Published in Pediatr Crit Care Med on March 01, 2017
The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med (1994) 27.68
Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med (2006) 23.62
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA (2016) 17.49
International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med (2005) 13.40
Chimeric antigen receptor T cells for sustained remissions in leukemia. N Engl J Med (2014) 8.21
Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia. Sci Transl Med (2014) 5.60
T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial. Lancet (2014) 5.42
The epidemiology of severe sepsis in children in the United States. Am J Respir Crit Care Med (2002) 4.72
Graft-versus-host disease. Nat Rev Immunol (2007) 4.26
A biomarker panel for acute graft-versus-host disease. Blood (2008) 3.83
Advances in graft-versus-host disease biology and therapy. Nat Rev Immunol (2012) 3.50
ST2 as a marker for risk of therapy-resistant graft-versus-host disease and death. N Engl J Med (2013) 3.27
Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients. Ann Intern Med (1993) 2.91
Current concepts in the diagnosis and management of cytokine release syndrome. Blood (2014) 2.63
Cumulative influence of organ dysfunctions and septic state on mortality of critically ill children. Am J Respir Crit Care Med (2004) 2.56
Pediatric acute respiratory distress syndrome: definition, incidence, and epidemiology: proceedings from the Pediatric Acute Lung Injury Consensus Conference. Pediatr Crit Care Med (2015) 2.44
Venoocclusive disease of the liver following bone marrow transplantation. Transplantation (1987) 2.35
Reliability of the identification of the systemic inflammatory response syndrome in critically ill infants and children. Pediatr Crit Care Med (2012) 2.29
Venocclusive disease of the liver after bone marrow transplantation: diagnosis, incidence, and predisposing factors. Hepatology (1984) 2.19
Pediatric acute respiratory distress syndrome: consensus recommendations from the Pediatric Acute Lung Injury Consensus Conference. Pediatr Crit Care Med (2015) 2.18
Defibrotide for prophylaxis of hepatic veno-occlusive disease in paediatric haemopoietic stem-cell transplantation: an open-label, phase 3, randomised controlled trial. Lancet (2012) 2.02
A prognostic score for acute graft-versus-host disease based on biomarkers: a multicentre study. Lancet Haematol (2014) 1.97
Hepatic veno-occlusive disease following stem cell transplantation: incidence, clinical course, and outcome. Biol Blood Marrow Transplant (2009) 1.87
Blood and marrow transplant clinical trials network toxicity committee consensus summary: thrombotic microangiopathy after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant (2005) 1.85
Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome following allogeneic HPC transplantation: a diagnostic dilemma. Transfusion (2004) 1.84
Changes in outcomes (1996-2004) for pediatric oncology and hematopoietic stem cell transplant patients requiring invasive mechanical ventilation. Pediatr Crit Care Med (2008) 1.68
Intestinal thrombotic microangiopathy after allogeneic bone marrow transplantation: a clinical imitator of acute enteric graft-versus-host disease. Bone Marrow Transplant (2004) 1.67
Pediatric Acute Lung Injury Epidemiology and Natural History study: Incidence and outcome of the acute respiratory distress syndrome in children. Crit Care Med (2012) 1.66
The syndrome of hepatic veno-occlusive disease after marrow transplantation. Blood (1995) 1.61
Prognostic factors in pediatric cancer patients admitted to the pediatric intensive care unit. J Pediatr Hematol Oncol (2009) 1.59
Dexamethasone reduces postoperative troponin levels in children undergoing cardiopulmonary bypass. Crit Care Med (2003) 1.56
NHLBI workshop summary. Idiopathic pneumonia syndrome after bone marrow transplantation. Am Rev Respir Dis (1993) 1.54
Outcome of severe sepsis in pediatric oncology patients. Pediatr Crit Care Med (2005) 1.50
The genetic fingerprint of susceptibility for transplant-associated thrombotic microangiopathy. Blood (2015) 1.43
Myocardial transcriptional profiles in a murine model of sepsis: evidence for the importance of age. Pediatr Crit Care Med (2008) 1.43
A pilot trial using lymphocytes genetically engineered with an NY-ESO-1-reactive T-cell receptor: long-term follow-up and correlates with response. Clin Cancer Res (2014) 1.42
