Widespread and tissue specific age-related DNA methylation changes in mice.

PubWeight™: 2.99‹?› | Rank: Top 1%

🔗 View Article (PMC 2840983)

Published in Genome Res on January 27, 2010

Authors

Shinji Maegawa1, George Hinkal, Hyun Soo Kim, Lanlan Shen, Li Zhang, Jiexin Zhang, Nianxiang Zhang, Shoudan Liang, Lawrence A Donehower, Jean-Pierre J Issa

Author Affiliations

1: Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

Articles citing this

(truncated to the top 100)

The hallmarks of aging. Cell (2013) 14.29

A decade of exploring the cancer epigenome - biological and translational implications. Nat Rev Cancer (2011) 11.33

Epigenetic predictor of age. PLoS One (2011) 3.46

Obesity accelerates epigenetic aging of human liver. Proc Natl Acad Sci U S A (2014) 2.68

DNA methylation dynamics in health and disease. Nat Struct Mol Biol (2013) 2.58

Aging of blood can be tracked by DNA methylation changes at just three CpG sites. Genome Biol (2014) 2.40

Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal. Cell Stem Cell (2014) 2.18

A DNA methylation fingerprint of 1628 human samples. Genome Res (2011) 2.16

Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock. Cell (2012) 2.15

Aging and chronic sun exposure cause distinct epigenetic changes in human skin. PLoS Genet (2010) 2.03

Manifestations and mechanisms of stem cell aging. J Cell Biol (2011) 1.93

Age-associated epigenetic drift: implications, and a case of epigenetic thrift? Hum Mol Genet (2013) 1.76

Targeted p16(Ink4a) epimutation causes tumorigenesis and reduces survival in mice. J Clin Invest (2014) 1.71

Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape. Genome Biol (2013) 1.69

Epigenetic variability in cells of normal cytology is associated with the risk of future morphological transformation. Genome Med (2012) 1.65

Aging and epigenetic drift: a vicious cycle. J Clin Invest (2014) 1.63

DNA secondary structures and epigenetic determinants of cancer genome evolution. Nat Struct Mol Biol (2011) 1.56

Epigenetic-aging-signature to determine age in different tissues. Aging (Albany NY) (2011) 1.55

Relationship between gene body DNA methylation and intragenic H3K9me3 and H3K36me3 chromatin marks. PLoS One (2011) 1.50

Identification of driver and passenger DNA methylation in cancer by epigenomic analysis. Adv Genet (2010) 1.44

The dynamics and prognostic potential of DNA methylation changes at stem cell gene loci in women's cancer. PLoS Genet (2012) 1.33

Acute multiple organ failure in adult mice deleted for the developmental regulator Wt1. PLoS Genet (2011) 1.27

The cerebellum ages slowly according to the epigenetic clock. Aging (Albany NY) (2015) 1.26

An integrative network algorithm identifies age-associated differential methylation interactome hotspots targeting stem-cell differentiation pathways. Sci Rep (2013) 1.26

A comparison of feature selection and classification methods in DNA methylation studies using the Illumina Infinium platform. BMC Bioinformatics (2012) 1.26

Epigenetic regulation of ageing: linking environmental inputs to genomic stability. Nat Rev Mol Cell Biol (2015) 1.24

Global LINE-1 DNA methylation is associated with blood glycaemic and lipid profiles. Int J Epidemiol (2012) 1.20

Aging and DNA methylation. BMC Biol (2015) 1.15

An integrative multi-scale analysis of the dynamic DNA methylation landscape in aging. PLoS Genet (2015) 1.13

Mechanisms of resistance to decitabine in the myelodysplastic syndrome. PLoS One (2011) 1.12

Genome-wide age-related changes in DNA methylation and gene expression in human PBMCs. Age (Dordr) (2014) 1.12

Hot topics in epigenetic mechanisms of aging: 2011. Aging Cell (2012) 1.09

Genome-wide age-related DNA methylation changes in blood and other tissues relate to histone modification, expression and cancer. Carcinogenesis (2013) 1.08

