Published in Medicine (Baltimore) on February 01, 2017
Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol (2010) 16.24
Acute lymphoblastic leukaemia. Lancet (2013) 3.44
DNA damage from micronutrient deficiencies is likely to be a major cause of cancer. Mutat Res (2001) 2.09
Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review. Am J Epidemiol (2004) 1.91
A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels. Pharmacogenetics (2004) 1.88
A novel single nucleotide polymorphism within the 5' tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity. Cancer Res (2003) 1.73
Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: results from the Malaysia-Singapore ALL Study Group. Leuk Res (2009) 1.60
Identification and functional analysis of single nucleotide polymorphism in the tandem repeat sequence of thymidylate synthase gene. Cancer Res (2003) 1.53
The association between two polymorphisms in the TYMS gene and breast cancer risk: a meta-analysis. Breast Cancer Res Treat (2010) 1.49
Thymidylate synthase polymorphisms and hematological cancer risk: a meta-analysis. Leuk Lymphoma (2012) 1.42
Folate and cancer: how DNA damage, repair and methylation impact on colon carcinogenesis. J Inherit Metab Dis (2010) 1.40
Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia. Blood (2008) 1.28
Genomic characterization of childhood acute lymphoblastic leukemia. Semin Hematol (2013) 1.19
Folate: metabolism, genes, polymorphisms and the associated diseases. Gene (2013) 1.18
Gene-gene interactions in the folate metabolic pathway influence the risk for acute lymphoblastic leukemia in children. Leuk Lymphoma (2007) 1.15
Recent research advances in childhood acute lymphoblastic leukemia. J Formos Med Assoc (2010) 1.15
Genetic variation in the folate metabolic pathway and risk of childhood leukemia. Blood (2010) 1.14
Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia. Br J Haematol (2009) 1.10
Thymidylate synthase as a translational regulator of cellular gene expression. Biochim Biophys Acta (2002) 1.10
Folic acid deficiency increases chromosomal instability, chromosome 21 aneuploidy and sensitivity to radiation-induced micronuclei. Mutat Res (2005) 1.06
Folate metabolic gene polymorphisms and childhood acute lymphoblastic leukemia: a case-control study. Leukemia (2006) 1.01
Xenobiotic and folate pathway gene polymorphisms and risk of childhood acute lymphoblastic leukaemia in Javanese children. Hematol Oncol (2010) 1.01
Polymorphism in the thymidylate synthase promoter enhancer region modifies the risk and survival of colorectal cancer. Cancer Epidemiol Biomarkers Prev (2003) 0.96
Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia. Leuk Res (2007) 0.93
Variants in the dihydropyrimidine dehydrogenase, methylenetetrahydrofolate reductase and thymidylate synthase genes predict early toxicity of 5-fluorouracil in colorectal cancer patients. J Int Med Res (2010) 0.92
Association of thymidylate synthase enhancer region polymorphisms with thymidylate synthase activity in vivo. Pharmacogenomics J (2010) 0.92
Impact of thymidylate synthase promoter and DNA repair gene polymorphisms on susceptibility to childhood acute lymphoblastic leukemia. Leuk Lymphoma (2011) 0.90
Role of cysteine amino acid residues on the RNA binding activity of human thymidylate synthase. Nucleic Acids Res (2003) 0.85
Future potential of thymidylate synthase inhibitors in cancer therapy. Expert Opin Investig Drugs (2002) 0.84
Polymorphisms involved in folate metabolism pathways and the risk of the development of childhood acute leukemia. Genet Test Mol Biomarkers (2013) 0.84
Folate-related nutrients, genetic polymorphisms, and colorectal cancer risk: the fukuoka colorectal cancer study. Asian Pac J Cancer Prev (2013) 0.83
Associations between gene polymorphisms of thymidylate synthase with its protein expression and chemosensitivity to 5-fluorouracil in pancreatic carcinoma cells. Chin Med J (Engl) (2011) 0.81
Thymidylate synthase enhancer region polymorphism not related to susceptibility to acute lymphoblastic leukemia in the Kashmir population. Genet Mol Res (2012) 0.80
Thymidylate synthase gene polymorphisms and markers of DNA methylation capacity. Mol Genet Metab (2010) 0.80
Joint effects of folate intake and one-carbon-metabolizing genetic polymorphisms on breast cancer risk: a case-control study in China. Sci Rep (2016) 0.78
