Published in Cancer J on May 31, 2012
MicroRNA silencing for cancer therapy targeted to the tumour microenvironment. Nature (2014) 2.70
miR-26a suppresses tumor growth and metastasis by targeting FGF9 in gastric cancer. PLoS One (2013) 1.09
Canonical and non-canonical barriers facing antimiR cancer therapeutics. Curr Med Chem (2013) 0.98
miR-193a-3p regulates the multi-drug resistance of bladder cancer by targeting the LOXL4 gene and the oxidative stress pathway. Mol Cancer (2014) 0.95
MicroRNAs in Cancer Biology and Therapy: Current Status and Perspectives. Genes Dis (2014) 0.94
Role of microRNA profile modifications in hepatitis C virus-related mixed cryoglobulinemia. PLoS One (2013) 0.91
MicroRNA and Epigenetics: Diagnostic and Therapeutic Opportunities. Curr Pathobiol Rep (2013) 0.86
MicroRNA and HER2-overexpressing cancer. Microrna (2013) 0.83
MicroRNAs as regulators of apoptosis mechanisms in cancer. Clujul Med (2016) 0.81
The miR-199a/Brm/EGR1 axis is a determinant of anchorage-independent growth in epithelial tumor cell lines. Sci Rep (2015) 0.81
MiR-493 suppresses the proliferation and invasion of gastric cancer cells by targeting RhoC. Iran J Basic Med Sci (2015) 0.78
MicroRNA-mediated transformation by the Kaposi's sarcoma-associated herpesvirus Kaposin locus. J Virol (2014) 0.78
Therapeutic strategy with artificially-designed i-lncRNA targeting multiple oncogenic microRNAs exhibits effective antitumor activity in diffuse large B-cell lymphoma. Oncotarget (2016) 0.77
MicroRNAs Involved in Anti-Tumour Immunity. Int J Mol Sci (2013) 0.77
Cancer prevention as biomodulation: targeting the initiating stimulus and secondary adaptations. Ann N Y Acad Sci (2012) 0.76
Investigation of MicroRNA-21 Expression Levels in Serum and Stool as a Potential Non-Invasive Biomarker for Diagnosis of Colorectal Cancer. Iran Biomed J (2016) 0.75
Metformin-induced ablation of microRNA 21-5p releases Sestrin-1 and CAB39L antitumoral activities. Cell Discov (2017) 0.75
The hallmarks of cancer. Cell (2000) 113.05
Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer (2006) 46.47
A microRNA polycistron as a potential human oncogene. Nature (2005) 40.21
A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A (2006) 40.09
Silencing of microRNAs in vivo with 'antagomirs'. Nature (2005) 32.56
Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A (2002) 32.26
c-Myc-regulated microRNAs modulate E2F1 expression. Nature (2005) 31.81
Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A (2004) 28.29
Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA. Science (2005) 16.84
Cancer. Addiction to oncogenes--the Achilles heal of cancer. Science (2002) 14.20
Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Proc Natl Acad Sci U S A (2005) 12.96
LNA-mediated microRNA silencing in non-human primates. Nature (2008) 11.45
microRNAs: tiny regulators with great potential. Cell (2001) 11.23
MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene (2007) 10.79
microRNA target predictions in animals. Nat Genet (2006) 10.76
Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice. Proc Natl Acad Sci U S A (2006) 10.65
miR-21-mediated tumor growth. Oncogene (2006) 9.90
MicroRNAs in Cancer. Annu Rev Med (2009) 9.37
Reversible tumorigenesis by MYC in hematopoietic lineages. Mol Cell (1999) 8.03
miRiad roles for the miR-17-92 cluster in development and disease. Cell (2008) 8.02
Progress and problems with the use of viral vectors for gene therapy. Nat Rev Genet (2003) 6.95
Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells. Proc Natl Acad Sci U S A (2005) 5.88
OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma. Nature (2010) 5.73
miR-21: a small multi-faceted RNA. J Cell Mol Med (2009) 5.59
An E2F/miR-20a autoregulatory feedback loop. J Biol Chem (2006) 5.20
Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy. Nat Rev Cancer (2011) 5.12
Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. Genes Dev (1994) 4.93
Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model. Nat Biotechnol (2010) 4.80
MicroRNA-125b is a novel negative regulator of p53. Genes Dev (2009) 4.43
Mechanisms and optimization of in vivo delivery of lipophilic siRNAs. Nat Biotechnol (2007) 4.02
A parsimonious model for gene regulation by miRNAs. Science (2011) 3.79
miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice. J Exp Med (2011) 3.78
MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis. Proc Natl Acad Sci U S A (2008) 3.77
Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21. Cancer Cell (2010) 3.72
MicroRNAs acting in a double-negative feedback loop to control a neuronal cell fate decision. Proc Natl Acad Sci U S A (2005) 3.69
Antagomir-17-5p abolishes the growth of therapy-resistant neuroblastoma through p21 and BIM. PLoS One (2008) 3.68
A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation. J Cell Biol (2008) 3.02
MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis. Nat Med (2010) 2.99
MicroRNA sponges: progress and possibilities. RNA (2010) 2.96
Up-regulated microRNA-143 transcribed by nuclear factor kappa B enhances hepatocarcinoma metastasis by repressing fibronectin expression. Hepatology (2009) 2.96
MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas. Cancer Res (2007) 2.90
let-7 regulates Dicer expression and constitutes a negative feedback loop. Carcinogenesis (2008) 2.75
miR-155: on the crosstalk between inflammation and cancer. Int Rev Immunol (2009) 2.64
Vectors expressing efficient RNA decoys achieve the long-term suppression of specific microRNA activity in mammalian cells. Nucleic Acids Res (2009) 2.52
Enhanced permeability and retention of macromolecular drugs in solid tumors: a royal gate for targeted anticancer nanomedicines. J Drug Target (2007) 2.50
Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia. Blood (2009) 2.26
MicroRNA regulation of a cancer network: consequences of the feedback loops involving miR-17-92, E2F, and Myc. Proc Natl Acad Sci U S A (2008) 2.24
miR-125b is methylated and functions as a tumor suppressor by regulating the ETS1 proto-oncogene in human invasive breast cancer. Cancer Res (2011) 2.22
Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines. Cell Host Microbe (2011) 2.13
Inhibition of microRNA function by antimiR oligonucleotides. Silence (2012) 2.02
MiR-21 induced angiogenesis through AKT and ERK activation and HIF-1α expression. PLoS One (2011) 1.90
The utility of LNA in microRNA-based cancer diagnostics and therapeutics. Semin Cancer Biol (2008) 1.84
Virally induced cellular microRNA miR-155 plays a key role in B-cell immortalization by Epstein-Barr virus. J Virol (2010) 1.83
Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155. Nat Med (2011) 1.79
Onco-miR-155 targets SHIP1 to promote TNFalpha-dependent growth of B cell lymphomas. EMBO Mol Med (2009) 1.73
Gene therapy finds its niche. Nat Biotechnol (2011) 1.70
Down-regulation of BRCA1 expression by miR-146a and miR-146b-5p in triple negative sporadic breast cancers. EMBO Mol Med (2011) 1.68
Knockdown of miR-21 in human breast cancer cell lines inhibits proliferation, in vitro migration and in vivo tumor growth. Breast Cancer Res (2011) 1.64
Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis. Cancer Cell (2011) 1.63
Oncogene addiction versus oncogene amnesia: perhaps more than just a bad habit? Cancer Res (2008) 1.58
Non-viral is superior to viral gene delivery. J Control Release (2007) 1.54
miR-21: an oncomir on strike in prostate cancer. Mol Cancer (2010) 1.54
Emerging roles of microRNAs as molecular switches in the integrated circuit of the cancer cell. RNA (2009) 1.48
Is miR-29 an oncogene or tumor suppressor in CLL? Oncotarget (2010) 1.46
Chemical modification and design of anti-miRNA oligonucleotides. Gene Ther (2011) 1.36
miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma. Nat Med (2010) 1.35
Expression and function of micro-RNAs in immune cells during normal or disease state. Int J Med Sci (2008) 1.30
Upregulation of miR-21 by Ras in vivo and its role in tumor growth. Oncogene (2010) 1.25
Epstein-Barr virus-mediated dysregulation of human microRNA expression. Cell Cycle (2008) 1.25
A single anti-microRNA antisense oligodeoxyribonucleotide (AMO) targeting multiple microRNAs offers an improved approach for microRNA interference. Nucleic Acids Res (2009) 1.23
Identification of small molecules that suppress microRNA function and reverse tumorigenesis. J Biol Chem (2010) 1.19
Targeted delivery of antisense inhibitor of miRNA for antiangiogenesis therapy using cRGD-functionalized nanoparticles. Mol Pharm (2010) 1.07
MicroRNA silencing of tumor suppressor DLC-1 promotes efficient hepatitis C virus replication in primary human hepatocytes. Hepatology (2010) 1.07
Silencing microRNA by interfering nanoparticles in mice. Nucleic Acids Res (2011) 1.02
