Published in J Virol on December 01, 1987
Physical characterization of the herpes simplex virus latency-associated transcript in neurons. J Virol (1988) 4.85
A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency. J Virol (1989) 4.85
Herpes simplex virus type 1 latency-associated transcripts are evidently not essential for latent infection. EMBO J (1989) 3.65
Fine mapping of the latency-related gene of herpes simplex virus type 1: alternative splicing produces distinct latency-related RNAs containing open reading frames. J Virol (1988) 3.51
Patterns of gene expression and sites of latency in human nerve ganglia are different for varicella-zoster and herpes simplex viruses. Proc Natl Acad Sci U S A (1988) 3.49
During latency, herpes simplex virus type 1 DNA is associated with nucleosomes in a chromatin structure. J Virol (1989) 3.29
The herpes simplex virus latency-associated transcript is spliced during the latent phase of infection. J Virol (1988) 3.22
Construction and characterization of a herpes simplex virus type 1 mutant unable to transinduce immediate-early gene expression. J Virol (1989) 3.19
Quantification of transcripts from the ICP4 and thymidine kinase genes in mouse ganglia latently infected with herpes simplex virus. J Virol (1995) 3.18
Human herpesviruses: a consideration of the latent state. Microbiol Rev (1989) 3.15
Spontaneous molecular reactivation of herpes simplex virus type 1 latency in mice. Proc Natl Acad Sci U S A (2002) 2.94
EBV gene expression in an NPC-related tumour. EMBO J (1989) 2.94
Activity of herpes simplex virus type 1 latency-associated transcript (LAT) promoter in neuron-derived cells: evidence for neuron specificity and for a large LAT transcript. J Virol (1990) 2.87
A viral function represses accumulation of transcripts from productive-cycle genes in mouse ganglia latently infected with herpes simplex virus. J Virol (1997) 2.83
Expression of herpes simplex virus type 1 latency-associated transcripts in the trigeminal ganglia of mice during acute infection and reactivation of latent infection. J Virol (1988) 2.80
Herpes simplex virus type 1 immediate-early protein Vmw110 reactivates latent herpes simplex virus type 2 in an in vitro latency system. J Virol (1989) 2.76
In vivo and in vitro reactivation impairment of a herpes simplex virus type 1 latency-associated transcript variant in a rabbit eye model. J Virol (1991) 2.54
Latent herpes simplex virus type 1 transcripts in peripheral and central nervous system tissues of mice map to similar regions of the viral genome. J Virol (1988) 2.46
RNA complementary to herpes simplex virus type 1 ICP0 gene demonstrated in neurons of human trigeminal ganglia. J Virol (1988) 2.24
Relationship between polyadenylated and nonpolyadenylated herpes simplex virus type 1 latency-associated transcripts. J Virol (1991) 2.20
Herpes simplex virus latent RNA (LAT) is not required for latent infection in the mouse. Proc Natl Acad Sci U S A (1989) 2.05
Reactivation of latent herpes simplex virus by adenovirus recombinants encoding mutant IE-0 gene products. J Virol (1990) 2.03
Latent herpes simplex virus type 1 transcription in human trigeminal ganglia. J Virol (1988) 2.02
Detection and preliminary characterization of herpes simplex virus type 1 transcripts in latently infected human trigeminal ganglia. J Virol (1988) 1.92
The herpes simplex virus type 1 latency-associated transcript (LAT) enhancer/rcr is hyperacetylated during latency independently of LAT transcription. J Virol (2004) 1.91
A novel latency-active promoter is contained within the herpes simplex virus type 1 UL flanking repeats. J Virol (1994) 1.86
Gene expression during reactivation of herpes simplex virus type 1 from latency in the peripheral nervous system is different from that during lytic infection of tissue cultures. J Virol (1997) 1.86
Regulation and cell-type-specific activity of a promoter located upstream of the latency-associated transcript of herpes simplex virus type 1. J Virol (1990) 1.85
Herpes simplex virus type 1 latency-associated transcription plays no role in establishment or maintenance of a latent infection in murine sensory neurons. J Virol (1989) 1.85
A herpes simplex virus type 1 latency-associated transcript mutant reactivates with normal kinetics from latent infection. J Virol (1990) 1.83
Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1. J Virol (1992) 1.79
Identification of a promoter mapping within the reiterated sequences that flank the herpes simplex virus type 1 UL region. J Virol (1993) 1.77
Regions of the herpes simplex virus type 1 latency-associated transcript that protect cells from apoptosis in vitro and protect neuronal cells in vivo. J Virol (2002) 1.67
