The ectodomain of the Toll-like receptor 4 prevents constitutive receptor activation.

PubWeight™: 0.99‹?› | Rank: Top 15%

🔗 View Article (PMC 3123098)

Published in J Biol Chem on May 04, 2011

Authors

Gabriela Panter1, Roman Jerala

Author Affiliations

1: Department of Biotechnology, National Institute of Chemistry, University of Ljubljana, 1000 Ljubljana, Slovenia.

Articles citing this

Assembly and localization of Toll-like receptor signalling complexes. Nat Rev Immunol (2014) 1.48

A novel pathway for human endothelial cell activation by antiphospholipid/anti-β2 glycoprotein I antibodies. Blood (2011) 1.07

NMR studies of hexaacylated endotoxin bound to wild-type and F126A mutant MD-2 and MD-2·TLR4 ectodomain complexes. J Biol Chem (2012) 0.96

Isolated Toll-like receptor transmembrane domains are capable of oligomerization. PLoS One (2012) 0.91

Modular extracellular sensor architecture for engineering mammalian cell-based devices. ACS Synth Biol (2014) 0.86

MD-2 determinants of nickel and cobalt-mediated activation of human TLR4. PLoS One (2015) 0.84

Toll/interleukin-1 receptor domain dimers as the platform for activation and enhanced inhibition of Toll-like receptor signaling. J Biol Chem (2012) 0.84

CD14 mediates binding of high doses of LPS but is dispensable for TNF-α production. Mediators Inflamm (2013) 0.82

Activation of lymphoma-associated MyD88 mutations via allostery-induced TIR-domain oligomerization. Blood (2014) 0.82

Reviewing and identifying amino acids of human, murine, canine and equine TLR4 / MD-2 receptor complexes conferring endotoxic innate immunity activation by LPS/lipid A, or antagonistic effects by Eritoran, in contrast to species-dependent modulation by lipid IVa. Comput Struct Biotechnol J (2013) 0.82

SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation. Proc Natl Acad Sci U S A (2016) 0.82

Suppression of TLR signaling by targeting TIR domain-containing proteins. Curr Protein Pept Sci (2012) 0.81

The COP II adaptor protein TMED7 is required to initiate and mediate the delivery of TLR4 to the plasma membrane. Sci Signal (2014) 0.81

Cytokine Spatzle binds to the Drosophila immunoreceptor Toll with a neurotrophin-like specificity and couples receptor activation. Proc Natl Acad Sci U S A (2013) 0.79

Drugging Membrane Protein Interactions. Annu Rev Biomed Eng (2016) 0.78

Contributions of unique intracellular domains to switchlike biosensing by Toll-like receptor 4. J Biol Chem (2015) 0.76

Spatial structure of TLR4 transmembrane domain in bicelles provides the insight into the receptor activation mechanism. Sci Rep (2017) 0.75

Articles cited by this

Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science (1998) 37.15

Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nat Biotechnol (2004) 36.25

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature (1997) 23.92

Toll-like receptor control of the adaptive immune responses. Nat Immunol (2004) 19.15

CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science (1990) 17.86

Toll-like receptors in innate immunity. Int Immunol (2005) 12.24

TLR signaling. Cell Death Differ (2006) 9.24

MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med (1999) 9.23

The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature (2009) 8.99

MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell (1998) 8.73

Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol (2000) 7.78

Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. J Immunol (2002) 7.07

Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell (2007) 6.84

Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses. Science (2009) 6.07

Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4. J Exp Med (2002) 5.70

Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat Immunol (2002) 5.41

High mobility group box 1 protein interacts with multiple Toll-like receptors. Am J Physiol Cell Physiol (2005) 5.04

Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein. Nature (2008) 4.85

The extra domain A of fibronectin activates Toll-like receptor 4. J Biol Chem (2001) 4.74

Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2. Science (2002) 4.45

Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat Immunol (2005) 4.30

Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J Immunol (2001) 3.76

The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage. J Immunol (1988) 3.69

