Hypothermia therapy after traumatic brain injury in children.

PubWeight™: 6.10‹?› | Rank: Top 1%

🔗 View Article (PMID 18525042)

Published in N Engl J Med on June 05, 2008

Authors

James S Hutchison1, Roxanne E Ward, Jacques Lacroix, Paul C Hébert, Marcia A Barnes, Desmond J Bohn, Peter B Dirks, Steve Doucette, Dean Fergusson, Ronald Gottesman, Ari R Joffe, Haresh M Kirpalani, Philippe G Meyer, Kevin P Morris, David Moher, Ram N Singh, Peter W Skippen, Hypothermia Pediatric Head Injury Trial Investigators and the Canadian Critical Care Trials Group

Author Affiliations

1: Department of Critical Care Medicine, Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8, Canada. jamie.hutchison@sickkids.ca

Articles citing this

Very early hypothermia induction in patients with severe brain injury (the National Acute Brain Injury Study: Hypothermia II): a randomised trial. Lancet Neurol (2010) 5.23

Therapeutic hypothermia after out-of-hospital cardiac arrest in children. N Engl J Med (2015) 4.90

Therapeutic Hypothermia after In-Hospital Cardiac Arrest in Children. N Engl J Med (2017) 3.89

Management of bleeding and coagulopathy following major trauma: an updated European guideline. Crit Care (2013) 3.65

Management of bleeding following major trauma: an updated European guideline. Crit Care (2010) 3.09

Multicenter cohort study of out-of-hospital pediatric cardiac arrest. Crit Care Med (2011) 3.05

Multicenter cohort study of in-hospital pediatric cardiac arrest. Pediatr Crit Care Med (2009) 2.81

In-hospital versus out-of-hospital pediatric cardiac arrest: a multicenter cohort study. Crit Care Med (2009) 2.70

Therapeutic hypothermia for acute ischemic stroke: ready to start large randomized trials? J Cereb Blood Flow Metab (2010) 1.85

Efficacy outcome selection in the therapeutic hypothermia after pediatric cardiac arrest trials. Pediatr Crit Care Med (2015) 1.82

Hypothermia increases interleukin-6 and interleukin-10 in juvenile endotoxemic mice. Pediatr Crit Care Med (2010) 1.60

Osmolar therapy in pediatric traumatic brain injury. Crit Care Med (2012) 1.55

Therapeutic hypothermia decreases phenytoin elimination in children with traumatic brain injury. Crit Care Med (2013) 1.51

Research as a Standard of Care in the PICU. Pediatr Crit Care Med (2016) 1.44

Comparison of the New Adult Ventilator-Associated Event Criteria to the Centers for Disease Control and Prevention Pediatric Ventilator-Associated Pneumonia Definition (PNU2) in a Population of Pediatric Traumatic Brain Injury Patients. Pediatr Crit Care Med (2016) 1.39

Rationale, timeline, study design, and protocol overview of the therapeutic hypothermia after pediatric cardiac arrest trials. Pediatr Crit Care Med (2013) 1.35

Mitochondrial mechanisms of cell death and neuroprotection in pediatric ischemic and traumatic brain injury. Exp Neurol (2009) 1.31

Hypothermia for acute brain injury--mechanisms and practical aspects. Nat Rev Neurol (2012) 1.28

The evidence for hypothermia as a neuroprotectant in traumatic brain injury. Neurotherapeutics (2010) 1.25

Prolonged mild therapeutic hypothermia versus fever control with tight hemodynamic monitoring and slow rewarming in patients with severe traumatic brain injury: a randomized controlled trial. J Neurotrauma (2015) 1.14

Differences in medical therapy goals for children with severe traumatic brain injury-an international study. Pediatr Crit Care Med (2013) 1.11

Cyclosporin A preserves mitochondrial function after traumatic brain injury in the immature rat and piglet. J Neurotrauma (2011) 1.01

Hypothermia as a cytoprotective strategy in ischemic tissue injury. Ageing Res Rev (2009) 1.00

Targeted suppression of claudin-5 decreases cerebral oedema and improves cognitive outcome following traumatic brain injury. Nat Commun (2012) 1.00

Neurocritical care update. J Intensive Care (2016) 1.00

Variation in intracranial pressure monitoring and outcomes in pediatric traumatic brain injury. Arch Pediatr Adolesc Med (2012) 0.93

Brain temperature and its fundamental properties: a review for clinical neuroscientists. Front Neurosci (2014) 0.93

