Published in PLoS One on July 21, 2017
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HTRA1 promoter polymorphism in wet age-related macular degeneration. Science (2006) 7.12
A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration. Science (2006) 5.67
PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest (2004) 5.29
The HtrA family of proteases: implications for protein composition and cell fate. Mol Cell (2002) 3.77
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HTRA proteases: regulated proteolysis in protein quality control. Nat Rev Mol Cell Biol (2011) 2.01
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The role of human HtrA1 in arthritic disease. J Biol Chem (2005) 1.91
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A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. Stem Cells Dev (2009) 1.87
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Implications of the serine protease HtrA1 in amyloid precursor protein processing. Proc Natl Acad Sci U S A (2005) 1.47
A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer. Oncogene (2004) 1.47
Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice. Proc Natl Acad Sci U S A (2011) 1.45
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Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis. Bone (2005) 1.23
Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling. Proc Natl Acad Sci U S A (2014) 1.19
Slow and continuous application of human recombinant bone morphogenetic protein via biodegradable poly(lactide-co-glycolide) foamspheres. Int J Oral Maxillofac Surg (2002) 1.17
HtrA1-dependent proteolysis of TGF-beta controls both neuronal maturation and developmental survival. Cell Death Differ (2008) 1.13
Serine protease HtrA1 associates with microtubules and inhibits cell migration. Mol Cell Biol (2009) 1.12
Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-β1 via cleavage of proTGF-β1. Hum Mol Genet (2011) 1.08
Serine proteases HTRA1 and HTRA3 are down-regulated with increasing grades of human endometrial cancer. Gynecol Oncol (2006) 1.07
HtrA1 inhibits mineral deposition by osteoblasts: requirement for the protease and PDZ domains. J Biol Chem (2007) 1.03
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Detrimental role for human high temperature requirement serine protease A1 (HTRA1) in the pathogenesis of intervertebral disc (IVD) degeneration. J Biol Chem (2012) 0.99
A missense HTRA1 mutation expands CARASIL syndrome to the Caucasian population. Neurology (2010) 0.98
Structural and functional analysis of HtrA1 and its subdomains. Structure (2012) 0.96
Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates. J Biol Chem (2012) 0.92
Serine protease HTRA1 antagonizes transforming growth factor-β signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation. PLoS One (2013) 0.92
Influence of defective bone marrow osteogenesis on fracture repair in an experimental model of senile osteoporosis. J Orthop Res (2010) 0.91
The serine protease HtrA1 specifically interacts and degrades the tuberous sclerosis complex 2 protein. Mol Cancer Res (2010) 0.90
The convergence of fracture repair and stem cells: interplay of genes, aging, environmental factors and disease. J Bone Miner Res (2014) 0.89
BMP signaling in mesenchymal stem cell differentiation and bone formation. J Biomed Sci Eng (2013) 0.89
PPARγ silencing enhances osteogenic differentiation of human adipose-derived mesenchymal stem cells. J Cell Mol Med (2013) 0.88
The emerging roles of HTRA1 in musculoskeletal disease. Am J Pathol (2013) 0.87
Fixation compliance in a mouse osteotomy model induces two different processes of bone healing but does not lead to delayed union. J Biomech (2009) 0.87
HtrA1 is a novel antagonist controlling fibroblast growth factor (FGF) signaling via cleavage of FGF8. Mol Cell Biol (2012) 0.86
HtrA1 is induced by oxidative stress and enhances cell senescence through p38 MAPK pathway. Exp Eye Res (2013) 0.84
HtrA1 is upregulated during RANKL-induced osteoclastogenesis, and negatively regulates osteoblast differentiation and BMP2-induced Smad1/5/8, ERK and p38 phosphorylation. FEBS Lett (2013) 0.83
The fate of soft callus chondrocytes during long bone fracture repair. J Orthop Res (2003) 0.81
Serum HtrA1 is differentially regulated between early-onset and late-onset preeclampsia. Placenta (2015) 0.79
Effects of In Utero Thyroxine Exposure on Murine Cranial Suture Growth. PLoS One (2016) 0.78
Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains. PLoS One (2015) 0.78
HtrA1: Its future potential as a novel biomarker for cancer. Oncol Rep (2015) 0.78
Novel Function of Serine Protease HTRA1 in Inhibiting Adipogenic Differentiation of Human Mesenchymal Stem Cells via MAP Kinase-Mediated MMP Upregulation. Stem Cells (2016) 0.78
Epigenetic silencing of serine protease HTRA1 drives polyploidy. BMC Cancer (2016) 0.77
Inhibition of cell proliferation and migration after HTRA1 knockdown in retinal pigment epithelial cells. Graefes Arch Clin Exp Ophthalmol (2014) 0.77
Abnormal development of placenta in HtrA1-deficient mice. Dev Biol (2014) 0.76
Association of frailty with the serine protease HtrA1 in older adults. Exp Gerontol (2016) 0.76
Loss-of-Function of HtrA1 Abrogates All-Trans Retinoic Acid-Induced Osteogenic Differentiation of Mouse Adipose-Derived Stromal Cells Through Deficiencies in p70S6K Activation. Stem Cells Dev (2016) 0.76
HtrA1 may regulate the osteogenic differentiation of human periodontal ligament cells by TGF-β1. J Mol Histol (2015) 0.76
A novel in vivo vascular imaging approach for hierarchical quantification of vasculature using contrast enhanced micro-computed tomography. PLoS One (2014) 0.90
Preparation and osteogenic differentiation of scaffold-free mouse adipose-derived stromal cell microtissue spheroids (ASC-MT). Curr Protoc Stem Cell Biol (2013) 0.78
Novel Function of Serine Protease HTRA1 in Inhibiting Adipogenic Differentiation of Human Mesenchymal Stem Cells via MAP Kinase-Mediated MMP Upregulation. Stem Cells (2016) 0.78