Published in Mol Endocrinol on March 16, 2010
Aromatase is a direct target of FOXL2: C134W in granulosa cell tumors via a single highly conserved binding site in the ovarian specific promoter. PLoS One (2010) 1.11
GnRH induces the c-Fos gene via phosphorylation of SRF by the calcium/calmodulin kinase II pathway. Mol Endocrinol (2011) 1.00
The transcriptional targets of mutant FOXL2 in granulosa cell tumours. PLoS One (2012) 0.97
Minireview: roles of the forkhead transcription factor FOXL2 in granulosa cell biology and pathology. Endocrinology (2011) 0.95
A FoxL in the Smad house: activin regulation of FSH. Trends Endocrinol Metab (2010) 0.89
Follicle-stimulating hormone synthesis and fertility depend on SMAD4 and FOXL2. FASEB J (2014) 0.88
Impaired fertility and FSH synthesis in gonadotrope-specific Foxl2 knockout mice. Mol Endocrinol (2013) 0.88
FOXL2 is involved in the synergy between activin and progestins on the follicle-stimulating hormone β-subunit promoter. Endocrinology (2012) 0.88
Impaired FSHbeta expression in the pituitaries of Foxl2 mutant animals. Mol Endocrinol (2011) 0.88
A human FSHB promoter SNP associated with low FSH levels in men impairs LHX3 binding and basal FSHB transcription. Endocrinology (2013) 0.84
Runt-related transcription factors impair activin induction of the follicle-stimulating hormone {beta}-subunit gene. Endocrinology (2010) 0.83
Fox tales: regulation of gonadotropin gene expression by forkhead transcription factors. Mol Cell Endocrinol (2013) 0.81
Cell-type specific modulation of pituitary cells by activin, inhibin and follistatin. Mol Cell Endocrinol (2012) 0.81
Stress levels of glucocorticoids inhibit LHβ-subunit gene expression in gonadotrope cells. Mol Endocrinol (2012) 0.81
Msx1 homeodomain protein represses the αGSU and GnRH receptor genes during gonadotrope development. Mol Endocrinol (2013) 0.80
Essential but differential role of FOXL2wt and FOXL2C134W in GDF-9 stimulation of follistatin transcription in co-operation with Smad3 in the human granulosa cell line COV434. Mol Cell Endocrinol (2013) 0.79
Granulosa cell tumor mutant FOXL2C134W suppresses GDF-9 and activin A-induced follistatin transcription in primary granulosa cells. Mol Cell Endocrinol (2013) 0.78
Constitutively active FOXO1 diminishes activin induction of Fshb transcription in immortalized gonadotropes. PLoS One (2014) 0.77
The Local Control of the Pituitary by Activin Signaling and Modulation. Open Neuroendocrinol J (2011) 0.77
The CpG island in the murine foxl2 proximal promoter is differentially methylated in primary and immortalized cells. PLoS One (2013) 0.76
Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHβ. Mol Endocrinol (2014) 0.76
The TGF-β Family in the Reproductive Tract. Cold Spring Harb Perspect Biol (2017) 0.76
SMAD3 Regulates Follicle-stimulating Hormone Synthesis by Pituitary Gonadotrope Cells in Vivo. J Biol Chem (2016) 0.75
Maximal expression of Foxl2 in pituitary gonadotropes requires ovarian hormones. PLoS One (2015) 0.75
Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell (2003) 25.94
TGF-beta signal transduction. Annu Rev Biochem (1998) 17.83
Transcriptional control by the TGF-beta/Smad signaling system. EMBO J (2000) 8.49
Signal transduction by the TGF-beta superfamily. Science (2002) 5.61
Forkhead transcription factors: key players in development and metabolism. Dev Biol (2002) 4.74
The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome. Nat Genet (2001) 4.15
Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling. Cell (1998) 3.86
Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility. Nat Genet (1997) 3.69
Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature (1997) 3.66
Characterization of type I receptors for transforming growth factor-beta and activin. Science (1994) 2.94
The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance. Development (2004) 2.52
Pituitary FSH is released by a heterodimer of the beta-subunits from the two forms of inhibin. Nature (1986) 2.37
