Th17 cells are refractory to senescence and retain robust antitumor activity after long-term ex vivo expansion.

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Published in JCI Insight on March 09, 2017

Authors

Jacob S Bowers1, Michelle H Nelson1, Kinga Majchrzak2, Stefanie R Bailey1, Baerbel Rohrer3, Andrew D M Kaiser4, Carl Atkinson5, Luca Gattinoni6, Chrystal M Paulos1

Author Affiliations

1: Department of Microbiology and Immunology,; Department of Dermatology,; Department of Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
2: Department of Microbiology and Immunology,; Department of Dermatology,; Department of Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.; Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland.
3: Department of Ophthalmology, Medical University of South Carolina, Charleston, South Carolina, USA.; Ralph H. Johnson VA Medical Center, Charleston, South Carolina, USA.
4: Center for Cancer Research.
5: Department of Microbiology and Immunology.
6: Experimental Transplantation and Immunology Branch, National Cancer Institute (NCI), NIH, Bethesda, Maryland, USA.

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