Published in Genetics on September 29, 2014
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Model systems for studying cellular mechanisms of SCN1A-related epilepsy. J Neurophysiol (2016) 0.79
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CRISPR/Cas9-mediated gene manipulation to create single-amino-acid-substituted and floxed mice with a cloning-free method. Sci Rep (2017) 0.79
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A Genetic Mechanism for Convergent Skin Lightening during Recent Human Evolution. Mol Biol Evol (2016) 0.78
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Exome sequencing in the knockin mice generated using the CRISPR/Cas system. Sci Rep (2016) 0.77
Systems biology of lens development: A paradigm for disease gene discovery in the eye. Exp Eye Res (2016) 0.77
Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome. Curr Alzheimer Res (2016) 0.77
Highly efficient in vitro and in vivo delivery of functional RNAs using new versatile MS2-chimeric retrovirus-like particles. Mol Ther Methods Clin Dev (2015) 0.76
A Vector with a Single Promoter for In Vitro Transcription and Mammalian Cell Expression of CRISPR gRNAs. PLoS One (2016) 0.76
Linking Core Promoter Classes to Circadian Transcription. PLoS Genet (2016) 0.76
Chemical Inhibitors of Non-Homologous End Joining Increase Targeted Construct Integration in Cryptococcus neoformans. PLoS One (2016) 0.76
A primer on the use of mouse models for identifying direct sex chromosome effects that cause sex differences in non-gonadal tissues. Biol Sex Differ (2016) 0.76
Co-incident insertion enables high efficiency genome engineering in mouse embryonic stem cells. Nucleic Acids Res (2016) 0.75
FGF treatment of host embryos injected with ES cells increases rates of chimaerism. Transgenic Res (2016) 0.75
Efficient genome editing of differentiated renal epithelial cells. Pflugers Arch (2016) 0.75
Jmjd6, a JmjC Dioxygenase with Many Interaction Partners and Pleiotropic Functions. Front Genet (2017) 0.75
Overview of the Use of Murine Models in Leukemia and Lymphoma Research. Front Oncol (2017) 0.75
Unraveling the genetic architecture of copy number variants associated with schizophrenia and other neuropsychiatric disorders. J Neurosci Res (2016) 0.75
High-Speed Mouse Backcrossing Through the Female Germ Line. PLoS One (2016) 0.75
Integration-defective lentiviral vector mediates efficient gene editing through homology-directed repair in human embryonic stem cells. Nucleic Acids Res (2016) 0.75
Targeted Mutagenesis of Duplicated Genes in Caenorhabditis elegans Using CRISPR-Cas9. J Genet Genomics (2016) 0.75
Optimization of the production of knock-in alleles by CRISPR/Cas9 microinjection into the mouse zygote. Sci Rep (2017) 0.75
Highly-Efficient Cpf1-Mediated Gene Targeting in Mice Following High Concentration Pronuclear Injection. G3 (Bethesda) (2016) 0.75
Efficient identification of CRISPR/Cas9-induced insertions/deletions by direct germline screening in zebrafish. BMC Genomics (2016) 0.75
C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility. Nat Commun (2016) 0.75
Germline Modification and Engineering in Avian Species. Mol Cells (2015) 0.75
BALB/c-congenic ANP32B-deficient mice reveal a modifying locus that determines viability. Exp Anim (2015) 0.75
Maternal Supply of Cas9 to Zygotes Facilitates the Efficient Generation of Site-Specific Mutant Mouse Models. PLoS One (2017) 0.75
To CRISPR and beyond: the evolution of genome editing in stem cells. Regen Med (2016) 0.75
Clustered Regularly Interspaced Short Palindromic Repeats: Challenges in Treating Retinal Disease. Asia Pac J Ophthalmol (Phila) (2016) 0.75
Of mice and CRISPR: The post-CRISPR future of the mouse as a model system for the human condition. EMBO Rep (2017) 0.75
An analysis of possible off target effects following CAS9/CRISPR targeted deletions of neuropeptide gene enhancers from the mouse genome. Neuropeptides (2016) 0.75
Sensitized mutagenesis screen in Factor V Leiden mice identifies thrombosis suppressor loci. Proc Natl Acad Sci U S A (2017) 0.75
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A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science (2012) 48.17
One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell (2013) 24.00