An official American Thoracic Society research statement: noninfectious lung injury after hematopoietic stem cell transplantation: idiopathic pneumonia syndrome. Am J Respir Crit Care Med (2011) 1.40
Diagnostic criteria for hematopoietic stem cell transplant-associated microangiopathy: results of a consensus process by an International Working Group. Haematologica (2007) 1.39
Abnormalities in the alternative pathway of complement in children with hematopoietic stem cell transplant-associated thrombotic microangiopathy. Blood (2013) 1.22
Diagnostic and risk criteria for HSCT-associated thrombotic microangiopathy: a study in children and young adults. Blood (2014) 1.19
Eculizumab therapy in children with severe hematopoietic stem cell transplantation-associated thrombotic microangiopathy. Biol Blood Marrow Transplant (2013) 1.16
How I manage sinusoidal obstruction syndrome after haematopoietic cell transplantation. Br J Haematol (2014) 1.15
Idiopathic pneumonia syndrome: changing spectrum of lung injury after marrow transplantation. Transplantation (1997) 1.10
Clinical course of idiopathic pneumonia after bone marrow transplantation. Am Rev Respir Dis (1993) 1.06
Venoocclusive disease of the liver: development of a model for predicting fatal outcome after marrow transplantation. J Clin Oncol (1993) 1.03
Human biomarker discovery and predictive models for disease progression for idiopathic pneumonia syndrome following allogeneic stem cell transplantation. Mol Cell Proteomics (2012) 0.97
Pulmonary arterial hypertension in pediatric patients with hematopoietic stem cell transplant-associated thrombotic microangiopathy. Biol Blood Marrow Transplant (2012) 0.97
Pulmonary hypertension after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant (2013) 0.96
The contribution of endothelial activation and injury to end-organ toxicity following allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant (2008) 0.94
Does early initiation of therapeutic plasma exchange improve outcome in pediatric stem cell transplant-associated thrombotic microangiopathy? Transfusion (2012) 0.94
The clinical features, risk factors and outcome of thrombotic thrombocytopenic purpura occurring after bone marrow transplantation. Br J Haematol (2001) 0.91
A new paradigm: Diagnosis and management of HSCT-associated thrombotic microangiopathy as multi-system endothelial injury. Blood Rev (2014) 0.91
Pathobiology of acute respiratory distress syndrome. Pediatr Crit Care Med (2015) 0.90
Nitric oxide delivery during cardiopulmonary bypass reduces postoperative morbidity in children--a randomized trial. J Thorac Cardiovasc Surg (2012) 0.88
Effects of age and ischemic times on biochemical evidence of myocardial injury after pediatric cardiac operations. J Thorac Cardiovasc Surg (1997) 0.87
A comparison of clinical criteria for the diagnosis of veno-occlusive disease of the liver after bone marrow transplantation. Bone Marrow Transplant (1992) 0.85
The inflammatory response to injury in children. Curr Opin Pediatr (2010) 0.85
Safety and efficacy of defibrotide for the treatment of severe hepatic veno-occlusive disease. Ther Adv Hematol (2012) 0.84
TNF-receptor inhibitor therapy for the treatment of children with idiopathic pneumonia syndrome. A joint Pediatric Blood and Marrow Transplant Consortium and Children's Oncology Group Study (ASCT0521). Biol Blood Marrow Transplant (2014) 0.83
Defibrotide as a promising treatment for thrombotic thrombocytopenic purpura in patients undergoing bone marrow transplantation. Bone Marrow Transplant (2002) 0.83
The outcomes of children with pediatric acute respiratory distress syndrome: proceedings from the Pediatric Acute Lung Injury Consensus Conference. Pediatr Crit Care Med (2015) 0.82
Comorbidities and assessment of severity of pediatric acute respiratory distress syndrome: proceedings from the Pediatric Acute Lung Injury Consensus Conference. Pediatr Crit Care Med (2015) 0.81
Nonrespiratory pediatric logistic organ dysfunction-2 score is a good predictor of mortality in children with acute respiratory failure. Pediatr Crit Care Med (2014) 0.78
Histologic Features of Intestinal Thrombotic Microangiopathy in Pediatric and Young Adult Patients after Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant (2015) 0.76