Associations between polymorphisms in folate-metabolizing genes and pancreatic cancer risk in Japanese subjects. BMC Gastroenterol (2016) 0.78
In vitro selected peptides bind with thymidylate synthase mRNA and inhibit its translation. Sci China C Life Sci (2007) 0.77
Effect of DNA Methylation in Various Diseases and the Probable Protective Role of Nutrition: A Mini-Review. Cureus (2015) 0.77
Association between polymorphic sites in thymidylate synthase gene and risk of non-Hodgkin lymphoma: a systematic review and pooled analysis. Leuk Lymphoma (2012) 0.76
Thymidylate synthase and methionine synthase polymorphisms are not associated with susceptibility to childhood acute lymphoblastic leukemia in Kurdish population from Western Iran. Mol Biol Rep (2011) 0.76
Laboratory diagnosis of four recent sporadic cases of community-acquired SARS, Guangdong Province, China. Emerg Infect Dis (2004) 1.65
An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus. J Pathol (2005) 1.12
Association between class III β-tubulin expression and response to paclitaxel/vinorebine-based chemotherapy for non-small cell lung cancer: a meta-analysis. Lung Cancer (2012) 1.04
Characterization of human coronavirus etiology in Chinese adults with acute upper respiratory tract infection by real-time RT-PCR assays. PLoS One (2012) 1.04
Human Coronaviruses HCoV-NL63 and HCoV-HKU1 in Hospitalized Children with Acute Respiratory Infections in Beijing, China. Adv Virol (2011) 0.98
[Chlamydia-like and coronavirus-like agents found in dead cases of atypical pneumonia by electron microscopy]. Zhonghua Yi Xue Za Zhi (2003) 0.98
Overexpression of microtubule-associated protein-1 light chain 3 is associated with melanoma metastasis and vasculogenic mimicry. Tohoku J Exp Med (2011) 0.93
A recombinant DNA and vaccinia virus prime-boost regimen induces potent long-term T-cell responses to HCV in BALB/c mice. Vaccine (2009) 0.90
Stability of SARS coronavirus in human specimens and environment and its sensitivity to heating and UV irradiation. Biomed Environ Sci (2003) 0.89
Paraquat inhibits cell viability via enhanced oxidative stress and apoptosis in human neural progenitor cells. Chem Biol Interact (2013) 0.87
Purification, characterization, and modification of T lymphocyte-stimulating polysaccharide from spores of Ganoderma lucidum. Chem Pharm Bull (Tokyo) (2002) 0.87
Human papillomavirus type 16 L1E7 chimeric capsomeres have prophylactic and therapeutic efficacy against papillomavirus in mice. Mol Cancer Ther (2008) 0.87
Consensus for the management of severe acute respiratory syndrome. Chin Med J (Engl) (2003) 0.85
Immunogenicity in mice and rhesus monkeys vaccinated with recombinant vaccinia virus expressing bivalent E7E6 fusion proteins from human papillomavirus types 16 and 18. Virol J (2011) 0.83
Optimisation of prime-boost immunization in mice using novel protein-based and recombinant vaccinia (Tiantan)-based HBV vaccine. PLoS One (2012) 0.83
Robust immunity and heterologous protection against influenza in mice elicited by a novel recombinant NP-M2e fusion protein expressed in E. coli. PLoS One (2012) 0.83
Optimization and proficiency testing of a pseudovirus-based assay for detection of HIV-1 neutralizing antibody in China. J Virol Methods (2012) 0.83
Poly(I:C)/alum mixed adjuvant priming enhances HBV subunit vaccine-induced immunity in mice when combined with recombinant adenoviral-based HBV vaccine boosting. PLoS One (2013) 0.82
Effect of route of delivery on heterologous protection against HCV induced by an adenovirus vector carrying HCV structural genes. Virol J (2011) 0.81
Influenza A virus nucleoprotein derived from Escherichia coli or recombinant vaccinia (Tiantan) virus elicits robust cross-protection in mice. Virol J (2012) 0.81
Recombinant DNA vaccine against neurite outgrowth inhibitors attenuates behavioral deficits and decreases Abeta in an Alzheimer's disease mouse model. Neuropharmacology (2012) 0.81
[Impact of different adjuvants on immunogenicity of the HBV particle vaccine containing the S + preS1 fusion antigen in Balb/C mice]. Sheng Wu Gong Cheng Xue Bao (2010) 0.81
[Oral exposure of fluorochloridone caused testes damage of Sparague-Dawley rats]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi (2014) 0.80
SARS-CoV spike proteins expressed by the vaccinia virus Tiantan strain: secreted sq protein induces robust neutralization antibody in mice. Viral Immunol (2009) 0.80
