Published in Front Mol Neurosci on July 18, 2017
Human DNA methylomes at base resolution show widespread epigenomic differences. Nature (2009) 34.27
DNA methylation patterns and epigenetic memory. Genes Dev (2002) 33.83
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (2009) 32.97
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science (1997) 28.30
Alpha-synuclein in Lewy bodies. Nature (1997) 20.83
alpha-Synuclein locus triplication causes Parkinson's disease. Science (2003) 20.20
The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet (2009) 18.90
Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature (1998) 18.36
Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A (2005) 15.46
The hallmarks of aging. Cell (2013) 14.29
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science (2011) 14.29
Genomic DNA methylation: the mark and its mediators. Trends Biochem Sci (2006) 13.32
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science (2011) 13.16
Comprehensive analysis of CpG islands in human chromosomes 21 and 22. Proc Natl Acad Sci U S A (2002) 12.33
Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet (2009) 10.34
Methylation-induced repression--belts, braces, and chromatin. Cell (1999) 9.89
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet (2007) 9.47
Variation in transcription factor binding among humans. Science (2010) 9.33
Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol (2003) 9.30
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet (2011) 9.10
5-Methylcytosine in eukaryotic DNA. Science (1981) 8.85
Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. PLoS Genet (2010) 8.74
Alpha-synuclein locus duplication as a cause of familial Parkinson's disease. Lancet (2004) 7.69
DNA methylation age of human tissues and cell types. Genome Biol (2013) 7.48
Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet (2009) 7.07
Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. Science (2000) 6.28
Global epigenomic reconfiguration during mammalian brain development. Science (2013) 6.14
Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains. Nat Genet (2011) 5.70
Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution. Science (2012) 5.17
Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains. Genome Res (2010) 5.08
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat Genet (2014) 4.60
MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system. Cell (2012) 4.56
Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal. J Neurosci (1988) 4.36
Distinct DNA methylomes of newborns and centenarians. Proc Natl Acad Sci U S A (2012) 4.26
Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease. JAMA (2006) 4.26
DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Hum Mol Genet (2009) 4.25
5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging. Nat Neurosci (2011) 4.15
Rethinking how DNA methylation patterns are maintained. Nat Rev Genet (2009) 4.03
Genetic control of individual differences in gene-specific methylation in human brain. Am J Hum Genet (2010) 3.91
Dynamic DNA methylation across diverse human cell lines and tissues. Genome Res (2013) 3.61
TET enzymes, TDG and the dynamics of DNA demethylation. Nature (2013) 3.49
TETonic shift: biological roles of TET proteins in DNA demethylation and transcription. Nat Rev Mol Cell Biol (2013) 3.18
A two-stage meta-analysis identifies several new loci for Parkinson's disease. PLoS Genet (2011) 3.16
Widespread and tissue specific age-related DNA methylation changes in mice. Genome Res (2010) 2.99
Dependence of transcriptional repression on CpG methylation density. Mol Cell Biol (1994) 2.97
DNA methylation represses transcription in vivo. Nat Genet (1999) 2.92
Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation. J Biol Chem (1999) 2.86
Maternal methyl supplements increase offspring DNA methylation at Axin Fused. Genesis (2006) 2.70
Aging of blood can be tracked by DNA methylation changes at just three CpG sites. Genome Biol (2014) 2.40
Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain. Nat Neurosci (2013) 2.38
Defining an epigenetic code. Nat Cell Biol (2007) 2.28
Chromatin and sequence features that define the fine and gross structure of genomic methylation patterns. Genome Res (2010) 2.25
Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child. PLoS One (2009) 2.23
Large-scale replication and heterogeneity in Parkinson disease genetic loci. Neurology (2012) 2.18
Dynamics of 5-hydroxymethylcytosine and chromatin marks in Mammalian neurogenesis. Cell Rep (2013) 2.10
Redefining CpG islands using hidden Markov models. Biostatistics (2010) 2.03
Geographical and ethnic variation of the 677C>T allele of 5,10 methylenetetrahydrofolate reductase (MTHFR): findings from over 7000 newborns from 16 areas world wide. J Med Genet (2003) 2.03
Prevalence of methylenetetrahydrofolate reductase 677T and 1298C alleles and folate status: a comparative study in Mexican, West African, and European populations. Am J Clin Nutr (2006) 1.98