Immortalization of pituitary cells at discrete stages of development by directed oncogenesis in transgenic mice. Development (1996) 1.87
Cell-specific transcriptional regulation of follicle-stimulating hormone-beta by activin and gonadotropin-releasing hormone in the LbetaT2 pituitary gonadotrope cell model. Endocrinology (2001) 1.82
Activation of signalling by the activin receptor complex. Mol Cell Biol (1996) 1.79
Both SMAD2 and SMAD3 mediate activin-stimulated expression of the follicle-stimulating hormone beta subunit in mouse gonadotrope cells. Mol Endocrinol (2003) 1.56
A novel AP-1 site is critical for maximal induction of the follicle-stimulating hormone beta gene by gonadotropin-releasing hormone. J Biol Chem (2003) 1.53
The gonadotropin releasing hormone (GnRH) receptor activating sequence (GRAS) is a composite regulatory element that interacts with multiple classes of transcription factors including Smads, AP-1 and a forkhead DNA binding protein. Mol Cell Endocrinol (2003) 1.45
Antagonists of activin signaling: mechanisms and potential biological applications. Trends Endocrinol Metab (2005) 1.40
Regulation of the rat follicle-stimulating hormone beta-subunit promoter by activin. Mol Endocrinol (2002) 1.38
Efficient TGF-beta induction of the Smad7 gene requires cooperation between AP-1, Sp1, and Smad proteins on the mouse Smad7 promoter. J Biol Chem (2000) 1.33
FoxL2 and Smad3 coordinately regulate follistatin gene transcription. J Biol Chem (2008) 1.32
Differential effects of gonadotropin-releasing hormone (GnRH) pulse frequency on gonadotropin subunit and GnRH receptor messenger ribonucleic acid levels in vitro. Endocrinology (1997) 1.32
Acute regulation of murine follicle-stimulating hormone beta subunit transcription by activin A. J Mol Endocrinol (2006) 1.27
LbetaT2 gonadotroph cells secrete follicle stimulating hormone (FSH) in response to active A. J Endocrinol (1999) 1.26
Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1. Mol Endocrinol (2004) 1.22
Regulation of the follicle-stimulating hormone beta gene by the LHX3 LIM-homeodomain transcription factor. Endocrinology (2004) 1.20
Activator protein-1 and smad proteins synergistically regulate human follicle-stimulating hormone beta-promoter activity. Endocrinology (2008) 1.19
Pituitary actions of ligands of the TGF-beta family: activins and inhibins. Reproduction (2006) 1.18
p38 mitogen-activated protein kinase is critical for synergistic induction of the FSH(beta) gene by gonadotropin-releasing hormone and activin through augmentation of c-Fos induction and Smad phosphorylation. Mol Endocrinol (2007) 1.13
Androgens, progestins, and glucocorticoids induce follicle-stimulating hormone beta-subunit gene expression at the level of the gonadotrope. Mol Endocrinol (2006) 1.10
Smad3 mediates activin-induced transcription of follicle-stimulating hormone beta-subunit gene. Mol Endocrinol (2005) 1.10
Synergy between activin A and gonadotropin-releasing hormone in transcriptional activation of the rat follicle-stimulating hormone-beta gene. Mol Endocrinol (2004) 1.09
Autocrine/paracrine regulation of pituitary function by activin, inhibin and follistatin. Mol Cell Endocrinol (2004) 1.09
Activin regulates luteinizing hormone beta-subunit gene expression through Smad-binding and homeobox elements. Mol Endocrinol (2005) 1.08
Transcriptional activation of the follicle-stimulating hormone beta-subunit gene by activin. Endocrinology (1995) 1.08
Gonadotropin-releasing hormone differentially regulates expression of the genes for luteinizing hormone alpha and beta subunits in male rats. Proc Natl Acad Sci U S A (1986) 1.08
A novel role for the forkhead transcription factor FOXL2 in activin A-regulated follicle-stimulating hormone beta subunit transcription. Mol Endocrinol (2009) 1.08
Two proximal activating protein-1-binding sites are sufficient to stimulate transcription of the ovine follicle-stimulating hormone-beta gene. Endocrinology (1997) 1.07
Production and regulation of inhibin subunits in pituitary gonadotropes. Endocrinology (1989) 1.06