Age-related epigenetic drift in the pathogenesis of MDS and AML. Genome Res (2014) 1.08

Whole-genome fingerprint of the DNA methylome during human B cell differentiation. Nat Genet (2015) 1.07

Epigenetic estimation of age in humpback whales. Mol Ecol Resour (2014) 1.06

Analysis of epigenetic changes in survivors of preterm birth reveals the effect of gestational age and evidence for a long term legacy. Genome Med (2013) 1.06

Pan-cancer patterns of DNA methylation. Genome Med (2014) 1.02

Conserved DNA methylation patterns in healthy blood cells and extensive changes in leukemia measured by a new quantitative technique. Epigenetics (2012) 1.02

Chromatin structure and transposable elements in organismal aging. Front Genet (2013) 1.00

Temporal stability of epigenetic markers: sequence characteristics and predictors of short-term DNA methylation variations. PLoS One (2012) 0.99

Ageing of the male germ line. Nat Rev Urol (2013) 0.99

Dissecting DNA hypermethylation in cancer. FEBS Lett (2010) 0.98

From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition? Clin Epigenetics (2015) 0.98

Developmentally programmed 3' CpG island methylation confers tissue- and cell-type-specific transcriptional activation. Mol Cell Biol (2013) 0.96

Emerging patterns of epigenomic variation. Trends Genet (2011) 0.95

Distinctive topology of age-associated epigenetic drift in the human interactome. Proc Natl Acad Sci U S A (2013) 0.94

Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and Disease. Cell Stem Cell (2015) 0.94

Age-related DNA methylation in normal breast tissue and its relationship with invasive breast tumor methylation. Epigenetics (2013) 0.94

Noncytotoxic differentiation treatment of renal cell cancer. Cancer Res (2011) 0.94

Increased inflammatory response in aged mice is associated with age-related zinc deficiency and zinc transporter dysregulation. J Nutr Biochem (2012) 0.94

A BRCA1-mutation associated DNA methylation signature in blood cells predicts sporadic breast cancer incidence and survival. Genome Med (2014) 0.93

The application of next generation sequencing in DNA methylation analysis. Genes (Basel) (2010) 0.93

Folate depletion during pregnancy and lactation reduces genomic DNA methylation in murine adult offspring. Genes Nutr (2010) 0.92

Epigenetic Aging Signatures Are Coherently Modified in Cancer. PLoS Genet (2015) 0.92

The epigenetic lorax: gene-environment interactions in human health. Epigenomics (2012) 0.92

An overview of epigenetics and chemoprevention. FEBS Lett (2010) 0.92

Structural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL/6J mice. BMC Med Genomics (2012) 0.92

Long noncoding RNAs(lncRNAs) and the molecular hallmarks of aging. Aging (Albany NY) (2014) 0.92

Replicative senescence is associated with nuclear reorganization and with DNA methylation at specific transcription factor binding sites. Clin Epigenetics (2015) 0.91

Epigenetic clock analyses of cellular senescence and ageing. Oncotarget (2016) 0.90

The myelodysplastic syndrome as a prototypical epigenetic disease. Blood (2013) 0.90

Cellular mechanisms of somatic stem cell aging. Curr Top Dev Biol (2014) 0.90

DNA methylome and transcriptome sequencing in human ovarian granulosa cells links age-related changes in gene expression to gene body methylation and 3'-end GC density. Oncotarget (2015) 0.89

Postnatal development- and age-related changes in DNA-methylation patterns in the human genome. Nucleic Acids Res (2012) 0.89

Modulation of age- and cancer-associated DNA methylation change in the healthy colon by aspirin and lifestyle. J Natl Cancer Inst (2014) 0.89

MicroRNA-191 triggers keratinocytes senescence by SATB1 and CDK6 downregulation. Biochem Biophys Res Commun (2012) 0.88

Genetic epidemiology and nonsyndromic structural birth defects: from candidate genes to epigenetics. JAMA Pediatr (2014) 0.88

Interplay between polymorphisms and methylation in the H19/IGF2 gene region may contribute to obesity in Mexican-American children. J Dev Orig Health Dis (2013) 0.87

