The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling.

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Published in Front Oncol on October 16, 2015

Authors

Veronica Krenn1, Andrea Musacchio2

Author Affiliations

1: Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology , Dortmund , Germany.
2: Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology , Dortmund , Germany ; Faculty of Biology, Centre for Medical Biotechnology, University Duisburg-Essen , Essen , Germany.

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The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends. Nature (2006) 4.06

Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1. EMBO J (1997) 4.05

The inner centromere protein (INCENP) antigens: movement from inner centromere to midbody during mitosis. J Cell Biol (1987) 4.05

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INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1. J Cell Biol (1998) 2.23

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