Changes in infectivity and plasmid profile of the Lyme disease spirochete, Borrelia burgdorferi, as a result of in vitro cultivation.

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Published in Infect Immun on August 01, 1988

Authors

T G Schwan1, W Burgdorfer, C F Garon

Author Affiliations

1: Laboratory of Pathobiology, Rocky Mountain Laboratories, National Institue of Allergy and Infectious Diseases, Hamilton, Montana 59840.

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Spiroplasmavirus citri 3: propagation, purification, proteins, and nucleic acid. Science (1977) 1.27

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