Published in Science on August 27, 1971
Activation of expression of latent Epstein-Barr herpesvirus after gene transfer with a small cloned subfragment of heterogeneous viral DNA. Proc Natl Acad Sci U S A (1985) 8.19
Pathogenesis of herpetic neuritis and ganglionitis in mice: evidence for intra-axonal transport of infection. Infect Immun (1973) 5.29
Physical characterization of the herpes simplex virus latency-associated transcript in neurons. J Virol (1988) 4.85
Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate. Proc Natl Acad Sci U S A (1989) 3.26
Use of [125I]deoxycytidine to detect herpes simplex virus-specific thymidine kinase in tissues of latently infected guinea pigs. J Virol (1980) 3.24
Quantification of transcripts from the ICP4 and thymidine kinase genes in mouse ganglia latently infected with herpes simplex virus. J Virol (1995) 3.18
Evidence that neurons harbor latent herpes simplex virus. Infect Immun (1974) 3.03
Spontaneous molecular reactivation of herpes simplex virus type 1 latency in mice. Proc Natl Acad Sci U S A (2002) 2.94
Rapid in vivo reactivation of herpes simplex virus in latently infected murine ganglionic neurons after transient hyperthermia. J Virol (1992) 2.90
Experimental investigation of herpes simplex virus latency. Clin Microbiol Rev (1997) 2.53
Latent herpes simplex virus in the central nervous system of rabbits and mice. J Exp Med (1973) 2.48
Latent herpes simplex virus type 1 transcripts in peripheral and central nervous system tissues of mice map to similar regions of the viral genome. J Virol (1988) 2.46
Herpes simplex type 1 DNA in human brain tissue. Proc Natl Acad Sci U S A (1981) 2.45
Herpes simplex virus type 1 DNA replication and gene expression during explant-induced reactivation of latently infected murine sensory ganglia. J Virol (1994) 2.27
RNA complementary to herpes simplex virus type 1 ICP0 gene demonstrated in neurons of human trigeminal ganglia. J Virol (1988) 2.24
Limited transcription of the herpes simplex virus genome when latent in human sensory ganglia. J Virol (1982) 2.12
Neonatal herpes simplex infection. Clin Microbiol Rev (2004) 2.06
Reactivation of latent herpes simplex virus by adenovirus recombinants encoding mutant IE-0 gene products. J Virol (1990) 2.03
Kinetics of CD4+ and CD8+ memory T-cell responses during hepatitis C virus rechallenge of previously recovered chimpanzees. J Virol (2003) 1.93
Gene expression during reactivation of herpes simplex virus type 1 from latency in the peripheral nervous system is different from that during lytic infection of tissue cultures. J Virol (1997) 1.86
A herpes simplex virus type 1 latency-associated transcript mutant reactivates with normal kinetics from latent infection. J Virol (1990) 1.83
ICP0, ICP4, or VP16 expressed from adenovirus vectors induces reactivation of latent herpes simplex virus type 1 in primary cultures of latently infected trigeminal ganglion cells. J Virol (2001) 1.76
Detection of an immediate early herpes simplex virus type 1 polypeptide in trigeminal ganglia from latently infected animals. Infect Immun (1981) 1.72
Epigenetic regulation of latent HSV-1 gene expression. Biochim Biophys Acta (2010) 1.65
Differences in attachment between herpes simplex type 1 and type 2 viruses to neurons and glial cells. Infect Immun (1980) 1.53
Accumulation of viral transcripts and DNA during establishment of latency by herpes simplex virus. J Virol (1998) 1.52
Modulation of acute and latent herpes simplex virus infection in C57BL/6 mice by adoptive transfer of immune lymphocytes with cytolytic activity. J Virol (1989) 1.51
Synthetic glycoprotein D-related peptides protect mice against herpes simplex virus challenge. J Virol (1985) 1.51
Divergent molecular pathways of productive and latent infection with a virulent strain of herpes simplex virus type 1. J Virol (1991) 1.50
Mechanisms of herpes simplex virus type 1 reactivation. J Virol (1996) 1.49
Characterization of nerve growth factor-dependent herpes simplex virus latency in neurons in vitro. J Virol (1988) 1.47
In vivo role of complement-interacting domains of herpes simplex virus type 1 glycoprotein gC. J Exp Med (1999) 1.46
Herpes simplex virus infection in guinea pigs: an animal model for studying latent and recurrent herpes simplex virus infection. Infect Immun (1975) 1.46
Rescue of a herpes simplex virus type 1 neurovirulence function with a cloned DNA fragment. J Virol (1985) 1.45