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CRISPR/Cas, the immune system of bacteria and archaea. Science (2010) 18.72
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. Nat Biotechnol (2013) 18.01
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Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria. Proc Natl Acad Sci U S A (2012) 16.48
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RNA-programmed genome editing in human cells. Elife (2013) 14.82
Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease. Nat Biotechnol (2013) 14.28
Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell (2013) 13.43
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell (2013) 13.37
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nat Biotechnol (2013) 11.35
A conditional knockout resource for the genome-wide study of mouse gene function. Nature (2011) 9.93
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One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering. Cell (2013) 7.99
Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos. Cell Res (2013) 7.41
Generation of gene-modified mice via Cas9/RNA-mediated gene targeting. Cell Res (2013) 6.89
Improving CRISPR-Cas nuclease specificity using truncated guide RNAs. Nat Biotechnol (2014) 6.85
A rapid and general assay for monitoring endogenous gene modification. Methods Mol Biol (2010) 6.77
Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases. Genome Res (2013) 6.19
Heritable genome editing in C. elegans via a CRISPR-Cas9 system. Nat Methods (2013) 5.93
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9. Nature (2014) 5.70
High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases. Nat Methods (2011) 5.68
Chromosome engineering in mice. Nature (1995) 5.48
Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells. Nat Biotechnol (2014) 5.07
Highly efficient targeted mutagenesis of Drosophila with the CRISPR/Cas9 system. Cell Rep (2013) 4.72
Heritable gene targeting in the mouse and rat using a CRISPR-Cas system. Nat Biotechnol (2013) 4.58
Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system. Proc Natl Acad Sci U S A (2013) 4.57
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Engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination. Nat Methods (2013) 3.59
Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis. Proc Natl Acad Sci U S A (2013) 3.53
Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system. Cell Res (2013) 3.50
Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects. Nat Methods (2014) 3.34
Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins. Genome Res (2014) 3.31
Correction of a genetic disease in mouse via use of CRISPR-Cas9. Cell Stem Cell (2013) 3.30
Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing. Cell Stem Cell (2014) 3.16
Highly efficient genome modifications mediated by CRISPR/Cas9 in Drosophila. Genetics (2013) 2.87
Optimization of scarless human stem cell genome editing. Nucleic Acids Res (2013) 2.78
Efficient mutagenesis by Cas9 protein-mediated oligonucleotide insertion and large-scale assessment of single-guide RNAs. PLoS One (2014) 2.69
Whole-genome sequencing analysis reveals high specificity of CRISPR/Cas9 and TALEN-based genome editing in human iPSCs. Cell Stem Cell (2014) 2.57
Generation of mutant mice by pronuclear injection of circular plasmid expressing Cas9 and single guided RNA. Sci Rep (2013) 2.41
Highly efficient gene knockout in mice and zebrafish with RNA-guided endonucleases. Genome Res (2013) 2.28
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Somatic mosaicism and allele complexity induced by CRISPR/Cas9 RNA injections in mouse zygotes. Dev Biol (2014) 1.96
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Donor DNA Utilization During Gene Targeting with Zinc-Finger Nucleases. G3 (Bethesda) (2013) 1.92
Gene disruption by cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNA. Genome Res (2014) 1.91
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Reversal of female infertility by Chk2 ablation reveals the oocyte DNA damage checkpoint pathway. Science (2014) 1.21
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Heritable multiplex genetic engineering in rats using CRISPR/Cas9. PLoS One (2014) 1.14
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