Published in Bone on September 01, 2005
Proteases involved in cartilage matrix degradation in osteoarthritis. Biochim Biophys Acta (2011) 1.73
NFATc1 and NFATc2 repress spontaneous osteoarthritis. Proc Natl Acad Sci U S A (2013) 1.61
Attenuation of osteoarthritis progression by reduction of discoidin domain receptor 2 in mice. Arthritis Rheum (2010) 1.39
Role of HTRA1, a serine protease, in the progression of articular cartilage degeneration. Histol Histopathol (2010) 1.24
Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo. J Biol Chem (2009) 1.17
Serine protease HtrA1 associates with microtubules and inhibits cell migration. Mol Cell Biol (2009) 1.12
High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-β family member growth differentiation factor 6. J Biol Chem (2011) 1.01
Composition and proteolytic processing of corneal deposits associated with mutations in the TGFBI gene. Exp Eye Res (2011) 0.99
Detrimental role for human high temperature requirement serine protease A1 (HTRA1) in the pathogenesis of intervertebral disc (IVD) degeneration. J Biol Chem (2012) 0.99
Identification of tubulins as substrates of serine protease HtrA1 by mixture-based oriented peptide library screening. J Cell Biochem (2009) 0.96
Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates. J Biol Chem (2012) 0.92
Serine protease HTRA1 antagonizes transforming growth factor-β signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation. PLoS One (2013) 0.92
Determinants of amyloid fibril degradation by the PDZ protease HTRA1. Nat Chem Biol (2015) 0.87
Complement 1s is the serine protease that cleaves IGFBP-5 in human osteoarthritic joint fluid. Osteoarthritis Cartilage (2008) 0.86
Intact pericellular matrix of articular cartilage is required for unactivated discoidin domain receptor 2 in the mouse model. Am J Pathol (2011) 0.85
Genetically Engineered Mouse Models Reveal the Importance of Proteases as Osteoarthritis Drug Targets. Curr Rheumatol Rep (2013) 0.84
BMP-2, hypoxia, and COL1A1/HtrA1 siRNAs favor neo-cartilage hyaline matrix formation in chondrocytes. Tissue Eng Part C Methods (2014) 0.84
Age-related macular degeneration-associated silent polymorphisms in HtrA1 impair its ability to antagonize insulin-like growth factor 1. Mol Cell Biol (2013) 0.83
Association of HTRA1 promoter polymorphism with spinal disc degeneration in Japanese women. J Bone Miner Metab (2009) 0.82
Proteomics analysis of the zebrafish skeletal extracellular matrix. PLoS One (2014) 0.79
IGFBP-5 Metabolism Is Disrupted in the Rat Medial Meniscal Tear Model of Osteoarthritis. Cartilage (2010) 0.78
HTRA3 expression in non-pregnant rhesus monkey ovary and endometrium, and at the maternal-fetal interface during early pregnancy. Reprod Biol Endocrinol (2008) 0.77
Enamel matrix derivative protein enhances production of matrixmetalloproteinase-2 by osteoblasts. BMC Oral Health (2014) 0.75
Generation and characterization of mice with a conditional null allele of the HtrA4 gene. Mol Med Rep (2015) 0.75
Macrophage migration inhibitory factor (MIF) modulates trophic signaling through interaction with serine protease HTRA1. Cell Mol Life Sci (2017) 0.75
Thyroxine Exposure Effects on the Cranial Base. Calcif Tissue Int (2017) 0.75
Role of HTRA1 in bone formation and regeneration: In vitro and in vivo evaluation. PLoS One (2017) 0.75
HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins. Development (2004) 1.91
Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain. Genes Dev (2012) 1.70
Dissection of the mitochondrial import and assembly pathway for human Tom40. J Biol Chem (2005) 1.66
The RNA-binding protein HuD regulates neuronal cell identity and maturation. Proc Natl Acad Sci U S A (2005) 1.66
The endoplasmic reticulum stress-C/EBP homologous protein pathway-mediated apoptosis in macrophages contributes to the instability of atherosclerotic plaques. Arterioscler Thromb Vasc Biol (2010) 1.56
Oxidative stress induced lipocalin 2 gene expression: addressing its expression under the harmful conditions. J Radiat Res (2007) 1.54
Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice. Proc Natl Acad Sci U S A (2011) 1.45
Recombination signal sequence-binding protein Jkappa alters mesodermal cell fate decisions by suppressing cardiomyogenesis. Proc Natl Acad Sci U S A (2003) 1.45
Neutrophil gelatinase-associated lipocalin acts as a protective factor against H(2)O(2) toxicity. Arch Med Res (2008) 1.40
Distribution of artificial radionuclides in abandoned cattle in the evacuation zone of the Fukushima Daiichi nuclear power plant. PLoS One (2013) 1.39
Nifedipine increases energy expenditure by increasing PGC-1α expression in skeletal muscle. Hypertens Res (2011) 1.38
Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease. Biochem J (2004) 1.30
The distribution of vascular endothelial growth factor-producing cells in clinical radiation necrosis of the brain: pathological consideration of their potential roles. J Neurooncol (2011) 1.30
Hypoxia-inducible factor 1 alpha (HIF-1 alpha) gene expression in human ovarian carcinoma. Cancer Lett (2002) 1.29
Angiopoietin-like protein 2 is an important facilitator of inflammatory carcinogenesis and metastasis. Cancer Res (2011) 1.29
Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling. Dev Growth Differ (2004) 1.29
Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane. J Biol Chem (2002) 1.23
Effects of radioactive caesium on bull testes after the Fukushima nuclear plant accident. Sci Rep (2013) 1.20
Primary osteosarcoma of the breast. Breast Cancer (2004) 1.17
Down-regulation of CIBZ, a novel substrate of caspase-3, induces apoptosis. J Biol Chem (2008) 1.15
Tyrosinase localization in mollusc shells. Comp Biochem Physiol B Biochem Mol Biol (2006) 1.14
Cirp protects against tumor necrosis factor-alpha-induced apoptosis via activation of extracellular signal-regulated kinase. Biochim Biophys Acta (2006) 1.13
Suppression of nonsense-mediated mRNA decay permits unbiased gene trapping in mouse embryonic stem cells. Nucleic Acids Res (2005) 1.09
Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein. J Biol Chem (2002) 1.09
Crucial role of peroxiredoxin III in placental antioxidant defense of mice. FEBS Lett (2008) 1.04
Association of gankyrin protein expression with early clinical stages and insulin-like growth factor-binding protein 5 expression in human hepatocellular carcinoma. Hepatology (2008) 1.04
Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance. Metabolism (2012) 1.03
Neutrophil gelatinase-associated lipocalin: a new antioxidant that exerts its cytoprotective effect independent on Heme Oxygenase-1. Free Radic Res (2011) 1.02
High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-β family member growth differentiation factor 6. J Biol Chem (2011) 1.01
A BTB/POZ gene, NAC-1, a tumor recurrence-associated gene, as a potential target for Taxol resistance in ovarian cancer. Clin Cancer Res (2008) 0.98
Cold-inducible RNA-binding protein (Cirp) interacts with Dyrk1b/Mirk and promotes proliferation of immature male germ cells in mice. Proc Natl Acad Sci U S A (2012) 0.98
Sorafenib: complexities of Raf-dependent and Raf-independent signaling are now unveiled. Med Mol Morphol (2011) 0.97
Angiopoietin-related growth factor enhances blood flow via activation of the ERK1/2-eNOS-NO pathway in a mouse hind-limb ischemia model. Arterioscler Thromb Vasc Biol (2008) 0.96
The methyl-CpG-binding protein CIBZ suppresses myogenic differentiation by directly inhibiting myogenin expression. Cell Res (2011) 0.95
Malgun (clear) cell change in Helicobacter pylori gastritis reflects epithelial genomic damage and repair. Am J Pathol (2003) 0.94
Pin1 is overexpressed in oral squamous cell carcinoma and its levels correlate with cyclin D1 overexpression. Oncol Rep (2003) 0.94
A type I DnaJ homolog, DjA1, regulates androgen receptor signaling and spermatogenesis. EMBO J (2005) 0.93
