Published in Small GTPases on March 21, 2014
Rho GTPase signalling in cell migration. Curr Opin Cell Biol (2015) 1.38
P21 activated kinase-1 mediates transforming growth factor β1-induced prostate cancer cell epithelial to mesenchymal transition. Biochim Biophys Acta (2015) 0.86
LIM Kinase, a Newly Identified Regulator of Presynaptic Remodeling by Rod Photoreceptors After Injury. Invest Ophthalmol Vis Sci (2015) 0.85
Signaling, Regulation, and Specificity of the Type II p21-activated Kinases. J Biol Chem (2015) 0.84
p21-activated kinase group II small compound inhibitor GNE-2861 perturbs estrogen receptor alpha signaling and restores tamoxifen-sensitivity in breast cancer cells. Oncotarget (2015) 0.82
Characterization of a P-Rex1 gene signature in breast cancer cells. Oncotarget (2016) 0.81
microRNA-126 suppresses PAK4 expression in ovarian cancer SKOV3 cells. Oncol Lett (2015) 0.80
FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabine. BMC Cancer (2016) 0.79
Functional role and therapeutic targeting of p21-associated kinase 4 (PAK4) in multiple myeloma. Blood (2017) 0.78
Structure, biochemistry, and biology of PAK kinases. Gene (2016) 0.77
Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex. MBio (2015) 0.77
P21-Activated Kinase Inhibitors FRAX486 and IPA3: Inhibition of Prostate Stromal Cell Growth and Effects on Smooth Muscle Contraction in the Human Prostate. PLoS One (2016) 0.77
Deciphering the link between PI3K and PAK: An opportunity to target key pathways in pancreatic cancer? Oncotarget (2016) 0.77
Rho GTPases at the crossroad of signaling networks in mammals. Small GTPases (2015) 0.76
PAK6 targets to cell-cell adhesions through its N-terminus in a Cdc42-dependent manner to drive epithelial colony escape. J Cell Sci (2015) 0.76
Structural insights into the intertwined dimer of fyn SH2. Protein Sci (2015) 0.76
The p21-activated kinase, PAK2, is important in the activation of numerous pancreatic acinar cell signaling cascades and in the onset of early pancreatitis events. Biochim Biophys Acta (2016) 0.75
Expression of p21-activated kinases 1 and 3 is altered in the brain of subjects with depression. Neuroscience (2016) 0.75
Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer. Mol Cancer Ther (2017) 0.75
Mechanisms of Yersinia YopO kinase substrate specificity. Sci Rep (2017) 0.75
p21-Activated Kinase 4 Promotes Intimal Hyperplasia and Vascular Smooth Muscle Cells Proliferation during Superficial Femoral Artery Restenosis after Angioplasty. Biomed Res Int (2017) 0.75
miR-29a/b/c function as invasion suppressors for gliomas by targeting CDC42 and predict the prognosis of patients. Br J Cancer (2017) 0.75
Pdx1-Cre-driven conditional gene depletion suggests PAK4 as dispensable for mouse pancreas development. Sci Rep (2017) 0.75
Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10. Cancer Res (1990) 9.85
A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature (1994) 9.18
Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase. Nature (1998) 7.76
Biology of the p21-activated kinases. Annu Rev Biochem (2003) 7.63
The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell (2002) 7.35
Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization. Nature (1998) 7.30
Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev (2007) 6.35
Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat Cell Biol (1999) 6.18
Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion. Genes Dev (1994) 5.71
Colorectal cancer: mutations in a signalling pathway. Nature (2005) 5.42
Inhibition of myosin light chain kinase by p21-activated kinase. Science (1999) 5.41
PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Mol Cell (1998) 4.82
Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma. Cancer Cell (2011) 4.54
p21-activated kinases in cancer. Nat Rev Cancer (2006) 4.24
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch. Cell (2000) 4.21
An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem Biol (2008) 3.94
Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation. J Biol Chem (1995) 3.69
MCF10DCIS.com xenograft model of human comedo ductal carcinoma in situ. J Natl Cancer Inst (2000) 3.44
A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1. Mol Cell Biol (1998) 2.92
A tale of two Paks. Biol Cell (2008) 2.90
PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia. EMBO J (1998) 2.62
MCF10AT: a model for the evolution of cancer from proliferative breast disease. Am J Pathol (1996) 2.62
PAK3 mutation in nonsyndromic X-linked mental retardation. Nat Genet (1998) 2.52
Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells. J Biol Chem (2000) 2.51
A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC. J Neurosci (2005) 2.48
Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1. Nat Cell Biol (2002) 2.45
Pak protein kinases and their role in cancer. Cancer Metastasis Rev (2009) 2.44
Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation. Mol Cell Biol (1997) 2.44
MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions. Cancer Res (2008) 2.32
The multifunctional GIT family of proteins. J Cell Sci (2006) 2.24
PAK signalling during the development and progression of cancer. Nat Rev Cancer (2014) 2.21
Role of a new Rho family member in cell migration and axon guidance in C. elegans. Cell (1997) 2.18
Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells. EMBO J (1998) 2.18
The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation. J Cell Biol (1998) 2.15
Phosphorylation of non-muscle myosin II regulatory light chain by p21-activated kinase (gamma-PAK). J Muscle Res Cell Motil (1998) 2.14
The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A. Mol Cell (2005) 2.11
Copy number alterations in pancreatic cancer identify recurrent PAK4 amplification. Cancer Biol Ther (2008) 2.09
Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines. J Biol Chem (2001) 2.07