Association analysis of MAPT H1 haplotype and subhaplotypes in Parkinson's disease. Ann Neurol (2007) 1.92
Genetic predisposition to hyperhomocysteinemia: deficiency of methylenetetrahydrofolate reductase (MTHFR). Thromb Haemost (1997) 1.90
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations. Am J Hum Genet (2009) 1.87
Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape. Genome Biol (2013) 1.69
Methylenetetrahydrofolate reductase C677T genotype and PD. Ann Neurol (2005) 1.64
TET1 controls CNS 5-methylcytosine hydroxylation, active DNA demethylation, gene transcription, and memory formation. Neuron (2013) 1.64
Tau haplotypes regulate transcription and are associated with Parkinson's disease. Ann Neurol (2004) 1.61
Expression of clock genes Per1 and Bmal1 in total leukocytes in health and Parkinson's disease. Eur J Neurol (2009) 1.58
Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains. J Neurosci (2010) 1.51
L-dopa increases α-synuclein DNA methylation in Parkinson's disease patients in vivo and in vitro. Mov Disord (2015) 1.50
Sleep and circadian rhythm regulation in early Parkinson disease. JAMA Neurol (2014) 1.50
Conjugal Parkinsonism and Parkinson disease: a case series with environmental risk factor analysis. Parkinsonism Relat Disord (2009) 1.46
Beta-synuclein inhibits formation of alpha-synuclein protofibrils: a possible therapeutic strategy against Parkinson's disease. Biochemistry (2003) 1.36
CpG demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson's disease. PLoS One (2010) 1.34
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway. Hum Mol Genet (2009) 1.33
Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases. J Biol Chem (2011) 1.32
Distinctive patterns of DNA methylation associated with Parkinson disease: identification of concordant epigenetic changes in brain and peripheral blood leukocytes. Epigenetics (2013) 1.29
Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet. Carcinogenesis (2007) 1.28
Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression. Nature (2016) 1.25
Caffeine exposure and the risk of Parkinson's disease: a systematic review and meta-analysis of observational studies. J Alzheimers Dis (2010) 1.21
Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human alpha-synuclein in transgenic mouse brain. Hum Mol Genet (2009) 1.21
Metal emissions and urban incident Parkinson disease: a community health study of Medicare beneficiaries by using geographic information systems. Am J Epidemiol (2010) 1.19
Association of folate-pathway gene polymorphisms with the risk of prostate cancer: a population-based nested case-control study, systematic review, and meta-analysis. Cancer Epidemiol Biomarkers Prev (2009) 1.18
Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model. Proc Natl Acad Sci U S A (2013) 1.17
Aging and DNA methylation. BMC Biol (2015) 1.15
Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain. Neurobiol Aging (2013) 1.15
Competition between DNA methylation and transcription factors determines binding of NRF1. Nature (2015) 1.14
Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease. Hum Mol Genet (2013) 1.12
Peptidyl argininedeiminase 2 CpG island in multiple sclerosis white matter is hypomethylated. J Neurosci Res (2007) 1.06
DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain. J Neuropathol Exp Neurol (2009) 1.05
Reading the unique DNA methylation landscape of the brain: Non-CpG methylation, hydroxymethylation, and MeCP2. Proc Natl Acad Sci U S A (2015) 1.05
Lipid-mediated oxidative stress and inflammation in the pathogenesis of Parkinson's disease. Parkinsons Dis (2011) 1.00
Prospective study on neurotoxic effects in manganese-exposed bridge construction welders. Neurotoxicology (2011) 1.00
Genetic variants in the folate pathway and risk of childhood acute lymphoblastic leukemia. Cancer Causes Control (2011) 1.00
Increased 5-methylcytosine and decreased 5-hydroxymethylcytosine levels are associated with reduced striatal A2AR levels in Huntington's disease. Neuromolecular Med (2013) 0.98
Evaluation of 64 candidate single nucleotide polymorphisms as risk factors for neural tube defects in a large Irish study population. Am J Med Genet A (2010) 0.96
Clinical spectrum of Kufor-Rakeb syndrome in the Chilean kindred with ATP13A2 mutations. Mov Disord (2010) 0.96
DNA Methylation Analysis: Choosing the Right Method. Biology (Basel) (2016) 0.95
Genetics and epigenetics of Parkinson's disease. ScientificWorldJournal (2012) 0.95
Genome-scale methylation analysis of Parkinson's disease patients' brains reveals DNA hypomethylation and increased mRNA expression of cytochrome P450 2E1. Neurogenetics (2012) 0.95
Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain. Neurobiol Aging (2014) 0.91
Different methylation of the TNF-alpha promoter in cortex and substantia nigra: Implications for selective neuronal vulnerability. Neurobiol Dis (2008) 0.91