Overview of the Use of Murine Models in Leukemia and Lymphoma Research.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28265553)

Published in Front Oncol on February 20, 2017

Authors

Rebecca Kohnken1, Pierluigi Porcu2, Anjali Mishra3

Author Affiliations

1: Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University , Columbus, OH , USA.
2: Comprehensive Cancer Center, James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH, USA; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
3: Comprehensive Cancer Center, James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH, USA; Division of Dermatology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.

Articles cited by this

Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15

Cancer statistics, 2016. CA Cancer J Clin (2016) 32.95

A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med (2005) 26.02

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell (2013) 24.00

miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A (2005) 21.51

Drug development: Raise standards for preclinical cancer research. Nature (2012) 20.64

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science (2004) 18.84

Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science (1990) 10.59

Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice. Blood (2005) 6.16

Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter. Proc Natl Acad Sci U S A (1994) 5.71

The mighty mouse: genetically engineered mouse models in cancer drug development. Nat Rev Drug Discov (2006) 5.11

Preclinical research: Make mouse studies work. Nature (2014) 4.82

The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia. Cancer Cell (2010) 4.71

Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nat Rev Cancer (2005) 4.30

The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity. J Exp Med (1999) 4.06

A primary xenograft model of small-cell lung cancer reveals irreversible changes in gene expression imposed by culture in vitro. Cancer Res (2009) 3.38

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response. Nat Med (2015) 2.95

Acute Myeloid Leukemia. N Engl J Med (2015) 2.85

AID is required for germinal center-derived lymphomagenesis. Nat Genet (2007) 2.79

The mouse ascending: perspectives for human-disease models. Nat Cell Biol (2007) 2.74

Classification of lymphoid neoplasms: the microscope as a tool for disease discovery. Blood (2008) 2.66

Russell and Burch's 3Rs then and now: the need for clarity in definition and purpose. J Am Assoc Lab Anim Sci (2015) 2.64

TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis. Leukemia (1995) 2.54

Chronic myeloid leukemia: mechanisms of blastic transformation. J Clin Invest (2010) 2.44

Mouse xenograft models vs GEM models for human cancer therapeutics. Dis Model Mech (2008) 2.37

Mouse models of non-Hodgkin lymphoma reveal Syk as an important therapeutic target. Blood (2008) 2.33

Novel t(5;9)(q33;q22) fuses ITK to SYK in unspecified peripheral T-cell lymphoma. Leukemia (2006) 2.24

Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia. EMBO Mol Med (2010) 2.23

Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis. Blood (2004) 2.11

VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia. Blood (2003) 2.05

Aberrant overexpression of IL-15 initiates large granular lymphocyte leukemia through chromosomal instability and DNA hypermethylation. Cancer Cell (2012) 2.01

Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance. Proc Natl Acad Sci U S A (2011) 1.97

Organs-on-chips at the frontiers of drug discovery. Nat Rev Drug Discov (2015) 1.95

A mouse geneticist's practical guide to CRISPR applications. Genetics (2014) 1.81

Non-germline genetically engineered mouse models for translational cancer research. Nat Rev Cancer (2010) 1.80

Genomics of chronic lymphocytic leukemia microRNAs as new players with clinical significance. Semin Oncol (2006) 1.71

Pathogenesis of follicular lymphoma. J Clin Invest (2012) 1.66

STAT5 signaling is required for the efficient induction and maintenance of CML in mice. Blood (2006) 1.63

Lost in translation: animal models and clinical trials in cancer treatment. Am J Transl Res (2014) 1.63

Cancer induction by restriction of oncogene expression to the stem cell compartment. EMBO J (2008) 1.52

E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia. Blood (2003) 1.51

Biology and treatment of infant leukemias. Leukemia (1995) 1.44

Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing. Nat Biotechnol (2014) 1.43

A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression. J Exp Med (2015) 1.42

PD-L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemia. Blood (2015) 1.39

TEL/AML-1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia. Blood (1996) 1.33

Modeling tumor-host interactions of chronic lymphocytic leukemia in xenografted mice to study tumor biology and evaluate targeted therapy. Leukemia (2013) 1.26

High incidence of proviral integrations in the Hoxa locus in a new model of E2a-PBX1-induced B-cell leukemia. Genes Dev (2005) 1.22

Utilization of pathway signatures to reveal distinct types of B lymphoma in the Emicro-myc model and human diffuse large B-cell lymphoma. Cancer Res (2008) 1.19

The impact of FDA and EMEA guidelines on drug development in relation to Phase 0 trials. Br J Cancer (2007) 1.17

Defining the oncogenic function of the TEL/AML1 (ETV6/RUNX1) fusion protein in a mouse model. Oncogene (2005) 1.10