Monoallelic silencing and haploinsufficiency in early murine intestinal neoplasms. Proc Natl Acad Sci U S A (2012) 0.86

Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain. Transl Psychiatry (2014) 0.86

Genome-wide DNA methylation changes in skeletal muscle between young and middle-aged pigs. BMC Genomics (2014) 0.85

Unique patterns of CpG island methylation in inflammatory bowel disease-associated colorectal cancers. Inflamm Bowel Dis (2011) 0.85

Effects of Sirt1 on DNA methylation and expression of genes affected by dietary restriction. Age (Dordr) (2012) 0.84

Chemoprevention of intestinal polyps in ApcMin/+ mice fed with western or balanced diets by drinking annurca apple polyphenol extract. Cancer Prev Res (Phila) (2011) 0.84

Epigenetics and aging. Sci Adv (2016) 0.84

Dark matters in AMD genetics: epigenetics and stochasticity. Invest Ophthalmol Vis Sci (2011) 0.84

Methylome of fetal and maternal monocytes and macrophages at the feto-maternal interface. Am J Reprod Immunol (2012) 0.84

Loss of the polycomb mark from bivalent promoters leads to activation of cancer-promoting genes in colorectal tumors. Cancer Res (2014) 0.84

Dynamic Alu methylation during normal development, aging, and tumorigenesis. Biomed Res Int (2014) 0.83

DNA methylation dynamics in muscle development and disease. Front Aging Neurosci (2015) 0.83

Maternal diet, aging and diabetes meet at a chromatin loop. Aging (Albany NY) (2011) 0.83

Natural compounds and aging: between autophagy and inflammasome. Biomed Res Int (2014) 0.82

Paradoxical changes in innate immunity in aging: recent progress and new directions. J Leukoc Biol (2015) 0.82

Unlike pancreatic cancer cells pancreatic cancer associated fibroblasts display minimal gene induction after 5-aza-2'-deoxycytidine. PLoS One (2012) 0.82

Stem cells and aging: a chicken-or-the-egg issue? Aging Dis (2012) 0.82

Age-associated hyper-methylated regions in the human brain overlap with bivalent chromatin domains. PLoS One (2012) 0.82

Turning over DNA methylation in the mind. Front Neurosci (2015) 0.81

Expression profiling after induction of demethylation in MCF-7 breast cancer cells identifies involvement of TNF-α mediated cancer pathways. Mol Cells (2012) 0.81

Omic personality: implications of stable transcript and methylation profiles for personalized medicine. Genome Med (2015) 0.81

Cellular Senescence as the Causal Nexus of Aging. Front Genet (2016) 0.80

Aberrant DNA methylation in ES cells. PLoS One (2014) 0.80

The use of mouse models to study epigenetics. Cold Spring Harb Perspect Biol (2013) 0.80

Mechanisms and consequences of injury and repair in older organ transplants. Transplantation (2014) 0.80

Expression of lactoperoxidase in differentiated mouse colon epithelial cells. Free Radic Biol Med (2012) 0.79

Establishment of a DNA methylation marker to evaluate cancer cell fraction in gastric cancer. Gastric Cancer (2015) 0.79

Proton irradiation induces persistent and tissue-specific DNA methylation changes in the left ventricle and hippocampus. BMC Genomics (2016) 0.79

Epigenetic alterations by NuRD and PRC2 in the neonatal mouse cochlea. Hear Res (2013) 0.79

The epigenetic landscape of age-related diseases: the geroscience perspective. Biogerontology (2017) 0.78

Defining the toxicology of aging. Trends Mol Med (2014) 0.78

Articles cited by this

The epigenomics of cancer. Cell (2007) 30.91

The fundamental role of epigenetic events in cancer. Nat Rev Genet (2002) 30.05

Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21

Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature (2006) 25.90

CpG-rich islands and the function of DNA methylation. Nature (1986) 24.90

DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet (2006) 18.08

Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med (2003) 18.04

GOTree Machine (GOTM): a web-based platform for interpreting sets of interesting genes using Gene Ontology hierarchies. BMC Bioinformatics (2004) 11.23

Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer. Nat Genet (2006) 10.47

Epigenetic stem cell signature in cancer. Nat Genet (2006) 9.62

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet (2007) 9.47

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet (1994) 8.34

CpG island methylator phenotype in cancer. Nat Rev Cancer (2004) 7.13

DNA methylation in cancer: too much, but also too little. Oncogene (2002) 6.96

Number of CpG islands and genes in human and mouse. Proc Natl Acad Sci U S A (1993) 6.79

Estimating the occurrence of false positives and false negatives in microarray studies by approximating and partitioning the empirical distribution of p-values. Bioinformatics (2003) 5.40

Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. PLoS Genet (2007) 5.16

Aging and DNA methylation in colorectal mucosa and cancer. Cancer Res (1998) 4.39

Suppression of intestinal neoplasia by DNA hypomethylation. Cell (1995) 4.16

CpG islands and genes. Curr Opin Genet Dev (1995) 3.83

Epigenetic patterns in the progression of esophageal adenocarcinoma. Cancer Res (2001) 3.70

CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression. Cancer Res (1999) 3.66

Investigating stem cells in human colon by using methylation patterns. Proc Natl Acad Sci U S A (2001) 3.56

Accelerated age-related CpG island methylation in ulcerative colitis. Cancer Res (2001) 3.02

LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability. PLoS One (2007) 2.99

Homeobox gene methylation in lung cancer studied by genome-wide analysis with a microarray-based methylated CpG island recovery assay. Proc Natl Acad Sci U S A (2007) 2.91

Epigenetic changes in colorectal cancer. Cancer Metastasis Rev (2004) 2.35

Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing. Genes Dev (2007) 2.34

Predicting aberrant CpG island methylation. Proc Natl Acad Sci U S A (2003) 2.25

DNA methylation as a therapeutic target in cancer. Clin Cancer Res (2007) 2.20

Methylation of polycomb target genes in intestinal cancer is mediated by inflammation. Cancer Res (2008) 2.08

DNA methylation and environmental exposures in human hepatocellular carcinoma. J Natl Cancer Inst (2002) 2.04

Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers. Proc Natl Acad Sci U S A (2009) 1.98

Methylation reveals a niche: stem cell succession in human colon crypts. Oncogene (2002) 1.88

Aberrant CpG island hypermethylation of chronic gastritis, in relation to aging, gender, intestinal metaplasia, and chronic inflammation. Am J Pathol (2003) 1.79

Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation. Am J Pathol (2002) 1.75

Distinct methylation patterns of two APC gene promoters in normal and cancerous gastric epithelia. Oncogene (2000) 1.63

Age-related methylation of tumor suppressor and tumor-related genes: an analysis of autopsy samples. Oncogene (2003) 1.59

Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. World J Gastroenterol (2004) 1.58

Epigenetic changes in solid and hematopoietic tumors. Semin Oncol (2005) 1.52

Aging, methylation and cancer. Histol Histopathol (2000) 1.40

Evidence for erosion of mouse CpG islands during mammalian evolution. Somat Cell Mol Genet (1993) 1.36

The expression and clinical significance of DNA methyltransferase proteins in human gastric cancer. Dig Dis Sci (2008) 1.24

Inactivation of p57KIP2 by regional promoter hypermethylation and histone deacetylation in human tumors. Oncogene (2002) 1.23

Infrequent occurrence of age-dependent changes in CpG island methylation as detected by restriction landmark genome scanning. Mech Ageing Dev (2002) 1.21

Gene-specific methylation and subsequent risk of colorectal adenomas among participants of the polyp prevention trial. Cancer Epidemiol Biomarkers Prev (2005) 1.01

Age and gender affect DNMT3a and DNMT3b expression in human liver. Cell Biol Toxicol (2007) 0.98

Epigenetics in colorectal cancer. Curr Opin Gastroenterol (2002) 0.97

Aging in heterozygous Dnmt1-deficient mice: effects on survival, the DNA methylation genes, and the development of amyloidosis. J Gerontol A Biol Sci Med Sci (2006) 0.97

