Published in J Am Chem Soc on May 29, 2017
Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines. J Immunol (2011) 1.83
The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes. PLoS One (2008) 1.70
Structural model of MD-2 and functional role of its basic amino acid clusters involved in cellular lipopolysaccharide recognition. J Biol Chem (2004) 1.48
Essential roles of hydrophobic residues in both MD-2 and toll-like receptor 4 in activation by endotoxin. J Biol Chem (2009) 1.38
Design of a single-chain polypeptide tetrahedron assembled from coiled-coil segments. Nat Chem Biol (2013) 1.32
Globular domain of the prion protein needs to be unlocked by domain swapping to support prion protein conversion. J Biol Chem (2011) 1.29
Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide. Biochem J (2005) 1.28
DNA-guided assembly of biosynthetic pathways promotes improved catalytic efficiency. Nucleic Acids Res (2011) 1.28
MD-2 as the target of curcumin in the inhibition of response to LPS. J Leukoc Biol (2007) 1.26
A second binding site for double-stranded RNA in TLR3 and consequences for interferon activation. Nat Struct Mol Biol (2008) 1.24
Enhancement of antibacterial and lipopolysaccharide binding activities of a human lactoferrin peptide fragment by the addition of acyl chain. J Antimicrob Chemother (2003) 1.24
The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition. PLoS Pathog (2012) 1.17
Toll-like receptor 4 activation in cancer progression and therapy. Clin Dev Immunol (2011) 1.14
Monoclonal antibody against a peptide of human prion protein discriminates between Creutzfeldt-Jacob's disease-affected and normal brain tissue. J Biol Chem (2003) 1.09
Taxanes inhibit human TLR4 signaling by binding to MD-2. FEBS Lett (2008) 1.09
Characterization of quercetin binding site on DNA gyrase. Biochem Biophys Res Commun (2003) 1.07
Green tea catechins inhibit bacterial DNA gyrase by interaction with its ATP binding site. J Med Chem (2007) 1.05
Similarities and specificities of fungal keratinolytic proteases: comparison of keratinases of Paecilomyces marquandii and Doratomyces microsporus to some known proteases. Appl Environ Microbiol (2005) 1.04
Curcumin binds to the alpha-helical intermediate and to the amyloid form of prion protein - a new mechanism for the inhibition of PrP(Sc) accumulation. J Neurochem (2007) 1.01
Structural origin of endotoxin neutralization and antimicrobial activity of a lactoferrin-based peptide. J Biol Chem (2005) 1.01
Nanoparticles isolated from blood: a reflection of vesiculability of blood cells during the isolation process. Int J Nanomedicine (2011) 1.01
The differential interaction of Brucella and ochrobactrum with innate immunity reveals traits related to the evolution of stealthy pathogens. PLoS One (2009) 1.01
The ectodomain of the Toll-like receptor 4 prevents constitutive receptor activation. J Biol Chem (2011) 0.99
The acyl group as the central element of the structural organization of antimicrobial lipopeptide. J Am Chem Soc (2007) 0.98
Identification of LPS-binding peptide fragment of MD-2, a toll-receptor accessory protein. Biochem Biophys Res Commun (2002) 0.96
Structural similarity between the hydrophobic fluorescent probe and lipid A as a ligand of MD-2. FASEB J (2006) 0.96
Novel roles of lysines 122, 125, and 58 in functional differences between human and murine MD-2. J Immunol (2009) 0.96
Expression, purification and structural studies of a short antimicrobial peptide. Biochim Biophys Acta (2008) 0.95
Alexidine and chlorhexidine bind to lipopolysaccharide and lipoteichoic acid and prevent cell activation by antibiotics. J Antimicrob Chemother (2008) 0.94
Structural features governing the activity of lactoferricin-derived peptides that act in synergy with antibiotics against Pseudomonas aeruginosa in vitro and in vivo. Antimicrob Agents Chemother (2010) 0.94
Functional activity of MD-2 polymorphic variant is significantly different in soluble and TLR4-bound forms: decreased endotoxin binding by G56R MD-2 and its rescue by TLR4 ectodomain. J Immunol (2008) 0.94
Free thiol group of MD-2 as the target for inhibition of the lipopolysaccharide-induced cell activation. J Biol Chem (2009) 0.93
Biophysical characterization of the interaction of Limulus polyphemus endotoxin neutralizing protein with lipopolysaccharide. Eur J Biochem (2004) 0.93
Comparative analysis of selected methods for the assessment of antimicrobial and membrane-permeabilizing activity: a case study for lactoferricin derived peptides. BMC Microbiol (2008) 0.92
The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists. J Biol Chem (2012) 0.92
Studies on lactoferricin-derived Escherichia coli membrane-active peptides reveal differences in the mechanism of N-acylated versus nonacylated peptides. J Biol Chem (2011) 0.92
De novo design of orthogonal peptide pairs forming parallel coiled-coil heterodimers. J Pept Sci (2010) 0.91
Influence of N-acylation of a peptide derived from human lactoferricin on membrane selectivity. Biochim Biophys Acta (2006) 0.91
Chemistry of lipid A: at the heart of innate immunity. Chemistry (2014) 0.91
What drives the binding of minor groove-directed ligands to DNA hairpins? Nucleic Acids Res (2007) 0.89
Tetracysteine-tagged prion protein allows discrimination between the native and converted forms. FEBS J (2010) 0.88