Efficacy of phosphonoacetic acid on herpes simplex virus infection of sensory ganglia. Infect Immun (1976) 1.45
PCR-based analysis of herpes simplex virus type 1 latency in the rat trigeminal ganglion established with a ribonucleotide reductase-deficient mutant. J Virol (1994) 1.45
Genital herpesvirus hominis infection in mice. I. Development of an experimental model. Infect Immun (1975) 1.41
Vaginal formulations of carrageenan protect mice from herpes simplex virus infection. Clin Diagn Lab Immunol (1997) 1.36
Herpes simplex virus 1 immediate-early and early gene expression during reactivation from latency under conditions that prevent infectious virus production. J Virol (2005) 1.35
Neutrophils aid in protection of the vaginal mucosae of immune mice against challenge with herpes simplex virus type 2. J Virol (1999) 1.35
Herpes simplex virus type 1 promoter activity during latency establishment, maintenance, and reactivation in primary dorsal root neurons in vitro. J Virol (2001) 1.32
Spontaneous activation of latent cytomegalovirus from murine spleen explants. Role of lymphocytes and macrophages in release and replication of virus. J Clin Invest (1982) 1.30
Histone deacetylase inhibitors induce reactivation of herpes simplex virus type 1 in a latency-associated transcript-independent manner in neuronal cells. J Neurovirol (2005) 1.27
Orofacial herpes simplex virus infection in hairless mice: latent virus in trigeminal ganglia after topical antiviral treatment. Infect Immun (1978) 1.26
Persistence of herpes simplex virus genes in cells of neuronal origin. J Virol (1980) 1.25
The herpes simplex virus type 1 reactivation function lies outside the latency-associated transcript open reading frame ORF-2. J Virol (1993) 1.25
Latent infections in spinal ganglia with thymidine kinase-deficient herpes simplex virus. J Virol (1989) 1.25
Evidence that the herpes simplex virus type 1 ICP0 protein does not initiate reactivation from latency in vivo. J Virol (2006) 1.24
Induction of cellular transcription factors in trigeminal ganglia of mice by corneal scarification, herpes simplex virus type 1 infection, and explantation of trigeminal ganglia. J Virol (1991) 1.24
Comparison of herpes simplex virus reactivation in ganglia in vivo and in explants demonstrates quantitative and qualitative differences. J Virol (2004) 1.24
Neutralizing antibodies inhibit axonal spread of herpes simplex virus type 1 to epidermal cells in vitro. J Virol (1999) 1.21
Quantitative analysis of herpes simplex virus reactivation in vivo demonstrates that reactivation in the nervous system is not inhibited at early times postinoculation. J Virol (2003) 1.20
Involvement of an early human cytomegalovirus function in reactivation of quiescent herpes simplex virus type 2. J Virol (1981) 1.18
Analysis of a herpes simplex virus type 1 LAT mutant with a deletion between the putative promoter and the 5' end of the 2.0-kilobase transcript. J Virol (1994) 1.17
Latency of Herpes Simiae (B virus) in rabbits. Br J Exp Pathol (1975) 1.14
Sequential changes in cell-mediated immune responses to herpes simplex virus after recurrent herpetic infection in humans. Infect Immun (1977) 1.13
Amplification by host cell factors of a sequence contained within the herpes simplex virus 1 genome. Proc Natl Acad Sci U S A (1990) 1.09
Protection from oral herpes simplex virus infection by a nucleic acid-free virus vaccine. Infect Immun (1977) 1.09
Effect of the transcription start region of the herpes simplex virus type 1 latency-associated transcript promoter on expression of productively infected neurons in vivo. J Virol (1994) 1.08
Pathology of the human spinal ganglia in varicella-zoster virus infection. Acta Neuropathol (1975) 1.08
ICP0 gene expression is a herpes simplex virus type 1 apoptotic trigger. J Virol (2006) 1.06
Detection of latent cytomegalovirus in murine salivary and prostate explant cultures and cells. Infect Immun (1977) 1.05
Route of infection, systemic host resistance, and integrity of ganglionic axons influence acute and latent herpes simplex virus infection of the superior cervical ganglion. Infect Immun (1979) 1.04
Encephalitis resulting from reactivation of latent herpes simplex virus in mice. J Virol (1984) 1.04
The polyserine tract of herpes simplex virus ICP4 is required for normal viral gene expression and growth in murine trigeminal ganglia. J Virol (1998) 1.04
