Published in Mol Pain on August 22, 2005
Cellular and molecular mechanisms of pain. Cell (2009) 9.36
Neuropathic pain: a maladaptive response of the nervous system to damage. Annu Rev Neurosci (2009) 5.00
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proc Natl Acad Sci U S A (2007) 2.60
Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders. J Clin Invest (2007) 2.58
Deconstructing the neuropathic pain phenotype to reveal neural mechanisms. Neuron (2012) 2.11
The roles of sodium channels in nociception: Implications for mechanisms of pain. Pain (2007) 2.06
Nociceptors: the sensors of the pain pathway. J Clin Invest (2010) 1.72
Neurological perspectives on voltage-gated sodium channels. Brain (2012) 1.62
Pain without nociceptors? Nav1.7-independent pain mechanisms. Cell Rep (2014) 1.50
Pain as a channelopathy. J Clin Invest (2010) 1.33
muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits. Proc Natl Acad Sci U S A (2006) 1.26
Are voltage-gated sodium channels on the dorsal root ganglion involved in the development of neuropathic pain? Mol Pain (2011) 1.23
Nerve injury induces robust allodynia and ectopic discharges in Nav1.3 null mutant mice. Mol Pain (2006) 1.21
Increased peripheral nerve excitability and local NaV1.8 mRNA up-regulation in painful neuropathy. Mol Pain (2009) 1.19
Recent developments regarding voltage-gated sodium channel blockers for the treatment of inherited and acquired neuropathic pain syndromes. Front Pharmacol (2011) 1.16
Subtype-selective targeting of voltage-gated sodium channels. Br J Pharmacol (2009) 1.13
A brief comparison of the pathophysiology of inflammatory versus neuropathic pain. Curr Opin Anaesthesiol (2011) 1.08
Nav1.7 expression is increased in painful human dental pulp. Mol Pain (2008) 1.00
Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain. J Clin Invest (2013) 0.99
Sensory neuron downregulation of the Kv9.1 potassium channel subunit mediates neuropathic pain following nerve injury. J Neurosci (2012) 0.98
Criticality and degeneracy in injury-induced changes in primary afferent excitability and the implications for neuropathic pain. Elife (2014) 0.95
Two novel mutations of SCN9A (Nav1.7) are associated with partial congenital insensitivity to pain. Eur J Pain (2010) 0.95
Correlational analysis for identifying genes whose regulation contributes to chronic neuropathic pain. Mol Pain (2009) 0.93
Sodium channels and mammalian sensory mechanotransduction. Mol Pain (2012) 0.91
AMPK: An emerging target for modification of injury-induced pain plasticity. Neurosci Lett (2013) 0.91
Differing alterations of sodium currents in small dorsal root ganglion neurons after ganglion compression and peripheral nerve injury. Mol Pain (2008) 0.91
Sodium channel blockers for the treatment of neuropathic pain. Neurotherapeutics (2009) 0.91
A multi PDZ-domain protein Pdzd2 contributes to functional expression of sensory neuron-specific sodium channel Na(V)1.8. Mol Cell Neurosci (2009) 0.89
Colonic Hypersensitivity and Sensitization of Voltage-gated Sodium Channels in Primary Sensory Neurons in Rats with Diabetes. J Neurogastroenterol Motil (2016) 0.89
Dorsal root ganglion myeloid zinc finger protein 1 contributes to neuropathic pain after peripheral nerve trauma. Pain (2015) 0.89
Identification of molecular pathologies sufficient to cause neuropathic excitability in primary somatosensory afferents using dynamical systems theory. PLoS Comput Biol (2012) 0.88
Electroacupuncture Reduces Carrageenan- and CFA-Induced Inflammatory Pain Accompanied by Changing the Expression of Nav1.7 and Nav1.8, rather than Nav1.9, in Mice Dorsal Root Ganglia. Evid Based Complement Alternat Med (2013) 0.88
A novel selective and orally bioavailable Nav 1.8 channel blocker, PF-01247324, attenuates nociception and sensory neuron excitability. Br J Pharmacol (2015) 0.88