A composite element that binds basic helix loop helix and basic leucine zipper transcription factors is important for gonadotropin-releasing hormone regulation of the follicle-stimulating hormone beta gene. Mol Endocrinol (2008) 1.02
Nuclear factor Y and steroidogenic factor 1 physically and functionally interact to contribute to cell-specific expression of the mouse Follicle-stimulating hormone-beta gene. Mol Endocrinol (2003) 1.01
Activin and glucocorticoids synergistically activate follicle-stimulating hormone beta-subunit gene expression in the immortalized LbetaT2 gonadotrope cell line. Endocrinology (2006) 1.01
Follicle-stimulating hormone beta subunit messenger ribonucleic acid concentrations during the rat estrous cycle. Endocrinology (1988) 0.99
Pituitary homeobox 1 activates the rat FSHbeta (rFSHbeta) gene through both direct and indirect interactions with the rFSHbeta gene promoter. Mol Endocrinol (2002) 0.99
Follistatin gene expression in the pituitary: localization in gonadotropes and folliculostellate cells in diestrous rats. Endocrinology (1992) 0.96
Androgen regulates follicle-stimulating hormone beta gene expression in an activin-dependent manner in immortalized gonadotropes. Mol Endocrinol (2003) 0.95
Human FSH beta subunit gene is highly conserved. Mol Hum Reprod (2005) 0.93
Synergistic induction of follicle-stimulating hormone beta-subunit gene expression by gonadal steroid hormone receptors and Smad proteins. Endocrinology (2007) 0.93
Smad3 and Pitx2 cooperate in stimulation of FSHbeta gene transcription. Mol Cell Endocrinol (2007) 0.89
Blockade of recruitment of ovarian follicles by suppression of the secondary surge of follicle-stimulating hormone with porcine follicular field. Proc Natl Acad Sci U S A (1980) 0.88
Discrete stages of anterior pituitary differentiation recapitulated in immortalized cell lines. Mol Cell Endocrinol (1998) 0.86
Homologous in vitro bioassay for follicle-stimulating hormone (FSH) reveals increased FSH biological signal during the mid- to late luteal phase of the human menstrual cycle. J Clin Endocrinol Metab (1996) 0.78
Loss-of-function mutation in the prokineticin 2 gene causes Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism. Proc Natl Acad Sci U S A (2007) 2.23
A unique case of combined pituitary hormone deficiency caused by a PROP1 gene mutation (R120C) associated with normal height and absent puberty. Clin Endocrinol (Oxf) (2002) 1.54
GnRH activates ERK1/2 leading to the induction of c-fos and LHbeta protein expression in LbetaT2 cells. Mol Endocrinol (2002) 1.53
A novel AP-1 site is critical for maximal induction of the follicle-stimulating hormone beta gene by gonadotropin-releasing hormone. J Biol Chem (2003) 1.53
Pulse sensitivity of the luteinizing hormone beta promoter is determined by a negative feedback loop Involving early growth response-1 and Ngfi-A binding protein 1 and 2. Mol Endocrinol (2007) 1.30
Circadian gene expression regulates pulsatile gonadotropin-releasing hormone (GnRH) secretory patterns in the hypothalamic GnRH-secreting GT1-7 cell line. J Neurosci (2003) 1.30
Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells. J Biol Chem (2002) 1.30
Hormones in synergy: regulation of the pituitary gonadotropin genes. Mol Cell Endocrinol (2009) 1.25
Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1. Mol Endocrinol (2004) 1.22
Developmental regulation of gonadotropin-releasing hormone gene expression by the MSX and DLX homeodomain protein families. J Biol Chem (2005) 1.17
Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Menopause (2002) 1.15
p38 mitogen-activated protein kinase is critical for synergistic induction of the FSH(beta) gene by gonadotropin-releasing hormone and activin through augmentation of c-Fos induction and Smad phosphorylation. Mol Endocrinol (2007) 1.13
Androgens, progestins, and glucocorticoids induce follicle-stimulating hormone beta-subunit gene expression at the level of the gonadotrope. Mol Endocrinol (2006) 1.10