IL-15 increases the frequency of effector memory CD8+ T cells in rhesus monkeys immunized with HIV vaccine. Cell Mol Immunol (2010) 0.80
[Modification of HPV type 16 E6 and E7 genes, and analysis of stability and immunogenicity of the modified proteins]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi (2002) 0.80
The novel replication-defective vaccinia virus (Tiantan strain)-based hepatitis C virus vaccine induces robust immunity in macaques. Mol Ther (2013) 0.80
The design and application of DNA chips for early detection of SARS-CoV from clinical samples. J Clin Virol (2005) 0.80
[Screening for EGFR mutations in lung cancer by a novel real-time PCR with double-loop probe and Sanger DNA sequencing]. Zhonghua Zhong Liu Za Zhi (2013) 0.79
Enhanced effect of DNA immunization plus in vivo electroporation with a combination of hepatitis B virus core-PreS1 and S-PreS1 plasmids. Clin Vaccine Immunol (2011) 0.79
Isolation and Identification of Acholeplasma sp. from the Mud Crab, Scylla serrata. Evid Based Complement Alternat Med (2011) 0.79
Prokaryotic expression and polyclonal antibody preparation of a novel Rab-like protein mRabL5. Protein Expr Purif (2006) 0.79
Chlorpyrifos exposure causes alternation in dopamine metabolism in PC12 cells. Toxicol Mech Methods (2012) 0.78
[The 50% effective dose (ED50a) of seasonal spilt influenza vaccine in mice]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi (2011) 0.78
[Identification specific T lymphocyte epitopes on E6 protein of human papillomavirus type 18 in mice]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi (2010) 0.78
[Development of infectious pseudo-particle harboring three subtypes hepatitis C virus glycoproteins and their application in neutralization assays]. Bing Du Xue Bao (2008) 0.78
[Expression of influenza A3 virus (H3N2) M2 gene in vaccinia virus Tiantan strain]. Bing Du Xue Bao (2007) 0.77
[Development and comparison of real-time and conventional RT-PCR assay for detection of human coronavirus NL63 and HKU1]. Bing Du Xue Bao (2008) 0.77
[Construction and evaluation of hepatitis C virus (HCV) DNA vaccine containing E2-gAD fusion gene]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi (2010) 0.77
[Efficient soluble expression and purification of influenza A nucleoprotein in Escherichia coli]. Bing Du Xue Bao (2011) 0.77
[Characterization of human coronavirus 229E infection among patients with respiratory symptom in Beijing, Oct-Dec, 2007]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi (2009) 0.77
[Boosting with HBV subunit particle vaccine enhance immune response of novel DNA vaccine consisting of S-PreS1 fusion gene in mice]. Sheng Wu Gong Cheng Xue Bao (2011) 0.77
[Peptide mapping of H-2d restricted T-cell epitope against six antigens of HIV-1 subtype B'/C by ELISPOT assay]. Bing Du Xue Bao (2011) 0.76
[Non-replicating recombinant vaccinia virus expressing HPV16 E6 and E7 proteins elicits anti-tumor immunity in mice]. Zhonghua Zhong Liu Za Zhi (2003) 0.76
A pilot study on morphology and the mechanism involved in linearly patterned programmed cell necrosis in melanoma. Oncol Lett (2010) 0.75
[The non-replicating recombinant vaccinia virus expressing six genes of HIV-1 can be passaged stably in CEF]. Bing Du Xue Bao (2011) 0.75
[Antigenicity characterization of six different fragments of SARS-CoV N protein expressed in E. coli]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi (2012) 0.75
[Dual gene amplification and selection system with dihydrofolate reductase and glutamine synthetase genes effectively increase the foreign gene expression]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi (2002) 0.75
[Two HCV vaccines based on adeno-associated virus vectors elicited durable and effective immune responses in mice]. Bing Du Xue Bao (2009) 0.75
[Vaccination with three HIV-1 cross neutralizing epitopes fused to HBV S antigen could induce robust antibody immune response in mice]. Bing Du Xue Bao (2008) 0.75
[Construction and identification of the replication-deficient recombinant vaccinia virus co-expressing HPV type 16 L1 and L2 proteins]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi (2002) 0.75
[Enhancement of the immune response in mice with a noval HCV DNA vaccine targeting NS3 to dendritic cells]. Bing Du Xue Bao (2011) 0.75