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9. Nat Immunol (2008) 3.61

The interface between innate and adaptive immunity. Nat Immunol (2004) 3.28

Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel. Nat Immunol (2010) 3.15

Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo. Genes Dev (1991) 2.98

Critical role for asparagine endopeptidase in endocytic Toll-like receptor signaling in dendritic cells. Immunity (2009) 2.86

Hyaluronan fragments stimulate endothelial recognition of injury through TLR4. J Biol Chem (2004) 2.81

Murine retroviruses activate B cells via interaction with toll-like receptor 4. Proc Natl Acad Sci U S A (2002) 2.70

Involvement of toll-like receptor 4 in innate immunity to respiratory syncytial virus. J Virol (2001) 2.70

Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells. J Biol Chem (2002) 2.66

Dimeric association and segmental variability in the structure of human CD4. Nature (1997) 2.35

Transfection of CD14 into 70Z/3 cells dramatically enhances the sensitivity to complexes of lipopolysaccharide (LPS) and LPS binding protein. J Exp Med (1992) 2.05

Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to Toll-like receptor 4. Proc Natl Acad Sci U S A (2001) 1.96

Activation of TLR2 and TLR4 by glycosylphosphatidylinositols derived from Toxoplasma gondii. J Immunol (2007) 1.95

MD-2 binds to bacterial lipopolysaccharide. J Biol Chem (2001) 1.91

Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors. J Biol Chem (2004) 1.85

Chlamydia pneumoniae and chlamydial heat shock protein 60 stimulate proliferation of human vascular smooth muscle cells via toll-like receptor 4 and p44/p42 mitogen-activated protein kinase activation. Circ Res (2001) 1.83

A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins. PLoS One (2007) 1.73

Crystal structure of CD14 and its implications for lipopolysaccharide signaling. J Biol Chem (2005) 1.70

The complete amino-acid sequence of hen ovalbumin. Eur J Biochem (1981) 1.66

Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor. Blood Cells Mol Dis (2000) 1.49

Conditional signaling by Toll-like receptor 4. FASEB J (2005) 1.42

Interleukin-8 up-regulation by neutrophil elastase is mediated by MyD88/IRAK/TRAF-6 in human bronchial epithelium. J Biol Chem (2001) 1.41

Neutrophil elastase up-regulates interleukin-8 via toll-like receptor 4. FEBS Lett (2003) 1.38

Specific high affinity interactions of monomeric endotoxin.protein complexes with Toll-like receptor 4 ectodomain. J Biol Chem (2006) 1.36

Multimerization and interaction of Toll and Spätzle in Drosophila. Proc Natl Acad Sci U S A (2004) 1.22

Integrin-nucleated Toll-like receptor (TLR) dimerization reveals subcellular targeting of TLRs and distinct mechanisms of TLR4 activation and signaling. FEBS Lett (2002) 1.16

The role of disulfide bonds in the assembly and function of MD-2. Proc Natl Acad Sci U S A (2003) 1.14

The 24 kDa N-terminal sub-domain of the DNA gyrase B protein binds coumarin drugs. Mol Microbiol (1994) 1.08

Cloning and modeling of the first nonmammalian CD4. J Immunol (1999) 1.07

FimH adhesin of type 1 fimbriae is a potent inducer of innate antimicrobial responses which requires TLR4 and type 1 interferon signalling. PLoS Pathog (2008) 1.06

Cutting edge: FimH adhesin of type 1 fimbriae is a novel TLR4 ligand. J Immunol (2008) 1.06

Ligand-receptor and receptor-receptor interactions act in concert to activate signaling in the Drosophila toll pathway. J Biol Chem (2005) 1.04

Cytoplasmic domain-mediated dimerizations of toll-like receptor 4 observed by beta-lactamase enzyme fragment complementation. J Biol Chem (2003) 1.03

Toll-like receptors (TLRs) and immune disorders. J Infect Chemother (2006) 0.95

Proinflammatory effects of pancreatic elastase are mediated through TLR4 and NF-kappaB. Biochem Biophys Res Commun (2004) 0.94

