Necroptosis and ferroptosis are alternative cell death pathways that operate in acute kidney failure.

Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Science (2014) 10.43

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature (2011) 6.31

Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell (2012) 6.31

RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature (2011) 6.03

Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3. Mol Cell (2014) 3.52

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis. Nat Cell Biol (2013) 3.29

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity (2013) 3.15

Necroptosis and its role in inflammation. Nature (2015) 3.01

Regulation of ferroptotic cancer cell death by GPX4. Cell (2014) 2.78

Course of acute renal failure studied by a model of creatinine kinetics. Kidney Int (1985) 2.69

MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates. Cell Rep (2014) 2.34

Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. J Biol Chem (2013) 2.24

The role of iron and reactive oxygen species in cell death. Nat Chem Biol (2014) 2.10

Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2013) 2.10

Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. Chem Biol (2008) 2.04

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models. Cell Death Dis (2012) 1.94

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death. Proc Natl Acad Sci U S A (2014) 1.78

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol (2014) 1.76

Synchronized renal tubular cell death involves ferroptosis. Proc Natl Acad Sci U S A (2014) 1.62

Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J Am Chem Soc (2014) 1.49

Regulated cell death and inflammation: an auto-amplification loop causes organ failure. Nat Rev Immunol (2014) 1.28

Molecular mechanisms of regulated necrosis. Semin Cell Dev Biol (2014) 1.28

Activation of necroptosis in multiple sclerosis. Cell Rep (2015) 1.21

The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury. Cell Death Dis (2014) 1.14

Regulated necrosis: disease relevance and therapeutic opportunities. Nat Rev Drug Discov (2016) 1.09

TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation. J Cell Biol (2014) 1.07

The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis. Dev Cell (2016) 1.02

Ferroptosis: process and function. Cell Death Differ (2016) 1.01

Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia. PLoS Pathog (2015) 0.98

MLKL forms cation channels. Cell Res (2016) 0.92

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol (2016) 0.91

Intermediate domain of receptor-interacting protein kinase 1 (RIPK1) determines switch between necroptosis and RIPK1 kinase-dependent apoptosis. J Biol Chem (2012) 0.90

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis. Proc Natl Acad Sci U S A (2016) 0.90

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death. ACS Chem Biol (2015) 0.89

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nat Chem Biol (2016) 0.88

An outline of necrosome triggers. Cell Mol Life Sci (2016) 0.86

Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop. Biochem J (2015) 0.85

Mechanisms of ferroptosis. Cell Mol Life Sci (2016) 0.84

Identification of ACSL4 as a biomarker and contributor of ferroptosis. Biochem Biophys Res Commun (2016) 0.80

HSPA5 Regulates Ferroptotic Cell Death in Cancer Cells. Cancer Res (2017) 0.78

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner. Proc Natl Acad Sci U S A (2017) 0.77

Biomarkers for the detection of necroptosis. Cell Mol Life Sci (2016) 0.76

Inhibition of regulated cell death by cell-penetrating peptides. Cell Mol Life Sci (2016) 0.75

Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association. Nat Commun (2017) 0.75