Promoter methylation of cyclin D2 gene in gastric carcinoma. Int J Oncol (2003) 0.94

CpG island methylation is frequently present in tubulovillous and villous adenomas and correlates with size, site, and villous component. Hum Pathol (2007) 0.92

Articles by these authors

Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol (2011) 18.34

A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell (2008) 18.18

Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science (2011) 11.12

SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N Engl J Med (2011) 11.07

p53 mutant mice that display early ageing-associated phenotypes. Nature (2002) 10.05

Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol (2010) 9.01

Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One (2008) 8.97

Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer (2006) 8.57

Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia. Blood (2006) 8.38

A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements. Nucleic Acids Res (2004) 7.92

Chemically derived, ultrasmooth graphene nanoribbon semiconductors. Science (2008) 7.65

The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models. Nat Biotechnol (2010) 7.08

Breast-cancer stromal cells with TP53 mutations and nodal metastases. N Engl J Med (2007) 6.47

Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol (2007) 5.48

MGMT promoter methylation and field defect in sporadic colorectal cancer. J Natl Cancer Inst (2005) 5.22

Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. PLoS Genet (2007) 5.16

Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation. Nat Genet (2008) 5.08

Dnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet (2011) 4.85

Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche. Nat Med (2007) 4.80

Narrow graphene nanoribbons from carbon nanotubes. Nature (2009) 4.66

Routine versus clinically indicated replacement of peripheral intravenous catheters: a randomised controlled equivalence trial. Lancet (2012) 4.51

Intercalated combination of chemotherapy and erlotinib for patients with advanced stage non-small-cell lung cancer (FASTACT-2): a randomised, double-blind trial. Lancet Oncol (2013) 4.20

SOX9 is required for the differentiation of paneth cells in the intestinal epithelium. Gastroenterology (2007) 4.17

Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer. Proc Natl Acad Sci U S A (2007) 4.16

Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders. Proc Natl Acad Sci U S A (2010) 3.78

Prognostically relevant gene signatures of high-grade serous ovarian carcinoma. J Clin Invest (2012) 3.64

A multigene predictor of outcome in glioblastoma. Neuro Oncol (2009) 3.57

Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload. Circulation (2004) 3.35

The prevalence of celiac disease in average-risk and at-risk Western European populations: a systematic review. Gastroenterology (2005) 3.33

The diagnostic accuracy of serologic tests for celiac disease: a systematic review. Gastroenterology (2005) 3.33

Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial. Lancet Oncol (2010) 3.30

Safety and clinical activity of the combination of 5-azacytidine, valproic acid, and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome. Blood (2007) 3.27

JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia. Blood (2005) 3.24

Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations. Diabetes (2007) 3.22

Histidines, heart of the hydrogen ion channel from influenza A virus: toward an understanding of conductance and proton selectivity. Proc Natl Acad Sci U S A (2006) 3.22

Identification of transcribed sequences in Arabidopsis thaliana by using high-resolution genome tiling arrays. Proc Natl Acad Sci U S A (2005) 3.21

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature (2016) 3.13

Integrated array-comparative genomic hybridization and expression array profiles identify clinically relevant molecular subtypes of glioblastoma. Cancer Res (2005) 3.10

N-doping of graphene through electrothermal reactions with ammonia. Science (2009) 3.07

Epidermal growth factor receptor variant III status defines clinically distinct subtypes of glioblastoma. J Clin Oncol (2007) 3.07

Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res (2011) 3.05

LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability. PLoS One (2007) 2.99

Icotinib versus gefitinib in previously treated advanced non-small-cell lung cancer (ICOGEN): a randomised, double-blind phase 3 non-inferiority trial. Lancet Oncol (2013) 2.94

Long QT syndrome in adults. J Am Coll Cardiol (2007) 2.93

Phosphoinositide 3-kinase(p110alpha) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy. Proc Natl Acad Sci U S A (2003) 2.90

DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proc Natl Acad Sci U S A (2007) 2.87