Molecular basis for lipopolysaccharide mimetic action of Taxol and flavolipin. J Endotoxin Res (2003) 0.94

Chlamydial heat shock protein 60 induces acute pulmonary inflammation in mice via the Toll-like receptor 4- and MyD88-dependent pathway. Infect Immun (2009) 0.89

Structure of toll-like receptors. Handb Exp Pharmacol (2008) 0.88

Coumermycin-induced dimerization of GyrB-containing fusion proteins. Methods Enzymol (2000) 0.87

Differential induction of gene promoter constructs by constitutively active human TLRs. Biochem Biophys Res Commun (2004) 0.86

The amino-terminal region of toll-like receptor 4 is essential for binding to MD-2 and receptor translocation to the cell surface. J Biol Chem (2004) 0.86

Toll-like receptor 4-MD-2 complex mediates the signal transduction induced by flavolipin, an amino acid-containing lipid unique to Flavobacterium meningosepticum. J Immunol (2002) 0.85

Different functional role of domain boundaries of Toll-like receptor 4. Biochem Biophys Res Commun (2009) 0.81

Irreversible self-assembly of ovalbumin into fibrils and the resulting network rheology. Int J Biol Macromol (2003) 0.80

Articles by these authors

Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines. J Immunol (2011) 1.83

The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes. PLoS One (2008) 1.70

Structural model of MD-2 and functional role of its basic amino acid clusters involved in cellular lipopolysaccharide recognition. J Biol Chem (2004) 1.48

Essential roles of hydrophobic residues in both MD-2 and toll-like receptor 4 in activation by endotoxin. J Biol Chem (2009) 1.38

Design of a single-chain polypeptide tetrahedron assembled from coiled-coil segments. Nat Chem Biol (2013) 1.32

Globular domain of the prion protein needs to be unlocked by domain swapping to support prion protein conversion. J Biol Chem (2011) 1.29

Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide. Biochem J (2005) 1.28

DNA-guided assembly of biosynthetic pathways promotes improved catalytic efficiency. Nucleic Acids Res (2011) 1.28

MD-2 as the target of curcumin in the inhibition of response to LPS. J Leukoc Biol (2007) 1.26

A second binding site for double-stranded RNA in TLR3 and consequences for interferon activation. Nat Struct Mol Biol (2008) 1.24

Enhancement of antibacterial and lipopolysaccharide binding activities of a human lactoferrin peptide fragment by the addition of acyl chain. J Antimicrob Chemother (2003) 1.24

The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition. PLoS Pathog (2012) 1.17

Toll-like receptor 4 activation in cancer progression and therapy. Clin Dev Immunol (2011) 1.14

Monoclonal antibody against a peptide of human prion protein discriminates between Creutzfeldt-Jacob's disease-affected and normal brain tissue. J Biol Chem (2003) 1.09

Taxanes inhibit human TLR4 signaling by binding to MD-2. FEBS Lett (2008) 1.09

Characterization of quercetin binding site on DNA gyrase. Biochem Biophys Res Commun (2003) 1.07

Green tea catechins inhibit bacterial DNA gyrase by interaction with its ATP binding site. J Med Chem (2007) 1.05

Similarities and specificities of fungal keratinolytic proteases: comparison of keratinases of Paecilomyces marquandii and Doratomyces microsporus to some known proteases. Appl Environ Microbiol (2005) 1.04

Structural origin of endotoxin neutralization and antimicrobial activity of a lactoferrin-based peptide. J Biol Chem (2005) 1.01

Curcumin binds to the alpha-helical intermediate and to the amyloid form of prion protein - a new mechanism for the inhibition of PrP(Sc) accumulation. J Neurochem (2007) 1.01

Nanoparticles isolated from blood: a reflection of vesiculability of blood cells during the isolation process. Int J Nanomedicine (2011) 1.01

