Published in J Biol Chem on December 19, 2003
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Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1. Genes Dev (2005) 4.43
MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay. EMBO J (2004) 4.08
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Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element. Mol Cell Biol (2006) 2.94
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Retracted The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling. PLoS Biol (2006) 2.42
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The tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritis. Arthritis Res Ther (2004) 2.05
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The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK. Mol Cell Biol (2006) 1.73
Immunological characterization of tristetraprolin as a low abundance, inducible, stable cytosolic protein. J Biol Chem (2004) 1.65
Phosphorylation of tristetraprolin by MK2 impairs AU-rich element mRNA decay by preventing deadenylase recruitment. Mol Cell Biol (2010) 1.63
Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin. Nucleic Acids Res (2011) 1.57
Functional analysis of KSRP interaction with the AU-rich element of interleukin-8 and identification of inflammatory mRNA targets. Mol Cell Biol (2007) 1.56
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Structural basis for the recruitment of the human CCR4-NOT deadenylase complex by tristetraprolin. Nat Struct Mol Biol (2013) 1.45
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The role of tristetraprolin in cancer and inflammation. Front Biosci (Landmark Ed) (2012) 1.33
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MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment. J Biol Chem (2010) 1.31
Tristetraprolin mediates interferon-gamma mRNA decay. J Biol Chem (2009) 1.30
Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis. Biochem J (2006) 1.26
The roles of TTP and BRF proteins in regulated mRNA decay. Wiley Interdiscip Rev RNA (2011) 1.24
The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages. FEBS Lett (2009) 1.24
Identification of the major site of O-linked beta-N-acetylglucosamine modification in the C terminus of insulin receptor substrate-1. Mol Cell Proteomics (2005) 1.23
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The AU-rich element mRNA decay-promoting activity of BRF1 is regulated by mitogen-activated protein kinase-activated protein kinase 2. RNA (2008) 1.18
Tristetraprolin impairs NF-kappaB/p65 nuclear translocation. J Biol Chem (2009) 1.17
C. elegans GLA-3 is a novel component of the MAP kinase MPK-1 signaling pathway required for germ cell survival. Genes Dev (2006) 1.15
Genome-wide assessment of AU-rich elements by the AREScore algorithm. PLoS Genet (2012) 1.15
Convergent actions of I kappa B kinase beta and protein kinase C delta modulate mRNA stability through phosphorylation of 14-3-3 beta complexed with tristetraprolin. Mol Cell Biol (2005) 1.13
Expression, purification, and biochemical characterization of the antiinflammatory tristetraprolin: a zinc-dependent mRNA binding protein affected by posttranslational modifications. Biochemistry (2004) 1.12
BRF1 protein turnover and mRNA decay activity are regulated by protein kinase B at the same phosphorylation sites. Mol Cell Biol (2006) 1.10
Phosphorylation site analysis of the anti-inflammatory and mRNA-destabilizing protein tristetraprolin. Expert Rev Proteomics (2007) 1.06
Activation of a nuclear Cdc2-related kinase within a mitogen-activated protein kinase-like TDY motif by autophosphorylation and cyclin-dependent protein kinase-activating kinase. Mol Cell Biol (2005) 1.04
Targeting mRNA stability arrests inflammatory bone loss. Mol Ther (2008) 1.04
The p38 mitogen-activated protein kinase signaling cascade in CD4 T cells. Arthritis Res Ther (2006) 1.03