Tetrodotoxin (TTX) as a therapeutic agent for pain. Mar Drugs (2012) 0.87
Conotoxins targeting neuronal voltage-gated sodium channel subtypes: potential analgesics? Toxins (Basel) (2012) 0.87
Contribution of primary afferent channels to neuropathic pain. Curr Pain Headache Rep (2009) 0.85
Identification of the sensory neuron specific regulatory region for the mouse gene encoding the voltage-gated sodium channel NaV1.8. J Neurochem (2008) 0.85
Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief. Expert Opin Ther Targets (2016) 0.84
Reduction of voltage gated sodium channel protein in DRG by vector mediated miRNA reduces pain in rats with painful diabetic neuropathy. Mol Pain (2012) 0.84
Structural determinants of drugs acting on the Nav1.8 channel. J Biol Chem (2009) 0.84
Na(v) 1.8-null mice show stimulus-dependent deficits in spinal neuronal activity. Mol Pain (2006) 0.84
A nonsense mutation in the SCN9A gene in congenital insensitivity to pain. Dermatology (2010) 0.82
Targeting neuroprotection as an alternative approach to preventing and treating neuropathic pain. Neurotherapeutics (2009) 0.82
Optogenetic Silencing of Nav1.8-Positive Afferents Alleviates Inflammatory and Neuropathic Pain. eNeuro (2016) 0.82
The role of sodium channels in chronic pain. Muscle Nerve (2012) 0.81
The pros and cons of degeneracy. Elife (2014) 0.80
Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain. ACS Med Chem Lett (2015) 0.79
Probing functional properties of nociceptive axons using a microfluidic culture system. PLoS One (2013) 0.78
Case Report: Neuropathic pain in a patient with congenital insensitivity to pain. F1000Res (2014) 0.77
Development of a μO-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8. J Biol Chem (2016) 0.77
Identifying the Ion Channels Responsible for Signaling Gastro-Intestinal Based Pain. Pharmaceuticals (Basel) (2010) 0.76
A 3.7 kb fragment of the mouse Scn10a gene promoter directs neural crest but not placodal lineage EGFP expression in a transgenic animal. J Neurosci (2015) 0.76
Food-Derived Natural Compounds for Pain Relief in Neuropathic Pain. Biomed Res Int (2016) 0.75
Conotoxins That Could Provide Analgesia through Voltage Gated Sodium Channel Inhibition. Toxins (Basel) (2015) 0.75
Electroacupuncture Attenuates CFA-induced Inflammatory Pain by suppressing Nav1.8 through S100B, TRPV1, Opioid, and Adenosine Pathways in Mice. Sci Rep (2017) 0.75
Inflammatory pain reduces C fibre activity-dependent slowing in a sex dependent manner, amplifying nociceptive input to the spinal cord. J Neurosci (2017) 0.75
Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods (1994) 23.05
A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature (1996) 4.63
The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways. Nat Neurosci (1999) 4.35
Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia. J Med Genet (2004) 3.45
Sodium channel mutations in epilepsy and other neurological disorders. J Clin Invest (2005) 3.17
Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain. Proc Natl Acad Sci U S A (2004) 3.07
Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons. Proc Natl Acad Sci U S A (1997) 2.75
The TTX-resistant sodium channel Nav1.8 (SNS/PN3): expression and correlation with membrane properties in rat nociceptive primary afferent neurons. J Physiol (2003) 2.59
Sodium channel beta subunits: anything but auxiliary. Neuroscientist (2001) 2.43
Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons. Brain (2005) 2.32
Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8. Pain (2002) 2.24
Sodium channel alpha-subunit mRNAs I, II, III, NaG, Na6 and hNE (PN1): different expression patterns in developing rat nervous system. Brain Res Mol Brain Res (1997) 2.12
