Demonstration that the leukocyte common antigen CD45 is a protein tyrosine phosphatase.

PubWeight™: 3.23‹?› | Rank: Top 1%

🔗 View Article (PMID 2853967)

Published in Biochemistry on November 29, 1988

Authors

N K Tonks1, H Charbonneau, C D Diltz, E H Fischer, K A Walsh

Author Affiliations

1: Department of Biochemistry, University of Washington, Seattle 98195.

Articles citing this

MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase. EMBO J (1992) 4.97

A family of receptor-linked protein tyrosine phosphatases in humans and Drosophila. Proc Natl Acad Sci U S A (1989) 3.18

Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines. Proc Natl Acad Sci U S A (1989) 2.99

cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family. Proc Natl Acad Sci U S A (1989) 2.95

Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR. EMBO J (1990) 2.94

Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. EMBO J (1990) 2.81

MAP kinase activator from insulin-stimulated skeletal muscle is a protein threonine/tyrosine kinase. EMBO J (1992) 2.71

Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase. Proc Natl Acad Sci U S A (1989) 2.70

Protein tyrosine phosphorylation is induced in murine B lymphocytes in response to stimulation with anti-immunoglobulin. EMBO J (1990) 2.50

Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production. Proc Natl Acad Sci U S A (1991) 2.45

Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13. Mol Cell Biol (1992) 2.41

Human placenta protein-tyrosine-phosphatase: amino acid sequence and relationship to a family of receptor-like proteins. Proc Natl Acad Sci U S A (1989) 2.40

Cloning of a cDNA for a major human protein-tyrosine-phosphatase. Proc Natl Acad Sci U S A (1990) 2.36

Cloning and expression of a protein-tyrosine-phosphatase. Proc Natl Acad Sci U S A (1990) 2.07

Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin. Proc Natl Acad Sci U S A (1991) 1.98

Substrate specificity of the protein tyrosine phosphatases. Proc Natl Acad Sci U S A (1993) 1.84

Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B. Proc Natl Acad Sci U S A (1990) 1.74

Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transduction. FEBS J (2013) 1.68

Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain. Proc Natl Acad Sci U S A (1990) 1.67

Molecular characterization of a protein-tyrosine-phosphatase enriched in striatum. Proc Natl Acad Sci U S A (1991) 1.62

Cloning and expression of a widely expressed receptor tyrosine phosphatase. Proc Natl Acad Sci U S A (1990) 1.61

Identification of an additional member of the protein-tyrosine-phosphatase family: evidence for alternative splicing in the tyrosine phosphatase domain. Proc Natl Acad Sci U S A (1990) 1.55

Structure and function of the T cell antigen receptor. J Clin Invest (1990) 1.45

Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45. J Exp Med (2005) 1.28

Microinjection of a protein-tyrosine-phosphatase inhibits insulin action in Xenopus oocytes. Proc Natl Acad Sci U S A (1990) 1.27

Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase. Mol Cell Biol (1994) 1.26

The fission yeast genes pyp1+ and pyp2+ encode protein tyrosine phosphatases that negatively regulate mitosis. Mol Cell Biol (1992) 1.23

Lymphokine regulation of CD45R expression on human T cell clones. J Exp Med (1989) 1.20

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity. Nat Commun (2014) 1.19

MPTP delta, a putative murine homolog of HPTP delta, is expressed in specialized regions of the brain and in the B-cell lineage. Mol Cell Biol (1993) 1.13

A fission-yeast gene encoding a protein with features of protein-tyrosine-phosphatases. Proc Natl Acad Sci U S A (1991) 1.12

Integrity of the exon 6 sequence is essential for tissue-specific alternative splicing of human leukocyte common antigen pre-mRNA. Mol Cell Biol (1989) 1.12

CD8+ T-cell clones deficient in the expression of the CD45 protein tyrosine phosphatase have impaired responses to T-cell receptor stimuli. Mol Cell Biol (1991) 1.11

CD22-mediated stimulation of T cells regulates T-cell receptor/CD3-induced signaling. Proc Natl Acad Sci U S A (1992) 1.10