Loss of cystic fibrosis transmembrane conductance regulator function enhances activation of p38 and ERK MAPKs, increasing interleukin-6 synthesis in airway epithelial cells exposed to Pseudomonas aeruginosa. J Biol Chem (2010) 0.99
The p38 MAPK Pathway in Rheumatoid Arthritis: A Sideways Look. Open Rheumatol J (2012) 0.99
A versatile ribosomal protein promoter-based reporter system for selective assessment of RNA stability and post-transcriptional control. RNA (2010) 0.98
Lesson from the stoichiometry determination of the cohesin complex: a short protease mediated elution increases the recovery from cross-linked antibody-conjugated beads. J Proteome Res (2010) 0.96
Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ. Biochem J (2006) 0.94
Tristetraprolin mediates anti-inflammatory effects of nicotine in lipopolysaccharide-stimulated macrophages. J Biol Chem (2011) 0.94
Mitogen-activated protein kinase-activated protein kinase 2 in angiotensin II-induced inflammation and hypertension: regulation of oxidative stress. Hypertension (2010) 0.94
Cell type- and stimulus-specific mechanisms for post-transcriptional control of neutrophil chemokine gene expression. J Leukoc Biol (2011) 0.94
Diversity in post-transcriptional control of neutrophil chemoattractant cytokine gene expression. Cytokine (2010) 0.93
MSK1 and MSK2 inhibit lipopolysaccharide-induced prostaglandin production via an interleukin-10 feedback loop. Mol Cell Biol (2013) 0.91
Translational control of NKT cell cytokine production by p38 MAPK. J Immunol (2011) 0.90
Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85. PLoS One (2010) 0.90
RNA-binding proteins as a point of convergence of the PI3K and p38 MAPK pathways. Front Immunol (2012) 0.89
Inhibition of tristetraprolin deadenylation by poly(A) binding protein. Am J Physiol Gastrointest Liver Physiol (2008) 0.87
Phosphorylation of recombinant tristetraprolin in vitro. Protein J (2008) 0.87
Silencing mitogen-activated protein kinase-activated protein kinase-2 arrests inflammatory bone loss. J Pharmacol Exp Ther (2010) 0.87
Aggregatibacter actinomycetemcomitans, a potent immunoregulator of the periodontal host defense system and alveolar bone homeostasis. Mol Oral Microbiol (2015) 0.87
Translating the Untranslated Region. J Immunol (2015) 0.86
Tristetraprolin down-regulates IL-23 expression in colon cancer cells. Mol Cells (2013) 0.85
Casein kinase 2 regulates the mRNA-destabilizing activity of tristetraprolin. J Biol Chem (2011) 0.84
Signaling pathways that control mRNA turnover. Cell Signal (2013) 0.84
Activation of ETB receptors regulates the abundance of ET-1 mRNA in vascular endothelial cells. Br J Pharmacol (2008) 0.83
Tristetraprolin Recruits Eukaryotic Initiation Factor 4E2 To Repress Translation of AU-Rich Element-Containing mRNAs. Mol Cell Biol (2015) 0.82
The RNA-binding protein TTP is a global post-transcriptional regulator of feedback control in inflammation. Nucleic Acids Res (2016) 0.82
Tristetraprolin mediates radiation-induced TNF-α production in lung macrophages. PLoS One (2013) 0.82
Protor-2 interacts with tristetraprolin to regulate mRNA stability during stress. Cell Signal (2011) 0.82
Quantitative evaluation of His-tag purification and immunoprecipitation of tristetraprolin and its mutant proteins from transfected human cells. Biotechnol Prog (2009) 0.82
MAPK-activated protein kinase 2 is required for mouse meiotic spindle assembly and kinetochore-microtubule attachment. PLoS One (2010) 0.81
A combination of hypoxia and lipopolysaccharide activates tristetraprolin to destabilize proinflammatory mRNAs such as tumor necrosis factor-alpha. Am J Pathol (2010) 0.81
Mutant tristetraprolin: a potent inhibitor of malignant glioma cell growth. J Neurooncol (2013) 0.81
Regulation of cytokines by small RNAs during skin inflammation. J Biomed Sci (2010) 0.81
The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinases (MAPKAPKs) in Inflammation. Genes (Basel) (2013) 0.81
Anthrax lethal toxin promotes dephosphorylation of TTP and formation of processing bodies. Cell Microbiol (2009) 0.80
Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes. Int J Biol Sci (2012) 0.80
Tristetraprolin inhibits poly(A)-tail synthesis in nuclear mRNA that contains AU-rich elements by interacting with poly(A)-binding protein nuclear 1. PLoS One (2012) 0.80
Reactive Oxygen Species, SUMOylation, and Endothelial Inflammation. Int J Inflam (2012) 0.80
Heat shock protein B1-deficient mice display impaired wound healing. PLoS One (2013) 0.79
Identification of a major phosphopeptide in human tristetraprolin by phosphopeptide mapping and mass spectrometry. PLoS One (2014) 0.78
Polyubiquitinated tristetraprolin protects from TNF-induced, caspase-mediated apoptosis. J Biol Chem (2014) 0.78
MAP kinases bind endothelial nitric oxide synthase. FEBS Open Bio (2012) 0.78
p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1. Nat Commun (2015) 0.78
The cAMP pathway regulates mRNA decay through phosphorylation of the RNA-binding protein TIS11b/BRF1. Mol Biol Cell (2016) 0.77
LPS-induced production of TNF-α and IL-6 in mast cells is dependent on p38 but independent of TTP. Cell Signal (2013) 0.77
Regulation of AU-Rich Element RNA Binding Proteins by Phosphorylation and the Prolyl Isomerase Pin1. Biomolecules (2015) 0.77
Role of RNA-Binding Proteins in MAPK Signal Transduction Pathway. J Signal Transduct (2011) 0.77
Structural basis for regulation of RNA-binding proteins by phosphorylation. ACS Chem Biol (2015) 0.76
p38MAPK and MK2 pathways are important for the differentiation-dependent human papillomavirus life cycle. J Virol (2014) 0.76
Pivotal Role of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in Inflammatory Pulmonary Diseases. Curr Protein Pept Sci (2016) 0.75
The control of inflammation via the phosphorylation and dephosphorylation of tristetraprolin: a tale of two phosphatases. Biochem Soc Trans (2016) 0.75
A Characterization of the expression of 14-3-3 isoforms in psoriasis, basal cell carcinoma, atopic dermatitis and contact dermatitis. Dermatol Reports (2010) 0.75
Control of mRNA stability by SAPKs. Top Curr Genet (2008) 0.75
Post-transcriptional Regulation of Immunological Responses through Riboclustering. Front Immunol (2016) 0.75
ACTH Action on Messenger RNA Stability Mechanisms. Front Endocrinol (Lausanne) (2017) 0.75
Peptide and protein sequence analysis by electron transfer dissociation mass spectrometry. Proc Natl Acad Sci U S A (2004) 13.14
Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae. Nat Biotechnol (2002) 8.37
Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains. Mol Cell (2003) 6.44
Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation. Nature (2005) 6.40
A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis. Nature (2002) 6.19
Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression. Mol Cell Biol (2002) 5.42
Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry. Proc Natl Acad Sci U S A (2007) 5.09
Novel linear quadrupole ion trap/FT mass spectrometer: performance characterization and use in the comparative analysis of histone H3 post-translational modifications. J Proteome Res (2004) 4.32
Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity. Curr Biol (2004) 4.20
The Vam6 GEF controls TORC1 by activating the EGO complex. Mol Cell (2009) 4.01
Organismal differences in post-translational modifications in histones H3 and H4. J Biol Chem (2006) 3.84
Chemical derivatization of histones for facilitated analysis by mass spectrometry. Nat Protoc (2007) 3.78
Gene silencing: trans-histone regulatory pathway in chromatin. Nature (2002) 3.77
Protein identification using sequential ion/ion reactions and tandem mass spectrometry. Proc Natl Acad Sci U S A (2005) 3.77
Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes. Proc Natl Acad Sci U S A (2003) 3.75
Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation. Cell (2008) 3.09
A neutral loss activation method for improved phosphopeptide sequence analysis by quadrupole ion trap mass spectrometry. Anal Chem (2004) 3.08