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints. Genes Dev (2005) 2.85

Adult murine prostate basal and luminal cells are self-sustained lineages that can both serve as targets for prostate cancer initiation. Cancer Cell (2012) 2.84

High efficacy of beta-blockers in long-QT syndrome type 1: contribution of noncompliance and QT-prolonging drugs to the occurrence of beta-blocker treatment "failures". Circulation (2008) 2.83

Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer. Mol Cell Biol (2003) 2.72

Epigenetics in cancer: what's the future? Oncology (Williston Park) (2011) 2.70

DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia. Cancer Res (2006) 2.69

Predicting protein functions from redundancies in large-scale protein interaction networks. Proc Natl Acad Sci U S A (2003) 2.63

High-throughput identification of transcription start sites, conserved promoter motifs and predicted regulons. Nat Biotechnol (2007) 2.57

The closed state of a H+ channel helical bundle combining precise orientational and distance restraints from solid state NMR. Biochemistry (2002) 2.56

Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet (2012) 2.53

Downregulation of histone H3 lysine 9 methyltransferase G9a induces centrosome disruption and chromosome instability in cancer cells. PLoS One (2008) 2.52

Season of conception in rural gambia affects DNA methylation at putative human metastable epialleles. PLoS Genet (2010) 2.49

Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers. Cancer Discov (2013) 2.49

Bone marrow-derived endothelial progenitor cells participate in cerebral neovascularization after focal cerebral ischemia in the adult mouse. Circ Res (2002) 2.45

Flavonoids: promising anticancer agents. Med Res Rev (2003) 2.43

Activated neural stem cells contribute to stroke-induced neurogenesis and neuroblast migration toward the infarct boundary in adult rats. J Cereb Blood Flow Metab (2004) 2.41

Risk factors for aborted cardiac arrest and sudden cardiac death in children with the congenital long-QT syndrome. Circulation (2008) 2.40

Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform. Proc Natl Acad Sci U S A (2011) 2.37

Human application of a metallic stent covered with a paclitaxel-incorporated membrane for malignant biliary obstruction: multicenter pilot study. Gastrointest Endosc (2007) 2.36

Epigenetic changes in colorectal cancer. Cancer Metastasis Rev (2004) 2.35

Syphilis among female sex workers in southwestern China: potential for HIV transmission. Sex Transm Dis (2006) 2.34

Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3. Oncogene (2005) 2.34

Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors. Nat Struct Mol Biol (2010) 2.34

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop. Cancer Cell (2007) 2.32

Transcriptome-wide identification of microRNA targets in rice. Plant J (2010) 2.31

A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans. Nat Med (2009) 2.31

The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway. J Biol Chem (2003) 2.28

Retracted Expression of concern: Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: the role of Nrf2-regulated proteasomal activity. Am J Respir Crit Care Med (2009) 2.28

Plasmacytoid dendritic cell-specific receptor ILT7-Fc epsilonRI gamma inhibits Toll-like receptor-induced interferon production. J Exp Med (2006) 2.26

Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats. Stroke (2002) 2.24

DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes. J Clin Oncol (2009) 2.23

Modulating effects of age and gender on the clinical course of long QT syndrome by genotype. J Am Coll Cardiol (2003) 2.22

Correlation of VEGF and angiopoietin expression with disruption of blood-brain barrier and angiogenesis after focal cerebral ischemia. J Cereb Blood Flow Metab (2002) 2.22

Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation. Mol Cell Biol (2003) 2.22

Increased risk of arrhythmic events in long-QT syndrome with mutations in the pore region of the human ether-a-go-go-related gene potassium channel. Circulation (2002) 2.20

Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos. Cell (2013) 2.16

Cancer epigenetics. CA Cancer J Clin (2010) 2.16

Epidermal growth factor receptor mutations and their correlation with gefitinib therapy in patients with non-small cell lung cancer: a meta-analysis based on updated individual patient data from six medical centers in mainland China. J Thorac Oncol (2007) 2.15

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet (2010) 2.15

Risk for life-threatening cardiac events in patients with genotype-confirmed long-QT syndrome and normal-range corrected QT intervals. J Am Coll Cardiol (2011) 2.15