Combinational therapy using hypothermia and the immunophilin ligand FK506 to target altered pial arteriolar reactivity, axonal damage, and blood-brain barrier dysfunction after traumatic brain injury in rat. J Cereb Blood Flow Metab (2010) 0.93

Multicenter trial of early hypothermia in severe brain injury. J Neurotrauma (2009) 0.92

Risk factors for mortality in children with abusive head trauma. J Pediatr (2012) 0.91

How I cool children in neurocritical care. Neurocrit Care (2010) 0.87

Clinical applications of targeted temperature management. Chest (2014) 0.86

Therapeutic hypothermia as a neuroprotective strategy in neonatal hypoxic-ischemic brain injury and traumatic brain injury. Curr Mol Med (2012) 0.86

Use of Rotterdam CT scores for mortality risk stratification in children with traumatic brain injury. Pediatr Crit Care Med (2014) 0.86

Pediatric traumatic brain injury in 2012: the year with new guidelines and common data elements. Crit Care Clin (2013) 0.85

Endothelin-1 is increased in cerebrospinal fluid and associated with unfavorable outcomes in children after severe traumatic brain injury. J Neurotrauma (2010) 0.84

Hypothermia following pediatric traumatic brain injury. J Neurotrauma (2009) 0.84

Therapeutic hypothermia and targeted temperature management in traumatic brain injury: Clinical challenges for successful translation. Brain Res (2015) 0.84

EEG monitoring during therapeutic hypothermia in neonates, children, and adults. Am J Electroneurodiagnostic Technol (2011) 0.83

Pediatric neurocritical care. Neurotherapeutics (2012) 0.83

Quo vadis 2010? - carpe diem: challenges and opportunities in pediatric traumatic brain injury. Dev Neurosci (2011) 0.82

Report of a consensus meeting on human brain temperature after severe traumatic brain injury: its measurement and management during pyrexia. Front Neurol (2010) 0.81

Comprehensive Evaluation of Neuroprotection Achieved by Extended Selective Brain Cooling Therapy in a Rat Model of Penetrating Ballistic-Like Brain Injury. Ther Hypothermia Temp Manag (2015) 0.81

The effect of admission spontaneous hypothermia on patients with severe traumatic brain injury. Injury (2012) 0.81

Establishing a Clinically Relevant Large Animal Model Platform for TBI Therapy Development: Using Cyclosporin A as a Case Study. Brain Pathol (2015) 0.81

Effect of Hypothermia and Targeted Temperature Management on Drug Disposition and Response Following Cardiac Arrest: A Comprehensive Review of Preclinical and Clinical Investigations. Ther Hypothermia Temp Manag (2016) 0.80

Primary Outcome Measures in Pediatric Septic Shock Trials: A Systematic Review. Pediatr Crit Care Med (2017) 0.80

Fever Control Management Is Preferable to Mild Therapeutic Hypothermia in Traumatic Brain Injury Patients with Abbreviated Injury Scale 3-4: A Multi-Center, Randomized Controlled Trial. J Neurotrauma (2015) 0.80

Emergency treatment options for pediatric traumatic brain injury. Ped Health (2009) 0.80

Early Hyperglycemia in Pediatric Traumatic Brain Injury Predicts for Mortality, Prolonged Duration of Mechanical Ventilation, and Intensive Care Stay. Int J Endocrinol (2015) 0.80

The collective therapeutic potential of cerebral ketone metabolism in traumatic brain injury. J Lipid Res (2014) 0.80

New concepts in treatment of pediatric traumatic brain injury. Anesthesiol Clin (2009) 0.79

Update on the 2012 guidelines for the management of pediatric traumatic brain injury - information for the anesthesiologist. Paediatr Anaesth (2014) 0.79

Management of raised intracranial pressure in children with traumatic brain injury. J Pediatr Neurosci (2015) 0.79

Severe traumatic brain injury in children: a vision for the future. Intensive Care Med (2016) 0.78

Fever control and application of hypothermia using intravenous cold saline. Pediatr Crit Care Med (2012) 0.78

Hypothermia decreases cerebrospinal fluid asymmetric dimethylarginine levels in children with traumatic brain injury. Pediatr Crit Care Med (2013) 0.78

The Brain and Hypothermia-From Aristotle to Targeted Temperature Management. Crit Care Med (2017) 0.78