In vitro system for studying the efficacy of antiviral agents in preventing the reactivation of latent herpes simplex virus. Antimicrob Agents Chemother (1979) 1.04
Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection. J Immunol (2012) 1.04
ICP0 is not required for efficient stress-induced reactivation of herpes simplex virus type 1 from cultured quiescently infected neuronal cells. J Virol (2006) 1.03
Reactivation of latent Herpes simplex virus after pneumococcal pneumonia in mice. Infect Immun (1975) 1.02
Distribution of bovine herpesvirus type 5 DNA in the central nervous systems of latently, experimentally infected calves. J Clin Microbiol (2003) 1.02
Temperature-sensitive host range mutants of herpes simplex virus type 2. J Virol (1975) 1.02
H-2-linked genes influence the severity of herpes simplex virus infection of the peripheral nervous system. J Exp Med (1989) 1.01
Herpes simplex virus and Alzheimer's disease: a search for virus DNA by spot hybridisation. J Neurol Neurosurg Psychiatry (1984) 1.01
Prolongation of herpes simplex virus latency in cultured human cells by temperature elevation. J Virol (1977) 1.01
Herpes simplex virus infection of motor neurons: hypoglossal model. Infect Immun (1983) 1.01
The latent herpes simplex virus. Bacteriol Rev (1974) 1.00
Expression of herpes simplex virus 1-encoded microRNAs in human trigeminal ganglia and their relation to local T-cell infiltrates. J Virol (2011) 1.00
Efficacy of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine against primary and recrudescent genital herpes simplex virus type 2 infections in guinea pigs. Antimicrob Agents Chemother (1983) 0.99
Reactivation of herpes simplex virus type 2 from a quiescent state by human cytomegalovirus. Proc Natl Acad Sci U S A (1979) 0.99
Peripheral infection in culture of rat sensory neurons by herpes simplex virus. Infect Immun (1980) 0.98
Recurrent cutaneous herpes simplex in hairless mice. Infect Immun (1974) 0.98
Reactivation of latent herpes simplex virus infection of the autonomic nervous system by postganglionic neurectomy. Infect Immun (1978) 0.98
Ocular herpes simplex virus: how are latency, reactivation, recurrent disease and therapy interrelated? Future Microbiol (2011) 0.97
Thymidine kinase-deficient herpes simplex virus type 2 genital infection in guinea pigs. J Virol (1985) 0.96
Rapid host immune response and viral dynamics in herpes simplex virus-2 infection. Nat Med (2013) 0.95
A comparison of herpes simplex virus type 1 and varicella-zoster virus latency and reactivation. J Gen Virol (2015) 0.93
Persistence of herpes simplex virus type 1 in rat neurotumor cells. J Virol (1979) 0.92
Latency of herpes simplex virus in ocular tissue of mice. Infect Immun (1983) 0.92
The transgenic ICP4 promoter is activated in Schwann cells in trigeminal ganglia of mice latently infected with herpes simplex virus type 1. J Virol (2001) 0.92
Latency-associated transcripts in corneas and ganglia of HSV-1 infected rabbits. Br J Ophthalmol (1991) 0.92
Murine epidermal antigen-presenting cells in primary and secondary T-cell proliferative responses to herpes simplex virus in vitro. Immunology (1991) 0.91
Herpes simplex virus, type 1 invasion of the rabbit and mouse nervous systems revealed by in situ hybridization. Acta Neuropathol (1987) 0.91
The outcome of corneal grafting in patients with stromal keratitis of herpetic and non-herpetic origin. Br J Ophthalmol (2002) 0.90
Latency-related gene encoded by bovine herpesvirus 1 promotes virus growth and reactivation from latency in tonsils of infected calves. J Clin Microbiol (2005) 0.89
Induction of 2',5'-oligoadenylate synthetase and interferon in mouse trigeminal ganglia infected with herpes simplex virus. Infect Immun (1980) 0.89
Search for latent cytomegalovirus in renal allografts. Infect Immun (1978) 0.89
RNA complementary to a herpesvirus alpha gene mRNA is prominent in latently infected neurons. Science (1987) 11.14
Pathogenesis of herpetic neuritis and ganglionitis in mice: evidence for intra-axonal transport of infection. Infect Immun (1973) 5.29
Physical characterization of the herpes simplex virus latency-associated transcript in neurons. J Virol (1988) 4.85
Herpes simplex virus latent phase transcription facilitates in vivo reactivation. Virology (1990) 4.00
Latent herpes simplex virus from trigeminal ganglia of rabbits with recurrent eye infection. Nat New Biol (1972) 3.23
