Alisertib induces G2/M arrest, apoptosis, and autophagy via PI3K/Akt/mTOR- and p38 MAPK-mediated pathways in human glioblastoma cells.

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Published in Am J Transl Res on March 15, 2017

Authors

Zheng Liu1, Feng Wang2, Zhi-Wei Zhou3, He-Chun Xia2, Xin-Yu Wang4, Yin-Xue Yang5, Zhi-Xu He6, Tao Sun2, Shu-Feng Zhou7

Author Affiliations

1: Department of Neurosurgery, General Hospital of Ningxia Medical UniversityYinchuan, Ningxia, China; Ningxia Key Laboratory of Cerebrocranial Disease, Incubation Base of National Key Laboratory, Ningxia Medical UniversityYinchuan, Ningxia, China; Department of Pharmaceutical Sciences, College of Pharmacy, University of South FloridaTampa, FL, USA.
2: Department of Neurosurgery, General Hospital of Ningxia Medical UniversityYinchuan, Ningxia, China; Ningxia Key Laboratory of Cerebrocranial Disease, Incubation Base of National Key Laboratory, Ningxia Medical UniversityYinchuan, Ningxia, China.
3: Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida Tampa, FL, USA.
4: Department of Pharmaceutical Sciences, College of Pharmacy, University of South FloridaTampa, FL, USA; Institute of Clinical Pharmacology, Department of Pharmacy, General Hospital of Ningxia Medical UniversityYinchuan, Ningxia, China.
5: Department of Colorectal Surgery, General Hospital of Ningxia Medical University Yinchuan, Ningxia, China.
6: Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center & Sino-US Joint Laboratory for Medical Sciences, Laboratory Animal Center, Guizhou Medical University Guiyang, China.
7: Department of Pharmaceutical Sciences, College of Pharmacy, University of South FloridaTampa, FL, USA; Department of Bioengineering and Biotechnology, College of Chemical Engineering, Huaqiao UniversityXiamen, Fujian, China.

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