Published in Mol Cell on April 03, 2014
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Necroptosis activation in Alzheimer's disease. Nat Neurosci (2017) 1.38
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The two faces of receptor interacting protein kinase-1. Mol Cell (2014) 1.37
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Activation of necroptosis in multiple sclerosis. Cell Rep (2015) 1.21
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Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics. Cell Res (2015) 1.15
RIP kinases: key decision makers in cell death and innate immunity. Cell Death Differ (2014) 1.14
GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death. EMBO J (2016) 1.13
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TAK1 control of cell death. Cell Death Differ (2014) 1.09
CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis. Nat Med (2016) 1.09
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A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis. Cell Death Dis (2015) 1.02
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Reactive oxygen species regulate Smac mimetic/TNFα-induced necroptotic signaling and cell death. Oncogene (2015) 0.99
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Neoalbaconol induces cell death through necroptosis by regulating RIPK-dependent autocrine TNFα and ROS production. Oncotarget (2015) 0.96
Necroptosis in development, inflammation and disease. Nat Rev Mol Cell Biol (2016) 0.96
Dying cells actively regulate adaptive immune responses. Nat Rev Immunol (2017) 0.94
TRAF2 is a biologically important necroptosis suppressor. Cell Death Differ (2015) 0.94
Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis. Sci Adv (2016) 0.94
A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis. Proc Natl Acad Sci U S A (2015) 0.93
A Role for Tubular Necroptosis in Cisplatin-Induced AKI. J Am Soc Nephrol (2015) 0.93
Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis. Nat Commun (2016) 0.92
MLKL forms cation channels. Cell Res (2016) 0.92
Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis. Cell Res (2016) 0.92
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RIP3-mediated necrotic cell death accelerates systematic inflammation and mortality. Proc Natl Acad Sci U S A (2015) 0.91
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Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it. Cell Death Differ (2015) 0.90
Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death. Cell Death Dis (2015) 0.89
Autophagy in acute kidney injury. Kidney Int (2016) 0.88
Questions and controversies: the role of necroptosis in liver disease. Cell Death Discov (2016) 0.88
An outline of necrosome triggers. Cell Mol Life Sci (2016) 0.86
The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis. J Clin Invest (2016) 0.86
Necrostatin-1 reduces intestinal inflammation and colitis-associated tumorigenesis in mice. Am J Cancer Res (2015) 0.85
Upregulated RIP3 Expression Potentiates MLKL Phosphorylation-Mediated Programmed Necrosis in Toxic Epidermal Necrolysis. J Invest Dermatol (2015) 0.85
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Ppm1b negatively regulates necroptosis through dephosphorylating Rip3. Nat Cell Biol (2015) 0.84
CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3. Nat Cell Biol (2016) 0.84
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Artesunate induces necrotic cell death in schwannoma cells. Cell Death Dis (2014) 0.83
Cationic nanocarriers induce cell necrosis through impairment of Na(+)/K(+)-ATPase and cause subsequent inflammatory response. Cell Res (2015) 0.83
Apoptosis, Necrosis, and Necroptosis in the Gut and Intestinal Homeostasis. Mediators Inflamm (2015) 0.83
Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides. J Immunol (2016) 0.82
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Hsp90 modulates the stability of MLKL and is required for TNF-induced necroptosis. Cell Death Dis (2016) 0.82
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Homoharringtonine, a clinically approved anti-leukemia drug, sensitizes tumor cells for TRAIL-induced necroptosis. Cell Commun Signal (2015) 0.82
Critical function of the necroptosis adaptor RIPK3 in protecting from intestinal tumorigenesis. Oncotarget (2016) 0.81
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Mitochondrial Protein PGAM5 Regulates Mitophagic Protection against Cell Necroptosis. PLoS One (2016) 0.81
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Two sides of one coin: massive hepatic necrosis and progenitor cell-mediated regeneration in acute liver failure. Front Physiol (2015) 0.80
RIP3 induces ischemic neuronal DNA degradation and programmed necrosis in rat via AIF. Sci Rep (2016) 0.80
Therapeutic applications of TRAIL receptor agonists in cancer and beyond. Pharmacol Ther (2015) 0.80
K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo. Cell Death Differ (2016) 0.79
Reactive astrocytes undergo M1 microglia/macrohpages-induced necroptosis in spinal cord injury. Mol Neurodegener (2016) 0.79
Roles of Caspases in Necrotic Cell Death. Cell (2016) 0.79
Evolutionary divergence of the necroptosis effector MLKL. Cell Death Differ (2016) 0.79
Controlled detonation: Evolution of necroptosis in pathogen defense. Immunol Cell Biol (2016) 0.79
A motive for killing: effector functions of regulated lytic cell death. Immunol Cell Biol (2016) 0.79
The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis. Immunity (2016) 0.79
Interleukin-1 Family Cytokines in Liver Diseases. Mediators Inflamm (2015) 0.79
Molecular Pathogenesis of NASH. Int J Mol Sci (2016) 0.78
Necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapy. Oncotarget (2016) 0.78
Necroptotic cell death in failing heart: relevance and proposed mechanisms. Heart Fail Rev (2016) 0.78
Readthrough acetylcholinesterase (AChE-R) and regulated necrosis: pharmacological targets for the regulation of ovarian functions? Cell Death Dis (2015) 0.78
Emerging roles for lipids in non-apoptotic cell death. Cell Death Differ (2016) 0.78
Necroptosis mediates TNF-induced toxicity of hippocampal neurons. Biomed Res Int (2014) 0.78
Macrophage- and RIP3-dependent inflammasome activation exacerbates retinal detachment-induced photoreceptor cell death. Cell Death Dis (2015) 0.78
Insane in the membrane: a structural perspective of MLKL function in necroptosis. Immunol Cell Biol (2017) 0.78
RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome. Nat Commun (2017) 0.78
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Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients. Cell Mol Immunol (2015) 0.82