The herpes simplex virus latency-associated transcript is spliced during the latent phase of infection. J Virol (1988) 3.22
Human herpesviruses: a consideration of the latent state. Microbiol Rev (1989) 3.15
A herpes simplex virus transcript abundant in latently infected neurons is dispensable for establishment of the latent state. Virology (1988) 3.11
Evidence that neurons harbor latent herpes simplex virus. Infect Immun (1974) 3.03
Latent herpes simplex virus and the nervous system,. Curr Top Microbiol Immunol (1975) 2.71
Variable-sized free episomes of Shope papilloma virus DNA are present in all non-virus-producing neoplasms and integrated episomes are detected in some. Proc Natl Acad Sci U S A (1982) 2.65
Restriction of herpes simplex virus by macrophages. An analysis of the cell-virus interaction. J Exp Med (1971) 2.61
Latent herpes simplex virus in the central nervous system of rabbits and mice. J Exp Med (1973) 2.48
Functional and molecular analyses of the avirulent wild-type herpes simplex virus type 1 strain KOS. J Virol (1986) 2.41
Molecular analysis of herpes simplex virus type 1 during epinephrine-induced reactivation of latently infected rabbits in vivo. J Virol (1994) 2.41
Effect of cytosine arabinoside on viral-specific protein synthesis in cells infected with herpes simplex virus. J Virol (1975) 2.40
Biological characterization of a herpes simplex virus intertypic recombinant which is completely and specifically non-neurovirulent. Virology (1983) 2.32
Herpes simplex virus type 1 DNA replication and gene expression during explant-induced reactivation of latently infected murine sensory ganglia. J Virol (1994) 2.27
Physical location of a herpes simplex virus type-1 gene function(s) specifically associated with a 10 million-fold increase in HSV neurovirulence. Virology (1983) 2.19
Prominence of the herpes simplex virus latency-associated transcript in trigeminal ganglia from seropositive humans. J Infect Dis (1988) 2.00
Replication of varicella-zoste virus in cell culture: an ultrastructural study. J Ultrastruct Res (1970) 1.99
A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation. J Virol (1996) 1.94
Maintenance of latent herpetic infection: an apparent role for anti-viral IgG. J Immunol (1974) 1.91
Herpes simplex virus type 1 latency-associated transcription plays no role in establishment or maintenance of a latent infection in murine sensory neurons. J Virol (1989) 1.85
Two colinear and spliced viral transcripts are present in non-virus-producing benign and malignant neoplasms induced by the shope (rabbit) papilloma virus. J Virol (1982) 1.83
Pathways of viral gene expression during acute neuronal infection with HSV-1. Virology (1992) 1.81
Pathogenesis of herpetic encephalitis in mice after ophthalmic inoculation. J Infect Dis (1974) 1.80
Immunosuppression reactivates and disseminates latent murine cytomegalovirus. J Gen Virol (1977) 1.79
Latency competence of thirteen HSV-1 temperature-sensitive mutants. J Gen Virol (1980) 1.75
Changes in nuclear basic proteins during pseudorabies virus infection. J Virol (1969) 1.60
The effect of pregnancy and menstruation on the size of the spleen. J Physiol (1928) 1.58
A latent, nonpathogenic HSV-1-derived vector stably expresses beta-galactosidase in mouse neurons. Neuron (1990) 1.57
Temperature-sensitive mutants of herpes simplex virus differ in the capacity to establish latent infections in mice. Virology (1977) 1.54
Nature of the scrapie agent: evidence against a viroid. J Virol (1974) 1.48
Latent infection can be established with drastically restricted transcription and replication of the HSV-1 genome. Virology (1993) 1.48
Latent herpes simplex virus. Isolation from rabbit trigeminal ganglia between episodes of recurrent ocular infection. Arch Ophthalmol (1972) 1.48
Rescue of a herpes simplex virus type 1 neurovirulence function with a cloned DNA fragment. J Virol (1985) 1.45
Latent herpetic infections following experimental viraemia. J Gen Virol (1976) 1.44
Modification by adoptive humoral immunity of murine cytomegalovirus infection. J Infect Dis (1981) 1.43
Genetic and biological analyses of a herpes simplex virus intertypic recombinant reduced specifically for neurovirulence. J Virol (1987) 1.40
Two avirulent herpes simplex viruses generate lethal recombinants in vivo. Science (1986) 1.40
Multiple copies of Shope virus DNA are present in cells of benign and malignant non-virus-producing neoplasms. J Virol (1979) 1.39