Transcriptional activation of the ovine follicle-stimulating hormone-beta gene by gonadotropin-releasing hormone involves multiple signal transduction pathways. Endocrinology (2002) 1.09
Activin regulates luteinizing hormone beta-subunit gene expression through Smad-binding and homeobox elements. Mol Endocrinol (2005) 1.08
Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LbetaT2 gonadotropes. Mol Endocrinol (2007) 1.08
Necdin, a Prader-Willi syndrome candidate gene, regulates gonadotropin-releasing hormone neurons during development. Hum Mol Genet (2008) 1.07
An Otx-related homeodomain protein binds an LHbeta promoter element important for activation during gonadotrope maturation. Mol Endocrinol (2002) 1.06
The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1. J Biol Chem (2005) 1.06
Hypothalamic dysregulation and infertility in mice lacking the homeodomain protein Six6. J Neurosci (2011) 1.04
TALE homeodomain proteins regulate gonadotropin-releasing hormone gene expression independently and via interactions with Oct-1. J Biol Chem (2004) 1.04
Phylogenetic footprinting reveals evolutionarily conserved regions of the gonadotropin-releasing hormone gene that enhance cell-specific expression. Mol Endocrinol (2004) 1.04
Activin modulates the transcriptional response of LbetaT2 cells to gonadotropin-releasing hormone and alters cellular proliferation. Mol Endocrinol (2006) 1.02
Neuron-restricted expression of the rat gonadotropin-releasing hormone gene is conferred by a cell-specific protein complex that binds repeated CAATT elements. Mol Endocrinol (2002) 1.02
Mouse GnRH receptor gene expression is mediated by the LHX3 homeodomain protein. Endocrinology (2005) 1.02
Nuclear factor Y and steroidogenic factor 1 physically and functionally interact to contribute to cell-specific expression of the mouse Follicle-stimulating hormone-beta gene. Mol Endocrinol (2003) 1.01
Activin and glucocorticoids synergistically activate follicle-stimulating hormone beta-subunit gene expression in the immortalized LbetaT2 gonadotrope cell line. Endocrinology (2006) 1.01
GnRH induces the c-Fos gene via phosphorylation of SRF by the calcium/calmodulin kinase II pathway. Mol Endocrinol (2011) 1.00
Neuron-specific expression in vivo by defined transcription regulatory elements of the GnRH gene. Endocrinology (2002) 0.98
Oocyte-specific overexpression of mouse bone morphogenetic protein-15 leads to accelerated folliculogenesis and an early onset of acyclicity in transgenic mice. Endocrinology (2008) 0.95
Androgen regulates follicle-stimulating hormone beta gene expression in an activin-dependent manner in immortalized gonadotropes. Mol Endocrinol (2003) 0.95
Synergistic induction of follicle-stimulating hormone beta-subunit gene expression by gonadal steroid hormone receptors and Smad proteins. Endocrinology (2007) 0.93
Different signaling pathways control acute induction versus long-term repression of LHbeta transcription by GnRH. Endocrinology (2002) 0.93
Otx2 induction of the gonadotropin-releasing hormone promoter is modulated by direct interactions with Grg co-repressors. J Biol Chem (2009) 0.93
Enhancers of GnRH transcription embedded in an upstream gene use homeodomain proteins to specify hypothalamic expression. Mol Endocrinol (2010) 0.92
A FoxL in the Smad house: activin regulation of FSH. Trends Endocrinol Metab (2010) 0.89
Progesterone Inhibits basal and gonadotropin-releasing hormone induction of luteinizing hormone beta-subunit gene expression. Endocrinology (2008) 0.88
FOXL2 is involved in the synergy between activin and progestins on the follicle-stimulating hormone β-subunit promoter. Endocrinology (2012) 0.88
Aberrant development of the suprachiasmatic nucleus and circadian rhythms in mice lacking the homeodomain protein Six6. J Biol Rhythms (2013) 0.87
Prenatal exposure to low levels of androgen accelerates female puberty onset and reproductive senescence in mice. Endocrinology (2012) 0.85
Different biological effects of unmodified prolactin and a molecular mimic of phosphorylated prolactin involve different signaling pathways. Biochemistry (2003) 0.85
