Published in J Hepatol on October 31, 2010
Conjugated bile acids promote cholangiocarcinoma cell invasive growth through activation of sphingosine 1-phosphate receptor 2. Hepatology (2014) 1.76
Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signaling. J Biol Chem (2013) 1.07
Liver acid sphingomyelinase inhibits growth of metastatic colon cancer. J Clin Invest (2013) 0.90
Exosome Adherence and Internalization by Hepatic Stellate Cells Triggers Sphingosine 1-Phosphate-dependent Migration. J Biol Chem (2015) 0.89
Sphingosine-1-phosphate/S1P receptors signaling modulates cell migration in human bone marrow-derived mesenchymal stem cells. Mediators Inflamm (2014) 0.85
Promising Therapy Candidates for Liver Fibrosis. Front Physiol (2016) 0.85
Sphingolipid regulation of tissue fibrosis. Open Rheumatol J (2012) 0.82
Exploring the role of sphingolipid machinery during the epithelial to mesenchymal transition program using an integrative approach. Oncotarget (2016) 0.78
The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice. Hepatology (2017) 0.77
Sphingosine 1-Phosphate Receptor Modulators and Drug Discovery. Biomol Ther (Seoul) (2017) 0.77
Essential Roles of RNA-binding Protein HuR in Activation of Hepatic Stellate Cells Induced by Transforming Growth Factor-β1. Sci Rep (2016) 0.76
Sphingosine kinase-1, S1P transporter spinster homolog 2 and S1P2 mRNA expressions are increased in liver with advanced fibrosis in human. Sci Rep (2016) 0.76
Understanding Metabolomics in Biomedical Research. Endocrinol Metab (Seoul) (2016) 0.76
The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined. World J Surg Oncol (2016) 0.75
Tricyclic Antidepressants Promote Ceramide Accumulation to Regulate Collagen Production in Human Hepatic Stellate Cells. Sci Rep (2017) 0.75
Sphingosine 1-phosphate (S1P) promotes mitochondrial biogenesis in Hep G2 cells by activating Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α). Cell Stress Chaperones (2013) 0.75
Serum lipid alterations identified in chronic hepatitis B, hepatitis B virus-associated cirrhosis and carcinoma patients. Sci Rep (2017) 0.75
Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate-Induced Cell Migration. Am J Pathol (2016) 0.75
Low sphingosine-1-phosphate plasma levels are predictive for increased mortality in patients with liver cirrhosis. PLoS One (2017) 0.75
Analysis of sphingolipids in human corneal fibroblasts from normal and keratoconus patients. J Lipid Res (2017) 0.75
Sphingosine 1-Phosphate Receptor 2 Regulates the Migration, Proliferation, and Differentiation of Mesenchymal Stem Cells. Int J Stem Cell Res Ther (2015) 0.75
Unravelling the interplay of sphingolipids and TGF-β signaling in the human corneal stroma. PLoS One (2017) 0.75
Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm. Cell (2012) 5.16
Incidence of treated cardiac arrest in hospitalized patients in the United States. Crit Care Med (2011) 4.43
CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis. Nat Med (2006) 4.36
A JNK-dependent pathway is required for TNFalpha-induced apoptosis. Cell (2003) 3.90
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature (2010) 3.84
Geographic variation in cardiovascular procedure use among Medicare fee-for-service vs Medicare Advantage beneficiaries. JAMA (2013) 3.30
Influenza-associated hospitalization in a subtropical city. PLoS Med (2006) 3.07
Retracted Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin. J Biol Chem (2002) 2.97
Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome. Nature (2004) 2.90
Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panel. Mol Cancer Ther (2007) 2.89
The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells. Cell Stem Cell (2010) 2.89
Coronary revascularization trends in the United States, 2001-2008. JAMA (2011) 2.81
Activation and overexpression of centrosome kinase BTAK/Aurora-A in human ovarian cancer. Clin Cancer Res (2003) 2.43
Third- and fourth-degree perineal lacerations: defining high-risk clinical clusters. Am J Obstet Gynecol (2011) 2.42
Commuting and health in Cambridge: a study of a 'natural experiment' in the provision of new transport infrastructure. BMC Public Health (2010) 2.31
Endothelial-dependent mechanisms of leukocyte recruitment to the vascular wall. Circ Res (2007) 2.15
Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215. J Biol Chem (2004) 2.11
Peptidomimetic targeting of critical androgen receptor-coregulator interactions in prostate cancer. Nat Commun (2013) 2.11
Robust segmentation of overlapping cells in histopathology specimens using parallel seed detection and repulsive level set. IEEE Trans Biomed Eng (2011) 2.08
Antifibrogenic role of the cannabinoid receptor CB2 in the liver. Gastroenterology (2005) 2.07
Efficacy and safety of omega-3 fatty acids for the prevention of atrial fibrillation: a meta-analysis. Can J Cardiol (2012) 2.06
