Published in J Virol on March 01, 1988
Patterns of gene expression and sites of latency in human nerve ganglia are different for varicella-zoster and herpes simplex viruses. Proc Natl Acad Sci U S A (1988) 3.49
Quantification of transcripts from the ICP4 and thymidine kinase genes in mouse ganglia latently infected with herpes simplex virus. J Virol (1995) 3.18
Spontaneous molecular reactivation of herpes simplex virus type 1 latency in mice. Proc Natl Acad Sci U S A (2002) 2.94
A viral function represses accumulation of transcripts from productive-cycle genes in mouse ganglia latently infected with herpes simplex virus. J Virol (1997) 2.83
Expression of herpes simplex virus type 1 latency-associated transcripts in the trigeminal ganglia of mice during acute infection and reactivation of latent infection. J Virol (1988) 2.80
Gamma interferon expression during acute and latent nervous system infection by herpes simplex virus type 1. J Virol (1995) 2.66
Experimental investigation of herpes simplex virus latency. Clin Microbiol Rev (1997) 2.53
A novel class of transcripts expressed with late kinetics in the absence of ICP4 spans the junction between the long and short segments of the herpes simplex virus type 1 genome. J Virol (1993) 2.28
Relationship between polyadenylated and nonpolyadenylated herpes simplex virus type 1 latency-associated transcripts. J Virol (1991) 2.20
Latent herpes simplex virus type 1 transcription in human trigeminal ganglia. J Virol (1988) 2.02
A novel latency-active promoter is contained within the herpes simplex virus type 1 UL flanking repeats. J Virol (1994) 1.86
Gene expression during reactivation of herpes simplex virus type 1 from latency in the peripheral nervous system is different from that during lytic infection of tissue cultures. J Virol (1997) 1.86
Herpes simplex virus type 1 and bovine herpesvirus 1 latency. Clin Microbiol Rev (2003) 1.62
Region of herpes simplex virus type 1 latency-associated transcript sufficient for wild-type spontaneous reactivation promotes cell survival in tissue culture. J Virol (2001) 1.55
Competitive quantitative PCR analysis of herpes simplex virus type 1 DNA and latency-associated transcript RNA in latently infected cells of the rat brain. J Virol (1994) 1.51
PCR-based analysis of herpes simplex virus type 1 latency in the rat trigeminal ganglion established with a ribonucleotide reductase-deficient mutant. J Virol (1994) 1.45
An antigen encoded by the latency-associated transcript in neuronal cell cultures latently infected with herpes simplex virus type 1. J Virol (1991) 1.41
The presence of cytomegalovirus nucleic acids in arterial walls of atherosclerotic and nonatherosclerotic patients. Am J Pathol (1989) 1.34
Characterization of herpes simplex virus type 2 transcription during latent infection of mouse trigeminal ganglia. J Virol (1990) 1.34
The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosine. J Virol (1997) 1.33
Detection of pseudorabies virus transcripts in trigeminal ganglia of latently infected swine. J Virol (1989) 1.31
Induction of cellular transcription factors in trigeminal ganglia of mice by corneal scarification, herpes simplex virus type 1 infection, and explantation of trigeminal ganglia. J Virol (1991) 1.24
Utilization of the herpes simplex virus type 1 latency-associated regulatory region to drive stable reporter gene expression in the nervous system. J Virol (1997) 1.19
Two open reading frames (ORF1 and ORF2) within the 2.0-kilobase latency-associated transcript of herpes simplex virus type 1 are not essential for reactivation from latency. J Virol (1994) 1.15
The molecular basis of herpes simplex virus latency. FEMS Microbiol Rev (2012) 1.12
Herpes simplex virus type 1 latency-associated transcript (LAT) promoter deletion mutants can express a 2-kilobase transcript mapping to the LAT region. J Virol (1993) 1.11
Detection of herpes simplex virus type 1 latency-associated transcript expression in trigeminal ganglia by in situ reverse transcriptase PCR. J Virol (1996) 1.06
