Metformin-induced ablation of microRNA 21-5p releases Sestrin-1 and CAB39L antitumoral activities.

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Published in Cell Discov on July 04, 2017

Authors

Claudio Pulito1, Federica Mori1, Andrea Sacconi2, Frauke Goeman2, Maria Ferraiuolo1, Patrizia Pasanisi3, Carlo Campagnoli4, Franco Berrino3, Maurizio Fanciulli5, Rebecca J Ford6, Massimo Levrero7, Natalia Pediconi8, Ludovica Ciuffreda9, Michele Milella9, Gregory R Steinberg6, Mario Cioce2, Paola Muti10, Sabrina Strano1,10, Giovanni Blandino2,10

Author Affiliations

1: Molecular Chemoprevention Unit, Italian National Cancer Institute 'Regina Elena', Rome, Italy.
2: Oncogenomic and Epigenetic Unit, Italian National Cancer Institute 'Regina Elena', Rome, Italy.
3: Department of Preventive & Predictive Medicine, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.
4: Unit of Endocrinological Gynecology, Ospedale Sant'Anna di Torino, Turin, Italy.
5: SAFU, 'Regina Elena' National Cancer Institute, Rome, Italy.
6: Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
7: Epigénétique et Épigénomique des Carcinomes Hépathocellulaires Viro-Induits du Centre de Recherche en Cancérologie de Lyon, Lyon, France.
8: Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
9: Division of Medical Oncology A, Italian National Cancer Institute 'Regina Elena', Rome, Italy.
10: Department of Oncology, Juravinski Cancer Center, McMaster University, Hamilton, Ontario, Canada.

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