Defining vasodilatory shock following cardiac surgery in children: when, where, how often? Pediatr Crit Care Med (2009) 0.76
Critically ill patients with 2009 influenza A(H1N1) infection in Canada. JAMA (2009) 13.00
Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis. Clin Infect Dis (2004) 6.65
Hypothermia therapy after traumatic brain injury in children. N Engl J Med (2008) 6.10
Validation of the paediatric logistic organ dysfunction (PELOD) score: prospective, observational, multicentre study. Lancet (2003) 5.40
Acute graft-versus-host disease does not require alloantigen expression on host epithelium. Nat Med (2002) 3.94
A biomarker panel for acute graft-versus-host disease. Blood (2008) 3.83
Prone ventilation reduces mortality in patients with acute respiratory failure and severe hypoxemia: systematic review and meta-analysis. Intensive Care Med (2010) 2.88
Risk factors of acute renal failure in critically ill children: A prospective descriptive epidemiological study. Pediatr Crit Care Med (2007) 2.60
Cumulative influence of organ dysfunctions and septic state on mortality of critically ill children. Am J Respir Crit Care Med (2004) 2.56
Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia. Blood (2012) 2.52
Red blood cell transfusion thresholds in pediatric patients with sepsis. Pediatr Crit Care Med (2011) 2.35
Identification of pediatric septic shock subclasses based on genome-wide expression profiling. BMC Med (2009) 2.23
Parental involvement in treatment decisions regarding their critically ill child: a comparative study of France and Quebec. Pediatr Crit Care Med (2007) 2.22
Validation of a gene expression-based subclassification strategy for pediatric septic shock. Crit Care Med (2011) 2.20
Developing a clinically feasible personalized medicine approach to pediatric septic shock. Am J Respir Crit Care Med (2015) 2.09
Outcomes of hematopoietic stem cell transplant patients who received continuous renal replacement therapy in a pediatric oncology intensive care unit. Pediatr Crit Care Med (2010) 2.08
The Withdrawal Assessment Tool-1 (WAT-1): an assessment instrument for monitoring opioid and benzodiazepine withdrawal symptoms in pediatric patients. Pediatr Crit Care Med (2008) 2.04
The pediatric sepsis biomarker risk model. Crit Care (2012) 1.99
Defining acute lung disease in children with the oxygenation saturation index. Pediatr Crit Care Med (2010) 1.92
Host dendritic cells alone are sufficient to initiate acute graft-versus-host disease. J Immunol (2004) 1.91
Care models and associated outcomes in congenital heart surgery. Pediatrics (2011) 1.90
Modes of death in pediatrics: differences in the ethical approach in neonatal and pediatric patients. J Pediatr (2013) 1.81
Procalcitonin and C-reactive protein as markers of bacterial infection in critically ill children at onset of systemic inflammatory response syndrome. Pediatr Crit Care Med (2008) 1.80
Targeted temperature management in critical care: a report and recommendations from five professional societies. Crit Care Med (2011) 1.72
Post-ICU admission fluid balance and pediatric septic shock outcomes: a risk-stratified analysis. Crit Care Med (2014) 1.72
Cardiac extracorporeal life support: state of the art in 2007. Cardiol Young (2007) 1.68
Prospective evaluation of sedation-related adverse events in pediatric patients ventilated for acute respiratory failure. Crit Care Med (2012) 1.67
Severe traumatic brain injury in children elevates glial fibrillary acidic protein in cerebrospinal fluid and serum. Pediatr Crit Care Med (2011) 1.64
Ventilator-associated pneumonia in intubated children: comparison of different diagnostic methods. Pediatr Crit Care Med (2003) 1.62
Evaluation of the pediatric risk of admission score in a pediatric emergency department. Ann Emerg Med (2003) 1.58
Noninvasive positive-pressure ventilation in children with lower airway obstruction. Pediatr Crit Care Med (2004) 1.58
The influence of developmental age on the early transcriptomic response of children with septic shock. Mol Med (2011) 1.57
Determinants of red blood cell transfusions in a pediatric critical care unit: a prospective, descriptive epidemiological study. Crit Care Med (2005) 1.57
Critical role of prostaglandin E2 overproduction in impaired pulmonary host response following bone marrow transplantation. J Immunol (2006) 1.56
