Published in Sci Rep on August 01, 2017
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell (2003) 15.43
Pancreatic cancer biology and genetics. Nat Rev Cancer (2002) 7.36
Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice. Proc Natl Acad Sci U S A (2003) 3.53
Etiology of type 1 diabetes. Immunity (2010) 3.28
A tale of two Paks. Biol Cell (2008) 2.90
PAK signalling during the development and progression of cancer. Nat Rev Cancer (2014) 2.21
Copy number alterations in pancreatic cancer identify recurrent PAK4 amplification. Cancer Biol Ther (2008) 2.09
Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin. J Biol Chem (2001) 1.93
Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer. Proc Natl Acad Sci U S A (2008) 1.92
Pancreatic neurogenin 3-expressing cells are unipotent islet precursors. Development (2009) 1.81
The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis. J Biol Chem (2001) 1.78
Pancreatic islet plasticity: interspecies comparison of islet architecture and composition. Islets (2010) 1.65
PAK4 kinase is essential for embryonic viability and for proper neuronal development. Mol Cell Biol (2003) 1.55
p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics. Blood (2009) 1.53
Abnormal long-lasting synaptic plasticity and cognition in mice lacking the mental retardation gene Pak3. J Neurosci (2005) 1.40
Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo. J Biol Chem (2011) 1.28
PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion. J Cell Sci (2010) 1.17
Targeted disruption of the gene for the PAK5 kinase in mice. Mol Cell Biol (2003) 1.17
p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-κB pathway. Oncotarget (2014) 1.15
Role of p-21-activated kinases in cancer progression. Int Rev Cell Mol Biol (2014) 1.13
Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion. Dev Biol (2008) 1.10
P21 activated kinases: structure, regulation, and functions. Small GTPases (2014) 1.06
Essential role for the Pak4 protein kinase in extraembryonic tissue development and vessel formation. Mech Dev (2009) 1.05
P21-activated kinase 4--not just one of the PAK. Eur J Cell Biol (2013) 0.99
p21-activated kinase 4 phosphorylation of integrin beta5 Ser-759 and Ser-762 regulates cell migration. J Biol Chem (2010) 0.98
Integrin-mediated cell attachment induces a PAK4-dependent feedback loop regulating cell adhesion through modified integrin alpha v beta 5 clustering and turnover. Mol Biol Cell (2010) 0.98
The role of glucose, insulin and glucagon in the regulation of food intake and body weight. Neurosci Biobehav Rev (1986) 0.94
Subgroup II PAK-mediated phosphorylation regulates Ran activity during mitosis. J Cell Biol (2010) 0.94
Treatment options for acute pancreatitis. Nat Rev Gastroenterol Hepatol (2014) 0.89
Mouse models of PAK function. Cell Logist (2012) 0.89
Role for p21-activated kinase PAK4 in development of the mammalian heart. Transgenic Res (2011) 0.86
A key role for Pak4 in proliferation and differentiation of neural progenitor cells. Dev Biol (2011) 0.84
p-21 activated kinase 4 (PAK4) maintains stem cell-like phenotypes in pancreatic cancer cells through activation of STAT3 signaling. Cancer Lett (2015) 0.84
The role of p21-activated kinases in pancreatic cancer. Pancreas (2015) 0.83
p21-Activated Kinase 4 (PAK4) as a Predictive Marker of Gemcitabine Sensitivity in Pancreatic Cancer Cell Lines. Cancer Res Treat (2014) 0.82
Pancreatic regulation of glucose homeostasis. Exp Mol Med (2016) 0.81
Genetics and treatment options for recurrent acute and chronic pancreatitis. Curr Treat Options Gastroenterol (2014) 0.80
Novel p21-Activated Kinase 4 (PAK4) Allosteric Modulators Overcome Drug Resistance and Stemness in Pancreatic Ductal Adenocarcinoma. Mol Cancer Ther (2016) 0.80
Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice. PLoS One (2013) 0.78
Pak3 promotes cell cycle exit and differentiation of β-cells in the embryonic pancreas and is necessary to maintain glucose homeostasis in adult mice. Diabetes (2013) 0.78
Structure, biochemistry, and biology of PAK kinases. Gene (2016) 0.77
PAK4 interacts with p85 alpha: implications for pancreatic cancer cell migration. Sci Rep (2017) 0.75
Differential sensitivity of Pak5, Pak6, and Pak5/Pak6 double-knockout mice to the stimulant effects of amphetamine and exercise-induced alterations in body weight. Nutr Neurosci (2013) 0.75