The expression of ETV6/CBFA2 (TEL/AML1) is not sufficient for the transformation of hematopoietic cell lines in vitro or the induction of hematologic disease in vivo. Cancer Genet Cytogenet (2001) 1.08

Generation of improved humanized mouse models for human infectious diseases. J Immunol Methods (2014) 1.08

Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy. Cell Stem Cell (2014) 1.04

Chronic B cell malignancies and bone marrow microenvironment. Semin Cancer Biol (2002) 1.03

Murine models of B-cell lymphomas: promising tools for designing cancer therapies. Adv Hematol (2012) 1.01

A novel xenograft model of cutaneous T-cell lymphoma. Exp Dermatol (2010) 0.99

Therapeutic antibody targeting of Notch1 in T-acute lymphoblastic leukemia xenografts. Leukemia (2013) 0.96

Xenograft models of chronic lymphocytic leukemia: problems, pitfalls and future directions. Leukemia (2012) 0.94

Myeloproliferative disease in transgenic mice expressing P230 Bcr/Abl: longer disease latency, thrombocytosis, and mild leukocytosis. Blood (2003) 0.93

BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells. Blood (2013) 0.92

Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia. J Clin Invest (2015) 0.92

Murine models of chronic lymphocytic leukaemia: role of microRNA-16 in the New Zealand Black mouse model. Br J Haematol (2007) 0.92

Mouse models as tools to understand and study BCR-ABL1 diseases. Am J Blood Res (2011) 0.88

Accelerated development of chronic lymphocytic leukemia in New Zealand Black mice expressing a low level of interferon regulatory factor 4. J Biol Chem (2013) 0.88

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell (2016) 0.87

The use of systematic reviews and reporting guidelines to advance the implementation of the 3Rs. J Am Assoc Lab Anim Sci (2015) 0.86

Chronic lymphocytic leukaemia: a short overview. Ann Oncol (2008) 0.85

Murine models of acute leukemia: important tools in current pediatric leukemia research. Front Oncol (2014) 0.84

Animal models of leukemia: any closer to the real thing? Cancer Metastasis Rev (2013) 0.84

Modeling BCR-ABL and MLL-AF9 leukemia in a human bone marrow-like scaffold-based xenograft model. Leukemia (2016) 0.83

Investigating the role of CD38 and functionally related molecular risk factors in the CLL NOD/SCID xenograft model. Eur J Haematol (2011) 0.82

A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL). Dis Model Mech (2013) 0.82

Galectin-1 drives lymphoma CD20 immunotherapy resistance: validation of a preclinical system to identify resistance mechanisms. Blood (2016) 0.82

KRAS (G12D) cooperates with AML1/ETO to initiate a mouse model mimicking human acute myeloid leukemia. Cell Physiol Biochem (2014) 0.82

Aggressive acute myeloid leukemia in PU.1/p53 double-mutant mice. Oncogene (2013) 0.81

Murine genetically engineered and human xenograft models of chronic lymphocytic leukemia. Semin Hematol (2014) 0.81

Modeling EBV infection and pathogenesis in new-generation humanized mice. Exp Mol Med (2015) 0.80

Modeling chronic myeloid leukemia in immunodeficient mice reveals expansion of aberrant mast cells and accumulation of pre-B cells. Blood Cancer J (2014) 0.80

Peripheral T cell lymphoma: new model + new insight. J Exp Med (2010) 0.79

Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5(+/-) leukemia. BMC Cancer (2015) 0.79

Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress. Nat Commun (2016) 0.78

Isolation of a novel chronic lymphocytic leukemic (CLL) cell line and development of an in vivo mouse model of CLL. Leuk Res (2015) 0.77

Premature terminal differentiation protects from deregulated lymphocyte activation by ITK-Syk. J Immunol (2013) 0.77

Mechanism, Consequences, and Therapeutic Targeting of Abnormal IL15 Signaling in Cutaneous T-cell Lymphoma. Cancer Discov (2016) 0.77

Chronic Myeloid Leukemia (CML) Mouse Model in Translational Research. Methods Mol Biol (2016) 0.76

Effects of lymphocyte profile on development of EBV-induced lymphoma subtypes in humanized mice. Proc Natl Acad Sci U S A (2015) 0.76

Animals Models of Human T Cell Leukemia Virus Type I Leukemogenesis. ILAR J (2016) 0.76

Generating Mouse Models Using CRISPR-Cas9-Mediated Genome Editing. Curr Protoc Mouse Biol (2016) 0.76

Intrahepatic Xenograft of Cutaneous T-Cell Lymphoma Cell Lines: A Useful Model for Rapid Biological and Therapeutic Evaluation. Am J Pathol (2016) 0.75

Preclinical modeling of novel therapeutics in chronic lymphocytic leukemia: the tools of the trade. Semin Oncol (2016) 0.75