Phylogenetic ctDNA analysis depicts early stage lung cancer evolution.

PubWeight™: 2.54^‹?› | Rank: Top 2%

🔗 View Article (PMID 28445469)

Published in Nature on April 26, 2017

Authors

Christopher Abbosh¹, Nicolai J Birkbak¹^,2, Gareth A Wilson¹^,2, Mariam Jamal-Hanjani¹, Tudor Constantin³, Raheleh Salari³, John Le Quesne⁴, David A Moore⁴, Selvaraju Veeriah¹, Rachel Rosenthal¹, Teresa Marafioti¹^,5, Eser Kirkizlar³, Thomas B K Watkins¹^,2, Nicholas McGranahan¹^,2, Sophia Ward¹^,2^,6, Luke Martinson⁴, Joan Riley⁴, Francesco Fraioli⁷, Maise Al Bakir², Eva Grönroos², Francisco Zambrana¹, Raymondo Endozo⁷, Wenya Linda Bi⁸^,9, Fiona M Fennessy⁸^,9, Nicole Sponer³, Diana Johnson¹, Joanne Laycock¹, Seema Shafi¹, Justyna Czyzewska-Khan¹, Andrew Rowan², Tim Chambers²^,6, Nik Matthews⁶^,10, Samra Turajlic²^,11, Crispin Hiley¹^,2, Siow Ming Lee¹^,12, Martin D Forster¹^,12, Tanya Ahmad¹², Mary Falzon⁵, Elaine Borg⁵, David Lawrence¹³, Martin Hayward¹³, Shyam Kolvekar¹³, Nikolaos Panagiotopoulos¹³, Sam M Janes¹^,14^,15, Ricky Thakrar¹⁴, Asia Ahmed¹⁶, Fiona Blackhall¹⁷^,18, Yvonne Summers¹⁸, Dina Hafez³, Ashwini Naik³, Apratim Ganguly³, Stephanie Kareht³, Rajesh Shah¹⁹, Leena Joseph²⁰, Anne Marie Quinn²⁰, Phil A Crosbie²¹, Babu Naidu²²^,23, Gary Middleton²⁴, Gerald Langman²⁵, Simon Trotter²⁵, Marianne Nicolson²⁶, Hardy Remmen²⁷, Keith Kerr²⁸, Mahendran Chetty²⁹, Lesley Gomersall³⁰, Dean A Fennell⁴, Apostolos Nakas³¹, Sridhar Rathinam³¹, Girija Anand³², Sajid Khan³³^,34, Peter Russell³⁵, Veni Ezhil³⁶, Babikir Ismail³⁷, Melanie Irvin-Sellers³⁸, Vineet Prakash³⁹, Jason F Lester⁴⁰, Malgorzata Kornaszewska⁴¹, Richard Attanoos⁴², Haydn Adams⁴³, Helen Davies⁴⁴, Dahmane Oukrif¹, Ayse U Akarca¹, John A Hartley⁴⁵, Helen L Lowe⁴⁵, Sara Lock⁴⁶, Natasha Iles⁴⁷, Harriet Bell⁴⁷, Yenting Ngai⁴⁷, Greg Elgar²^,6, Zoltan Szallasi⁴⁸^,49^,50, Roland F Schwarz⁵¹, Javier Herrero⁵², Aengus Stewart⁵³, Sergio A Quezada⁵⁴, Karl S Peggs⁵⁴^,55, Peter Van Loo⁵⁶^,57, Caroline Dive¹^,58, C Jimmy Lin³, Matthew Rabinowitz³, Hugo J W L Aerts⁸^,9^,59, Allan Hackshaw⁴⁷, Jacqui A Shaw⁴, Bernhard G Zimmermann³, TRACERx consortium, PEACE consortium, Charles Swanton¹^,2