Potent analgesic effects of GDNF in neuropathic pain states. Science (2000) 2.06
Voltage-gated sodium channels and hyperalgesia. Annu Rev Pharmacol Toxicol (2004) 1.93
A novel tetrodotoxin-sensitive, voltage-gated sodium channel expressed in rat and human dorsal root ganglia. J Biol Chem (1997) 1.91
Tetrodotoxin-resistant impulses in single nociceptor nerve terminals in guinea-pig cornea. J Physiol (1998) 1.76
Upregulation of sodium channel Nav1.3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury. J Neurosci (2003) 1.76
Sensory and electrophysiological properties of guinea-pig sensory neurones expressing Nav 1.7 (PN1) Na+ channel alpha subunit protein. J Physiol (2003) 1.75
A role for the TTX-resistant sodium channel Nav 1.8 in NGF-induced hyperalgesia, but not neuropathic pain. Neuroreport (2001) 1.74
Nociceptor-specific gene deletion using heterozygous NaV1.8-Cre recombinase mice. Pain (2005) 1.72
Involvement of Na+ channels in pain pathways. Trends Pharmacol Sci (2001) 1.58
The tetrodotoxin-resistant Na+ channel Nav1.8 is essential for the expression of spontaneous activity in damaged sensory axons of mice. J Physiol (2003) 1.54
Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction. Pain (1992) 1.45
Ibuprofen blocks changes in Na v 1.7 and 1.8 sodium channels associated with complete Freund's adjuvant-induced inflammation in rat. J Pain (2004) 1.10
Tetrodotoxin inhibits neuropathic ectopic activity in neuromas, dorsal root ganglia and dorsal horn neurons. Pain (1997) 0.97
Absence of an association between axotomy-induced changes in sodium currents and excitability in DRG neurons from the adult rat. Pain (2004) 0.96
Ion channel activities implicated in pathological pain. Novartis Found Symp (2004) 0.91
Intrathecal fentanyl depresses nociceptive flexion reflexes in patients with chronic pain. Anesthesiology (1989) 0.83
An SCN9A channelopathy causes congenital inability to experience pain. Nature (2006) 7.01
SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes. Neuron (2006) 3.96
The cell and molecular basis of mechanical, cold, and inflammatory pain. Science (2008) 3.46
A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome. Neuron (2010) 3.31
Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain. Proc Natl Acad Sci U S A (2004) 3.07
Parallel "pain" pathways arise from subpopulations of primary afferent nociceptor. Neuron (2005) 3.03
Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures. Nature (2007) 2.71
The TTX-resistant sodium channel Nav1.8 (SNS/PN3): expression and correlation with membrane properties in rat nociceptive primary afferent neurons. J Physiol (2003) 2.59
Acid-sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurones. J Physiol (2004) 2.48
Distinct mechanosensitive properties of capsaicin-sensitive and -insensitive sensory neurons. J Neurosci (2002) 2.40
Nav1.8 expression is not restricted to nociceptors in mouse peripheral nervous system. Pain (2012) 2.34
Loss-of-function mutations in sodium channel Nav1.7 cause anosmia. Nature (2011) 2.31
Genetic variation in SCN10A influences cardiac conduction. Nat Genet (2010) 2.30
The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nat Neurosci (2012) 2.28
VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch. Neuron (2010) 2.22
Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia. Pain (2011) 1.90
Annexin II light chain regulates sensory neuron-specific sodium channel expression. Nature (2002) 1.88
Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons. Nat Commun (2012) 1.72
Nociceptor-specific gene deletion using heterozygous NaV1.8-Cre recombinase mice. Pain (2005) 1.72
Remote optogenetic activation and sensitization of pain pathways in freely moving mice. J Neurosci (2013) 1.62
