Published in Circ Res on March 17, 2017
The incidence of congenital heart disease. J Am Coll Cardiol (2002) 16.13
The failing heart--an engine out of fuel. N Engl J Med (2007) 12.06
Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene. Nature (1991) 11.44
Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome. Nat Genet (2001) 6.96
Mutations in a new member of the chromodomain gene family cause CHARGE syndrome. Nat Genet (2004) 6.90
MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure. Circulation (2007) 6.41
Myocardial substrate metabolism in the normal and failing heart. Physiol Rev (2005) 6.06
Comparison of shunt types in the Norwood procedure for single-ventricle lesions. N Engl J Med (2010) 5.43
De novo mutations in histone-modifying genes in congenital heart disease. Nature (2013) 5.15
Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice. Nature (2001) 4.41
DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1. Nat Genet (2001) 4.35
Carvedilol for children and adolescents with heart failure: a randomized controlled trial. JAMA (2007) 4.27
Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload. Proc Natl Acad Sci U S A (1988) 4.23
The human phenome project. Nat Genet (2003) 3.75
Is the failing heart energy starved? On using chemical energy to support cardiac function. Circ Res (2004) 3.72
Cell therapy for heart failure: a comprehensive overview of experimental and clinical studies, current challenges, and future directions. Circ Res (2013) 3.56
The incidence of pediatric cardiomyopathy in two regions of the United States. N Engl J Med (2003) 3.28
Enalapril in infants with single ventricle: results of a multicenter randomized trial. Circulation (2010) 3.13
Myosin heavy chain isoform expression in the failing and nonfailing human heart. Circ Res (2000) 3.08
Epidemiology of heart failure. Circ Res (2013) 2.84
Seeking causes: Classifying and evaluating congenital heart defects in etiologic studies. Birth Defects Res A Clin Mol Teratol (2007) 2.69
The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Cell (2014) 2.65
Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart. Genes Dev (2008) 2.58
Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart. Nature (2015) 2.58
Myosin heavy chain gene expression in human heart failure. J Clin Invest (1997) 2.39
MiR-15 family regulates postnatal mitotic arrest of cardiomyocytes. Circ Res (2011) 2.32
Transcoronary infusion of cardiac progenitor cells in hypoplastic left heart syndrome: Three-year follow-up of the Transcoronary Infusion of Cardiac Progenitor Cells in Patients With Single-Ventricle Physiology (TICAP) trial. J Thorac Cardiovasc Surg (2015) 2.19
Mutation in the alpha-cardiac actin gene associated with apical hypertrophic cardiomyopathy, left ventricular non-compaction, and septal defects. Eur Heart J (2007) 2.14
Transcriptional activation of energy metabolic switches in the developing and hypertrophied heart. Clin Exp Pharmacol Physiol (2002) 2.14
Long-term outcome in congenitally corrected transposition of the great arteries: a multi-institutional study. J Am Coll Cardiol (2000) 2.14
Deep phenotyping for precision medicine. Hum Mutat (2012) 2.10
Nomenclature for congenital and paediatric cardiac disease: historical perspectives and The International Pediatric and Congenital Cardiac Code. Cardiol Young (2008) 2.10
Cyclin D1 overexpression promotes cardiomyocyte DNA synthesis and multinucleation in transgenic mice. J Clin Invest (1997) 2.00
Characterization and functionality of cardiac progenitor cells in congenital heart patients. Circulation (2011) 1.99
Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation. J Clin Invest (2011) 1.84
Mutation in myosin heavy chain 6 causes atrial septal defect. Nat Genet (2005) 1.76
Beta-adrenergic adaptation in paediatric idiopathic dilated cardiomyopathy. Eur Heart J (2012) 1.76
Early developmental outcome in children with hypoplastic left heart syndrome and related anomalies: the single ventricle reconstruction trial. Circulation (2012) 1.72
Risk factors for interstage death after stage 1 reconstruction of hypoplastic left heart syndrome and variants. J Thorac Cardiovasc Surg (2008) 1.69
Non-coding RNAs in cardiac remodeling and heart failure. Circ Res (2013) 1.66
Adrenergic nervous system in heart failure: pathophysiology and therapy. Circ Res (2013) 1.62
Development of microRNA therapeutics is coming of age. EMBO Mol Med (2014) 1.60
Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure. Circ Res (2014) 1.60
Targeted next-generation sequencing identifies pathogenic variants in familial congenital heart disease. J Am Coll Cardiol (2014) 1.59
Mitochondrial dysfunction in septic shock and multiple organ dysfunction syndrome. Mitochondrion (2004) 1.56
Effect of valsartan on systemic right ventricular function: a double-blind, randomized, placebo-controlled pilot trial. Circulation (2012) 1.54
A switch in metabolism precedes increased mitochondrial biogenesis in respiratory chain-deficient mouse hearts. Proc Natl Acad Sci U S A (2004) 1.53
The New York University Pediatric Heart Failure Index: a new method of quantifying chronic heart failure severity in children. J Pediatr (2001) 1.50
Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy. Nat Med (2013) 1.49
Developmental changes in contractility and sarcomeric proteins from the early embryonic to the adult stage in the mouse heart. J Physiol (2003) 1.47
Risk factors for hospital morbidity and mortality after the Norwood procedure: A report from the Pediatric Heart Network Single Ventricle Reconstruction trial. J Thorac Cardiovasc Surg (2012) 1.46