Cooperative control of tumor suppressor genes by a network of oncogenic microRNAs. Cell Cycle (2011) 0.99
Human T cell leukemia virus type 1 (HTLV-1) and oncogene or oncomiR addiction? Oncotarget (2010) 0.87
Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer (2006) 46.47
RAS is regulated by the let-7 microRNA family. Cell (2005) 30.24
Small non-coding RNAs in animal development. Nat Rev Mol Cell Biol (2008) 12.35
Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science (2010) 9.78
The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res (2007) 9.32
The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3'UTR. Genes Dev (2004) 8.42
The C elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target. Dev Cell (2003) 6.74
The let-7 family of microRNAs. Trends Cell Biol (2008) 6.24
OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma. Nature (2010) 5.73
Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy. Nat Rev Cancer (2011) 5.12
A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk. Cancer Res (2008) 5.05
The let-7 microRNA reduces tumor growth in mouse models of lung cancer. Cell Cycle (2008) 4.95
let-7 microRNAs in development, stem cells and cancer. Trends Mol Med (2008) 4.29
The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter. Dev Biol (2003) 3.92
MicroRNAs as potential agents to alter resistance to cytotoxic anticancer therapy. Cancer Res (2007) 3.68
Micro-RNAs: small is plentiful. J Cell Biol (2002) 2.95
The temporal patterning microRNA let-7 regulates several transcription factors at the larval to adult transition in C. elegans. Dev Cell (2005) 2.81
Dynamic expression of small non-coding RNAs, including novel microRNAs and piRNAs/21U-RNAs, during Caenorhabditis elegans development. Genome Biol (2009) 2.81
microRNAs and cancer: an overview. Cell Cycle (2008) 2.80
Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice. Mol Ther (2011) 2.75
Architecture of a validated microRNA::target interaction. Chem Biol (2004) 2.36
The evolution of animal microRNA function. Curr Opin Genet Dev (2007) 2.22
A KRAS-variant in ovarian cancer acts as a genetic marker of cancer risk. Cancer Res (2010) 2.15
Reciprocal expression of lin-41 and the microRNAs let-7 and mir-125 during mouse embryogenesis. Dev Dyn (2005) 2.14
miRNA-34 prevents cancer initiation and progression in a therapeutically resistant K-ras and p53-induced mouse model of lung adenocarcinoma. Cancer Res (2012) 2.13
An elegant miRror: microRNAs in stem cells, developmental timing and cancer. Chromosoma (2009) 1.99
MicroRNA signatures differentiate melanoma subtypes. Cell Cycle (2011) 1.99
MicroRNAs both promote and antagonize longevity in C. elegans. Curr Biol (2010) 1.99
Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma. Proc Natl Acad Sci U S A (2012) 1.91
microRNAs: small molecules with big roles - C. elegans to human cancer. Biol Cell (2008) 1.82
MicroRNA in cancer prognosis. N Engl J Med (2008) 1.66
Rare BRCA1 haplotypes including 3'UTR SNPs associated with breast cancer risk. Cell Cycle (2011) 1.64
FGF regulates TGF-β signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression. Cell Rep (2012) 1.63
MicroRNAs and their roles in aging. J Cell Sci (2012) 1.60
The role of microRNAs in cancer. Yale J Biol Med (2006) 1.54
C. elegans sym-1 is a downstream target of the hunchback-like-1 developmental timing transcription factor. Cell Cycle (2009) 1.50
Inhibition of hypoxia-induced miR-155 radiosensitizes hypoxic lung cancer cells. Cancer Biol Ther (2011) 1.50
kin-19/casein kinase Iα has dual functions in regulating asymmetric division and terminal differentiation in C. elegans epidermal stem cells. Cell Cycle (2010) 1.49
The Caenorhabditis elegans pumilio homolog, puf-9, is required for the 3'UTR-mediated repression of the let-7 microRNA target gene, hbl-1. Dev Biol (2007) 1.46
MicroRNA predictors of longevity in Caenorhabditis elegans. PLoS Genet (2011) 1.39
The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans. Dev Biol (2008) 1.36
The let-7 microRNA target gene, Mlin41/Trim71 is required for mouse embryonic survival and neural tube closure. Cell Cycle (2008) 1.32
Age-associated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans. RNA (2011) 1.31
MicroRNAs in the ionizing radiation response and in radiotherapy. Curr Opin Genet Dev (2013) 1.30
Longevity and stress in Caenorhabditis elegans. Aging (Albany NY) (2011) 1.28