The pathophysiology of acute graft-versus-host disease. Int J Hematol (2003) 1.55
Survey on transfusion practices of pediatric intensivists. Pediatr Crit Care Med (2002) 1.55
Experiencing the pediatric intensive care unit: perspective from parents of children with severe antecedent disabilities. Crit Care Med (2009) 1.53
Children with chronic conditions in pediatric intensive care units located in predominantly French-speaking regions: Prevalence and implications on rehabilitation care need and utilization. Crit Care Med (2009) 1.52
Clinical equipoise regarding glycemic control: a survey of pediatric intensivist perceptions. Pediatr Crit Care Med (2013) 1.52
Bronchiolitis obliterans syndrome (BOS), bronchiolitis obliterans organizing pneumonia (BOOP), and other late-onset noninfectious pulmonary complications following allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant (2007) 1.52
Prospective cohort study comparing intravenous busulfan to total body irradiation in hematopoietic cell transplantation. Blood (2013) 1.50
Outcome of severe sepsis in pediatric oncology patients. Pediatr Crit Care Med (2005) 1.50
Clinical outcomes of children receiving intensive cardiopulmonary support during hematopoietic stem cell transplant. Pediatr Crit Care Med (2013) 1.50
A Multibiomarker-Based Model for Estimating the Risk of Septic Acute Kidney Injury. Crit Care Med (2015) 1.49
Validation of the Individualized Numeric Rating Scale (INRS): a pain assessment tool for nonverbal children with intellectual disability. Pain (2010) 1.47
Prone positioning can be safely performed in critically ill infants and children. Pediatr Crit Care Med (2006) 1.46
Role of CXCR3-induced donor T-cell migration in acute GVHD. Exp Hematol (2003) 1.46
Respiratory Dysfunction Associated With RBC Transfusion in Critically Ill Children: A Prospective Cohort Study. Pediatr Crit Care Med (2015) 1.46
Paediatric logistic organ dysfunction (PELOD) score. Lancet (2006) 1.45
Clinical Outcomes Associated With RBC Transfusions in Critically Ill Children: A 1-Year Prospective Study. Pediatr Crit Care Med (2015) 1.44
Cardiac arrhythmias associated with severe traumatic brain injury and hypothermia therapy. Pediatr Crit Care Med (2010) 1.42
PICU mortality: is it better 9 to 5? Pediatr Crit Care Med (2005) 1.42
Survey on stated transfusion practices in PICUs*. Pediatr Crit Care Med (2014) 1.42
Judgment, inquiry, engagement, voice: reenvisioning an undergraduate nursing curriculum using a shared decision-making model. J Prof Nurs (2013) 1.40
An official American Thoracic Society research statement: noninfectious lung injury after hematopoietic stem cell transplantation: idiopathic pneumonia syndrome. Am J Respir Crit Care Med (2011) 1.40
Ventilator-Associated Events in Neonates and Children-A New Paradigm. Crit Care Med (2016) 1.40
Nurse decision making regarding the use of analgesics and sedatives in the pediatric cardiac ICU. Pediatr Crit Care Med (2014) 1.40
Risk factors associated with iatrogenic opioid and benzodiazepine withdrawal in critically ill pediatric patients: a systematic review and conceptual model. Pediatr Crit Care Med (2015) 1.40
Invasive Mechanical Ventilation and Mortality in Pediatric Hematopoietic Stem Cell Transplantation: A Multicenter Study. Pediatr Crit Care Med (2016) 1.39
Patterns of Sedation Weaning in Critically Ill Children Recovering From Acute Respiratory Failure. Pediatr Crit Care Med (2016) 1.38
Interleukin-27 is a novel candidate diagnostic biomarker for bacterial infection in critically ill children. Crit Care (2012) 1.31
Anemia, blood loss, and blood transfusions in North American children in the intensive care unit. Am J Respir Crit Care Med (2008) 1.25
Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients. Transfusion (2010) 1.25
Blockade of CXCR3 receptor:ligand interactions reduces leukocyte recruitment to the lung and the severity of experimental idiopathic pneumonia syndrome. J Immunol (2004) 1.24
The pediatric multiple organ dysfunction syndrome. Pediatr Crit Care Med (2009) 1.24
Association between length of storage of red blood cell units and outcome of critically ill children: a prospective observational study. Crit Care (2010) 1.23
Pilot trial on the use of etanercept and methylprednisolone as primary treatment for acute graft-versus-host disease. Biol Blood Marrow Transplant (2005) 1.21
