Gain-of-function mutation of tristetraprolin impairs negative feedback control of macrophages in vitro, yet has overwhelmingly anti-inflammatory consequences in vivo.

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Published in Mol Cell Biol on March 06, 2017

Authors

John D O'Neil1, Ewan A Ross1, Michael L Ridley1, Qize Ding2, Tina Tang1, Dalya R Rosner1, Thomas Crowley1, Deepak Malhi1, Jonathan L Dean3, Tim Smallie1, Christopher D Buckley1, Andrew R Clark4

Author Affiliations

1: Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.
2: Faculty of Medicine, Imperial College London, London, United Kingdom.
3: Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford University, Oxford, United Kingdom.
4: Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom a.r.clark@bham.ac.uk.

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