Towards an understanding of the herpes simplex virus type 1 latency-reactivation cycle. Interdiscip Perspect Infect Dis (2010) 1.05
Herpes simplex virus type 1 mutant strain in1814 establishes a unique, slowly progressing infection in SCID mice. J Virol (1992) 1.05
Current status review: molecular biology of herpes simplex virus latency. J Exp Pathol (Oxford) (1990) 0.99
Effect of apolipoprotein E on the cerebral load of latent herpes simplex virus type 1 DNA. J Virol (2006) 0.97
Selective spread of herpes simplex virus in the central nervous system after ocular inoculation. J Virol (1989) 0.96
Analysis of protein expression from within the region encoding the 2.0-kilobase latency-associated transcript of herpes simplex virus type 1. J Virol (2001) 0.96
Latent herpes simplex virus type 1 in human geniculate ganglia. Acta Neuropathol (1992) 0.95
Targets of herpes simplex virus type 1 infection in a mouse corneal model. Acta Neuropathol (1991) 0.93
Interference with major histocompatibility complex class II-restricted antigen presentation in the brain by herpes simplex virus type 1: a possible mechanism of evasion of the immune response. Proc Natl Acad Sci U S A (1993) 0.91
HSV-1 and Alzheimer's disease: more than a hypothesis. Front Pharmacol (2014) 0.91
Expression of herpes simplex virus type 2 latency-associated transcript in neurons and nonneurons. J Virol (1991) 0.89
Efficient reactivation of latent herpes simplex virus from mouse central nervous system tissues. J Virol (2006) 0.87
Targets of infection in a herpes simplex-reactivation model. Acta Neuropathol (1989) 0.87
The herpes simplex virus type 1 locus that encodes the latency-associated transcript enhances the frequency of encephalitis in male BALB/c mice. J Virol (2005) 0.86
Herpes simplex latent infection: quantitation of latency-associated transcript-positive neurons and reactivable neurons. Yale J Biol Med (1989) 0.85
Herpes simplex virus type 1 latency-associated transcript inhibits apoptosis and promotes neurite sprouting in neuroblastoma cells following serum starvation by maintaining protein kinase B (AKT) levels. J Gen Virol (2009) 0.84
In vivo reactivation of latent herpes simplex virus 1 in mice can occur in the brain before occurring in the trigeminal ganglion. J Virol (2014) 0.83
cis-acting elements involved in transcriptional regulation of the herpes simplex virus type 1 latency-associated promoter 1 (LAP1) in vitro and in vivo. J Virol (1996) 0.83
HSV-1-based vectors for gene therapy of neurological diseases and brain tumors: part I. HSV-1 structure, replication and pathogenesis. Neoplasia (1999) 0.81
Secondary herpes simplex virus latent infection in transplanted ganglia. J Virol (1994) 0.80
Identification of a novel herpes simplex virus type 1 transcript and protein (AL3) expressed during latency. J Gen Virol (2009) 0.80
Bovine Herpes Virus 1 (BHV-1) and Herpes Simplex Virus Type 1 (HSV-1) Promote Survival of Latently Infected Sensory Neurons, in Part by Inhibiting Apoptosis. J Cell Death (2013) 0.79
The case for immunomodulatory approaches in treating HSV encephalitis. Future Virol (2013) 0.78
Nervous system inflammatory lesions and viral nucleic acids in rabbits with herpes simplex virus encephalitis-induced rotational behaviour. Acta Neuropathol (1994) 0.78
Recurrent herpes labialis as a potential risk factor for nonarteritic anterior ischemic optic neuropathy. J Natl Med Assoc (1996) 0.77
Reactivation of HSV-1 following explant of tree shrew brain. J Neurovirol (2015) 0.75
Modeling HSV-1 Latency in Human Embryonic Stem Cell-Derived Neurons. Pathogens (2017) 0.75
Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. J Histochem Cytochem (1974) 20.88
RNA complementary to a herpesvirus alpha gene mRNA is prominent in latently infected neurons. Science (1987) 11.14
Latent herpes simplex virus in spinal ganglia of mice. Science (1971) 7.04