The differential interaction of Brucella and ochrobactrum with innate immunity reveals traits related to the evolution of stealthy pathogens. PLoS One (2009) 1.01

The acyl group as the central element of the structural organization of antimicrobial lipopeptide. J Am Chem Soc (2007) 0.98

Identification of LPS-binding peptide fragment of MD-2, a toll-receptor accessory protein. Biochem Biophys Res Commun (2002) 0.96

Structural similarity between the hydrophobic fluorescent probe and lipid A as a ligand of MD-2. FASEB J (2006) 0.96

Novel roles of lysines 122, 125, and 58 in functional differences between human and murine MD-2. J Immunol (2009) 0.96

Expression, purification and structural studies of a short antimicrobial peptide. Biochim Biophys Acta (2008) 0.95

Alexidine and chlorhexidine bind to lipopolysaccharide and lipoteichoic acid and prevent cell activation by antibiotics. J Antimicrob Chemother (2008) 0.94

Structural features governing the activity of lactoferricin-derived peptides that act in synergy with antibiotics against Pseudomonas aeruginosa in vitro and in vivo. Antimicrob Agents Chemother (2010) 0.94

Functional activity of MD-2 polymorphic variant is significantly different in soluble and TLR4-bound forms: decreased endotoxin binding by G56R MD-2 and its rescue by TLR4 ectodomain. J Immunol (2008) 0.94

Biophysical characterization of the interaction of Limulus polyphemus endotoxin neutralizing protein with lipopolysaccharide. Eur J Biochem (2004) 0.93

Free thiol group of MD-2 as the target for inhibition of the lipopolysaccharide-induced cell activation. J Biol Chem (2009) 0.93

Comparative analysis of selected methods for the assessment of antimicrobial and membrane-permeabilizing activity: a case study for lactoferricin derived peptides. BMC Microbiol (2008) 0.92

The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists. J Biol Chem (2012) 0.92

Studies on lactoferricin-derived Escherichia coli membrane-active peptides reveal differences in the mechanism of N-acylated versus nonacylated peptides. J Biol Chem (2011) 0.92

De novo design of orthogonal peptide pairs forming parallel coiled-coil heterodimers. J Pept Sci (2010) 0.91

Influence of N-acylation of a peptide derived from human lactoferricin on membrane selectivity. Biochim Biophys Acta (2006) 0.91

Chemistry of lipid A: at the heart of innate immunity. Chemistry (2014) 0.91

Tetracysteine-tagged prion protein allows discrimination between the native and converted forms. FEBS J (2010) 0.88

Therapeutic applications of nucleic acids as ligands for Toll-like receptors. Curr Opin Mol Ther (2009) 0.87

NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1β and neuronal toxicity. Cell Mol Life Sci (2012) 0.86

Interaction of the HIV-1 gp120 viral protein V3 loop with bacterial lipopolysaccharide: a pattern recognition inhibition. J Biol Chem (2011) 0.86

Postulates for validating TLR4 agonists. Eur J Immunol (2015) 0.85

Chimeric flagellin as the self-adjuvanting antigen for the activation of immune response against Helicobacter pylori. Vaccine (2012) 0.85

Semiautomatic sequence-specific assignment of proteins based on the tertiary structure--the program st2nmr. J Comput Chem (2002) 0.85

Self-assembled bionanostructures: proteins following the lead of DNA nanostructures. J Nanobiotechnology (2014) 0.85

Determination of the physiological 2:2 TLR5:flagellin activation stoichiometry revealed by the activity of a fusion receptor. Biochem Biophys Res Commun (2013) 0.84

Toll/interleukin-1 receptor domain dimers as the platform for activation and enhanced inhibition of Toll-like receptor signaling. J Biol Chem (2012) 0.84

MD-2 and Der p 2 - a tale of two cousins or distant relatives? J Endotoxin Res (2005) 0.84

In silico discovery and biophysical evaluation of novel 5-(2-hydroxybenzylidene) rhodanine inhibitors of DNA gyrase B. Bioorg Med Chem (2012) 0.83