[Construction of recombinant vaccinia virus co-expressing mutant E6 plus E7 proteins and detection of its immunogenicity and antitumor response]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi (2002) 0.75
[Construction of bicistronic eukaryotic expression vector containing HA and M2 genes derived from high pathogenic avian influenza virus (HPAI) H5N1 (Anhui strain)and its efficient expression in mammalian cells]. Bing Du Xue Bao (2008) 0.75
[Research and development of M2- and M2e-based broad-spectrum influenza A vaccines]. Bing Du Xue Bao (2011) 0.75
[Development and application of a safe SARS-CoV neutralization assay based on lentiviral vectors pseudotyped with SARS-CoV spike protein]. Bing Du Xue Bao (2007) 0.75
[Micro RNA alteration after paraquat induced PC12 cells damage and regulatory mechanism of bcl-2]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi (2014) 0.75
[Highly efficient expression of codon-optimized human papillomavirus 16 L2E7 gene in Escherichia coli]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao (2007) 0.75
[The high expression of HPV31 and 52 L2 fusion protein in E. coli and detection of its immunogenicity]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi (2013) 0.75
[Prokaryotic expression and purification of human papillomavirus type 11 L2E7 fusion protein vaccine and its immunnogenicity]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi (2007) 0.75
[The expression and preliminary evaluation of HPV6bL2deltaN360E7E6 fusion protein in E. coli for genital warts]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi (2010) 0.75
[Deletion of IV a2 gene from adenoviral genome by lambda-Red recombinase system and packaging of the recombinant adenovirus]. Bing Du Xue Bao (2011) 0.75
[Expression and immunity of multi-HIV B'/C subype genes in replicating DNA vaccines]. Bing Du Xue Bao (2010) 0.75
[Macrobenthic faunal diversity in Xiangshan Bay]. Ying Yong Sheng Tai Xue Bao (2010) 0.75
[The immunogenicity in mice enhanced significantly via prime-boost vaccination with DNA-based or recombinant vaccinia(Tiantan) viral-based H5N1 vaccine candidates containing multi-structural antigens]. Bing Du Xue Bao (2011) 0.75
[CpG-ODN is a potential candidate adjuvant for human vaccines]. Zhonghua Yi Xue Za Zhi (2002) 0.75
[HBV DNA vaccination with electroporation enhances significantly the specific cell-mediated immune response in mice against HBV protein vaccine consisting of S-PreS1 fusion particles]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi (2010) 0.75
[Expression of IL-6 in recombinant non-replicating vaccinia virus and studying its effects on immunogenicity]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi (2002) 0.75
[Augmentation of the immunostimulatory effects of plasmid DNA by incorporation of human CpG-oligodeoxynucletide]. Zhonghua Yi Xue Za Zhi (2002) 0.75
Experimental study on induction of renal cell carcinoma apoptosis by antisense oligonucleotide targeting survivin. J Huazhong Univ Sci Technolog Med Sci (2004) 0.75
[Calcineurin subunit B is not an effective adjuvant when combined with a novel HBV protein particle vaccine]. Bing Du Xue Bao (2014) 0.75
[Consecutive five-year follow-up analysis of specific IgG antibody of 22 cases of SARS patients after recovery]. Bing Du Xue Bao (2010) 0.75
[Construction of recombinant vaccina virus of HPV16 and its antitumor effect]. Ai Zheng (2005) 0.75
[DNA vaccination via in vivo electroporation can elicit specific immune response against highly pathogenic H5N1 influenza viral structural antigens in mice]. Bing Du Xue Bao (2010) 0.75
[Construction and identification of non-replication recombinant vaccinia virus co-expressing human papillomavirus type 16 L1/L2/E6/E7 proteins]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi (2005) 0.75
[High expression of HPV16L2N120E7E6 fusion protein in E. coli and its inhibitory effect on tumor growth in mice]. Zhonghua Zhong Liu Za Zhi (2012) 0.75
[Immune protective effectiveness of seasonal influenza spilt vaccine against homologous and heterogonous subtypes of influenza virus in mice]. Bing Du Xue Bao (2011) 0.75
[Expression of the human papillomavirus type 16L/E7 fusion protein in E. coli and observation of its immunogenicity in mice]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi (2006) 0.75
[Construction of recombinant vaccinia virus expressing HPV18E7E6 fusion proteins and detection of its immunogenicity in mice]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi (2008) 0.75