Physiological Growth, Remodeling Potential, and Preserved Function of a Novel Bioprosthetic Tricuspid Valve: Tubular Bioprosthesis Made of Small Intestinal Submucosa-Derived Extracellular Matrix. J Am Coll Cardiol (2015) 1.45
Ventricular septal defect in infants and children; a correlation of clinical, physiologic, and autopsy data. Circulation (1958) 1.45
Heart failure in children: part I: history, etiology, and pathophysiology. Circ Heart Fail (2009) 1.44
A common angiotensin-converting enzyme polymorphism and preoperative angiotensin-converting enzyme inhibition modify risk of tachyarrhythmias after congenital heart surgery. Heart Rhythm (2014) 1.41
Elastin: mutational spectrum in supravalvular aortic stenosis. Eur J Hum Genet (2000) 1.40
De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies. Science (2015) 1.36
Dissecting spatio-temporal protein networks driving human heart development and related disorders. Mol Syst Biol (2010) 1.35
Left ventricular non-compaction: prevalence in congenital heart disease. Int J Cardiol (2012) 1.31
Elastin: genomic structure and point mutations in patients with supravalvular aortic stenosis. Hum Mol Genet (1997) 1.31
Troponin T isoform expression in humans. A comparison among normal and failing adult heart, fetal heart, and adult and fetal skeletal muscle. Circ Res (1991) 1.28
Outcome of 121 patients with congenitally corrected transposition of the great arteries. Pediatr Cardiol (2002) 1.26
Mutations in the sarcomere gene MYH7 in Ebstein anomaly. Circ Cardiovasc Genet (2010) 1.24
Transplantation-free survival and interventions at 3 years in the single ventricle reconstruction trial. Circulation (2014) 1.22
Alpha-cardiac actin mutations produce atrial septal defects. Hum Mol Genet (2007) 1.21
Association of impaired linear growth and worse neurodevelopmental outcome in infants with single ventricle physiology: a report from the pediatric heart network infant single ventricle trial. J Pediatr (2012) 1.17
Adrenergic signaling polymorphisms and their impact on cardiovascular disease. Physiol Rev (2010) 1.15
Abnormal muscle mechanosignaling triggers cardiomyopathy in mice with Marfan syndrome. J Clin Invest (2014) 1.13
Switching metabolic genes to build a better heart. Circulation (2002) 1.13
Prevalence, morbidity, and mortality of heart failure-related hospitalizations in children in the United States: a population-based study. J Card Fail (2012) 1.13
Skeletal actin mRNA increases in the human heart during ontogenic development and is the major isoform of control and failing adult hearts. J Clin Invest (1991) 1.11
Phenomics: expanding the role of clinical evaluation in genomic studies. J Investig Med (2010) 1.10
Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development. Proc Natl Acad Sci U S A (2012) 1.08
Plasma norepinephrine levels in infants and children with congestive heart failure. Am J Cardiol (1987) 1.08
The International Society for Heart and Lung Transplantation Guidelines for the management of pediatric heart failure: Executive summary. [Corrected]. J Heart Lung Transplant (2014) 1.07
Renin-angiotensin-aldosterone genotype influences ventricular remodeling in infants with single ventricle. Circulation (2011) 1.06
Complex neonatal single ventricle palliation using antegrade cerebral perfusion. Ann Thorac Surg (2006) 1.05
The diagnostic value of next generation sequencing in familial nonsyndromic congenital heart defects. Am J Med Genet A (2015) 1.04
Genetic basis of congenital cardiovascular malformations. Eur J Med Genet (2014) 1.00
Integrating the myocardial matrix into heart failure recognition and management. Circ Res (2013) 1.00
Epidemiology of heart failure in a tertiary pediatric center. Clin Cardiol (2008) 0.98
Molecular mechanism of ventricular trabeculation/compaction and the pathogenesis of the left ventricular noncompaction cardiomyopathy (LVNC). Am J Med Genet C Semin Med Genet (2013) 0.96
Genetic determinants of right-ventricular remodeling after tetralogy of Fallot repair. Pediatr Res (2012) 0.96
A molecular and genetic outline of cardiac morphogenesis. Acta Physiol (Oxf) (2013) 0.95
Incidence and risk distribution of heart failure in adolescents and adults with congenital heart disease after cardiac surgery. Am J Cardiol (2006) 0.95
Age-related differences in phosphodiesterase activity and effects of chronic phosphodiesterase inhibition in idiopathic dilated cardiomyopathy. Circ Heart Fail (2014) 0.95
Research advances in heart failure: a compendium. Circ Res (2013) 0.94
Mitochondrial DNA content and expression of genes involved in mtDNA transcription, regulation and maintenance during human fetal development. Mitochondrion (2010) 0.94
Genomic profiling of left and right ventricular hypertrophy in congenital heart disease. J Card Fail (2008) 0.93
Human genotype-phenotype databases: aims, challenges and opportunities. Nat Rev Genet (2015) 0.93
Long noncoding RNA Chast promotes cardiac remodeling. Sci Transl Med (2016) 0.92
Non-cardiomyocyte microRNAs in heart failure. Cardiovasc Res (2011) 0.92
Circulating miR-133a and miR-423-5p fail as biomarkers for left ventricular remodeling after myocardial infarction. Int J Cardiol (2013) 0.92
Exome analysis of a family with pleiotropic congenital heart disease. Circ Cardiovasc Genet (2012) 0.92
Genetics and genetic testing in congenital heart disease. Clin Perinatol (2015) 0.91
Cardiovascular disease in Noonan syndrome. Arch Dis Child (2014) 0.91
Influence of right heart size on outcome in pulmonary atresia with intact ventricular septum. Circulation (1993) 0.89
Echocardiographic diagnosis alone for the complete repair of major congenital heart defects. J Am Coll Cardiol (1999) 0.89
Myocardial consumption of oxygen and carbohydrates in newborn sheep. Pediatr Res (1981) 0.88