Targeting the AKT/GSK3β/cyclin D1/Cdk4 survival signaling pathway for eradication of tumor radioresistance acquired by fractionated radiotherapy. Int J Radiat Oncol Biol Phys (2011) 0.93
Cayman ataxia protein caytaxin is transported by kinesin along neurites through binding to kinesin light chains. J Cell Sci (2009) 0.92
Evidence that the Upf1-related molecular motor scans the 3'-UTR to ensure mRNA integrity. Nucleic Acids Res (2012) 0.92
Identification of a novel BTB-zinc finger transcriptional repressor, CIBZ, that interacts with CtBP corepressor. Genes Cells (2005) 0.91
Expression profiling with arrays of randomly disrupted genes in mouse embryonic stem cells leads to in vivo functional analysis. Proc Natl Acad Sci U S A (2004) 0.91
Cyclin D1 overexpression perturbs DNA replication and induces replication-associated DNA double-strand breaks in acquired radioresistant cells. Cell Cycle (2013) 0.90
Mei4p coordinates the onset of meiosis I by regulating cdc25+ in fission yeast. Proc Natl Acad Sci U S A (2007) 0.90
The role of cyclin D1 in response to long-term exposure to ionizing radiation. Cell Cycle (2013) 0.90
Ethnic difference of Helicobacter pylori gastritis: Korean and Japanese gastritis is characterized by male- and antrum-predominant acute foveolitis in comparison with American gastritis. World J Gastroenterol (2005) 0.89
Regulatory effects of the mitochondrial energetic status on mitochondrial p66Shc. Biol Chem (2006) 0.89
A narrow microbeam is more effective for tumor growth suppression than a wide microbeam: an in vivo study using implanted human glioma cells. J Synchrotron Radiat (2011) 0.89
Runx1 deficiency in CD4+ T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells. J Immunol (2012) 0.89
Curcumin and its analogues (PGV-0 and PGV-1) enhance sensitivity of resistant MCF-7 cells to doxorubicin through inhibition of HER2 and NF-kB activation. Asian Pac J Cancer Prev (2014) 0.88
Gene expression profiles in mouse liver cells after exposure to different types of radiation. J Radiat Res (2007) 0.88
The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in mice. PLoS One (2012) 0.88
Spectromicroscopic film dosimetry for high-energy microbeam from synchrotron radiation. Appl Radiat Isot (2008) 0.88
Modulation of chaperone activities of Hsp70 and Hsp70-2 by a mammalian DnaJ/Hsp40 homolog, DjA4. J Biochem (2004) 0.88
A duplicated NUCLEOLIN gene with antagonistic activity is required for chromatin organization of silent 45S rDNA in Arabidopsis. Plant Cell (2014) 0.87
Copper-transporting P-type adenosine triphosphatase (ATP7B) is expressed in human breast carcinoma. Jpn J Cancer Res (2002) 0.87
Smap1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia. J Clin Invest (2013) 0.87
Over-expression of Runx1 transcription factor impairs the development of thymocytes from the double-negative to double-positive stages. Immunology (2010) 0.87
The modified high-density survival assay is the useful tool to predict the effectiveness of fractionated radiation exposure. J Radiat Res (2010) 0.87
Involvement of osteopontin and its signaling molecule CD44 in clinicopathological features of adult T cell leukemia. Leuk Res (2011) 0.87
Clinically relevant radioresistant cells efficiently repair DNA double-strand breaks induced by X-rays. Cancer Sci (2009) 0.86
Prognostic value of overexpression of p53 in human ovarian carcinoma patients receiving cisplatin. Cancer Lett (2003) 0.86
Sox21 is a repressor of neuronal differentiation and is antagonized by YB-1. Neurosci Lett (2004) 0.86
Plasminogen plays a crucial role in bone repair. J Bone Miner Res (2013) 0.86
Induction of DNA double-strand breaks and cellular migration through bystander effects in cells irradiated with the slit-type microplanar beam of the spring-8 synchrotron. Int J Radiat Oncol Biol Phys (2009) 0.86
Evaluation of transfection efficiency in skeletal muscle using nano/microbubbles and ultrasound. Ultrasound Med Biol (2010) 0.86
Role of matrix metalloproteinase-10 in the BMP-2 inducing osteoblastic differentiation. Endocr J (2013) 0.85
