2002) 9.51
Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr Biol (2003) 9.13
Histone H3 lysine 4 methylation patterns in higher eukaryotic genes. Nat Cell Biol (2003) 8.82
SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. Genes Dev (2002) 8.78
Histone and chromatin cross-talk. Curr Opin Cell Biol (2003) 8.69
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev (2004) 8.66
MLL targets SET domain methyltransferase activity to Hox gene promoters. Mol Cell (2002) 8.17
The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation. Mol Cell (2003) 7.47
Dot1p modulates silencing in yeast by methylation of the nucleosome core. Cell (2002) 6.29
The many faces of histone lysine methylation. Curr Opin Cell Biol (2002) 6.01
Regulation of p53 activity through lysine methylation. Nature (2004) 5.78
Many paths to methyltransfer: a chronicle of convergence. Trends Biochem Sci (2003) 5.65
Histone lysine methylation: a signature for chromatin function. Trends Genet (2003) 5.55
Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain. Curr Biol (2002) 5.53
Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3. Mol Cell (2004) 5.06
Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage. Cell (2004) 4.99
SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. Nat Cell Biol (2004) 4.72
Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa. Nat Genet (2003) 4.56
Structural basis for the product specificity of histone lysine methyltransferases. Mol Cell (2003) 4.42
The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexes. EMBO J (1994) 4.36
Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association. Genes Dev (2002) 4.07
Structure and catalytic mechanism of the human histone methyltransferase SET7/9. Nature (2003) 4.00
SET domain proteins modulate chromatin domains in eu- and heterochromatin. Cell Mol Life Sci (1998) 3.78
Polycomb group protein ezh2 controls actin polymerization and cell signaling. Cell (2005) 3.01
Dimethylation of histone H3 lysine 9 is a critical mark for DNA methylation and gene silencing in Arabidopsis thaliana. Chromosoma (2004) 3.00
Structure of the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase. Cell (2002) 2.94
Histone H3-K9 methyltransferase ESET is essential for early development. Mol Cell Biol (2004) 2.92
In vitro and in vivo analyses of a Phe/Tyr switch controlling product specificity of histone lysine methyltransferases. J Biol Chem (2004) 2.86
The Drosophila Polycomb-group gene Enhancer of zeste contains a region with sequence similarity to trithorax. Mol Cell Biol (1993) 2.85
NSD1 is essential for early post-implantation development and has a catalytically active SET domain. EMBO J (2003) 2.72
Identification of novel histone post-translational modifications by peptide mass fingerprinting. Chromosoma (2003) 2.67
Gene-specific modulation of TAF10 function by SET9-mediated methylation. Mol Cell (2004) 2.56
PR-Set7-dependent methylation of histone H4 Lys 20 functions in repression of gene expression and is essential for mitosis. Genes Dev (2005) 2.51
Structure and catalytic mechanism of a SET domain protein methyltransferase. Cell (2002) 2.45
Crystal structure and functional analysis of the histone methyltransferase SET7/9. Cell (2002) 2.27
Role of histone methyltransferase G9a in CpG methylation of the Prader-Willi syndrome imprinting center. J Biol Chem (2003) 2.25
A switch in mitotic histone H4 lysine 20 methylation status is linked to M phase defects upon loss of HCF-1. Mol Cell (2004) 1.91
Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet. EMBO J (2003) 1.89
The Drosophila trithorax proteins contain a novel variant of the nuclear receptor type DNA binding domain and an ancient conserved motif found in other chromosomal proteins. Mech Dev (1995) 1.87
The active site of the SET domain is constructed on a knot. Nat Struct Biol (2002) 1.78
Mechanism of multiple lysine methylation by the SET domain enzyme Rubisco LSMT. Nat Struct Biol (2003) 1.73
Structure of the SET domain histone lysine methyltransferase Clr4. Nat Struct Biol (2002) 1.70
A dimeric viral SET domain methyltransferase specific to Lys27 of histone H3. Nat Struct Biol (2003) 1.67
Transcriptional repression of euchromatic genes by Drosophila heterochromatin protein 1 and histone modifiers. Proc Natl Acad Sci U S A (2001) 1.63
Structure and function of histone methyltransferases. Crit Rev Eukaryot Gene Expr (2004) 1.13