Corticosteroids are associated with repression of adaptive immunity gene programs in pediatric septic shock. Am J Respir Crit Care Med (2014) 1.20
Hypothermia therapy after pediatric cardiac arrest. Circulation (2009) 1.19
Identification of candidate serum biomarkers for severe septic shock-associated kidney injury via microarray. Crit Care (2011) 1.16
PELOD-2: an update of the PEdiatric logistic organ dysfunction score. Crit Care Med (2013) 1.16
Inspiratory muscle unloading by neurally adjusted ventilatory assist during maximal inspiratory efforts in healthy subjects. Chest (2007) 1.15
The lung as a target organ of graft-versus-host disease. Semin Hematol (2006) 1.14
Fatality rates in published reports of RSV hospitalizations among high-risk and otherwise healthy children. Curr Med Res Opin (2010) 1.14
Survey of transfusion policies at US and Canadian children's hospitals in 2008 and 2009. Transfusion (2010) 1.14
Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury. Intensive Care Med (2009) 1.14
Impaired thymic negative selection causes autoimmune graft-versus-host disease. Blood (2003) 1.11
Prolonged neural expiratory time induced by mechanical ventilation in infants. Pediatr Res (2004) 1.10
Incidence of deep vein thrombosis related to peripherally inserted central catheters in children and adolescents. CMAJ (2007) 1.08
Re: Risk and associated factors of pressure ulcers in hospitalized children over 1 year of age. J Spec Pediatr Nurs (2014) 1.08
Combining Prognostic and Predictive Enrichment Strategies to Identify Children With Septic Shock Responsive to Corticosteroids. Crit Care Med (2016) 1.08
Daily estimation of the severity of multiple organ dysfunction syndrome in critically ill children. CMAJ (2010) 1.07
Characteristics of children intubated and mechanically ventilated in 16 PICUs. Chest (2009) 1.06
Comparison of two red-cell transfusion strategies after pediatric cardiac surgery: a subgroup analysis. Crit Care Med (2010) 1.05
A critical role for CCR2/MCP-1 interactions in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation. Blood (2003) 1.03
Etanercept (Enbrel) administration for idiopathic pneumonia syndrome after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant (2002) 1.03
Pain assessment in nonverbal children with severe cognitive impairments: the Individualized Numeric Rating Scale (INRS). J Pediatr Nurs (2003) 1.02
National Cancer Institute-National Heart, Lung and Blood Institute/pediatric Blood and Marrow Transplant Consortium First International Consensus Conference on late effects after pediatric hematopoietic cell transplantation: long-term organ damage and dysfunction. Biol Blood Marrow Transplant (2011) 1.01
National Cancer Institute, National Heart, Lung and Blood Institute/Pediatric Blood and Marrow Transplantation Consortium First International Consensus Conference on late effects after pediatric hematopoietic cell transplantation: the need for pediatric-specific long-term follow-up guidelines. Biol Blood Marrow Transplant (2012) 1.01
Multicenter validation of a computer-based clinical decision support tool for glucose control in adult and pediatric intensive care units. J Diabetes Sci Technol (2008) 1.00
Validity and generalizability of the Withdrawal Assessment Tool-1 (WAT-1) for monitoring iatrogenic withdrawal syndrome in pediatric patients. Pain (2011) 0.99
Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis. J Exp Med (2010) 0.99
CCR1/CCL5 (RANTES) receptor-ligand interactions modulate allogeneic T-cell responses and graft-versus-host disease following stem-cell transplantation. Blood (2007) 0.98
LRPPRC mutations cause a phenotypically distinct form of Leigh syndrome with cytochrome c oxidase deficiency. J Med Genet (2011) 0.98
In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity on CYP-450 (Part 2). Bioorg Med Chem (2007) 0.98
Pretreatment of donors with interleukin-18 attenuates acute graft-versus-host disease via STAT6 and preserves graft-versus-leukemia effects. Blood (2002) 0.98
Randomized clinical trials in pediatric critical care: Rarely done but desperately needed. Pediatr Crit Care Med (2002) 0.97
Human biomarker discovery and predictive models for disease progression for idiopathic pneumonia syndrome following allogeneic stem cell transplantation. Mol Cell Proteomics (2012) 0.97