Cloning of the latency gene and the early protein 0 gene of pseudorabies virus. J Virol (1991) 1.64
The regulation of synthesis and properties of the protein product of open reading frame P of the herpes simplex virus 1 genome. J Virol (1995) 1.63
Expression of the herpes simplex virus type 2 latency-associated transcript enhances spontaneous reactivation of genital herpes in latently infected guinea pigs. J Exp Med (1995) 1.63
Accumulation of viral transcripts and DNA during establishment of latency by herpes simplex virus. J Virol (1998) 1.52
Characterization of the latency-related transcriptionally active region of the bovine herpesvirus 1 genome. J Virol (1990) 1.51
Competitive quantitative PCR analysis of herpes simplex virus type 1 DNA and latency-associated transcript RNA in latently infected cells of the rat brain. J Virol (1994) 1.51
Mechanisms of herpes simplex virus type 1 reactivation. J Virol (1996) 1.49
Virus-encoded homologs of cellular interleukin-10 and their control of host immune function. J Virol (2009) 1.49
PCR-based analysis of herpes simplex virus type 1 latency in the rat trigeminal ganglion established with a ribonucleotide reductase-deficient mutant. J Virol (1994) 1.45
Phenotypic properties of herpes simplex virus 1 containing a derepressed open reading frame P gene. J Virol (1996) 1.44
Latent infection with herpes simplex virus is associated with ongoing CD8+ T-cell stimulation by parenchymal cells within sensory ganglia. J Virol (2005) 1.43
The characteristic site-specific reactivation phenotypes of HSV-1 and HSV-2 depend upon the latency-associated transcript region. J Exp Med (1996) 1.41
An antigen encoded by the latency-associated transcript in neuronal cell cultures latently infected with herpes simplex virus type 1. J Virol (1991) 1.41
Herpes simplex virus type 1 latency-associated transcripts suppress viral replication and reduce immediate-early gene mRNA levels in a neuronal cell line. J Virol (1998) 1.40
Two herpes simplex virus type 1 latency-active promoters differ in their contributions to latency-associated transcript expression during lytic and latent infections. J Virol (1995) 1.37
A gene capable of blocking apoptosis can substitute for the herpes simplex virus type 1 latency-associated transcript gene and restore wild-type reactivation levels. J Virol (2002) 1.37
Characterization of herpes simplex virus type 2 transcription during latent infection of mouse trigeminal ganglia. J Virol (1990) 1.34
The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosine. J Virol (1997) 1.33
Detection of pseudorabies virus transcripts in trigeminal ganglia of latently infected swine. J Virol (1989) 1.31
A novel herpes simplex virus type 1 transcript (AL-RNA) antisense to the 5' end of the latency-associated transcript produces a protein in infected rabbits. J Virol (2002) 1.30
Long-term promoter activity during herpes simplex virus latency. J Virol (1994) 1.27
A major portion of the latent pseudorabies virus genome is transcribed in trigeminal ganglia of pigs. J Virol (1990) 1.25
The herpes simplex virus type 1 reactivation function lies outside the latency-associated transcript open reading frame ORF-2. J Virol (1993) 1.25
Induction of cellular transcription factors in trigeminal ganglia of mice by corneal scarification, herpes simplex virus type 1 infection, and explantation of trigeminal ganglia. J Virol (1991) 1.24
Immunomodulatory properties of a viral homolog of human interleukin-10 expressed by human cytomegalovirus during the latent phase of infection. J Virol (2008) 1.22
The checkpoints of viral gene expression in productive and latent infection: the role of the HDAC/CoREST/LSD1/REST repressor complex. J Virol (2011) 1.20
Quantitative analysis of herpes simplex virus reactivation in vivo demonstrates that reactivation in the nervous system is not inhibited at early times postinoculation. J Virol (2003) 1.20
In vivo deletion analysis of the herpes simplex virus type 1 latency-associated transcript promoter. J Virol (1995) 1.20
Mutational inactivation of herpes simplex virus 1 microRNAs identifies viral mRNA targets and reveals phenotypic effects in culture. J Virol (2013) 1.19
Two open reading frames (ORF1 and ORF2) within the 2.0-kilobase latency-associated transcript of herpes simplex virus type 1 are not essential for reactivation from latency. J Virol (1994) 1.15
The nucleotide sequence, 5' end, promoter domain, and kinetics of expression of the gene encoding the herpes simplex virus type 2 latency-associated transcript. J Virol (1991) 1.14
Localization of cis-acting sequence requirements in the promoter of the latency-associated transcript of herpes simplex virus type 1 required for cell-type-specific activity. J Virol (1992) 1.13