KISS1R signals independently of Gαq/11 and triggers LH secretion via the β-arrestin pathway in the male mouse. Endocrinology (2014) 0.84
NeuroD1 and Mash1 temporally regulate GnRH receptor gene expression in immortalized mouse gonadotrope cells. Mol Cell Endocrinol (2008) 0.84
Heterozygous deletion of ventral anterior homeobox (vax1) causes subfertility in mice. Endocrinology (2014) 0.84
The protein kinase C pathway acts through multiple transcription factors to repress gonadotropin-releasing hormone gene expression in hypothalamic GT1-7 neuronal cells. Mol Endocrinol (2005) 0.83
GnRH increases c-Fos half-life contributing to higher FSHβ induction. Mol Endocrinol (2012) 0.83
Pituitary tumorigenesis targeted by the ovine follicle-stimulating hormone beta-subunit gene regulatory region in transgenic mice. Mol Cell Endocrinol (2003) 0.83
Runt-related transcription factors impair activin induction of the follicle-stimulating hormone {beta}-subunit gene. Endocrinology (2010) 0.83
PPARG regulates gonadotropin-releasing hormone signaling in LbetaT2 cells in vitro and pituitary gonadotroph function in vivo in mice. Biol Reprod (2010) 0.83
Gene dosage of Otx2 is important for fertility in male mice. Mol Cell Endocrinol (2013) 0.82
Dynamic chromatin modifications control GnRH gene expression during neuronal differentiation and protein kinase C signal transduction. Mol Endocrinol (2011) 0.82
Orexin A induces GnRH gene expression and secretion from GT1-7 hypothalamic GnRH neurons. Neuroendocrinology (2006) 0.82
Stress levels of glucocorticoids inhibit LHβ-subunit gene expression in gonadotrope cells. Mol Endocrinol (2012) 0.81
Msx1 homeodomain protein represses the αGSU and GnRH receptor genes during gonadotrope development. Mol Endocrinol (2013) 0.80
Androgen receptor repression of GnRH gene transcription. Mol Endocrinol (2011) 0.80
Phosphorylation of ATF2 and interaction with NFY induces c-Jun in the gonadotrope. Mol Cell Endocrinol (2012) 0.80
Glucocorticoids induce human glycoprotein hormone alpha-subunit gene expression in the gonadotrope. Endocrinology (2008) 0.80
Neurokinin B causes acute GnRH secretion and repression of GnRH transcription in GT1-7 GnRH neurons. Mol Endocrinol (2013) 0.79
Leptin increases L-type Ca2+ channel expression and GnRH-stimulated LH release in LbetaT2 gonadotropes. Mol Cell Endocrinol (2008) 0.79
Pseudophosphorylated prolactin (S179D PRL) inhibits growth and promotes beta-casein gene expression in the rat mammary gland. Cell Tissue Res (2002) 0.79
Mutational analysis of the necdin gene in patients with congenital isolated hypogonadotropic hypogonadism. Eur J Endocrinol (2011) 0.78
Kisspeptin regulates gonadotropin genes via immediate early gene induction in pituitary gonadotropes. Mol Endocrinol (2013) 0.78
Androgen receptor repression of gonadotropin-releasing hormone gene transcription via enhancer 1. Mol Cell Endocrinol (2012) 0.77
Neurokinin B induces c-fos transcription via protein kinase C and activation of serum response factor and Elk-1 in immortalized GnRH neurons. Endocrinology (2014) 0.76
Maternal prolactin composition can permanently affect epidermal gammadeltaT cell function in the offspring. Dev Comp Immunol (2002) 0.76
Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHβ. Mol Endocrinol (2014) 0.76
Trans-resveratrol inhibits phosphorylation of Smad2/3 and represses FSHβ gene expression by a SirT1-independent pathway in LβT2 gonadotrope cells. Reprod Toxicol (2011) 0.76
Complementary expression of IGF-II and IGFBP-5 during anterior pituitary development. Dev Biol (2002) 0.76
Transcriptional Activation of the Ovine Follicle-Stimulating Hormone-β Gene by Gonadotropin- Releasing Hormone Involves Multiple Signal Transduction Pathways. Endocrinology (2002) 0.75
Cell-Specific Transcriptional Regulation of Follicle-Stimulating Hormone-β by Activin and Gonadotropin-Releasing Hormone in the LβT2 Pituitary Gonadotrope Cell Model. Endocrinology (2001) 0.75