Author Affiliations

1: Cancer Research UK Lung Cancer Centre of Excellence London and Manchester, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
2: Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
3: Natera Inc., 201 Industrial Road, San Carlos, California 94070, USA.
4: Cancer Studies, University of Leicester, Leicester LE2 7LX, UK.
5: Department of Pathology, University College London Hospitals, 21 University Street, London WC1 6JJ, UK.
6: Advanced Sequencing Facility, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
7: Department of Nuclear Medicine, University College London Hospitals, 235 Euston Road, Fitzrovia, London, NW1 2BU, UK.
8: Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
9: Harvard Medical School, Boston, Massachusetts 02115, USA.
10: Tumour Profiling Unit Genomics Facility, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.
11: Renal and Skin Units, The Royal Marsden Hospital, London SW3 6JJ, UK.
12: Department of Oncology, University College London Hospitals, 250 Euston Road, London NW1 2BU, UK.
13: Department of Cardiothoracic Surgery, University College London Hospitals, 235 Euston Road, Fitzrovia, London NW1 2BU, UK.
14: Department of Respiratory Medicine, University College London Hospitals, 235 Euston Road, Fitzrovia, London NW1 2BU, UK.
15: Lungs for Living Research Centre, UCL Respiratory, Division of Medicine, Rayne Building, University College London, 5 University Street, London WC1E 6JF, UK.
16: Department of Radiology, University College London Hospitals, 235 Euston Road, Fitzrovia, London NW1 2BU, UK.
17: Institute of Cancer Studies, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
18: The Christie Hospital, Manchester M20 4BX, UK.
19: Department of Cardiothoracic Surgery, University Hospital South Manchester, Manchester M23 9LT, UK.
20: Department of Pathology, University Hospital South Manchester, Manchester M23 9LT, UK.
21: North West Lung Centre, University Hospital South Manchester, Manchester M23 9LT, UK.
22: Department of Thoracic Surgery, Birmingham Heartlands Hospital, Birmingham B9 5SS, UK.
23: Institute of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK. University College London Hospitals NHS Foundation Trust, London, UK.
24: Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK.
25: Department of Cellular Pathology, Birmingham Heartlands Hospital, Birmingham B9 5SS, UK.
26: Department of Medical Oncology, Aberdeen University Medical School and Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, UK.
27: Department of Cardiothoracic Surgery, Aberdeen University Medical School and Aberdeen Royal Infirmary, Aberdeen AB25 2ZD, UK.
28: Department of Pathology, Aberdeen University Medical School and Aberdeen Royal Infirmary, Aberdeen AB25 2ZD, UK.
29: Department of Respiratory Medicine, Aberdeen University Medical School and Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, UK.
30: Department of Radiology, Aberdeen University Medical School and Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, UK.
31: Department of Thoracic Surgery, Glenfield Hospital, Leicester LE3 9QP, UK.
32: Department of Radiotherapy, North Middlesex University Hospital, London N18 1QX, UK.
33: Department of Respiratory Medicine, Royal Free Hospital, Pond Street, London NW3 2QG, UK.
34: Department of Respiratory Medicine, Barnet and Chase Farm Hospitals, Wellhouse Lane, Barnet EN5 3DJ, UK.
35: Department of Respiratory Medicine, The Princess Alexandra Hospital, Hamstel Road, Harlow CM20 1QX, UK.
36: Department of Clinical Oncology, St.Luke's Cancer Centre, Royal Surrey County Hospital, Guildford GU2 7XX, UK.
37: Department of Pathology, Ashford and St. Peter's Hospital, Guildford Road, Chertsey, Surrey KT16 0PZ, UK.
38: Department of Respiratory Medicine, Ashford and St. Peter's Hospital, Guildford Road, Chertsey, Surrey KT16 0PZ, UK.
39: Department of Radiology, Ashford and St. Peter's Hospital, Guildford Road, Chertsey, Surrey KT16 0PZ, UK.
40: Department of Clinical Oncology, Velindre Hospital, Cardiff CF14 2TL, UK.
41: Department of Cardiothoracic Surgery, University Hospital of Wales, Cardiff CF14 4XW, UK.
42: Department of Cellular Pathology, University Hospital of Wales and Cardiff University, Heath Park, Cardiff, UK.
43: Department of Radiology, University Hospital Llandough, Cardiff CF64 2XX, UK.
44: Department of Respiratory Medicine, University Hospital Llandough, Cardiff CF64 2XX, UK.
45: University College London Experimental Cancer Medicine Centre GCLP Facility, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
46: Department of Respiratory Medicine, The Whittington Hospital NHS Trust, London, N19 5NF, UK.
47: University College London, Cancer Research UK and UCL Cancer Trials Centre, London W1T 4TJ, UK.
48: Centre for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, Denmark.
49: Computational Health Informatics Program (CHIP), Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
50: MTA-SE-NAP, Brain Metastasis Research Group, 2nd Department of Pathology, Semmelweis University, 1091 Budapest, Hungary.
51: Berlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
52: Bill Lyons Informatics Centre, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
53: Department of Bioinformatics and Biostatistics, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
54: Cancer Immunology Unit, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6DD, UK.
55: Research Department of Haematology, University College Cancer Institute, London WC1E 6DD, UK.
56: Cancer Genomics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
57: Department of Human Genetics, University of Leuven, B-3000 Leuven, Belgium.
58: Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
59: Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215-5450, USA.