The product of ORF O located within the domain of herpes simplex virus 1 genome transcribed during latent infection binds to and inhibits in vitro binding of infected cell protein 4 to its cognate DNA site. Proc Natl Acad Sci U S A (1997) 1.11
Herpes simplex virus type 1 latency-associated transcript (LAT) promoter deletion mutants can express a 2-kilobase transcript mapping to the LAT region. J Virol (1993) 1.11
Three herpes simplex virus type 1 latency-associated transcript mutants with distinct and asymmetric effects on virulence in mice compared with rabbits. J Virol (2001) 1.09
Requirement of an integrated immune response for successful neuroattenuated HSV-1 therapy in an intracranial metastatic melanoma model. Mol Ther (2003) 1.09
Effect of the transcription start region of the herpes simplex virus type 1 latency-associated transcript promoter on expression of productively infected neurons in vivo. J Virol (1994) 1.08
Structural and kinetic analyses of herpes simplex virus type 1 latency-associated transcripts in human trigeminal ganglia and in cell culture. J Clin Invest (1990) 1.08
The latency-associated promoter of herpes simplex virus type 1 requires a region downstream of the transcription start site for long-term expression during latency. J Virol (1997) 1.07
Evidence for a bidirectional element located downstream from the herpes simplex virus type 1 latency-associated promoter that increases its activity during latency. J Virol (2000) 1.06
Herpes simplex virus type 1 mutant strain in1814 establishes a unique, slowly progressing infection in SCID mice. J Virol (1992) 1.05
Activities of ICP0 involved in the reversal of silencing of quiescent herpes simplex virus 1. J Virol (2011) 1.05
The polyserine tract of herpes simplex virus ICP4 is required for normal viral gene expression and growth in murine trigeminal ganglia. J Virol (1998) 1.04
Alternative splicing of the latency-related transcript of bovine herpesvirus 1 yields RNAs containing unique open reading frames. J Virol (1998) 1.03
ICP22 is required for wild-type composition and infectivity of herpes simplex virus type 1 virions. J Virol (2006) 1.02
Herpes simplex virus 1 microRNAs expressed abundantly during latent infection are not essential for latency in mouse trigeminal ganglia. Virology (2011) 1.01
Identification of latency-associated transcripts that map antisense to the ICP4 homolog gene of Marek's disease virus. J Virol (1994) 0.99
Sodium butyrate: a chemical inducer of in vivo reactivation of herpes simplex virus type 1 in the ocular mouse model. J Virol (2007) 0.98
A 2.9-kilobase noncoding nuclear RNA functions in the establishment of persistent Hz-1 viral infection. J Virol (1998) 0.97
Analysis of protein expression from within the region encoding the 2.0-kilobase latency-associated transcript of herpes simplex virus type 1. J Virol (2001) 0.96
Herpes simplex virus VP16, but not ICP0, is required to reduce histone occupancy and enhance histone acetylation on viral genomes in U2OS osteosarcoma cells. J Virol (2009) 0.95
Latent herpes simplex virus type 1 in human geniculate ganglia. Acta Neuropathol (1992) 0.95
Reversal of heterochromatic silencing of quiescent herpes simplex virus type 1 by ICP0. J Virol (2010) 0.95
Herpes simplex virus type 1 vector-mediated expression of nerve growth factor protects dorsal root ganglion neurons from peroxide toxicity. J Virol (1999) 0.95
Identification of an immediate-early gene in the Marek's disease virus long internal repeat region which encodes a unique 14-kilodalton polypeptide. J Virol (1994) 0.95
Mammalian alphaherpesvirus miRNAs. Biochim Biophys Acta (2011) 0.93
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RNA complementary to a herpesvirus alpha gene mRNA is prominent in latently infected neurons. Science (1987) 11.14
A cis-acting element from the Epstein-Barr viral genome that permits stable replication of recombinant plasmids in latently infected cells. Proc Natl Acad Sci U S A (1984) 10.91
Herpes simplex virus type 1 ICP27 is an essential regulatory protein. J Virol (1985) 6.67
Cloning of reiterated and nonreiterated herpes simplex virus 1 sequences as BamHI fragments. Proc Natl Acad Sci U S A (1980) 6.66
Separation and characterization of herpes simplex virus type 1 immediate-early mRNA's. J Virol (1979) 5.21
RNA from an immediate early region of the type 1 herpes simplex virus genome is present in the trigeminal ganglia of latently infected mice. Proc Natl Acad Sci U S A (1987) 4.98
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Detection of herpes simplex RNA in human sensory ganglia. Virology (1979) 2.23
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