Homozygous carriers of the TCF7L2 rs7903146 T-allele show altered postprandial response in triglycerides and triglyceride-rich lipoproteins.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28220878)

Published in Sci Rep on February 21, 2017

Authors

L Engelbrechtsen1,2, T H Hansen1, Y Mahendran1,2, P Pyl1, E Andersson1, A Jonsson1, A Gjesing1, A Linneberg3,4,5, T Jørgensen3,6,7, T Hansen1, H Vestergaard1,8

Author Affiliations

1: Section of Metabolic Genetics, Novo Nordisk Research Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Universitetsparken 1, DIKU-building 1. Floor, DK-2100 Copenhagen.
2: Danish Diabetes Academy, Odense, Denmark.
3: Research Centre for Prevention and Health, The Capital Region of Denmark, Denmark.
4: Department of Clinical Experimental Research, Rigshospitalet, Denmark.
5: Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
6: Department of Public health, Faculty of Health Science, University of Copenhagen, Denmark.
7: Faculty of Medicine, Aalborg University, Denmark.
8: Steno Diabetes Center, Gentofte, Denmark.

Articles cited by this

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet (2006) 19.03

Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care (1993) 17.66

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96

Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. JAMA (2007) 9.68

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest (2007) 5.02

A randomized non-pharmacological intervention study for prevention of ischaemic heart disease: baseline results Inter99. Eur J Cardiovasc Prev Rehabil (2003) 4.25

Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat Genet (2012) 4.08

Elevated remnant cholesterol causes both low-grade inflammation and ischemic heart disease, whereas elevated low-density lipoprotein cholesterol causes ischemic heart disease without inflammation. Circulation (2013) 3.80

The independent effect of type 2 diabetes mellitus on ischemic heart disease, stroke, and death: a population-based study of 13,000 men and women with 20 years of follow-up. Arch Intern Med (2004) 3.34

Nonfasting triglycerides and risk of ischemic stroke in the general population. JAMA (2008) 3.10

High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism. Analyst (2009) 2.49

Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell (2012) 2.45

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function. Hum Mol Genet (2009) 2.29

Identification of common genetic variants that account for transcript isoform variation between human populations. Hum Genet (2008) 1.96

Nonfasting triglycerides, cholesterol, and ischemic stroke in the general population. Ann Neurol (2011) 1.87

Tissue-specific alternative splicing of TCF7L2. Hum Mol Genet (2009) 1.80

Transcription factor 7-like 2 polymorphisms and type 2 diabetes, glucose homeostasis traits and gene expression in US participants of European and African descent. Diabetologia (2007) 1.73

Metabolic signatures of adiposity in young adults: Mendelian randomization analysis and effects of weight change. PLoS Med (2014) 1.42

Triglycerides and heart disease: still a hypothesis? Arterioscler Thromb Vasc Biol (2011) 1.32

Selective retention of VLDL, IDL, and LDL in the arterial intima of genetically hyperlipidemic rabbits in vivo. Molecular size as a determinant of fractional loss from the intima-inner media. Arterioscler Thromb Vasc Biol (1995) 1.25

Effects of the diabetes linked TCF7L2 polymorphism in a representative older population. BMC Med (2006) 1.15

The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue. Cell Metab (2014) 1.04

Transcription factor 7-like 2 polymorphism modulates glucose and lipid homeostasis, adipokine profile, and hepatocyte apoptosis in NASH. Hepatology (2009) 1.02

TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals. Diabetologia (2012) 1.01

Single nucleotide polymorphisms of TCF7L2 are linked to diabetic coronary atherosclerosis. PLoS One (2011) 0.95

Effects of rs7903146 variation in the Tcf7l2 gene in the lipid metabolism of three different populations. PLoS One (2012) 0.92

The Wnt signaling pathway effector TCF7L2 is upregulated by insulin and represses hepatic gluconeogenesis. Am J Physiol Endocrinol Metab (2012) 0.91

Plasma metabolomics reveal alterations of sphingo- and glycerophospholipid levels in non-diabetic carriers of the transcription factor 7-like 2 polymorphism rs7903146. PLoS One (2013) 0.90

Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test. Diabetologia (2010) 0.88

The mechanisms of genome-wide target gene regulation by TCF7L2 in liver cells. Nucleic Acids Res (2014) 0.86

Association of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) polymorphisms in TCF7L2 with type 2 diabetes in 9,619 Han Chinese population. PLoS One (2013) 0.85

Triglyceride-Rich Lipoproteins and Atherosclerotic Cardiovascular Disease: New Insights From Epidemiology, Genetics, and Biology. Circ Res (2016) 0.85

Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the TCF7L2 rs7903146 risk T allele. Diabetes Obes Metab (2012) 0.82

The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in Type 2 Diabetes: A Meta-Analysis. J Diabetes Res (2015) 0.80

Clinical and non-targeted metabolomic profiling of homozygous carriers of Transcription Factor 7-like 2 variant rs7903146. Sci Rep (2014) 0.80

Impact of the Content of Fatty Acids of Oral Fat Tolerance Tests on Postprandial Triglyceridemia: Systematic Review and Meta-Analysis. Nutrients (2016) 0.76