GTP-induced tetrodotoxin-resistant Na+ current regulates excitability in mouse and rat small diameter sensory neurones. J Physiol (2003) 1.62
Neurological perspectives on voltage-gated sodium channels. Brain (2012) 1.62
The tetrodotoxin-resistant Na+ channel Nav1.8 is essential for the expression of spontaneous activity in damaged sensory axons of mice. J Physiol (2003) 1.54
Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons. Neuron (2008) 1.52
GTP up-regulated persistent Na+ current and enhanced nociceptor excitability require NaV1.9. J Physiol (2007) 1.49
Deficits in visceral pain and referred hyperalgesia in Nav1.8 (SNS/PN3)-null mice. J Neurosci (2002) 1.48
High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain. PLoS One (2007) 1.38
Modulation of sensory neuron mechanotransduction by PKC- and nerve growth factor-dependent pathways. Proc Natl Acad Sci U S A (2006) 1.38
Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis. Proc Natl Acad Sci U S A (2013) 1.34
Pain as a channelopathy. J Clin Invest (2010) 1.33
Small RNAs control sodium channel expression, nociceptor excitability, and pain thresholds. J Neurosci (2010) 1.28
Nociceptor-derived brain-derived neurotrophic factor regulates acute and inflammatory but not neuropathic pain. Mol Cell Neurosci (2006) 1.24
The roles of sodium channels in nociception: implications for mechanisms of neuropathic pain. Pain Med (2011) 1.23
Pain genes. PLoS Genet (2008) 1.23
Nerve injury induces robust allodynia and ectopic discharges in Nav1.3 null mutant mice. Mol Pain (2006) 1.21
Increasingly irritable and close to tears: TRPA1 in inflammatory pain. Cell (2006) 1.18
Genetic tracing of Nav1.8-expressing vagal afferents in the mouse. J Comp Neurol (2011) 1.16
TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells. Open Biol (2012) 1.16
GRK2: a novel cell-specific regulator of severity and duration of inflammatory pain. J Neurosci (2010) 1.15
Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling. EMBO J (2012) 1.15
FM1-43 is a permeant blocker of mechanosensitive ion channels in sensory neurons and inhibits behavioural responses to mechanical stimuli. Mol Pain (2007) 1.12
Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior. J Neurosci (2006) 1.11
Kinetic properties of mechanically activated currents in spinal sensory neurons. J Physiol (2009) 1.10
Pain channelopathies. J Physiol (2010) 1.09
Annexin II light chain p11 promotes functional expression of acid-sensing ion channel ASIC1a. J Biol Chem (2005) 1.08
Low nociceptor GRK2 prolongs prostaglandin E2 hyperalgesia via biased cAMP signaling to Epac/Rap1, protein kinase Cepsilon, and MEK/ERK. J Neurosci (2010) 1.06
Sensory neuron voltage-gated sodium channels as analgesic drug targets. Curr Opin Neurobiol (2008) 1.06
Extensive co-localization and heteromultimer formation of the vanilloid receptor-like protein TRPV2 and the capsaicin receptor TRPV1 in the adult rat cerebral cortex. Eur J Neurosci (2005) 1.06
Electrophysiological characterization of the tetrodotoxin-resistant Na+ channel, Na(v)1.9, in mouse dorsal root ganglion neurons. Pflugers Arch (2004) 1.04
Nerve growth factor and pain. N Engl J Med (2010) 1.03
RET signaling is required for survival and normal function of nonpeptidergic nociceptors. J Neurosci (2010) 1.03
Sensory axon-derived neuregulin-1 is required for axoglial signaling and normal sensory function but not for long-term axon maintenance. J Neurosci (2009) 1.00
No pain, more gain. Nat Genet (2013) 1.00
Identification of binding domains in the sodium channel Na(V)1.8 intracellular N-terminal region and annexin II light chain p11. FEBS Lett (2004) 1.00
Proteomic profiling of neuromas reveals alterations in protein composition and local protein synthesis in hyper-excitable nerves. Mol Pain (2008) 0.98
