Published in Endocrinology on June 01, 2001
Loss-of-function mutation in the prokineticin 2 gene causes Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism. Proc Natl Acad Sci U S A (2007) 2.23
A unique case of combined pituitary hormone deficiency caused by a PROP1 gene mutation (R120C) associated with normal height and absent puberty. Clin Endocrinol (Oxf) (2002) 1.54
A novel AP-1 site is critical for maximal induction of the follicle-stimulating hormone beta gene by gonadotropin-releasing hormone. J Biol Chem (2003) 1.53
GnRH activates ERK1/2 leading to the induction of c-fos and LHbeta protein expression in LbetaT2 cells. Mol Endocrinol (2002) 1.53
Pulse sensitivity of the luteinizing hormone beta promoter is determined by a negative feedback loop Involving early growth response-1 and Ngfi-A binding protein 1 and 2. Mol Endocrinol (2007) 1.30
Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells. J Biol Chem (2002) 1.30
Circadian gene expression regulates pulsatile gonadotropin-releasing hormone (GnRH) secretory patterns in the hypothalamic GnRH-secreting GT1-7 cell line. J Neurosci (2003) 1.30
Hormones in synergy: regulation of the pituitary gonadotropin genes. Mol Cell Endocrinol (2009) 1.25
Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1. Mol Endocrinol (2004) 1.22
Developmental regulation of gonadotropin-releasing hormone gene expression by the MSX and DLX homeodomain protein families. J Biol Chem (2005) 1.17
Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Menopause (2002) 1.15
p38 mitogen-activated protein kinase is critical for synergistic induction of the FSH(beta) gene by gonadotropin-releasing hormone and activin through augmentation of c-Fos induction and Smad phosphorylation. Mol Endocrinol (2007) 1.13
Androgens, progestins, and glucocorticoids induce follicle-stimulating hormone beta-subunit gene expression at the level of the gonadotrope. Mol Endocrinol (2006) 1.10
Transcriptional activation of the ovine follicle-stimulating hormone-beta gene by gonadotropin-releasing hormone involves multiple signal transduction pathways. Endocrinology (2002) 1.09
Activin regulates luteinizing hormone beta-subunit gene expression through Smad-binding and homeobox elements. Mol Endocrinol (2005) 1.08
Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LbetaT2 gonadotropes. Mol Endocrinol (2007) 1.08
Necdin, a Prader-Willi syndrome candidate gene, regulates gonadotropin-releasing hormone neurons during development. Hum Mol Genet (2008) 1.07
An Otx-related homeodomain protein binds an LHbeta promoter element important for activation during gonadotrope maturation. Mol Endocrinol (2002) 1.06
The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1. J Biol Chem (2005) 1.06
TALE homeodomain proteins regulate gonadotropin-releasing hormone gene expression independently and via interactions with Oct-1. J Biol Chem (2004) 1.04
Hypothalamic dysregulation and infertility in mice lacking the homeodomain protein Six6. J Neurosci (2011) 1.04
Phylogenetic footprinting reveals evolutionarily conserved regions of the gonadotropin-releasing hormone gene that enhance cell-specific expression. Mol Endocrinol (2004) 1.04
FoxL2 Is required for activin induction of the mouse and human follicle-stimulating hormone beta-subunit genes. Mol Endocrinol (2010) 1.03
Neuron-restricted expression of the rat gonadotropin-releasing hormone gene is conferred by a cell-specific protein complex that binds repeated CAATT elements. Mol Endocrinol (2002) 1.02
Activin modulates the transcriptional response of LbetaT2 cells to gonadotropin-releasing hormone and alters cellular proliferation. Mol Endocrinol (2006) 1.02
Mouse GnRH receptor gene expression is mediated by the LHX3 homeodomain protein. Endocrinology (2005) 1.02
Nuclear factor Y and steroidogenic factor 1 physically and functionally interact to contribute to cell-specific expression of the mouse Follicle-stimulating hormone-beta gene. Mol Endocrinol (2003) 1.01
Activin and glucocorticoids synergistically activate follicle-stimulating hormone beta-subunit gene expression in the immortalized LbetaT2 gonadotrope cell line. Endocrinology (2006) 1.01
GnRH induces the c-Fos gene via phosphorylation of SRF by the calcium/calmodulin kinase II pathway. Mol Endocrinol (2011) 1.00
Neuron-specific expression in vivo by defined transcription regulatory elements of the GnRH gene. Endocrinology (2002) 0.98
Oocyte-specific overexpression of mouse bone morphogenetic protein-15 leads to accelerated folliculogenesis and an early onset of acyclicity in transgenic mice. Endocrinology (2008) 0.95
