Published in Sci Rep on May 26, 2017
An SCN9A channelopathy causes congenital inability to experience pain. Nature (2006) 7.01
International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. Pharmacol Rev (2005) 5.40
SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes. Neuron (2006) 3.96
De novo pathogenic SCN8A mutation identified by whole-genome sequencing of a family quartet affected by infantile epileptic encephalopathy and SUDEP. Am J Hum Genet (2012) 3.58
Gain of function Naν1.7 mutations in idiopathic small fiber neuropathy. Ann Neurol (2011) 3.53
Sodium channels in normal and pathological pain. Annu Rev Neurosci (2010) 3.47
The cell and molecular basis of mechanical, cold, and inflammatory pain. Science (2008) 3.46
A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome. Neuron (2010) 3.31
Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain. Proc Natl Acad Sci U S A (2004) 3.07
Parallel "pain" pathways arise from subpopulations of primary afferent nociceptor. Neuron (2005) 3.03
A data integration methodology for systems biology. Proc Natl Acad Sci U S A (2005) 2.93
The Na(V)1.7 sodium channel: from molecule to man. Nat Rev Neurosci (2012) 2.71
Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures. Nature (2007) 2.71
Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons. J Physiol (2006) 2.62
A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons. Proc Natl Acad Sci U S A (2006) 2.61
Activated microglia contribute to the maintenance of chronic pain after spinal cord injury. J Neurosci (2006) 2.60
The TTX-resistant sodium channel Nav1.8 (SNS/PN3): expression and correlation with membrane properties in rat nociceptive primary afferent neurons. J Physiol (2003) 2.59
Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders. J Clin Invest (2007) 2.58
Acid-sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurones. J Physiol (2004) 2.48
Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance. Pharmacol Rev (2013) 2.42
Distinct mechanosensitive properties of capsaicin-sensitive and -insensitive sensory neurons. J Neurosci (2002) 2.40
Nav1.8 expression is not restricted to nociceptors in mouse peripheral nervous system. Pain (2012) 2.34
A widespread family of bacterial cell wall assembly proteins. EMBO J (2011) 2.33
Loss-of-function mutations in sodium channel Nav1.7 cause anosmia. Nature (2011) 2.31
Genetic variation in SCN10A influences cardiac conduction. Nat Genet (2010) 2.30
The toxicogenomic multiverse: convergent recruitment of proteins into animal venoms. Annu Rev Genomics Hum Genet (2009) 2.30
From genes to pain: Na v 1.7 and human pain disorders. Trends Neurosci (2007) 2.29
Membrane localization of MinD is mediated by a C-terminal motif that is conserved across eubacteria, archaea, and chloroplasts. Proc Natl Acad Sci U S A (2002) 2.28
The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nat Neurosci (2012) 2.28
VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch. Neuron (2010) 2.22
Distinct repriming and closed-state inactivation kinetics of Nav1.6 and Nav1.7 sodium channels in mouse spinal sensory neurons. J Physiol (2003) 2.21
Changes in the expression of tetrodotoxin-sensitive sodium channels within dorsal root ganglia neurons in inflammatory pain. Pain (2004) 2.10
A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons. EMBO J (2004) 2.07
The roles of sodium channels in nociception: Implications for mechanisms of pain. Pain (2007) 2.06
Intense isolectin-B4 binding in rat dorsal root ganglion neurons distinguishes C-fiber nociceptors with broad action potentials and high Nav1.9 expression. J Neurosci (2006) 2.05
Division site placement in E.coli: mutations that prevent formation of the MinE ring lead to loss of the normal midcell arrest of growth of polar MinD membrane domains. EMBO J (2002) 2.02
Molecular changes in neurons in multiple sclerosis: altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+/Ca2+ exchanger. Proc Natl Acad Sci U S A (2004) 1.99
Inherited erythermalgia: limb pain from an S4 charge-neutral Na channelopathy. Neurology (2006) 1.95
Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones. J Physiol (2005) 1.95
An SMN-dependent U12 splicing event essential for motor circuit function. Cell (2012) 1.94