Evidence for defective transmembrane signaling in B cells from patients with Wiskott-Aldrich syndrome. J Clin Invest (1992) 1.08

Protein-tyrosine-phosphatase CD45 is phosphorylated transiently on tyrosine upon activation of Jurkat T cells. Proc Natl Acad Sci U S A (1991) 1.08

Expression of soluble isoforms of rat CD45. Analysis by electron microscopy and use in epitope mapping of anti-CD45R monoclonal antibodies. Immunology (1992) 1.07

Intimate association of Thy-1 and the T-cell antigen receptor with the CD45 tyrosine phosphatase. Proc Natl Acad Sci U S A (1990) 1.07

The CD45 tyrosine phosphatase regulates phosphotyrosine homeostasis and its loss reveals a novel pattern of late T cell receptor-induced Ca2+ oscillations. J Exp Med (1992) 1.04

Identification of nucleotide pyrophosphatase/alkaline phosphodiesterase I activity associated with the mouse plasma cell differentiation antigen PC-1. Proc Natl Acad Sci U S A (1991) 1.03

Interleukin 2 regulates Raf-1 kinase activity through a tyrosine phosphorylation-dependent mechanism in a T-cell line. Proc Natl Acad Sci U S A (1993) 0.99

Effect of microinjection of a low-Mr human placenta protein tyrosine phosphatase on induction of meiotic cell division in Xenopus oocytes. Mol Cell Biol (1990) 0.95

T cell dominated inflammatory reactions in the bronchioles of asymptomatic asthmatics are also present in the nasal mucosa. Postgrad Med J (1991) 0.91

Hepatic protein tyrosine phosphatases in the rat. Biochem J (1991) 0.91

CD45RO expression on bovine T cells: relation to biological function. Immunology (1995) 0.91

CD8+ T-cell subsets defined by expression of CD45 isoforms differ in their capacity to produce IL-2, IFN-gamma and TNF-beta. Immunology (1994) 0.91

Activation of MAP-2 kinase activity by the CD2 receptor in Jurkat T cells can be reversed by CD45 phosphatase. Immunology (1991) 0.90

CD50 (intercellular adhesion molecule 3) stimulation induces calcium mobilization and tyrosine phosphorylation through p59fyn and p56lck in Jurkat T cell line. J Exp Med (1994) 0.89

Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-β in murine brain. Acta Neuropathol (2012) 0.88

Receptor type protein tyrosine phosphatases (RPTPs) - roles in signal transduction and human disease. J Cell Commun Signal (2012) 0.88

Intracellular localization of tyrosine kinase substrates beneath crosslinked surface immunoglobulins in B cells. J Exp Med (1991) 0.87

Specific CD45 isoforms differentially regulate T cell receptor signaling. EMBO J (1994) 0.86

Tyrosine phosphorylation-dependent activation of phosphatidylinositide 3-kinase occurs upstream of Ca2+-signalling induced by Fcgamma receptor cross-linking in human neutrophils. Biochem J (1997) 0.86

Receptor-type tyrosine phosphatase ligands: looking for the needle in the haystack. FEBS J (2012) 0.86

Insulin receptor and epidermal growth factor receptor dephosphorylation by three major rat liver protein-tyrosine phosphatases expressed in a recombinant bacterial system. Biochem J (1992) 0.86

Autoantibodies specific for different isoforms of CD45 in systemic lupus erythematosus. J Exp Med (1990) 0.86

Presence of B220 within thymocytes and its expression on the cell surface during apoptosis. Immunology (2000) 0.84

Cellular signalling mechanisms in B lymphocytes. Biochem J (1993) 0.84

CD45 molecule cross-linking inhibits natural killer cell-mediated lysis independently of lytic triggering. Immunology (1990) 0.84

CD45 cell surface antigens are linked to stimulation of early human myeloid progenitor cells by interleukin 3 (IL-3), granulocyte/macrophage colony-stimulating factor (GM-CSF), a GM-CSF/IL-3 fusion protein, and mast cell growth factor (a c-kit ligand). J Exp Med (1991) 0.84

