Published in Gene on December 19, 2016
Pdx1-Cre-driven conditional gene depletion suggests PAK4 as dispensable for mouse pancreas development. Sci Rep (2017) 0.75
Quantitative cardiac phosphoproteomics profiling during ischemic/reperfusion in an immature swine model. Am J Physiol Heart Circ Physiol (2017) 0.75
Patterns of somatic mutation in human cancer genomes. Nature (2007) 38.41
A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature (1994) 9.18
Biology of the p21-activated kinases. Annu Rev Biochem (2003) 7.63
Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat Cell Biol (1999) 6.18
Colorectal cancer: mutations in a signalling pathway. Nature (2005) 5.42
Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma. Cancer Cell (2011) 4.54
p21-activated kinases in cancer. Nat Rev Cancer (2006) 4.24
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch. Cell (2000) 4.21
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol Cell (2005) 3.89
A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. EMBO J (1995) 2.99
A tale of two Paks. Biol Cell (2008) 2.90
Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors. Science (1995) 2.87
Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients. J Natl Cancer Inst (2006) 2.71
Identification of a mouse p21Cdc42/Rac activated kinase. J Biol Chem (1995) 2.69
PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia. EMBO J (1998) 2.62
A novel regulator of p21-activated kinases. J Biol Chem (1998) 2.60
PAK3 mutation in nonsyndromic X-linked mental retardation. Nat Genet (1998) 2.52
Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells. J Biol Chem (2000) 2.51
The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1. J Biol Chem (1996) 2.45
Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1. Nat Cell Biol (2002) 2.45
Emerging from the Pak: the p21-activated protein kinase family. Trends Cell Biol (1997) 2.44
Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase. Nat Cell Biol (2000) 2.37
From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. Cancer Res (2004) 2.19
PAK signaling in oncogenesis. Oncogene (2009) 2.13
Copy number alterations in pancreatic cancer identify recurrent PAK4 amplification. Cancer Biol Ther (2008) 2.09
Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease. Nat Neurosci (2006) 2.09
Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functions. Cancer Res (2005) 2.09
Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines. J Biol Chem (2001) 2.07
Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase. J Biol Chem (1998) 2.06
Role of Raf in vascular protection from distinct apoptotic stimuli. Science (2003) 2.02
The genetics of Pak. J Cell Sci (2004) 2.00
Regulation of microtubule destabilizing activity of Op18/stathmin downstream of Rac1. J Biol Chem (2003) 1.99
A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins. J Biol Chem (1999) 1.95
Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proc Natl Acad Sci U S A (2010) 1.94
Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes. Cancer Cell (2004) 1.93
Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin. J Biol Chem (2001) 1.93
Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer. Proc Natl Acad Sci U S A (2008) 1.92
A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids. J Biol Chem (1998) 1.89
LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells. J Cell Biol (2010) 1.79
P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium. EMBO J (2002) 1.75
PAK4 mediates morphological changes through the regulation of GEF-H1. J Cell Sci (2005) 1.75
p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1). J Biol Chem (2000) 1.61
AR and ER interaction with a p21-activated kinase (PAK6). Mol Endocrinol (2002) 1.60
Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A. J Cell Biol (2010) 1.60
Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6. J Biol Chem (2001) 1.59
P21-activated kinase 1 regulation of estrogen receptor-alpha activation involves serine 305 activation linked with serine 118 phosphorylation. Cancer Res (2006) 1.58
p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. Mol Cell Biol (2003) 1.57
PAK4 kinase is essential for embryonic viability and for proper neuronal development. Mol Cell Biol (2003) 1.55
Cyclin D1/cyclin-dependent kinase 4 interacts with filamin A and affects the migration and invasion potential of breast cancer cells. Cancer Res (2010) 1.55
p21-Activated kinase 6 (PAK6) inhibits prostate cancer growth via phosphorylation of androgen receptor and tumorigenic E3 ligase murine double minute-2 (Mdm2). J Biol Chem (2012) 1.55
The mental retardation protein PAK3 contributes to synapse formation and plasticity in hippocampus. J Neurosci (2004) 1.54
HER2/Neu (ErbB2) signaling to Rac1-Pak1 is temporally and spatially modulated by transforming growth factor beta. Cancer Res (2006) 1.52
Functional inactivation of a transcriptional corepressor by a signaling kinase. Nat Struct Biol (2003) 1.50
PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells. Mol Cell Biol (2002) 1.49
Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity. Mol Biol Cell (2008) 1.49
A Rac1/PAK1 cascade controls β-catenin activation in colon cancer cells. Oncogene (2011) 1.49
The pak4 protein kinase plays a key role in cell survival and tumorigenesis in athymic mice. Mol Cancer Res (2008) 1.48
Formation of endothelial lumens requires a coordinated PKCepsilon-, Src-, Pak- and Raf-kinase-dependent signaling cascade downstream of Cdc42 activation. J Cell Sci (2009) 1.47
A dominant-negative p65 PAK peptide inhibits angiogenesis. Circ Res (2002) 1.46
Akt phosphorylation of serine 21 on Pak1 modulates Nck binding and cell migration. Mol Cell Biol (2003) 1.44
Amplification of CCND1 and PAK1 as predictors of recurrence and tamoxifen resistance in postmenopausal breast cancer. Oncogene (2007) 1.43
Abnormal long-lasting synaptic plasticity and cognition in mice lacking the mental retardation gene Pak3. J Neurosci (2005) 1.40
A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases. J Mol Biol (2006) 1.39
A PAK4-LIMK1 pathway drives prostate cancer cell migration downstream of HGF. Cell Signal (2008) 1.38
Conformational switch and role of phosphorylation in PAK activation. Mol Cell Biol (2001) 1.37
LIM kinase 1 increases tumor metastasis of human breast cancer cells via regulation of the urokinase-type plasminogen activator system. Int J Cancer (2006) 1.34
Nuclear localization and chromatin targets of p21-activated kinase 1. J Biol Chem (2005) 1.34
Proteogenomics connects somatic mutations to signalling in breast cancer. Nature (2016) 1.33
High-resolution genomic and expression profiling reveals 105 putative amplification target genes in pancreatic cancer. Neoplasia (2004) 1.33
p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells. EMBO Rep (2002) 1.30
Regulation of hippocampal long-term potentiation by p21-activated protein kinase 1 (PAK1). Neuropharmacology (2008) 1.28
A FOXO-Pak1 transcriptional pathway controls neuronal polarity. Genes Dev (2010) 1.27
P21-activated kinase is required for mitotic progression and regulates Plk1. Oncogene (2008) 1.26
Signaling-dependent and coordinated regulation of transcription, splicing, and translation resides in a single coregulator, PCBP1. Proc Natl Acad Sci U S A (2007) 1.25
Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins. Prostate (2008) 1.24
Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor. Mol Cell Biol (2009) 1.23
P21-activated kinases in human cancer. Cancer Metastasis Rev (2003) 1.23
Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak. EMBO J (2001) 1.23
p21-activated kinase 1 (PAK1) interacts with the Grb2 adapter protein to couple to growth factor signaling. J Biol Chem (2003) 1.22
p21-Activated kinases 1 and 3 control brain size through coordinating neuronal complexity and synaptic properties. Mol Cell Biol (2010) 1.21
Nuclear p21-activated kinase 1 in breast cancer packs off tamoxifen sensitivity. Cancer Res (2006) 1.20
p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B. Mol Cell Biol (2005) 1.19
Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart. Circulation (2011) 1.18
DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3. J Neurosci (2003) 1.18
Roles of cortactin in tumor pathogenesis. Biochim Biophys Acta (2007) 1.18
Vascular endothelial growth factor up-regulation via p21-activated kinase-1 signaling regulates heregulin-beta1-mediated angiogenesis. J Biol Chem (2000) 1.18
PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion. J Cell Sci (2010) 1.17
A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly. Nat Cell Biol (2014) 1.15
p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-κB pathway. Oncotarget (2014) 1.15
Pak1 phosphorylation on t212 affects microtubules in cells undergoing mitosis. Curr Biol (2002) 1.15
Neurotrophic 3,9-bis[(alkylthio)methyl]-and-bis(alkoxymethyl)-K-252a derivatives. J Med Chem (1997) 1.13
Group I and II mammalian PAKs have different modes of activation by Cdc42. EMBO Rep (2012) 1.13
The K252a derivatives, inhibitors for the PAK/MLK kinase family selectively block the growth of RAS transformants. Cancer J (2002) 1.12
p21-Activated kinase 4 promotes prostate cancer progression through CREB. Oncogene (2012) 1.12
Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer. Proc Natl Acad Sci U S A (2013) 1.12
p21-Activated kinase-1 and its role in integrated regulation of cardiac contractility. Am J Physiol Regul Integr Comp Physiol (2007) 1.11
p21-activated protein kinase gamma-PAK is activated by ionizing radiation and other DNA-damaging agents. Similarities and differences to alpha-PAK. J Biol Chem (1999) 1.10
Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion. Dev Biol (2008) 1.10
Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A. J Mol Cell Cardiol (2011) 1.09
Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells. Cancer Res (2013) 1.09