Provenance of SET-domain histone methyltransferases through duplication of a simple structural unit. Cell Cycle (2003) 0.96
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature (2007) 11.14
Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature (2007) 8.33
Many paths to methyltransfer: a chronicle of convergence. Trends Biochem Sci (2003) 5.65
Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa. Nat Genet (2003) 4.56
Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression. Nature (2007) 4.49
Structural basis for the product specificity of histone lysine methyltransferases. Mol Cell (2003) 4.42
5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging. Nat Neurosci (2011) 4.15
Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase. Nat Struct Mol Biol (2007) 3.77
Protein lysine methyltransferase G9a acts on non-histone targets. Nat Chem Biol (2008) 3.53
The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin. Cell (2006) 3.46
Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proc Natl Acad Sci U S A (2004) 3.31
The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix. Nature (2008) 3.28
The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules. Nat Struct Mol Biol (2008) 3.20
Structural and sequence motifs of protein (histone) methylation enzymes. Annu Rev Biophys Biomol Struct (2005) 3.17
Dimethylation of histone H3 lysine 9 is a critical mark for DNA methylation and gene silencing in Arabidopsis thaliana. Chromosoma (2004) 3.00
Structure of the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase. Cell (2002) 2.94
Measuring the thermal conductivity of a single carbon nanotube. Phys Rev Lett (2005) 2.94
Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases. Nat Struct Mol Biol (2009) 2.87
In vitro and in vivo analyses of a Phe/Tyr switch controlling product specificity of histone lysine methyltransferases. J Biol Chem (2004) 2.86
Molecular interactions in rotavirus assembly and uncoating seen by high-resolution cryo-EM. Proc Natl Acad Sci U S A (2009) 2.65
Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase. Genes Dev (2005) 2.56
Molecular recognition of histone H3 by the WD40 protein WDR5. Nat Struct Mol Biol (2006) 2.55
Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation. Nucleic Acids Res (2012) 2.55
The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J Clin Invest (2009) 2.52
Synergy among nuclear receptor coactivators: selective requirement for protein methyltransferase and acetyltransferase activities. Mol Cell Biol (2002) 2.51
Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nat Struct Mol Biol (2009) 2.50
Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase. Mol Cell (2008) 2.35
Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells. J Biol Chem (2007) 2.34
Structure of the predominant protein arginine methyltransferase PRMT1 and analysis of its binding to substrate peptides. Structure (2003) 2.30
A common mode of recognition for methylated CpG. Trends Biochem Sci (2013) 2.28
The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds. Nat Struct Biol (2002) 2.24
Structural basis for the methylation site specificity of SET7/9. Nat Struct Mol Biol (2006) 2.18
Histone modifying enzymes: structures, mechanisms, and specificities. Biochim Biophys Acta (2008) 2.07
Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling. Nat Immunol (2010) 2.07
Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation. J Biol Chem (2002) 2.06
Nab2p is required for poly(A) RNA export in Saccharomyces cerevisiae and is regulated by arginine methylation via Hmt1p. J Biol Chem (2002) 1.99
Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP. J Biol Chem (2002) 1.94
A coupled fluorescent assay for histone methyltransferases. Anal Biochem (2005) 1.76
The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription. Cell Host Microbe (2010) 1.76
Structural origins for the product specificity of SET domain protein methyltransferases. Proc Natl Acad Sci U S A (2008) 1.72
Structure of the SET domain histone lysine methyltransferase Clr4. Nat Struct Biol (2002) 1.70
Putative autocleavage of outer capsid protein micro1, allowing release of myristoylated peptide micro1N during particle uncoating, is critical for cell entry by reovirus. J Virol (2004) 1.69
Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells. Nat Med (2007) 1.69
Protein arginine methyltransferase 1: positively charged residues in substrate peptides distal to the site of methylation are important for substrate binding and catalysis. Biochemistry (2007) 1.55