Regulation of membrane-associated tyrosine phosphatases in UMR 106.06 osteoblast-like cells. Biochem J (1995) 0.82

Surface expression of a heterologous phosphatase complements CD45 deficiency in a T cell clone. J Exp Med (1994) 0.82

Anti-leucocyte common (CD45) antibodies inhibit dendritic cell stimulation of CD4 and CD8 T-lymphocyte proliferation. Immunology (1990) 0.81

Beta 1 integrins mediate adherent phenotype of human erythroblastic cell lines after phorbol 12-myristate 13-acetate induction. Biochem J (1995) 0.80

Protein kinase C isoform expression in CD45RA+ and CD45RO+ T lymphocytes. Immunology (1995) 0.80

Cell surface markers in HTLV-1 pathogenesis. Viruses (2011) 0.80

Identification, characterization and purification to near-homogeneity of a novel 67 kDa phosphotyrosyl protein phosphatase associated with pig lung annexin extract. Biochem J (1991) 0.80

Evidence for involvement of glycoprotein-CD45 phosphatase in reversing glycoprotein-CD3-induced microtubule-associated protein-2 kinase activity in Jurkat T-cells. Biochem J (1991) 0.77

Protein-tyrosine phosphatase activity of CD45 is activated by sequential phosphorylation by two kinases. Mol Cell Biol (1994) 0.77

Placental expression of CD100, CD72 and CD45 is dysregulated in human miscarriage. PLoS One (2012) 0.76

Detection of a tyrosine phosphatase LAR on intestinal epithelial cells and intraepithelial lymphocytes in the human duodenum. Mediators Inflamm (2005) 0.75

Cloning and expression of protein tyrosine phosphatase-like protein derived from a rat pheochromocytoma cell line. Biochem J (1995) 0.75

Trace Evidence: Identifying Natural Cancer Killers After the Crime. EBioMedicine (2015) 0.75

Characterization of a monoclonal antibody that recognizes a lymphocyte surface antigen for the cetacean homologue to CD45R. Immunology (1998) 0.75

Articles by these authors

Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. Cell (1999) 5.98

Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes. Science (1991) 4.72

Ovalbumin: a secreted protein without a transient hydrophobic leader sequence. Proc Natl Acad Sci U S A (1978) 4.46

Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel. Science (1992) 4.44

Krebs EG: Purification and characterization of a protein inhibitor of adenosine 3',5'-monophosphate-dependent protein kinases. J Biol Chem (1971) 4.41

Application of sequenator analyses to the study of proteins. Biochemistry (1972) 3.88

Characterization of the major protein-tyrosine-phosphatases of human placenta. J Biol Chem (1988) 3.84

Multiple components in an epidermal growth factor-stimulated protein kinase cascade. In vitro activation of a myelin basic protein/microtubule-associated protein 2 kinase. J Biol Chem (1991) 3.81

The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase. Proc Natl Acad Sci U S A (1988) 3.57

Purification of the centromere-specific protein CENP-A and demonstration that it is a distinctive histone. Proc Natl Acad Sci U S A (1991) 3.55

Purification of the major protein-tyrosine-phosphatases of human placenta. J Biol Chem (1988) 3.54

Recoverin: a calcium sensitive activator of retinal rod guanylate cyclase. Science (1991) 3.27

Complete amino acid sequence of the catalytic subunit of bovine cardiac muscle cyclic AMP-dependent protein kinase. Proc Natl Acad Sci U S A (1981) 3.07

cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family. Proc Natl Acad Sci U S A (1989) 2.95

SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma. EMBO J (1992) 2.82

A calcium-dependent protein kinase with a regulatory domain similar to calmodulin. Science (1991) 2.74

Amino acid sequence of human von Willebrand factor. Biochemistry (1986) 2.73

Guanosine cyclic 3',5'-phosphate dependent protein kinase, a chimeric protein homologous with two separate protein families. Biochemistry (1984) 2.62

CD45 regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T or B cells. Proc Natl Acad Sci U S A (1988) 2.46