Therapeutic Hypothermia in Children and Adults with Severe Traumatic Brain Injury. Ther Hypothermia Temp Manag (2014) 0.77

Therapeutic Hypothermia and the Risk of Hemorrhage: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Medicine (Baltimore) (2015) 0.77

Better Glasgow outcome score, cerebral perfusion pressure and focal brain oxygenation in severely traumatized brain following direct regional brain hypothermia therapy: A prospective randomized study. Asian J Neurosurg (2015) 0.77

The Effect of Paracetamol on Core Body Temperature in Acute Traumatic Brain Injury: A Randomised, Controlled Clinical Trial. PLoS One (2015) 0.77

Is therapeutic hypothermia beneficial for pediatric patients with traumatic brain injury? A meta-analysis. Childs Nerv Syst (2013) 0.77

Ventilator-Associated Pneumonia in Pediatric Traumatic Brain Injury. J Neurotrauma (2015) 0.77

Seizures in Children With Severe Traumatic Brain Injury. Pediatr Crit Care Med (2016) 0.76

Hypothermia for children after severe brain injury does not work. Medscape J Med (2008) 0.76

Evaluating processes of care and outcomes of children in hospital (EPOCH): study protocol for a randomized controlled trial. Trials (2015) 0.76

Neurotrauma and Repair Research: Traumatic Brain Injury (TBI) and its Treatments. Biomed Eng Comput Biol (2013) 0.76

The changing "epidemiology" of pediatric head injury and its impact on the daily clinical practice. Childs Nerv Syst (2009) 0.76

Revisiting therapeutic hypothermia for severe traumatic brain injury... again. Crit Care (2014) 0.76

Brain-systemic temperature gradient is temperature-dependent in children with severe traumatic brain injury. Pediatr Crit Care Med (2011) 0.76

Initial management of traumatic brain injury in the rural setting. J Neurosci Rural Pract (2013) 0.75

Hypothermia therapy after traumatic brain injury in children. N Engl J Med (2008) 0.75

International Survey of Critically Ill Children With Acute Neurologic Insults: The Prevalence of Acute Critical Neurological Disease in Children: A Global Epidemiological Assessment Study. Pediatr Crit Care Med (2017) 0.75

Selective head cooling for the treatment of neurologic complications of acute liver failure in a newborn with disseminated herpes infection. Springerplus (2013) 0.75

Mortality Risk Stratification After Traumatic Brain Injury and Hazard of Death With Titrated Hypothermia in the Eurotherm3235Trial. Crit Care Med (2017) 0.75

Insufficient Humidification of Respiratory Gases in Patients Who Are Undergoing Therapeutic Hypothermia at a Paediatric and Adult Intensive Care Unit. Can Respir J (2017) 0.75

Pediatric Traumatic Brain Injury: Characteristic Features, Diagnosis, and Management. Neurol Med Chir (Tokyo) (2017) 0.75

Acute brain injury and therapeutic hypothermia in the PICU: A rehabilitation perspective. J Pediatr Rehabil Med (2009) 0.75

Targeted temperature management in the ICU: guidelines from a French expert panel. Ann Intensive Care (2017) 0.75

Hypothermia therapy after traumatic brain injury in children. N Engl J Med (2008) 0.75

Therapeutic hypothermia for acute neurological injuries. Neurotherapeutics (2012) 0.75

Hypothermia therapy after traumatic brain injury in children. N Engl J Med (2008) 0.75

Neuroprotective measures in children with traumatic brain injury. World J Crit Care Med (2016) 0.75

Targeted Temperature Management in Pediatric Central Nervous System Disease. Curr Treat Options Pediatr (2015) 0.75

The Anesthesiologist's Role in Treating Abusive Head Trauma. Anesth Analg (2016) 0.75

Commentary. J Neurosci Rural Pract (2012) 0.75

Hypothermia therapy after traumatic brain injury in children. N Engl J Med (2008) 0.75

Pediatric head injury: a pain for the emergency physician? Clin Exp Emerg Med (2015) 0.75

A "Metamorphosis" in Our Approach to Treatment Is Not Likely to Result From a Meta-Analysis of the Use of Therapeutic Hypothermia in Severe Traumatic Brain Injury. Crit Care Med (2017) 0.75

Treatment and outcomes for pediatric head injuries in Mississippi. Childs Nerv Syst (2010) 0.75

Therapeutic Hypothermia and Targeted Temperature Management With or Without the "Cold Stress" Response. Ther Hypothermia Temp Manag (2017) 0.75