miRNA modulation of the cellular stress response. Future Oncol (2008) 1.25
Epstein-Barr virus-mediated dysregulation of human microRNA expression. Cell Cycle (2008) 1.25
MicroRNA control of lifespan and metabolism. Cell Cycle (2006) 1.20
Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans. PLoS Biol (2013) 1.18
A truth serum for cancer--microRNAs have major potential as cancer biomarkers. Cell Res (2008) 1.16
Developmental timing in C. elegans is regulated by kin-20 and tim-1, homologs of core circadian clock genes. Dev Cell (2005) 1.11
MicroRNAs in mutagenesis, genomic instability, and DNA repair. Semin Oncol (2011) 1.09
microRNA-mediated silencing inside P-bodies. RNA Biol (2006) 1.08
The let-7 microRNA interfaces extensively with the translation machinery to regulate cell differentiation. Cell Cycle (2008) 1.07
Combinatorial Action of MicroRNAs let-7 and miR-34 Effectively Synergizes with Erlotinib to Suppress Non-small Cell Lung Cancer Cell Proliferation. Cell Cycle (2015) 1.05
A developmental timing switch promotes axon outgrowth independent of known guidance receptors. PLoS Genet (2010) 1.04
Inhibiting microRNA function in vivo. Nat Methods (2009) 1.04
Identification of specific let-7 microRNA binding complexes in Caenorhabditis elegans. RNA (2008) 1.02
Developmental biomarkers of aging in Caenorhabditis elegans. Dev Dyn (2010) 1.02
Transcription of the C. elegans let-7 microRNA is temporally regulated by one of its targets, hbl-1. Dev Biol (2009) 1.02
Potential microRNA therapies targeting Ras, NFkappaB and p53 signaling. Curr Opin Mol Ther (2010) 1.01
Canonical and non-canonical barriers facing antimiR cancer therapeutics. Curr Med Chem (2013) 0.98
The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition. Dev Biol (2010) 0.97
Transcriptional control of microRNA expression in C. elegans: promoting better understanding. RNA Biol (2009) 0.94
Ageing and the small, non-coding RNA world. Ageing Res Rev (2012) 0.93
Biases and errors on allele frequency estimation and disease association tests of next-generation sequencing of pooled samples. Genet Epidemiol (2012) 0.93
MicroRNA therapeutics in preclinical cancer models. Lancet Oncol (2011) 0.93
The age of high-throughput microRNA profiling. Nat Methods (2004) 0.92
Ribosomal protein RPS-14 modulates let-7 microRNA function in Caenorhabditis elegans. Dev Biol (2009) 0.90
And now introducing mammalian mirtrons. Dev Cell (2007) 0.87
Micromanagement: a role for microRNAs in mRNA stability. ACS Chem Biol (2006) 0.87
Estrogen withdrawal, increased breast cancer risk and the KRAS-variant. Cell Cycle (2015) 0.86
C. elegans microRNAs. WormBook (2005) 0.85
KRAS alleles: the LCS6 3'UTR variant and KRAS coding sequence mutations in the NCI-60 panel. Cell Cycle (2012) 0.84
The POU transcription factor UNC-86 controls the timing and ventral guidance of Caenorhabditis elegans axon growth. Dev Dyn (2011) 0.83
Joint analysis of expression profiles from multiple cancers improves the identification of microRNA-gene interactions. Bioinformatics (2013) 0.82
siRNA. A guide for RNA silencing. Chem Biol (2002) 0.81
MicroRNAs and cancer: a meeting summary of the eponymous Keystone Conference. Epigenetics (2010) 0.81
A 'pivotal' new rule for microRNA-mRNA interactions. Nat Struct Mol Biol (2012) 0.80
Stem cells: Big roles for small RNAs. Nature (2010) 0.80
The Inescapable Influence of Noncoding RNAs in Cancer. Cancer Res (2015) 0.79
Transcriptional (dys)regulation and aging in Caenorhabditis elegans. Genome Biol (2008) 0.79
Cigarette-Smoke-Induced Dysregulation of MicroRNA Expression and Its Role in Lung Carcinogenesis. Pulm Med (2011) 0.79
KRAS rs61764370 in Epithelial Ovarian Cancer-Letter. Clin Cancer Res (2011) 0.78
Arresting the Culprit: Targeted Antagomir Delivery to Sequester Oncogenic miR-221 in HCC. Mol Ther Nucleic Acids (2012) 0.78
MiR-33 connects cholesterol to the cell cycle. Cell Cycle (2012) 0.78
Targeting noncoding RNAs in disease. J Clin Invest (2017) 0.78
Small RNAs deliver a blow to ovarian cancer. Cancer Discov (2013) 0.77
Temporal and spatial patterning of an organ by a single transcription factor. Genome Biol (2005) 0.77
MicroRNAs circulate around Alzheimer's disease. Genome Biol (2013) 0.75
MicroRNAs micromanage themselves. Circ Res (2012) 0.75
Robust and specific inhibition of microRNAs in Caenorhabditis elegans. J Biol (2010) 0.75