Nobel laureates' letter to President Bush. Washington Post (2001) 2.43

Human placenta protein-tyrosine-phosphatase: amino acid sequence and relationship to a family of receptor-like proteins. Proc Natl Acad Sci U S A (1989) 2.40

Amino acid sequence of Escherichia coli alkaline phosphatase. Proc Natl Acad Sci U S A (1981) 2.35

Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tail. EMBO J (1995) 2.22

Association of mitogen-activated protein kinase with the microtubule cytoskeleton. Proc Natl Acad Sci U S A (1995) 2.18

Amino acid sequence of the catalytic subunit of bovine type II adenosine cyclic 3',5'-phosphate dependent protein kinase. Biochemistry (1983) 2.18

Amino acid sequence of monkey amyloid protein A. Biochemistry (1972) 2.17

Use of gene fusions and protein-protein interaction in the isolation of a biologically active regulatory protein: the replication initiator protein of plasmid R6K. Proc Natl Acad Sci U S A (1983) 2.14

Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase. Proc Natl Acad Sci U S A (1986) 2.14

Role of proteolytic enzymes in biological regulation (a review). Proc Natl Acad Sci U S A (1976) 2.12

Purification of plant calmodulin by fluphenazine-Sepharose affinity chromatography. Biochem Biophys Res Commun (1979) 2.01

Identification of the calmodulin-binding domain of skeletal muscle myosin light chain kinase. Proc Natl Acad Sci U S A (1985) 2.00

Complete amino acid sequence of rabbit muscle glycogen phosphorylase. Proc Natl Acad Sci U S A (1977) 2.00

Adenosine 5'-O(3-thiotriphosphate) in the control of phosphorylase activity. Biochem Biophys Res Commun (1974) 1.99

Interpreting DNA mixtures. J Forensic Sci (1997) 1.97

Identification of an inhibitory region of the heat-stable protein inhibitor of the cAMP-dependent protein kinase. Proc Natl Acad Sci U S A (1985) 1.94

Precursor of egg white lysozyme. Amino acid sequence of an NH2-terminal extension. J Biol Chem (1977) 1.93

Identification of disulfide-bridged substructures within human von Willebrand factor. Biochemistry (1987) 1.89

Evolution of structure and function of proteases. Science (1967) 1.89

Net1 stimulates RNA polymerase I transcription and regulates nucleolar structure independently of controlling mitotic exit. Mol Cell (2001) 1.88

Control of phosphorylase activity in a muscle glycogen particle. II. Activation by calcium. J Biol Chem (1970) 1.88

Murine tissue amyloid protein AA. NH2-terminal sequence identity with only one of two serum amyloid protein (ApoSAA) gene products. J Exp Med (1984) 1.88

Characterization of the plant nicotinamide adenine dinucleotide kinase activator protein and its identification as calmodulin. Biochemistry (1980) 1.86

Adenosine 3':5'-monophosphate dependent protein kinase from bovine heart. Characterization of the catalytic subunit. Biochemistry (1977) 1.84

Climate change and the integrity of science. Science (2010) 1.80

Comparison of amino acid sequence of bovine coagulation Factor IX (Christmas Factor) with that of other vitamin K-dependent plasma proteins. Proc Natl Acad Sci U S A (1979) 1.77

Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII. J Biol Chem (1994) 1.76

Covalently bound myristate in a lymphoma tyrosine protein kinase. Proc Natl Acad Sci U S A (1984) 1.76

Isolation and properties of the rabbit skeletal muscle protein inhibitor of adenosine 3',5'-monophosphate dependent protein kinases. Biochemistry (1977) 1.74

Amino acid sequence of the regulatory subunit of bovine type I adenosine cyclic 3',5'-phosphate dependent protein kinase. Biochemistry (1984) 1.74

Control of phosphorylase activity in a muscle glycogen particle. I. Isolation and characterization of the protein-glycogen complex. J Biol Chem (1970) 1.74

Identification of a conserved domain among cyclic nucleotide phosphodiesterases from diverse species. Proc Natl Acad Sci U S A (1986) 1.73