Growth cone guidance: first steps towards a deeper understanding. Annu Rev Neurosci (1999) 2.06
p21-activated kinase links Rac/Cdc42 signaling to merlin. J Biol Chem (2001) 2.05
Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. EMBO J (2005) 2.02
UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans. Cell (1998) 2.02
Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1. Mol Cell (2002) 2.00
The p21Rac/Cdc42-activated kinases (PAKs). Int J Biochem Cell Biol (1998) 2.00
p21-activated protein kinase: a crucial component of morphological signaling? Trends Biochem Sci (1999) 1.94
Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proc Natl Acad Sci U S A (2010) 1.94
Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin. J Biol Chem (2001) 1.93
Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer. Proc Natl Acad Sci U S A (2008) 1.92
Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine 16. J Biol Chem (2000) 1.90
Specific contributions of the small GTPases Rho, Rac, and Cdc42 to Dbl transformation. J Biol Chem (1999) 1.88
Transformation of human breast epithelial cells by c-Ha-ras oncogene. Mol Carcinog (1991) 1.87
A novel Cdc42Hs mutant induces cellular transformation. Curr Biol (1997) 1.87
PAK promotes morphological changes by acting upstream of Rac. EMBO J (1998) 1.84
Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization. J Biol Chem (2002) 1.82
Intracellular localization and functional effects of P21-activated kinase-1 (Pak1) in cardiac myocytes. Circ Res (2003) 1.82
A Drosophila homolog of the Rac- and Cdc42-activated serine/threonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures. Mol Cell Biol (1996) 1.79
The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis. J Biol Chem (2001) 1.78
Activated PAK4 regulates cell adhesion and anchorage-independent growth. Mol Cell Biol (2001) 1.76
PAK4 mediates morphological changes through the regulation of GEF-H1. J Cell Sci (2005) 1.75
Cytoskeletal events in growth cone steering. Curr Opin Neurobiol (1994) 1.69
p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor. J Biol Chem (2004) 1.69
P21-activated kinase 1 (PAK1) as a therapeutic target in BRAF wild-type melanoma. J Natl Cancer Inst (2013) 1.68
Survey of differentially methylated promoters in prostate cancer cell lines. Neoplasia (2005) 1.63
AR and ER interaction with a p21-activated kinase (PAK6). Mol Endocrinol (2002) 1.60
Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6. J Biol Chem (2001) 1.59
PAK1 hyperactivation is sufficient for mammary gland tumor formation. Oncogene (2006) 1.57
p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. Mol Cell Biol (2003) 1.57
PAK4 kinase is essential for embryonic viability and for proper neuronal development. Mol Cell Biol (2003) 1.55
p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics. Blood (2009) 1.53
A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells. Oncogene (2010) 1.53
p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients. Proc Natl Acad Sci U S A (2010) 1.50
PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells. Mol Cell Biol (2002) 1.49
Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1. J Biol Chem (2000) 1.49
Increase in neurite outgrowth mediated by overexpression of actin depolymerizing factor. J Neurosci (2000) 1.49
The pak4 protein kinase plays a key role in cell survival and tumorigenesis in athymic mice. Mol Cancer Res (2008) 1.48
p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer. Neoplasia (2008) 1.48
Phosphorylation of myosin light chain kinase by p21-activated kinase PAK2. J Biol Chem (2000) 1.45
A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases. J Mol Biol (2006) 1.39
A PAK4-LIMK1 pathway drives prostate cancer cell migration downstream of HGF. Cell Signal (2008) 1.38
Conformational switch and role of phosphorylation in PAK activation. Mol Cell Biol (2001) 1.37
Signalling to cancer cell invasion through PAK family kinases. Front Biosci (Landmark Ed) (2011) 1.36
p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association. J Biol Chem (2005) 1.34
An emerging link between cytoskeletal dynamics and cell adhesion molecules in growth cone guidance. Curr Opin Neurobiol (1998) 1.34
High-resolution genomic and expression profiling reveals 105 putative amplification target genes in pancreatic cancer. Neoplasia (2004) 1.33
Validation of the p21-activated kinases as targets for inhibition in neurofibromatosis type 2. Cancer Res (2008) 1.31
Targeting group II PAKs in cancer and metastasis. Cancer Metastasis Rev (2009) 1.30
Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo. J Biol Chem (2011) 1.28
Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain. Oncogene (2002) 1.27
Estrogen regulation of Pak1 and FKHR pathways in breast cancer cells. FEBS Lett (2003) 1.27
PAK4 functions in tumor necrosis factor (TNF) alpha-induced survival pathways by facilitating TRADD binding to the TNF receptor. J Biol Chem (2005) 1.27
Drosophila Rac1 controls motor axon guidance. Development (1998) 1.27
P21-activated kinase is required for mitotic progression and regulates Plk1. Oncogene (2008) 1.26
Different molecular mechanisms for Rho family GTPase-dependent, Ca2+-independent contraction of smooth muscle. J Biol Chem (1998) 1.26
PAK4 is activated via PI3K in HGF-stimulated epithelial cells. J Cell Sci (2002) 1.24
Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins. Prostate (2008) 1.24
Mechanism of p21-activated kinase 6-mediated inhibition of androgen receptor signaling. J Biol Chem (2003) 1.24
Cell attachment to the extracellular matrix induces proteasomal degradation of p21(CIP1) via Cdc42/Rac1 signaling. Mol Cell Biol (2002) 1.23
Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor. Mol Cell Biol (2009) 1.23
Targeting large kinase active site with rigid, bulky octahedral ruthenium complexes. J Am Chem Soc (2008) 1.21
alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini. J Cell Sci (2007) 1.20