Electrophysiological properties of mutant Nav1.7 sodium channels in a painful inherited neuropathy. J Neurosci (2004) 1.93
NaN/Nav1.9: a sodium channel with unique properties. Trends Neurosci (2002) 1.93
Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier of dorsal root axons. J Neurosci (2004) 1.91
Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia. Pain (2011) 1.90
Annexin II light chain regulates sensory neuron-specific sodium channel expression. Nature (2002) 1.88
Molecular dissection of the Munc18c/syntaxin4 interaction: implications for regulation of membrane trafficking. Traffic (2006) 1.88
Neuropathic pain develops normally in mice lacking both Na(v)1.7 and Na(v)1.8. Mol Pain (2005) 1.86
Nav1.6 channels generate resurgent sodium currents in spinal sensory neurons. FEBS Lett (2005) 1.85
The presence and role of the tetrodotoxin-resistant sodium channel Na(v)1.9 (NaN) in nociceptive primary afferent neurons. J Neurosci (2002) 1.85
Early- and late-onset inherited erythromelalgia: genotype-phenotype correlation. Brain (2009) 1.82
A sodium channel mutation linked to epilepsy increases ramp and persistent current of Nav1.3 and induces hyperexcitability in hippocampal neurons. Exp Neurol (2010) 1.78
A data integration methodology for systems biology: experimental verification. Proc Natl Acad Sci U S A (2005) 1.77
Upregulation of sodium channel Nav1.3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury. J Neurosci (2003) 1.76
The MinD membrane targeting sequence is a transplantable lipid-binding helix. J Biol Chem (2003) 1.75
Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke. Brain (2011) 1.73
Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons. Nat Commun (2012) 1.72
Nociceptor-specific gene deletion using heterozygous NaV1.8-Cre recombinase mice. Pain (2005) 1.72
Dual feedback loops in the GAL regulon suppress cellular heterogeneity in yeast. Nat Genet (2006) 1.70
Conus venom peptide pharmacology. Pharmacol Rev (2012) 1.69
No gain, no pain: NaV1.7 as an analgesic target. ACS Chem Neurosci (2014) 1.65
Modulation of the cardiac sodium channel Nav1.5 by fibroblast growth factor homologous factor 1B. J Biol Chem (2002) 1.64
GTP-induced tetrodotoxin-resistant Na+ current regulates excitability in mouse and rat small diameter sensory neurones. J Physiol (2003) 1.62
Remote optogenetic activation and sensitization of pain pathways in freely moving mice. J Neurosci (2013) 1.62
Neurological perspectives on voltage-gated sodium channels. Brain (2012) 1.62
Structure and mechanism of action of Sda, an inhibitor of the histidine kinases that regulate initiation of sporulation in Bacillus subtilis. Mol Cell (2004) 1.61
A rational nomenclature for naming peptide toxins from spiders and other venomous animals. Toxicon (2008) 1.61
A case of inherited erythromelalgia. Nat Clin Pract Neurol (2007) 1.60
The mobile nucleoporin Nup2p and chromatin-bound Prp20p function in endogenous NPC-mediated transcriptional control. J Cell Biol (2005) 1.59
A channelopathy contributes to cerebellar dysfunction in a model of multiple sclerosis. Ann Neurol (2012) 1.59
Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases. Proc Natl Acad Sci U S A (2011) 1.57
Characterization of the sporulation initiation pathway of Clostridium difficile and its role in toxin production. J Bacteriol (2009) 1.57
Exacerbation of experimental autoimmune encephalomyelitis after withdrawal of phenytoin and carbamazepine. Ann Neurol (2007) 1.56
Interactions between lipids and voltage sensor paddles detected with tarantula toxins. Nat Struct Mol Biol (2009) 1.56
Were arachnids the first to use combinatorial peptide libraries? Peptides (2005) 1.55
The tetrodotoxin-resistant Na+ channel Nav1.8 is essential for the expression of spontaneous activity in damaged sensory axons of mice. J Physiol (2003) 1.54
Early treatment suppresses the development of spike-wave epilepsy in a rat model. Epilepsia (2007) 1.53
Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons. Neuron (2008) 1.52
FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels. Mol Cell Neurosci (2009) 1.51
Gain-of-function Nav1.8 mutations in painful neuropathy. Proc Natl Acad Sci U S A (2012) 1.50