Sensory neuron proteins interact with the intracellular domains of sodium channel NaV1.8. Brain Res Mol Brain Res (2003) 0.96
The mechanosensitive cell line ND-C does not express functional thermoTRP channels. Neuropharmacology (2009) 0.95
Autophagy impairment in a mouse model of neuropathic pain. Mol Pain (2011) 0.95
A sensory subpopulation depends on vesicular glutamate transporter 2 for mechanical pain, and together with substance P, inflammatory pain. Proc Natl Acad Sci U S A (2011) 0.94
Temporal control of gene deletion in sensory ganglia using a tamoxifen-inducible Advillin-Cre-ERT2 recombinase mouse. Mol Pain (2011) 0.94
Regulation of ASIC activity by ASIC4--new insights into ASIC channel function revealed by a yeast two-hybrid assay. Eur J Neurosci (2008) 0.92
Roles of ASIC3, TRPV1, and NaV1.8 in the transition from acute to chronic pain in a mouse model of fibromyalgia. Mol Pain (2014) 0.92
Sodium channels and mammalian sensory mechanotransduction. Mol Pain (2012) 0.91
Transient receptor potential channels and mechanosensation. Annu Rev Neurosci (2013) 0.91
A peripheral nervous system actin-binding protein regulates neurite outgrowth. Eur J Neurosci (2002) 0.90
Mechanical allodynia. Pflugers Arch (2014) 0.90
A multi PDZ-domain protein Pdzd2 contributes to functional expression of sensory neuron-specific sodium channel Na(V)1.8. Mol Cell Neurosci (2009) 0.89
Worm sensation! Mol Pain (2005) 0.88
Tamoxifen-inducible NaV1.8-CreERT2 recombinase activity in nociceptive neurons of dorsal root ganglia. Genesis (2006) 0.87
Novel mutations mapping to the fourth sodium channel domain of Nav1.7 result in variable clinical manifestations of primary erythromelalgia. Neuromolecular Med (2013) 0.87
Nociceptor-expressed ephrin-B2 regulates inflammatory and neuropathic pain. Mol Pain (2010) 0.85
Na(v) 1.8-null mice show stimulus-dependent deficits in spinal neuronal activity. Mol Pain (2006) 0.84
Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice. PLoS One (2013) 0.84
Multiple postnatal craniofacial anomalies are characterized by conditional loss of polycystic kidney disease 2 (Pkd2). Hum Mol Genet (2013) 0.84
Mechanisms of cold pain. Channels (Austin) (2007) 0.82
G protein-coupled receptor kinase 6 acts as a critical regulator of cytokine-induced hyperalgesia by promoting phosphatidylinositol 3-kinase and inhibiting p38 signaling. Mol Med (2012) 0.82
Botulinum toxin-A treatment reduces human mechanical pain sensitivity and mechanotransduction. Ann Neurol (2014) 0.82
Pyramidal cells of rodent presubiculum express a tetrodotoxin-insensitive Na+ current. J Physiol (2009) 0.82
Na(v)1.8 channelopathy in mutant mice deficient for myelin protein zero is detrimental to motor axons. Brain (2010) 0.81
(-)-Linalool attenuates allodynia in neuropathic pain induced by spinal nerve ligation in c57/bl6 mice. Int Rev Neurobiol (2009) 0.79
TRPs and pain. Handb Exp Pharmacol (2014) 0.79
Splice variants of Na(V)1.7 sodium channels have distinct β subunit-dependent biophysical properties. PLoS One (2012) 0.79
The lidocaine metabolite N-ethylglycine has antinociceptive effects in experimental inflammatory and neuropathic pain. Pain (2015) 0.77
Sodium channels and pain. Handb Exp Pharmacol (2015) 0.77
Results in analgesia--Darwin 1, pharma 0. N Engl J Med (2013) 0.76
Chapter 5 Molecular mechanisms of nociception and pain. Handb Clin Neurol (2006) 0.76
Fat location defines sensation. Proc Natl Acad Sci U S A (2009) 0.75
Corrigendum: Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a. Sci Rep (2017) 0.75
From transduction to pain sensation: defining genes, cells, and circuits. Pain (2011) 0.75
Dying for a change: junior doctors and care of the dying patient. Br J Hosp Med (Lond) (2015) 0.75