Cloning of reiterated and nonreiterated herpes simplex virus 1 sequences as BamHI fragments. Proc Natl Acad Sci U S A (1980) 6.66
Cloning of herpes simplex virus type 1 sequences representing the whole genome. J Virol (1981) 5.66
Detection of herpes simplex virus type 1 transcripts during latent infection in mice. J Virol (1987) 5.12
RNA from an immediate early region of the type 1 herpes simplex virus genome is present in the trigeminal ganglia of latently infected mice. Proc Natl Acad Sci U S A (1987) 4.98
Regulation of herpesvirus macromolecular synthesis: transcription-initiation sites and domains of alpha genes. Proc Natl Acad Sci U S A (1980) 4.75
A method for identifying the viral genes required for herpesvirus DNA replication. Proc Natl Acad Sci U S A (1986) 4.61
THE PATHOGENESIS OF HERPES VIRUS ENCEPHALITIS. I. VIRUS PATHWAYS TO THE NERVOUS SYSTEM OF SUCKLING MICE DEMONSTRATED BY FLUORESCENT ANTIBODY STAINING. J Exp Med (1964) 4.39
Detection of HSV-1 genome in central nervous system of latently infected mice. Nature (1983) 3.95
Localization of herpes simplex virus in the trigeminal and olfactory systems of the mouse central nervous system during acute and latent infections by in situ hybridization. Lab Invest (1984) 3.67
Orientation of herpes simplex virus type 1 immediate early mRNA's. Nucleic Acids Res (1979) 3.54
Cloning of herpes simplex type 1 DNA fragments in a bacteriophage lambda vector. Science (1979) 3.47
Detection of herpes simplex virus-specific DNA sequences in latently infected mice and in humans. J Virol (1986) 3.36
Evidence that neurons harbor latent herpes simplex virus. Infect Immun (1974) 3.03
Herpes simplex virus type 1 HindIII fragment L encodes spliced and complementary mRNA species. J Virol (1981) 2.97
Continued expression of a poly(A)+ transcript of herpes simplex virus type 1 in trigeminal ganglia of latently infected mice. J Virol (1987) 2.78
Latent ganglionic infection with herpes simplex virus types 1 and 2: viral reactivation in vivo after neurectomy. Science (1974) 2.71
Isolation of latent herpes simplex virus from the superior cervical and vagus ganglions of human beings. N Engl J Med (1978) 2.55
Latent herpes simplex virus in the central nervous system of rabbits and mice. J Exp Med (1973) 2.48
Herpes simplex type 1 DNA in human brain tissue. Proc Natl Acad Sci U S A (1981) 2.45
Characterization of a major late herpes simplex virus type 1 mRNA. J Virol (1981) 2.29
Detection of herpes simplex RNA in human sensory ganglia. Virology (1979) 2.23
Detection of herpes simplex virus mRNA in latently infected trigeminal ganglion neurons by in situ hybridization. Ann Neurol (1982) 2.12
Herpes simplex virus latency: the cellular location of virus in dorsal root ganglia and the fate of the infected cell following virus activation. J Gen Virol (1980) 2.07
Herpes simplex virus DNA and mRNA sequences in acutely and chronically infected trigeminal ganglia of mice. Virology (1978) 1.99
Herpes simplex virus DNA sequences in the CNS of latently infected mice. Nature (1980) 1.95
Latent herpes simplex virus type 1 DNA contains two copies of the virion DNA joint region. J Virol (1985) 1.90
Experimental herpes simplex encephalitis: early neuropathologic changes. J Neuropathol Exp Neurol (1970) 1.65
Spread of virus and distribution of latent infection following ocular herpes simplex in the non-immune and immune mouse. J Gen Virol (1982) 1.52
Herpes simplex virus infection of nervous tissue in animals and man. Prog Med Virol (1975) 1.52
Latent herpetic infections following experimental viraemia. J Gen Virol (1976) 1.44
RNA structures near poly(A) of adenovirus-2 late messenger RNAs. J Mol Biol (1978) 1.41
Localization of low abundance DNA sequences in tissue sections by in situ hybridization. J Cell Sci (1986) 1.39
Pathogenesis of latent herpes simplex virus infection of the trigeminal ganglion in guinea pigs: effects of age, passive immunization, and hydrocortisone. Infect Immun (1977) 1.39