Noninvasive high-throughput single-cell analysis of HIV protease activity using ratiometric flow cytometry. Sensors (Basel) (2013) 0.83

Tetraacylated lipid A and paclitaxel-selective activation of TLR4/MD-2 conferred through hydrophobic interactions. J Immunol (2014) 0.82

Suppression of TLR signaling by targeting TIR domain-containing proteins. Curr Protein Pept Sci (2012) 0.81

Different functional role of domain boundaries of Toll-like receptor 4. Biochem Biophys Res Commun (2009) 0.81

Conformationally constrained lipid A mimetics for exploration of structural basis of TLR4/MD-2 activation by lipopolysaccharide. ACS Chem Biol (2013) 0.81

The role of intermediary domain of MyD88 in cell activation and therapeutic inhibition of TLRs. J Immunol (2011) 0.81

New designed protein assemblies. Curr Opin Chem Biol (2013) 0.81

Production of recombinant antimicrobial peptides in bacteria. Methods Mol Biol (2010) 0.81

Functional self-assembling polypeptide bionanomaterials. Biochem Soc Trans (2012) 0.80

Comparison of backbone dynamics of monomeric and domain-swapped stefin A. Proteins (2004) 0.80

Disulfide mapping reveals the domain swapping as the crucial process of the structural conversion of prion protein. Prion (2011) 0.80

MARCKS as a negative regulator of lipopolysaccharide signaling. J Immunol (2012) 0.80

Mixed-valence Cu(II)/Cu(I) complex of quinolone ciprofloxacin isolated by a hydrothermal reaction in the presence of L-histidine: comparison of biological activities of various copper-ciprofloxacin compounds. J Inorg Biochem (2005) 0.79

In silico fragment-based discovery of indolin-2-one analogues as potent DNA gyrase inhibitors. Bioorg Med Chem Lett (2005) 0.79

Prevention of microvesiculation by adhesion of buds to the mother cell membrane--a possible anticoagulant effect of healthy donor plasma. Autoimmun Rev (2007) 0.79

Introduction of glutamines into the B2-H2 loop promotes prion protein conversion. Biochem Biophys Res Commun (2011) 0.78

Expression of soluble versatile peroxidase of Bjerkandera adusta in Escherichia coli. Bioresour Technol (2008) 0.78

Interactions of archaeal chromatin proteins Alba1 and Alba2 with nucleic acids. PLoS One (2013) 0.77

Protein inhibitors form complexes with procathepsin L and augment cleavage of the propeptide. Arch Biochem Biophys (2003) 0.77

Development of αGlcN(1↔1)αMan-based lipid A mimetics as a novel class of potent Toll-like receptor 4 agonists. J Med Chem (2014) 0.77

TOPOFOLD, the designed modular biomolecular folds: polypeptide-based molecular origami nanostructures following the footsteps of DNA. Wiley Interdiscip Rev Nanomed Nanobiotechnol (2014) 0.77

Delivery system for the enhanced efficiency of immunostimulatory nucleic acids. Innate Immun (2012) 0.77

Effect of hydrophobic mutations in the H2-H3 subdomain of prion protein on stability and conversion in vitro and in vivo. PLoS One (2011) 0.76

Combination of antimicrobial and endotoxin-neutralizing activities of novel oleoylamines. Antimicrob Agents Chemother (2005) 0.76

Modulation of CD14 and TLR4·MD-2 activities by a synthetic lipid A mimetic. Chembiochem (2013) 0.76

Trehalose- and glucose-derived glycoamphiphiles: small-molecule and nanoparticle Toll-like receptor 4 (TLR4) modulators. J Med Chem (2014) 0.76

A DNA origami of slovenia in nano dimensions. Acta Chim Slov (2011) 0.75

Preparation of chimeric genes without subcloning. Biotechniques (2004) 0.75

Modulation of coiled-coil dimer stability through surface residues while preserving pairing specificity. J Am Chem Soc (2017) 0.75