Molecular and biological characterization of a herpes simplex virus type 1 (HSV-1) neuroinvasiveness gene. J Exp Med (1990) 1.36
Pathogenesis of reactivated latent murine cytomegalovirus infection. Am J Pathol (1979) 1.28
A major portion of the latent pseudorabies virus genome is transcribed in trigeminal ganglia of pigs. J Virol (1990) 1.25
The herpes simplex virus type 1 reactivation function lies outside the latency-associated transcript open reading frame ORF-2. J Virol (1993) 1.25
Latent infections in spinal ganglia with thymidine kinase-deficient herpes simplex virus. J Virol (1989) 1.25
Latent infections induced by herpes simplex viruses. Cancer Res (1973) 1.20
Acute infection of differentiated neuroblastoma cells by latency-positive and latency-negative herpes simplex virus ts mutants. Virology (1979) 1.18
Latent characteristics of selected herpesviruses. Adv Cancer Res (1978) 1.18
Shope papilloma virus DNA is extensively methylated in non-virus-producing neoplasms. Virology (1983) 1.14
Labile coat: reason for noninfectious cell-free varicella-zoster virus in culture. J Virol (1968) 1.13
Neuroinvasive properties of herpes simplex virus type 1 glycoprotein variants are controlled by the immune response. J Immunol (1996) 1.12
Decreased reporter gene expression during latent infection with HSV LAT promoter constructs. Virology (1993) 1.12
Restriction of herpes simplex virus replication by poliovirus: a selective inhibition of viral translation. Virology (1972) 1.12
Activation of latent murine cytomegalovirus in vivo and in vitro: a pathogenetic role for acute infection. J Infect Dis (1982) 1.11
Molecular and biological characterization of a type 1 herpes simplex virus (HSV-1) specifically deleted for expression of the latency-associated transcript (LAT). Microb Pathog (1989) 1.11
Murine cytomegalovirus is present in both chronic active and latent states in persistently infected mice. Virology (1994) 1.10
Pathogenesis of a lethal mixed infection in mice with two nonneuroinvasive herpes simplex virus strains. J Virol (1988) 1.08
Protozoa in subsurface sediments from sites contaminated with aviation gasoline or jet fuel. Appl Environ Microbiol (1993) 1.07
Glycoprotein B is a specific determinant of herpes simplex virus type 1 neuroinvasiveness. J Virol (1993) 1.06
Neuron-specific restriction of a herpes simplex virus recombinant maps to the UL5 gene. J Virol (1994) 1.06
Localization of a herpes simplex virus neurovirulence gene dissociated from high-titer virus replication in the brain. J Virol (1988) 1.04
Biological basis for virulence of three strains of herpes simplex virus type 1. J Gen Virol (1987) 1.04
Reactivation of latent Herpes simplex virus after pneumococcal pneumonia in mice. Infect Immun (1975) 1.02
Transcription of the viral genome in papillomas and carcinomas induced by the Shope virus. Virology (1981) 1.02
The 5' and 3' limits of transcription in the pseudorabies virus latency associated transcription unit. Virology (1991) 1.02
Intraaxonal transport of Herpes simplex virus in the rat central nervous system. Brain Res (1977) 1.00
Differential accumulation of herpes simplex virus type 1 latency-associated transcripts in sensory and autonomic ganglia. Virology (1992) 0.99
An evaluation of some methods for the determination of fluoride in potable waters and other aqueous solutions. Analyst (1968) 0.98
Restricted replication of herpes simplex virus in spinal ganglia of resistant mice is accompanied by an early infiltration of immunoglobulin G-bearing cells. Infect Immun (1983) 0.97
Murine cytomegalovirus DNA in peripheral blood of latently infected mice is detectable only in monocytes and polymorphonuclear leukocytes. Virology (1996) 0.96
Herpes simplex virus immediate-early protein ICP4 in murine models of latency. Graefes Arch Clin Exp Ophthalmol (1986) 0.96
Mutagenesis of a cAMP response element within the latency-associated transcript promoter of HSV-1 reduces adrenergic reactivation. Virology (1997) 0.93
Selective inhibition of herpesvirus DNA synthesis at elevated temperature. Virology (1966) 0.91
Newcastle disease as a model for paramyxovirus-induced neurologic syndromes. II. Detailed characterization of the encephalitis. Am J Pathol (1977) 0.90
Herpes simplex virus latency analyzed by in situ hybridization. Curr Top Microbiol Immunol (1989) 0.90
Experimental herpes virus arthritis. Factors in chronicity. Ann Rheum Dis (1974) 0.89