Extensive elongation of axons from rat brain into peripheral nerve grafts. Nature (1982) 1.38
Isolation of Herpes simplex virus from human trigeminal ganglia, including ganglia from one patient with multiple sclerosis. Lancet (1977) 1.30
Effect of immune serum on the establishment of herpes simplex virus infection in trigeminal ganglia of hairless mice. J Gen Virol (1980) 1.24
Novobiocin and coumermycin A1 inhibit viral replication and the reactivation of herpes simplex virus type 1 from the trigeminal ganglia of latently infected mice. J Virol (1987) 1.23
The nerve cell body response to axotomy. Exp Neurol (1975) 1.06
A herpes simplex virus type 1 variant which fails to synthesize immediate early polypeptide VmwIE63. J Gen Virol (1987) 1.05
Dissociation of the inhibitory effects of 2-deoxy-D-glucose on Vero cell growth and the replication of herpes simplex virus. Antimicrob Agents Chemother (1982) 1.04
Chronic infections by herpes simplex viruses and by the horse and cat herpesviruses. Infect Immun (1970) 1.02
Detection of herpes simplex virus type 1 transcripts during latent infection in mice. J Virol (1987) 5.12
RNA from an immediate early region of the type 1 herpes simplex virus genome is present in the trigeminal ganglia of latently infected mice. Proc Natl Acad Sci U S A (1987) 4.98
Modification of discrete nuclear domains induced by herpes simplex virus type 1 immediate early gene 1 product (ICP0). J Gen Virol (1993) 4.32
Detection of HSV-1 genome in central nervous system of latently infected mice. Nature (1983) 3.95
Localization of herpes simplex virus in the trigeminal and olfactory systems of the mouse central nervous system during acute and latent infections by in situ hybridization. Lab Invest (1984) 3.67
Herpes simplex virus type 1 latency-associated transcripts are evidently not essential for latent infection. EMBO J (1989) 3.65
Retracted Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript. Nature (2006) 3.47
During latency, herpes simplex virus type 1 DNA is associated with nucleosomes in a chromatin structure. J Virol (1989) 3.29
Early Ad-2 transcription units: only promoter-proximal RNA continues to be made in the presence of DRB. Virology (1979) 3.06
Expression of herpes simplex virus type 1 latency-associated transcripts in the trigeminal ganglia of mice during acute infection and reactivation of latent infection. J Virol (1988) 2.80
In vivo and in vitro reactivation impairment of a herpes simplex virus type 1 latency-associated transcript variant in a rabbit eye model. J Virol (1991) 2.54
Deletion of the VP16 open reading frame of herpes simplex virus type 1. J Virol (1992) 2.50
Herpes simplex type 1 DNA in human brain tissue. Proc Natl Acad Sci U S A (1981) 2.45
Experimental allergic encephalomyelitis and multiple sclerosis: lesion characterization with magnetization transfer imaging. Radiology (1992) 2.41
Mapping of low abundance latency-associated RNA in the trigeminal ganglia of mice latently infected with herpes simplex virus type 1. J Gen Virol (1990) 2.25
Mapping of RNA initiation sites by high doses of uv irradiation: evidence for three independent promoters within the left 11% of the Ad-2 genome. Virology (1979) 2.22
Magnetic resonance imaging of Creutzfeldt-Jacob disease. Ann Neurol (1991) 2.06
Physical state of the latent herpes simplex virus genome in a mouse model system: evidence suggesting an episomal state. Virology (1987) 2.05
The major late adenovirus type-2 transcription unit: termination is downstream from the last poly(A) site. J Mol Biol (1979) 2.04
Latent herpes simplex virus type 1 transcription in human trigeminal ganglia. J Virol (1988) 2.02
DRB-induced premature termination of late adenovirus transcription. Nature (1978) 1.98
Correlation between herpes simplex virus type 1 rate of reactivation from latent infection and the number of infected neurons in trigeminal ganglia. Virology (1996) 1.96
Multiple discrete sites for premature RNA chain termination late in adenovirus-2 infection: enhancement by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole. Proc Natl Acad Sci U S A (1979) 1.92