Serum protein S100A9, SOD3, and MMP9 as new diagnostic biomarkers for pulmonary tuberculosis by iTRAQ-coupled two-dimensional LC-MS/MS. Proteomics (2014) 1.55
Catalytic roles for carbon-oxygen hydrogen bonding in SET domain lysine methyltransferases. J Biol Chem (2006) 1.53
Coxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1. Proc Natl Acad Sci U S A (2009) 1.52
A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability. Nat Struct Mol Biol (2010) 1.52
Antiapoptotic effect of serum and glucocorticoid-inducible protein kinase is mediated by novel mechanism activating I{kappa}B kinase. Cancer Res (2005) 1.48
Comprehensive alanine-scanning mutagenesis of Escherichia coli CsrA defines two subdomains of critical functional importance. J Biol Chem (2006) 1.47
Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L. Nucleic Acids Res (2008) 1.46
A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion. Mol Pharmacol (2012) 1.46
A nearly modern amphibious bird from the Early Cretaceous of northwestern China. Science (2006) 1.45
UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications. Epigenetics (2009) 1.45
Hypoxic preconditioning attenuates hypoxia/reoxygenation-induced apoptosis in mesenchymal stem cells. Acta Pharmacol Sin (2008) 1.43
Molecular coupling of DNA methylation and histone methylation. Epigenomics (2010) 1.43
Simultaneous measurements of the specific heat and thermal conductivity of suspended thin samples by transient electrothermal method. Rev Sci Instrum (2009) 1.43
Follicle-stimulating hormone induces multiple signaling cascades: evidence that activation of Rous sarcoma oncogene, RAS, and the epidermal growth factor receptor are critical for granulosa cell differentiation. Mol Endocrinol (2007) 1.42
Insulin alleviates posttrauma cardiac dysfunction by inhibiting tumor necrosis factor-α-mediated reactive oxygen species production. Crit Care Med (2013) 1.42
Potential role of α-synuclein in neurodegeneration: studies in a rat animal model. J Neurochem (2012) 1.41
Activation of antioxidant pathways in ras-mediated oncogenic transformation of human surface ovarian epithelial cells revealed by functional proteomics and mass spectrometry. Cancer Res (2004) 1.41
Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma. PLoS Pathog (2010) 1.40
High-resolution enzymatic mapping of genomic 5-hydroxymethylcytosine in mouse embryonic stem cells. Cell Rep (2013) 1.40
Reduced expression of NDUFS3 and its clinical significance in serous ovarian cancer. Int J Gynecol Cancer (2013) 1.40
Calmodulin methyltransferase is an evolutionarily conserved enzyme that trimethylates Lys-115 in calmodulin. Nat Commun (2010) 1.40
Phosphorylation-mediated inactivation of coactivator-associated arginine methyltransferase 1. Proc Natl Acad Sci U S A (2007) 1.40
An atomic model of Zfp57 recognition of CpG methylation within a specific DNA sequence. Genes Dev (2012) 1.38
Structure of the conserved core of the yeast Dot1p, a nucleosomal histone H3 lysine 79 methyltransferase. J Biol Chem (2004) 1.38
Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. J Mol Biol (2010) 1.37
Transition from nonspecific to specific DNA interactions along the substrate-recognition pathway of dam methyltransferase. Cell (2005) 1.36
Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation. Nucleic Acids Res (2012) 1.35
An antibody to the putative aphid recognition site on cucumber mosaic virus recognizes pentons but not hexons. J Virol (2002) 1.35
Improvement of antibiotic activity of Xenorhabdus bovienii by medium optimization using response surface methodology. Microb Cell Fact (2011) 1.35
Carbon-oxygen hydrogen bonding in biological structure and function. J Biol Chem (2012) 1.35
Analysis of the substrate specificity of the Dim-5 histone lysine methyltransferase using peptide arrays. Chem Biol (2008) 1.34
A Structural-informatics approach for tracing beta-sheets: building pseudo-C(alpha) traces for beta-strands in intermediate-resolution density maps. J Mol Biol (2004) 1.34
The structure of RalF, an ADP-ribosylation factor guanine nucleotide exchange factor from Legionella pneumophila, reveals the presence of a cap over the active site. J Biol Chem (2004) 1.33
The density of macrophages in the invasive front is inversely correlated to liver metastasis in colon cancer. J Transl Med (2010) 1.33