Therapeutic applications of nucleic acids as ligands for Toll-like receptors. Curr Opin Mol Ther (2009) 0.87
NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1β and neuronal toxicity. Cell Mol Life Sci (2012) 0.86
Interaction of the HIV-1 gp120 viral protein V3 loop with bacterial lipopolysaccharide: a pattern recognition inhibition. J Biol Chem (2011) 0.86
Postulates for validating TLR4 agonists. Eur J Immunol (2015) 0.85
Semiautomatic sequence-specific assignment of proteins based on the tertiary structure--the program st2nmr. J Comput Chem (2002) 0.85
Self-assembled bionanostructures: proteins following the lead of DNA nanostructures. J Nanobiotechnology (2014) 0.85
Chimeric flagellin as the self-adjuvanting antigen for the activation of immune response against Helicobacter pylori. Vaccine (2012) 0.85
Determination of the physiological 2:2 TLR5:flagellin activation stoichiometry revealed by the activity of a fusion receptor. Biochem Biophys Res Commun (2013) 0.84
Toll/interleukin-1 receptor domain dimers as the platform for activation and enhanced inhibition of Toll-like receptor signaling. J Biol Chem (2012) 0.84
MD-2 and Der p 2 - a tale of two cousins or distant relatives? J Endotoxin Res (2005) 0.84
Noninvasive high-throughput single-cell analysis of HIV protease activity using ratiometric flow cytometry. Sensors (Basel) (2013) 0.83
In silico discovery and biophysical evaluation of novel 5-(2-hydroxybenzylidene) rhodanine inhibitors of DNA gyrase B. Bioorg Med Chem (2012) 0.83
Tetraacylated lipid A and paclitaxel-selective activation of TLR4/MD-2 conferred through hydrophobic interactions. J Immunol (2014) 0.82
Suppression of TLR signaling by targeting TIR domain-containing proteins. Curr Protein Pept Sci (2012) 0.81
Production of recombinant antimicrobial peptides in bacteria. Methods Mol Biol (2010) 0.81
Different functional role of domain boundaries of Toll-like receptor 4. Biochem Biophys Res Commun (2009) 0.81
Conformationally constrained lipid A mimetics for exploration of structural basis of TLR4/MD-2 activation by lipopolysaccharide. ACS Chem Biol (2013) 0.81
The role of intermediary domain of MyD88 in cell activation and therapeutic inhibition of TLRs. J Immunol (2011) 0.81
New designed protein assemblies. Curr Opin Chem Biol (2013) 0.81
Functional self-assembling polypeptide bionanomaterials. Biochem Soc Trans (2012) 0.80
Disulfide mapping reveals the domain swapping as the crucial process of the structural conversion of prion protein. Prion (2011) 0.80
MARCKS as a negative regulator of lipopolysaccharide signaling. J Immunol (2012) 0.80
Comparison of backbone dynamics of monomeric and domain-swapped stefin A. Proteins (2004) 0.80
Prevention of microvesiculation by adhesion of buds to the mother cell membrane--a possible anticoagulant effect of healthy donor plasma. Autoimmun Rev (2007) 0.79
In silico fragment-based discovery of indolin-2-one analogues as potent DNA gyrase inhibitors. Bioorg Med Chem Lett (2005) 0.79
Mixed-valence Cu(II)/Cu(I) complex of quinolone ciprofloxacin isolated by a hydrothermal reaction in the presence of L-histidine: comparison of biological activities of various copper-ciprofloxacin compounds. J Inorg Biochem (2005) 0.79
Introduction of glutamines into the B2-H2 loop promotes prion protein conversion. Biochem Biophys Res Commun (2011) 0.78
Fluorescence microspectroscopy as a tool to study mechanism of nanoparticles delivery into living cancer cells. Biomed Opt Express (2011) 0.78
Expression of soluble versatile peroxidase of Bjerkandera adusta in Escherichia coli. Bioresour Technol (2008) 0.78
Delivery system for the enhanced efficiency of immunostimulatory nucleic acids. Innate Immun (2012) 0.77
TOPOFOLD, the designed modular biomolecular folds: polypeptide-based molecular origami nanostructures following the footsteps of DNA. Wiley Interdiscip Rev Nanomed Nanobiotechnol (2014) 0.77
Development of αGlcN(1↔1)αMan-based lipid A mimetics as a novel class of potent Toll-like receptor 4 agonists. J Med Chem (2014) 0.77
Interactions of archaeal chromatin proteins Alba1 and Alba2 with nucleic acids. PLoS One (2013) 0.77
Protein inhibitors form complexes with procathepsin L and augment cleavage of the propeptide. Arch Biochem Biophys (2003) 0.77
Modulation of CD14 and TLR4·MD-2 activities by a synthetic lipid A mimetic. Chembiochem (2013) 0.76
Effect of hydrophobic mutations in the H2-H3 subdomain of prion protein on stability and conversion in vitro and in vivo. PLoS One (2011) 0.76
Combination of antimicrobial and endotoxin-neutralizing activities of novel oleoylamines. Antimicrob Agents Chemother (2005) 0.76
Bleaching-corrected fluorescence microspectroscopy with nanometer peak position resolution. Opt Express (2013) 0.76
Trehalose- and glucose-derived glycoamphiphiles: small-molecule and nanoparticle Toll-like receptor 4 (TLR4) modulators. J Med Chem (2014) 0.76
Coexistence of probe conformations in lipid phases-a polarized fluorescence microspectroscopy study. Biophys J (2013) 0.75
Differences in Unfolding Energetics of CcdB Toxins From V. fischeri and E. coli. Acta Chim Slov (2012) 0.75
Preparation of chimeric genes without subcloning. Biotechniques (2004) 0.75
A DNA origami of slovenia in nano dimensions. Acta Chim Slov (2011) 0.75