Latent herpes simplex virus type 1 DNA contains two copies of the virion DNA joint region. J Virol (1985) 1.90
The latency-associated transcripts of herpes simplex virus: RNA in search of function. Virology (1992) 1.89
Pathogenesis of chimeric MHV4/MHV-A59 recombinant viruses: the murine coronavirus spike protein is a major determinant of neurovirulence. J Virol (1999) 1.86
Gene expression during reactivation of herpes simplex virus type 1 from latency in the peripheral nervous system is different from that during lytic infection of tissue cultures. J Virol (1997) 1.86
During lytic infection herpes simplex virus type 1 is associated with histones bearing modifications that correlate with active transcription. J Virol (2004) 1.84
A herpes simplex virus type 1 latency-associated transcript mutant reactivates with normal kinetics from latent infection. J Virol (1990) 1.83
In situ DNA PCR and RNA hybridization detection of herpes simplex virus sequences in trigeminal ganglia of latently infected mice. Virology (1995) 1.77
An HSV LAT null mutant reactivates slowly from latent infection and makes small plaques on CV-1 monolayers. Virology (1993) 1.69
A point mutation in the env gene of a murine leukemia virus induces syncytium formation and neurologic disease. J Virol (1994) 1.65
Spinal dural arteriovenous fistula: the pathology of venous hypertensive myelopathy. Neurology (1995) 1.64
Experimental demyelination produced by the A59 strain of mouse hepatitis virus. Neurology (1984) 1.64
Tumor necrosis factor alpha and lymphotoxin alpha are not required for induction of acute experimental autoimmune encephalomyelitis. J Exp Med (1997) 1.61
Demyelination determinants map to the spike glycoprotein gene of coronavirus mouse hepatitis virus. J Virol (2000) 1.55
Autoproteolysis of herpes simplex virus type 1 protease releases an active catalytic domain found in intermediate capsid particles. J Virol (1993) 1.49
Immunohistochemical analysis of CCR2, CCR3, CCR5, and CXCR4 in the human brain: potential mechanisms for HIV dementia. Exp Mol Pathol (2000) 1.48
Development of a syngenic murine B16 cell line-derived melanoma susceptible to destruction by neuroattenuated HSV-1. Mol Ther (2001) 1.47
Altered pathogenesis of a mutant of the murine coronavirus MHV-A59 is associated with a Q159L amino acid substitution in the spike protein. Virology (1997) 1.46
MHV-A59 fusion mutants are attenuated and display altered hepatotropism. Virology (1994) 1.45
Murine coronavirus spike protein determines the ability of the virus to replicate in the liver and cause hepatitis. J Virol (2001) 1.43
Chromosomal organization of the herpes simplex virus genome during acute infection of the mouse central nervous system. J Virol (1986) 1.41
Antibodies against IL-12 prevent superantigen-induced and spontaneous relapses of experimental autoimmune encephalomyelitis. J Immunol (1998) 1.39
Persistence of mouse hepatitis virus A59 RNA in a slow virus demyelinating infection in mice as detected by in situ hybridization. J Virol (1984) 1.38
Hemangiopericytoma of the third ventricle. Case report. J Neurosurg (1999) 1.37
Microinjection of pp60v-src into Xenopus oocytes increases phosphorylation of ribosomal protein S6 and accelerates the rate of progesterone-induced meiotic maturation. Mol Cell Biol (1984) 1.34
Characterization of herpes simplex virus type 2 transcription during latent infection of mouse trigeminal ganglia. J Virol (1990) 1.34
The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosine. J Virol (1997) 1.33
Phorbol ester, serum, and rous sarcoma virus transforming gene product induce similar phosphorylations of ribosomal protein S6. Proc Natl Acad Sci U S A (1984) 1.33
Coronavirus infection induces H-2 antigen expression on oligodendrocytes and astrocytes. Science (1986) 1.31
The effects of human immunodeficiency virus in the central nervous system. Adv Virus Res (1998) 1.27