Framing Financial Incentives to Increase Physical Activity Among Overweight and Obese Adults: A Randomized, Controlled Trial. Ann Intern Med (2016) 1.96
Suppression versus induction of androgen receptor functions by the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer LNCaP cells with different passage numbers. J Biol Chem (2003) 1.90
DNAshape: a method for the high-throughput prediction of DNA structural features on a genomic scale. Nucleic Acids Res (2013) 1.86
Coordinated redistribution of leukocyte LFA-1 and endothelial cell ICAM-1 accompany neutrophil transmigration. J Exp Med (2004) 1.85
Human papillomavirus infection and bladder cancer risk: a meta-analysis. J Infect Dis (2011) 1.81
AKT/PKB signaling mechanisms in cancer and chemoresistance. Front Biosci (2005) 1.72
Structure of transmembrane pore induced by Bax-derived peptide: evidence for lipidic pores. Proc Natl Acad Sci U S A (2008) 1.70
Inactivation of Brca2 promotes Trp53-associated but inhibits KrasG12D-dependent pancreatic cancer development in mice. Gastroenterology (2011) 1.70
Histone H3 as a novel substrate for MAP kinase phosphatase-1. Am J Physiol Cell Physiol (2008) 1.68
Effect of continuous compressions and 30:2 cardiopulmonary resuscitation on global ventilation/perfusion values during resuscitation in a porcine model. Crit Care Med (2010) 1.65
Retracted Activation of phosphatidylinositol 3-kinase/Akt pathway by androgen through interaction of p85alpha, androgen receptor, and Src. J Biol Chem (2003) 1.63
Critical role of amyloid-like oligomers of Drosophila Orb2 in the persistence of memory. Cell (2012) 1.57
Excess mortality associated with influenza A and B virus in Hong Kong, 1998-2009. J Infect Dis (2012) 1.54
Interictal spike analysis of high-density EEG in patients with partial epilepsy. Clin Neurophysiol (2010) 1.51
The impact of new cardiovascular device technology on health care costs. Arch Intern Med (2011) 1.50
Loss of heterozygosity analysis on chromosome 12q in disseminated superficial actinic porokeratosis. J Invest Dermatol (2006) 1.48
Infection fatality risk of the pandemic A(H1N1)2009 virus in Hong Kong. Am J Epidemiol (2013) 1.47
MR imaging of acute pancreatitis: correlation of abdominal wall edema with severity scores. Eur J Radiol (2012) 1.47
Studies on correlation between single-nucleotide polymorphisms of tumor necrosis factor gene and different stages of ankylosing spondylitis. Cell Biochem Biophys (2013) 1.45
An autoimmune domain-reduced HCV core gene remains effective in stimulating anti-core cytotoxic T lymphocyte activity. Vaccine (2005) 1.45
Assembly of a Ca2+-dependent BK channel signaling complex by binding to beta2 adrenergic receptor. EMBO J (2004) 1.41
ImageMiner: a software system for comparative analysis of tissue microarrays using content-based image retrieval, high-performance computing, and grid technology. J Am Med Inform Assoc (2011) 1.40
Regulation of leukocyte transmigration: cell surface interactions and signaling events. J Immunol (2004) 1.40
On the applicability of temperature and precipitation data from CMIP3 for China. PLoS One (2012) 1.40
Role of the dissolved zinc ion and reactive oxygen species in cytotoxicity of ZnO nanoparticles. Toxicol Lett (2010) 1.38
Defining the BK channel domains required for beta1-subunit modulation. Proc Natl Acad Sci U S A (2006) 1.38
Location of KCNE1 relative to KCNQ1 in the I(KS) potassium channel by disulfide cross-linking of substituted cysteines. Proc Natl Acad Sci U S A (2009) 1.35
Elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid. J Neurochem (2008) 1.35
A phase I, multicenter, open-label, first-in-human, dose-escalation study of the oral smoothened inhibitor Sonidegib (LDE225) in patients with advanced solid tumors. Clin Cancer Res (2014) 1.35
Locations of the beta1 transmembrane helices in the BK potassium channel. Proc Natl Acad Sci U S A (2008) 1.34
FMRI connectivity analysis of acupuncture effects on an amygdala-associated brain network. Mol Pain (2008) 1.32
Position and role of the BK channel alpha subunit S0 helix inferred from disulfide crosslinking. J Gen Physiol (2008) 1.31
Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways. Mol Cancer Ther (2006) 1.29
The sphingosine 1-phosphate receptor S1P2 triggers hepatic wound healing. FASEB J (2007) 1.25
Structure of the alamethicin pore reconstructed by x-ray diffraction analysis. Biophys J (2008) 1.24
Distribution and clinical correlates of viral and host genotypes in Chinese patients with chronic hepatitis C virus infection. J Gastroenterol Hepatol (2014) 1.23
Electrophysiological imaging of brain activity and connectivity-challenges and opportunities. IEEE Trans Biomed Eng (2011) 1.22
Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis. J Hepatol (2009) 1.21
Evidence of cholesterol accumulated in high curvature regions: implication to the curvature elastic energy for lipid mixtures. Biophys J (2007) 1.20