A new functional screening system for identification of regulators for the generation of amyloid beta-protein. J Biol Chem (2002) 0.85
Analysis of Common Deletion (CD) and a novel deletion of mitochondrial DNA induced by ionizing radiation. Int J Radiat Biol (2007) 0.85
Plasminogen activator inhibitor-1 is involved in streptozotocin-induced bone loss in female mice. Diabetes (2013) 0.85
The physiological roles of vesicular GABA transporter during embryonic development: a study using knockout mice. Mol Brain (2010) 0.84
12(S)-Hydroxyeicosatetraenoic acid induces cAMP production via increasing intracellular calcium concentration. FEBS Lett (2003) 0.84
Identification of a novel TATA element-binding protein binding region at the N terminus of the Saccharomyces cerevisiae TAF1 protein. J Biol Chem (2003) 0.84
Hepatocellular carcinoma and liver transplantation: clinical perspective on molecular targeted strategies. Med Mol Morphol (2011) 0.84
HtrA1 is induced by oxidative stress and enhances cell senescence through p38 MAPK pathway. Exp Eye Res (2013) 0.84
Using hidden Markov models to investigate G-quadruplex motifs in genomic sequences. BMC Genomics (2014) 0.83
Cytochrome p450 gene expression levels in peripheral blood mononuclear cells in comparison with the liver. Cancer Sci (2004) 0.83
Expression of uridine and thymidine phosphorylase genes in human breast carcinoma. Int J Cancer (2002) 0.82
Hexahydrocurcumin enhances inhibitory effect of 5-fluorouracil on HT-29 human colon cancer cells. World J Gastroenterol (2012) 0.82
Autonomous function of the amino-terminal inhibitory domain of TAF1 in transcriptional regulation. Mol Cell Biol (2004) 0.82
Effect of retinoic acid-induced transglutaminase on cell growth in regenerating liver. Biomed Res (2006) 0.82
CD4+ T-cell dysfunctions through the impaired lipid rafts ameliorate concanavalin A-induced hepatitis in sphingomyelin synthase 1-knockout mice. Int Immunol (2012) 0.82
Deficiency of sphingomyelin synthase-1 but not sphingomyelin synthase-2 causes hearing impairments in mice. J Physiol (2012) 0.82
Overexpression of gankyrin in mouse hepatocytes induces hemangioma by suppressing factor inhibiting hypoxia-inducible factor-1 (FIH-1) and activating hypoxia-inducible factor-1. Biochem Biophys Res Commun (2013) 0.81
Beneficial effect of cepharanthine on overcoming drug-resistance of hepatocellular carcinoma. Int J Oncol (2004) 0.81
Awareness of disaster reduction frameworks and risk perception of natural disaster: a questionnaire survey among Philippine and Indonesian health care personnel and public health students. Tohoku J Exp Med (2014) 0.81
Recombinant hybrid protein, Shiga toxin and granulocyte macrophage colony stimulating factor effectively induce apoptosis of colon cancer cells. World J Gastroenterol (2006) 0.81
Mutations in the histone fold domain of the TAF12 gene show synthetic lethality with the TAF1 gene lacking the TAF N-terminal domain (TAND) by different mechanisms from those in the SPT15 gene encoding the TATA box-binding protein (TBP). Nucleic Acids Res (2003) 0.81
Plasminogen activator inhibitor-1 deficiency ameliorates insulin resistance and hyperlipidemia but not bone loss in obese female mice. Endocrinology (2014) 0.81
Guanine nucleotide-binding protein 1 is one of the key molecules contributing to cancer cell radioresistance. Cancer Sci (2014) 0.81
Hypothermia protects against fulminant hepatitis in mice by reducing reactive oxygen species production. Dig Dis (2013) 0.81
Prognostic significance of p53 immunoexpression in the survival of oral squamous cell carcinoma patients treated with surgery and neoadjuvant chemotherapy. Oncol Lett (2013) 0.80
Wound-induced expression of DEFECTIVE IN ANTHER DEHISCENCE1 and DAD1-like lipase genes is mediated by both CORONATINE INSENSITIVE1-dependent and independent pathways in Arabidopsis thaliana. Plant Cell Rep (2014) 0.80
Characterization of the RNA-binding protein Musashi1 in zebrafish. Brain Res (2012) 0.80