Androgen regulates follicle-stimulating hormone beta gene expression in an activin-dependent manner in immortalized gonadotropes. Mol Endocrinol (2003) 0.95
Otx2 induction of the gonadotropin-releasing hormone promoter is modulated by direct interactions with Grg co-repressors. J Biol Chem (2009) 0.93
Synergistic induction of follicle-stimulating hormone beta-subunit gene expression by gonadal steroid hormone receptors and Smad proteins. Endocrinology (2007) 0.93
Different signaling pathways control acute induction versus long-term repression of LHbeta transcription by GnRH. Endocrinology (2002) 0.93
Enhancers of GnRH transcription embedded in an upstream gene use homeodomain proteins to specify hypothalamic expression. Mol Endocrinol (2010) 0.92
A FoxL in the Smad house: activin regulation of FSH. Trends Endocrinol Metab (2010) 0.89
FOXL2 is involved in the synergy between activin and progestins on the follicle-stimulating hormone β-subunit promoter. Endocrinology (2012) 0.88
Progesterone Inhibits basal and gonadotropin-releasing hormone induction of luteinizing hormone beta-subunit gene expression. Endocrinology (2008) 0.88
Aberrant development of the suprachiasmatic nucleus and circadian rhythms in mice lacking the homeodomain protein Six6. J Biol Rhythms (2013) 0.87
Prenatal exposure to low levels of androgen accelerates female puberty onset and reproductive senescence in mice. Endocrinology (2012) 0.85
KISS1R signals independently of Gαq/11 and triggers LH secretion via the β-arrestin pathway in the male mouse. Endocrinology (2014) 0.84
NeuroD1 and Mash1 temporally regulate GnRH receptor gene expression in immortalized mouse gonadotrope cells. Mol Cell Endocrinol (2008) 0.84
Heterozygous deletion of ventral anterior homeobox (vax1) causes subfertility in mice. Endocrinology (2014) 0.84
Pituitary tumorigenesis targeted by the ovine follicle-stimulating hormone beta-subunit gene regulatory region in transgenic mice. Mol Cell Endocrinol (2003) 0.83
Runt-related transcription factors impair activin induction of the follicle-stimulating hormone {beta}-subunit gene. Endocrinology (2010) 0.83
The protein kinase C pathway acts through multiple transcription factors to repress gonadotropin-releasing hormone gene expression in hypothalamic GT1-7 neuronal cells. Mol Endocrinol (2005) 0.83
PPARG regulates gonadotropin-releasing hormone signaling in LbetaT2 cells in vitro and pituitary gonadotroph function in vivo in mice. Biol Reprod (2010) 0.83
Gene dosage of Otx2 is important for fertility in male mice. Mol Cell Endocrinol (2013) 0.82
Orexin A induces GnRH gene expression and secretion from GT1-7 hypothalamic GnRH neurons. Neuroendocrinology (2006) 0.82
Dynamic chromatin modifications control GnRH gene expression during neuronal differentiation and protein kinase C signal transduction. Mol Endocrinol (2011) 0.82
Stress levels of glucocorticoids inhibit LHβ-subunit gene expression in gonadotrope cells. Mol Endocrinol (2012) 0.81
Msx1 homeodomain protein represses the αGSU and GnRH receptor genes during gonadotrope development. Mol Endocrinol (2013) 0.80
Androgen receptor repression of GnRH gene transcription. Mol Endocrinol (2011) 0.80
Glucocorticoids induce human glycoprotein hormone alpha-subunit gene expression in the gonadotrope. Endocrinology (2008) 0.80
Leptin increases L-type Ca2+ channel expression and GnRH-stimulated LH release in LbetaT2 gonadotropes. Mol Cell Endocrinol (2008) 0.79
Neurokinin B causes acute GnRH secretion and repression of GnRH transcription in GT1-7 GnRH neurons. Mol Endocrinol (2013) 0.79
Kisspeptin regulates gonadotropin genes via immediate early gene induction in pituitary gonadotropes. Mol Endocrinol (2013) 0.78
Mutational analysis of the necdin gene in patients with congenital isolated hypogonadotropic hypogonadism. Eur J Endocrinol (2011) 0.78
Androgen receptor repression of gonadotropin-releasing hormone gene transcription via enhancer 1. Mol Cell Endocrinol (2012) 0.77
Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHβ. Mol Endocrinol (2014) 0.76
Complementary expression of IGF-II and IGFBP-5 during anterior pituitary development. Dev Biol (2002) 0.76
Trans-resveratrol inhibits phosphorylation of Smad2/3 and represses FSHβ gene expression by a SirT1-independent pathway in LβT2 gonadotrope cells. Reprod Toxicol (2011) 0.76
Neurokinin B induces c-fos transcription via protein kinase C and activation of serum response factor and Elk-1 in immortalized GnRH neurons. Endocrinology (2014) 0.76
Transcriptional Activation of the Ovine Follicle-Stimulating Hormone-β Gene by Gonadotropin- Releasing Hormone Involves Multiple Signal Transduction Pathways. Endocrinology (2002) 0.75