Targeted temperature management in neurological intensive care unit. World J Methodol (2017) 0.75

Articles by these authors

Identification of human brain tumour initiating cells. Nature (2004) 38.87

The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ (2011) 29.14

Intensive versus conventional glucose control in critically ill patients. N Engl J Med (2009) 26.30

Identification of a cancer stem cell in human brain tumors. Cancer Res (2003) 24.02

CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMJ (2010) 22.34

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ (2009) 22.18

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med (2009) 21.74

Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res (2006) 17.42

CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials. Ann Intern Med (2010) 16.11

Extending the CONSORT statement to randomized trials of nonpharmacologic treatment: explanation and elaboration. Ann Intern Med (2008) 13.87

Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol (2007) 13.46

Critically ill patients with 2009 influenza A(H1N1) infection in Canada. JAMA (2009) 13.00

Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg (2010) 12.98

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med (2009) 12.16

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol (2009) 11.80

Better reporting of harms in randomized trials: an extension of the CONSORT statement. Ann Intern Med (2004) 11.47

Does the CONSORT checklist improve the quality of reports of randomised controlled trials? A systematic review. Med J Aust (2006) 11.40

Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med (2008) 11.00

Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative. BMJ (2003) 10.80

The STARD statement for reporting studies of diagnostic accuracy: explanation and elaboration. Ann Intern Med (2003) 10.28

Improving the reporting of pragmatic trials: an extension of the CONSORT statement. BMJ (2008) 9.98

CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials. BMC Med (2010) 9.30

SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials. BMJ (2013) 9.01

Towards complete and accurate reporting of studies of diagnostic accuracy: The STARD Initiative. Ann Intern Med (2003) 8.58

SPIRIT 2013 statement: defining standard protocol items for clinical trials. Ann Intern Med (2013) 8.21

Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative. Standards for Reporting of Diagnostic Accuracy. Clin Chem (2003) 8.13

The STARD statement for reporting studies of diagnostic accuracy: explanation and elaboration. Clin Chem (2003) 7.92

Comparison of registered and published primary outcomes in randomized controlled trials. JAMA (2009) 7.89

Better reporting of interventions: template for intervention description and replication (TIDieR) checklist and guide. BMJ (2014) 7.55

Transfusion strategies for patients in pediatric intensive care units. N Engl J Med (2007) 7.21

CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. PLoS Med (2010) 6.88

Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ (2011) 6.80

Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: a randomized controlled trial. JAMA (2012) 6.69

Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis. Clin Infect Dis (2004) 6.65

The need for an institute of continuing health education. CMAJ (2008) 6.36

Reporting randomized, controlled trials of herbal interventions: an elaborated CONSORT statement. Ann Intern Med (2006) 6.34

Hypoglycemia and risk of death in critically ill patients. N Engl J Med (2012) 6.17

The CARE guidelines: consensus-based clinical case report guideline development. J Clin Epidemiol (2013) 5.93

How quickly do systematic reviews go out of date? A survival analysis. Ann Intern Med (2007) 5.86

CONSORT for reporting randomized controlled trials in journal and conference abstracts: explanation and elaboration. PLoS Med (2008) 5.85

Effectiveness of quality improvement strategies on the management of diabetes: a systematic review and meta-analysis. Lancet (2012) 5.65

Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease: a randomized trial. Ann Intern Med (2007) 5.51

Validation of the paediatric logistic organ dysfunction (PELOD) score: prospective, observational, multicentre study. Lancet (2003) 5.40

A comparison of aprotinin and lysine analogues in high-risk cardiac surgery. N Engl J Med (2008) 5.20

Reporting of patient-reported outcomes in randomized trials: the CONSORT PRO extension. JAMA (2013) 4.98

Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomised controlled trials. BMJ (2005) 4.74

The use of aspirin for primary prevention of colorectal cancer: a systematic review prepared for the U.S. Preventive Services Task Force. Ann Intern Med (2007) 4.74

The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med (2015) 4.49

Does this patient have deep vein thrombosis? JAMA (2006) 4.44

Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement. Open Med (2009) 4.43

Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: a propensity-matched analysis. Crit Care Med (2010) 4.39

Does use of the CONSORT Statement impact the completeness of reporting of randomised controlled trials published in medical journals? A Cochrane review. Syst Rev (2012) 4.36

CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials. Trials (2010) 4.28

Consolidated Health Economic Evaluation Reporting Standards (CHEERS)--explanation and elaboration: a report of the ISPOR Health Economic Evaluation Publication Guidelines Good Reporting Practices Task Force. Value Health (2013) 4.22

CONSORT for reporting randomised trials in journal and conference abstracts. Lancet (2008) 4.20

Endorsement of the CONSORT Statement by high impact factor medical journals: a survey of journal editors and journal 'Instructions to Authors'. Trials (2008) 4.17

Tumour-initiating cells: challenges and opportunities for anticancer drug discovery. Nat Rev Drug Discov (2009) 4.12

Cancer stem cells in nervous system tumors. Oncogene (2004) 4.09

Clinical trial registration--looking back and moving ahead. N Engl J Med (2007) 4.07

No more dithering on e-health: let's keep patients safe instead. CMAJ (2010) 4.01

An evidence-based practice guideline for the peer review of electronic search strategies. J Clin Epidemiol (2009) 3.98

CONSORT 2010 Statement: Updated guidelines for reporting parallel group randomised trials. J Clin Epidemiol (2010) 3.96

Reliability of point-of-care testing for glucose measurement in critically ill adults. Crit Care Med (2005) 3.84

Prophylactic vaccination against human papillomavirus infection and disease in women: a systematic review of randomized controlled trials. CMAJ (2007) 3.77

CONSORT 2010 changes and testing blindness in RCTs. Lancet (2010) 3.68

Nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors for primary prevention of colorectal cancer: a systematic review prepared for the U.S. Preventive Services Task Force. Ann Intern Med (2007) 3.64

Revised STandards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA): extending the CONSORT statement. PLoS Med (2010) 3.63

Methods and processes of the CONSORT Group: example of an extension for trials assessing nonpharmacologic treatments. Ann Intern Med (2008) 3.63

Influence of reported study design characteristics on intervention effect estimates from randomized, controlled trials. Ann Intern Med (2012) 3.63

Clinical consequences of red cell storage in the critically ill. Transfusion (2006) 3.57

Systematic review: the Trousseau syndrome revisited: should we screen extensively for cancer in patients with venous thromboembolism? Ann Intern Med (2008) 3.56

Effectiveness and safety of vitamin D in relation to bone health. Evid Rep Technol Assess (Full Rep) (2007) 3.51

Consolidated standards of reporting trials (CONSORT) and the completeness of reporting of randomised controlled trials (RCTs) published in medical journals. Cochrane Database Syst Rev (2012) 3.37

The prevalence of celiac disease in average-risk and at-risk Western European populations: a systematic review. Gastroenterology (2005) 3.33

The diagnostic accuracy of serologic tests for celiac disease: a systematic review. Gastroenterology (2005) 3.33

Why IQ is not a covariate in cognitive studies of neurodevelopmental disorders. J Int Neuropsychol Soc (2009) 3.23

Overdiagnosis of asthma in obese and nonobese adults. CMAJ (2008) 3.23

Guidelines for reporting health research: the EQUATOR network's survey of guideline authors. PLoS Med (2008) 3.22

Reprint--preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Phys Ther (2009) 3.15

EQUATOR: reporting guidelines for health research. Lancet (2008) 3.15

An international registry of systematic-review protocols. Lancet (2010) 3.12

A randomized, double-blind, placebo-controlled noninferiority trial of amoxicillin for clinically diagnosed acute otitis media in children 6 months to 5 years of age. CMAJ (2005) 3.10

Should meta-analysts search Embase in addition to Medline? J Clin Epidemiol (2003) 3.06

A randomized trial of aspirin on the risk of embolic events in patients with infective endocarditis. J Am Coll Cardiol (2003) 3.02

The H1N1 vaccine race: can we beat the pandemic? CMAJ (2009) 3.01

CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. Int J Surg (2011) 3.00

Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative. Fam Pract (2004) 2.99

Correlates of severe disease in patients with 2009 pandemic influenza (H1N1) virus infection. CMAJ (2010) 2.96

Chemical genetics reveals a complex functional ground state of neural stem cells. Nat Chem Biol (2007) 2.88

The nuts and bolts of PROSPERO: an international prospective register of systematic reviews. Syst Rev (2012) 2.86

Binge drinking: all too prevalent and hazardous. CMAJ (2011) 2.85

Fluids after cardiac surgery: a pilot study of the use of colloids versus crystalloids. Crit Care Med (2010) 2.82