Targeted recombination within the spike gene of murine coronavirus mouse hepatitis virus-A59: Q159 is a determinant of hepatotropism. J Virol (1998) 1.24
Induction of cellular transcription factors in trigeminal ganglia of mice by corneal scarification, herpes simplex virus type 1 infection, and explantation of trigeminal ganglia. J Virol (1991) 1.24
The effect of human herpesvirus-6 (HHV-6) on cultured human neural cells: oligodendrocytes and microglia. J Neurovirol (1998) 1.23
Novobiocin and coumermycin A1 inhibit viral replication and the reactivation of herpes simplex virus type 1 from the trigeminal ganglia of latently infected mice. J Virol (1987) 1.23
A herpes simplex virus type 1 variant, deleted in the promoter region of the latency-associated transcripts, does not produce any detectable minor RNA species during latency in the mouse trigeminal ganglion. J Gen Virol (1990) 1.23
Dependence of apparent diffusion coefficients on axonal spacing, membrane permeability, and diffusion time in spinal cord white matter. J Magn Reson Imaging (1998) 1.21
The replicating intermediates of herpes simplex virus type 1 DNA are relatively short. J Neurovirol (1995) 1.21
Herpesvirus vector gene transfer and expression of beta-glucuronidase in the central nervous system of MPS VII mice. Nat Genet (1992) 1.21
Investigation of herpes simplex virus type 1 (HSV-1) gene expression and DNA synthesis during the establishment of latent infection by an HSV-1 mutant, in1814, that does not replicate in mouse trigeminal ganglia. J Gen Virol (1991) 1.21
CpG frequency in large DNA segments. J Mol Evol (1983) 1.20
T1rho imaging of murine brain tumors at 4 T. Acad Radiol (2001) 1.17
Identification of the serine residue at the active site of the herpes simplex virus type 1 protease. J Biol Chem (1994) 1.17
Analysis of a herpes simplex virus type 1 LAT mutant with a deletion between the putative promoter and the 5' end of the 2.0-kilobase transcript. J Virol (1994) 1.17
Mouse hepatitis virus type-2 infection in mice: an experimental model system of acute meningitis and hepatitis. Exp Mol Pathol (2001) 1.15
The herpes simplex virus type 1 strain 17+ gamma 34.5 deletion mutant 1716 is avirulent in SCID mice. J Gen Virol (1994) 1.15
Egg proteins in cod serum. Natural occurrence and induction by injections of oestradiol 3-benzoate. Biochem J (1971) 1.15
Two open reading frames (ORF1 and ORF2) within the 2.0-kilobase latency-associated transcript of herpes simplex virus type 1 are not essential for reactivation from latency. J Virol (1994) 1.15
Investigation of the specificity of the herpes simplex virus type 1 protease by point mutagenesis of the autoproteolysis sites. J Virol (1994) 1.15
Intracerebral hemorrhages and syncytium formation induced by endothelial cell infection with a murine leukemia virus. J Virol (1993) 1.14
A herpes simplex virus type 1 mutant with a deletion immediately upstream of the LAT locus establishes latency and reactivates from latently infected mice with normal kinetics. J Neurovirol (1996) 1.13
The organ tropism of mouse hepatitis virus A59 in mice is dependent on dose and route of inoculation. Lab Anim Sci (1986) 1.12
Herpes simplex virus type 1 latency-associated transcript (LAT) promoter deletion mutants can express a 2-kilobase transcript mapping to the LAT region. J Virol (1993) 1.11
Neither B cells nor T cells are required for CNS demyelination in mice persistently infected with MHV-A59. J Neurovirol (2002) 1.10
The transcriptional activation domain of VP16 is required for efficient infection and establishment of latency by HSV-1 in the murine peripheral and central nervous systems. Virology (1999) 1.10
Epidural haemangiomas during pregnancy. J Neurol Neurosurg Psychiatry (1986) 1.09
Latent herpes simplex virus type 1 DNA is not extensively methylated in vivo. J Gen Virol (1987) 1.08
An HSV-1 mutant lacking the LAT TATA element reactivates normally in explant cocultivation. Virology (1993) 1.07