Suppression of androgen receptor-mediated transactivation and cell growth by the glycogen synthase kinase 3 beta in prostate cells. J Biol Chem (2004) 1.20
Frequency, immunogenetics, and clinical characteristics of latent autoimmune diabetes in China (LADA China study): a nationwide, multicenter, clinic-based cross-sectional study. Diabetes (2012) 1.19
Shen-fu injection attenuates postresuscitation myocardial dysfunction in a porcine model of cardiac arrest. Shock (2011) 1.19
Activation of the BK (SLO1) potassium channel by mallotoxin. J Biol Chem (2005) 1.17
Hospital variation in survival after in-hospital cardiac arrest. J Am Heart Assoc (2014) 1.16
A microRNA profile comparison between thoracic aortic dissection and normal thoracic aorta indicates the potential role of microRNAs in contributing to thoracic aortic dissection pathogenesis. J Vasc Surg (2011) 1.15
eConnectome: A MATLAB toolbox for mapping and imaging of brain functional connectivity. J Neurosci Methods (2010) 1.14
Automated image analysis of skeletal muscle fiber cross-sectional area. J Appl Physiol (1985) (2012) 1.12
Biomolecular solution X-ray scattering at the National Synchrotron Light Source. J Synchrotron Radiat (2010) 1.11
The prevalence of BRCA1 and BRCA2 germline mutations in high-risk breast cancer patients of Chinese Han nationality: two recurrent mutations were identified. Breast Cancer Res Treat (2007) 1.10
The relation between collagen fibril kinematics and mechanical properties in the mitral valve anterior leaflet. J Biomech Eng (2007) 1.10
Degradation of MDM2 by the interaction between berberine and DAXX leads to potent apoptosis in MDM2-overexpressing cancer cells. Cancer Res (2010) 1.10
ST-segment elevation in the early repolarization syndrome, idiopathic ventricular fibrillation, and the Brugada syndrome: cellular and clinical linkage. J Electrocardiol (2005) 1.10
Exome sequencing identifies SLC24A5 as a candidate gene for nonsyndromic oculocutaneous albinism. J Invest Dermatol (2013) 1.09
Clusters of sudden unexplained death associated with the mushroom, Trogia venenata, in rural Yunnan Province, China. PLoS One (2012) 1.09
Automated image interpretation computer-assisted diagnostics. Anal Cell Pathol (Amst) (2011) 1.07
Ascorbate transport by primary cultured neurons and its role in neuronal function and protection against excitotoxicity. J Neurosci Res (2007) 1.07
Telocytes in mice bone marrow: electron microscope evidence. J Cell Mol Med (2014) 1.07
Genomic approaches to deconstruct pluripotency. Annu Rev Genomics Hum Genet (2011) 1.06
Microcephalin regulates BRCA2 and Rad51-associated DNA double-strand break repair. Cancer Res (2009) 1.06
Surgical management of tracheal compression caused by mediastinal goiter: is extracorporeal circulation requisite? J Thorac Dis (2009) 1.05
Two states of cyclic antimicrobial peptide RTD-1 in lipid bilayers. Biochemistry (2002) 1.04
Excess winter mortality and cold temperatures in a subtropical city, Guangzhou, China. PLoS One (2013) 1.04
MicroRNA-29a regulates pro-inflammatory cytokine secretion and scavenger receptor expression by targeting LPL in oxLDL-stimulated dendritic cells. FEBS Lett (2011) 1.04
Interruption of nuclear factor kappaB signaling by the androgen receptor facilitates 12-O-tetradecanoylphorbolacetate-induced apoptosis in androgen-sensitive prostate cancer LNCaP cells. Cancer Res (2003) 1.03
Perceptual learning increases the strength of the earliest signals in visual cortex. J Neurosci (2010) 1.03
Evaluating statistical methods using plasmode data sets in the age of massive public databases: an illustration using false discovery rates. PLoS Genet (2008) 1.03
Automatic Ki-67 counting using robust cell detection and online dictionary learning. IEEE Trans Biomed Eng (2014) 1.03
Global structure changes associated with Ca2+ activation of full-length human plasma gelsolin. J Biol Chem (2007) 1.03
SNP identification and allelic-specific PCR markers development for TaGW2, a gene linked to wheat kernel weight. Theor Appl Genet (2012) 1.02
Interaction of antimicrobial peptides with lipopolysaccharides. Biochemistry (2003) 1.02
Involvement of sphingosine 1-phosphate (SIP)/S1P3 signaling in cholestasis-induced liver fibrosis. Am J Pathol (2009) 1.01
Regulation of microRNA-155 in atherosclerotic inflammatory responses by targeting MAP3K10. PLoS One (2012) 1.01
Acute ZnO nanoparticles exposure induces developmental toxicity, oxidative stress and DNA damage in embryo-larval zebrafish. Aquat Toxicol (2013) 1.01
Classification of hematologic malignancies using texton signatures. Pattern Anal Appl (2007) 1.01
Tumor necrosis factor alpha (TNF-alpha) receptor-II is required for TNF-alpha-induced leukocyte-endothelial interaction in vivo. Blood (2006) 1.01
SARS CoV main proteinase: The monomer-dimer equilibrium dissociation constant. Biochemistry (2006) 1.01