Purification and physical properties of inducible Escherichia coli lysine decarboxylase. Biochemistry (1974) 1.73

Homology of the gamma subunit of phosphorylase b kinase with cAMP-dependent protein kinase. Biochemistry (1984) 1.71

Collagen type IX: evidence for covalent linkages to type II collagen in cartilage. FEBS Lett (1987) 1.69

Okadaic acid mimics the action of insulin in stimulating protein kinase activity in isolated adipocytes. The role of protein phosphatase 2a in attenuation of the signal. J Biol Chem (1990) 1.68

Determination of the amino acid sequence of porcine trypsin by sequenator aalysis. Biochemistry (1973) 1.68

Inhibitory sites in enzymes: zinc removal and reactivation by thionein. Proc Natl Acad Sci U S A (1999) 1.68

Sequence of two phosphorylated sites in the catalytic subunit of bovine cardiac muscle adenosine 3':5'-monophosphate-dependent protein kinase. J Biol Chem (1979) 1.66

Orientations to seeking professional help: development and research utility of an attitude scale. J Consult Clin Psychol (1970) 1.60

COOH-terminal sequence motifs target the T cell protein tyrosine phosphatase to the ER and nucleus. J Cell Biol (1995) 1.60

Primary structure of the regulatory subunit of type II cAMP-dependent protein kinase from bovine cardiac muscle. Proc Natl Acad Sci U S A (1982) 1.58

CD45, an integral membrane protein tyrosine phosphatase. Characterization of enzyme activity. J Biol Chem (1990) 1.56

The amino acid sequence of bovine carboxypeptidase A. Proc Natl Acad Sci U S A (1969) 1.56

A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains. Proc Natl Acad Sci U S A (1993) 1.56

Identification of a noncatalytic cGMP-binding domain conserved in both the cGMP-stimulated and photoreceptor cyclic nucleotide phosphodiesterases. Proc Natl Acad Sci U S A (1990) 1.55

The activity of Cdc14p, an oligomeric dual specificity protein phosphatase from Saccharomyces cerevisiae, is required for cell cycle progression. J Biol Chem (1997) 1.54

Expression of a human T-cell protein-tyrosine-phosphatase in baby hamster kidney cells. Proc Natl Acad Sci U S A (1990) 1.52

Recycling of cold-stable microtubules: evidence that cold stability is due to substoichiometric polymer blocks. Biochemistry (1982) 1.50

Amino acid sequence of the calcium-dependent photoprotein aequorin. Biochemistry (1985) 1.49

Amino acid sequence of the heat-stable inhibitor of the cAMP-dependent protein kinase from rabbit skeletal muscle. Proc Natl Acad Sci U S A (1985) 1.47

Osteogenesis imperfecta. The position of substitution for glycine by cysteine in the triple helical domain of the pro alpha 1(I) chains of type I collagen determines the clinical phenotype. J Clin Invest (1989) 1.45

Amino acid sequence of the beta subunit of bovine lung casein kinase II. Proc Natl Acad Sci U S A (1987) 1.44

Purification and characterization of a human recombinant T-cell protein-tyrosine-phosphatase from a baculovirus expression system. Biochemistry (1991) 1.43

Purification of a fatty acid-stimulated protein-serine/threonine phosphatase from bovine brain and its identification as a homolog of protein phosphatase 5. J Biol Chem (1997) 1.42

Amino acid sequence of spinach ferredoxin:NADP+ oxidoreductase. Biochemistry (1984) 1.41

Rapid disassembly of cold-stable microtubules by calmodulin. Proc Natl Acad Sci U S A (1981) 1.40

The rod transducin alpha subunit amino terminus is heterogeneously fatty acylated. J Biol Chem (1992) 1.40

The multiple causes of multiple sclerosis: the importance of age of infections in childhood. J Child Neurol (1987) 1.40

Amino acid sequence of the biotinyl subunit from transcarboxylase. J Biol Chem (1979) 1.40

Identification and characterization of the calmodulin-binding domain of neuromodulin, a neurospecific calmodulin-binding protein. J Biol Chem (1988) 1.39