Expression patterns and post-translational modifications associated with mammalian histone H3 variants. J Biol Chem (2005) 3.00
The utility of ETD mass spectrometry in proteomic analysis. Biochim Biophys Acta (2006) 2.85
Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis. Sci Signal (2010) 2.79
Identification of a human heme exporter that is essential for erythropoiesis. Cell (2004) 2.66
Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini. Proc Natl Acad Sci U S A (2007) 2.43
Cutting edge: Critical role for A2A adenosine receptors in the T cell-mediated regulation of colitis. J Immunol (2006) 2.37
N-terminal alpha-methylation of RCC1 is necessary for stable chromatin association and normal mitosis. Nat Cell Biol (2007) 2.36
Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1. J Biol Chem (2006) 2.32
The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment. Curr Biol (2004) 2.31
Mass spectrometry analysis of Arabidopsis histone H3 reveals distinct combinations of post-translational modifications. Nucleic Acids Res (2004) 2.28
O-GlcNAc regulates FoxO activation in response to glucose. J Biol Chem (2008) 2.27
Electron transfer dissociation of peptide anions. J Am Soc Mass Spectrom (2005) 2.26
RNAi-dependent H3K27 methylation is required for heterochromatin formation and DNA elimination in Tetrahymena. Genes Dev (2007) 2.26
Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation. Curr Biol (2005) 2.20
Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites. J Biol Chem (2002) 2.01
Genomic and functional evolution of the Drosophila melanogaster sperm proteome. Nat Genet (2006) 1.97
Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation. J Biol Chem (2002) 1.96
NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein. Nature (2010) 1.95
Characterization of histones and their post-translational modifications by mass spectrometry. Curr Opin Chem Biol (2006) 1.92
Serine 31 phosphorylation of histone variant H3.3 is specific to regions bordering centromeres in metaphase chromosomes. Proc Natl Acad Sci U S A (2005) 1.91
Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire. Proc Natl Acad Sci U S A (2012) 1.89
Methods for analyzing peptides and proteins on a chromatographic timescale by electron-transfer dissociation mass spectrometry. Nat Protoc (2008) 1.87
Par3 controls epithelial spindle orientation by aPKC-mediated phosphorylation of apical Pins. Curr Biol (2010) 1.86
Post-acquisition ETD spectral processing for increased peptide identifications. J Am Soc Mass Spectrom (2009) 1.86
Proteome-wide prediction of acetylation substrates. Proc Natl Acad Sci U S A (2009) 1.81
A PGC-1alpha-O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucose. J Biol Chem (2008) 1.76
Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets. Proc Natl Acad Sci U S A (2012) 1.75
Enrichment and site mapping of O-linked N-acetylglucosamine by a combination of chemical/enzymatic tagging, photochemical cleavage, and electron transfer dissociation mass spectrometry. Mol Cell Proteomics (2009) 1.72
RNA binding properties of the AU-rich element-binding recombinant Nup475/TIS11/tristetraprolin protein. J Biol Chem (2002) 1.71
A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. Genes Dev (2006) 1.70
Tandem mass spectrometry for peptide and protein sequence analysis. Biotechniques (2005) 1.70
Codependent functions of RSK2 and the apoptosis-promoting factor TIA-1 in stress granule assembly and cell survival. Mol Cell (2008) 1.67
Use of differential isotopic labeling and mass spectrometry to analyze capacitation-associated changes in the phosphorylation status of mouse sperm proteins. J Proteome Res (2009) 1.64
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. J Proteome Res (2006) 1.63
Toward a protein profile of Escherichia coli: comparison to its transcription profile. Proc Natl Acad Sci U S A (2003) 1.60
Analysis of intact proteins on a chromatographic time scale by electron transfer dissociation tandem mass spectrometry. Int J Mass Spectrom (2007) 1.56