Published in Proc Natl Acad Sci U S A on June 01, 1979
Identification of residues required for ligand binding to the beta-adrenergic receptor. Proc Natl Acad Sci U S A (1987) 2.81
Isolation, characterization, and purification to homogeneity of an endogenous polypeptide with agonistic action on benzodiazepine receptors. Proc Natl Acad Sci U S A (1983) 2.76
Cloning of the cDNA for human 5-lipoxygenase. Proc Natl Acad Sci U S A (1988) 2.06
Primary structure of corticotropin-releasing factor from ovine hypothalamus. Proc Natl Acad Sci U S A (1981) 1.78
Nucleotide sequence of a cloned structural gene coding for a precursor of pancreatic somatostatin. Proc Natl Acad Sci U S A (1980) 1.19
Primary structure of ovine hypothalamic somatostatin-28 and somatostatin-25. Proc Natl Acad Sci U S A (1980) 1.18
Somatostatin. Br Med J (Clin Res Ed) (1987) 1.09
Sequence analysis of a cDNA coding for a pancreatic precursor to somatostatin. Proc Natl Acad Sci U S A (1981) 1.06
Occurrence of two somatostatin variants in the frog brain: characterization of the cDNAs, distribution of the mRNAs, and receptor-binding affinities of the peptides. Proc Natl Acad Sci U S A (1996) 0.83
Somatostatin: an endogenous peptide in the toad urinary bladder inhibits vasopressin-stimulated water flow. Proc Natl Acad Sci U S A (1980) 0.82
Processing of an anglerfish somatostatin precursor to a hydroxylysine-containing somatostatin 28. Proc Natl Acad Sci U S A (1985) 0.75
Isolation and characterization of immunoreactive somatostatin from fish pancreatic islets. J Clin Invest (1980) 0.75
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
The preparation and enzymatic hydrolysis of reduced and S-carboxymethylated proteins. J Biol Chem (1963) 14.93
Separation of dansyl-amino acids by polyamide layer chromatography. Biochim Biophys Acta (1967) 12.65
Strategy and tactics in protein chemistry. Biochem J (1970) 8.11
Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone. Science (1973) 7.47
Direct microsequence analysis of polypeptides using an improved sequenator, a nonprotein carrier (polybrene), and high pressure liquid chromatography. Biochemistry (1978) 4.10
Polyquarternary amines prevent peptide loss from sequenators. Anal Biochem (1978) 3.61
Somatostatin: abundance of immunoreactive hormone in rat stomach and pancreas. Science (1975) 2.00
Immunoreactive somatostatin is present in discrete cells of the endocrine pancreas. Proc Natl Acad Sci U S A (1975) 1.74
Somatostatin. Recent Prog Horm Res (1975) 1.67
The regional distribution of somatostatin in the rat brain. Endocrinology (1975) 1.48
Isolation and structure of somatostatin from porcine hypothalami. Biochemistry (1976) 1.46
Primary structure of somatostatin, a hypothalamic peptide that inhibits the secretion of pituitary growth hormone. Proc Natl Acad Sci U S A (1973) 1.31
Dihydrofolate reductase: the amino acid sequence of the enzyme from a methotrexate-resistant mutant of Escherichia coli. Biochemistry (1978) 1.23
Biologic and immunologic activities and applications of somatostatin analogs. Metabolism (1978) 1.23
Anatomic and phylogenetic distribution of somatostatin. Metabolism (1976) 1.08
Investigation of larger forms of somatostatin in pigeon pancreas and rat brain. Metabolism (1978) 0.95
Somatostatin analogs. Relative importance of the disulfide bridge and of the Ala-Gly side chain for biological activity. J Med Chem (1975) 0.94
Conversion of big pancreatic somatostatin without peptide bond cleavage into somatostatin tetradecapeptide. Life Sci (1976) 0.89
Micro-Edman degradation: the use of high pressure liquid chromatography and gas chromatography in the amino terminal sequence determination of 8 nanomoles of dihydrofolate reductase from a mouse sarcoma. Biochem Biophys Res Commun (1976) 0.84
Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science (1981) 9.64
Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone. Science (1973) 7.47
Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin. Nature (1986) 7.06
Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse. J Comp Neurol (2000) 4.17
The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization. J Comp Neurol (1992) 3.53
Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor. Science (1987) 3.45
Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin. EMBO J (1988) 3.26
cDNA cloning reveals that the major group rhinovirus receptor on HeLa cells is intercellular adhesion molecule 1. Proc Natl Acad Sci U S A (1989) 3.09
Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. Neuron (1998) 3.08
Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. Science (1984) 2.83
Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A. Mol Cell Biol (1993) 2.79
Isolation, characterization, and purification to homogeneity of an endogenous polypeptide with agonistic action on benzodiazepine receptors. Proc Natl Acad Sci U S A (1983) 2.76
beta-Endorphin and adrenocorticotropin are selected concomitantly by the pituitary gland. Science (1977) 2.68
Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour. Nature (1982) 2.44
Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid. Nature (1986) 2.29
Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures. Cell (1990) 2.22
Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: differential roles of CRF receptors 1 and 2. J Neurosci (1999) 2.20
Betaglycan binds inhibin and can mediate functional antagonism of activin signalling. Nature (2000) 2.17
Distribution of corticotropin-releasing factor receptor mRNA expression in the rat brain and pituitary. Proc Natl Acad Sci U S A (1994) 2.14
Culture of enzymatically dispersed pituitary cells: functional validation of a method. Endocrinology (1972) 2.09
Rapid regression of uterine leiomyomas in response to daily administration of gonadotropin-releasing hormone antagonist. Fertil Steril (1993) 2.09
Cloning of the cDNA for human 5-lipoxygenase. Proc Natl Acad Sci U S A (1988) 2.06
Rat liver glutathione S-transferases. Construction of a cDNA clone complementary to a Yc mRNA and prediction of the complete amino acid sequence of a Yc subunit. J Biol Chem (1985) 2.06
Appetite-suppressing effects of urocortin, a CRF-related neuropeptide. Science (1996) 1.91
Deletion of crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2. Nat Genet (2000) 1.90
Synthetic competitive antagonists of corticotropin-releasing factor: effect on ACTH secretion in the rat. Science (1984) 1.87
Identification of a second corticotropin-releasing factor receptor gene and characterization of a cDNA expressed in heart. Proc Natl Acad Sci U S A (1995) 1.86
Chemical and biological characterization of corticotropin releasing factor. Recent Prog Horm Res (1983) 1.86
Corticotropin releasing factor produces behavioural activation in rats. Nature (1982) 1.82
Suppression of pancreatic endocrine tumour secretion by long-acting somatostatin analogue. Lancet (1979) 1.81
Primary structure of corticotropin-releasing factor from ovine hypothalamus. Proc Natl Acad Sci U S A (1981) 1.78
Corticotropin releasing factor decreases postburst hyperpolarizations and excites hippocampal neurons. Science (1983) 1.77
Stimulation of noradrenergic sympathetic outflow by calcitonin gene-related peptide. Nature (1983) 1.70
Amino acid sequence of the BSC-1 cell growth inhibitor (polyergin) deduced from the nucleotide sequence of the cDNA. Proc Natl Acad Sci U S A (1988) 1.70
Somatostatin. Recent Prog Horm Res (1975) 1.67
Preliminary observations on the effect of synthetic thyrotropin releasing factor on plasma thyrotropin levels in man. J Clin Endocrinol Metab (1970) 1.67
Regulatory peptides of the hypothalamus. Annu Rev Physiol (1977) 1.64
Modulation of stress-induced ACTH release by corticotropin-releasing factor, catecholamines and vasopressin. Nature (1983) 1.64
Differential regulation of corticotropin-releasing factor mRNA in rat brain regions by glucocorticoids and stress. J Neurosci (1991) 1.62
Somatotroph hyperplasia. Successful treatment of acromegaly by removal of a pancreatic islet tumor secreting a growth hormone-releasing factor. J Clin Invest (1982) 1.60
Corticotropin-releasing factor: actions on the sympathetic nervous system and metabolism. Endocrinology (1982) 1.58
Characterization of rat hypothalamic corticotropin-releasing factor. Proc Natl Acad Sci U S A (1983) 1.58
"Medical oophorectomy" using a long-acting GNRH agonist--a possible new approach to the treatment of endometriosis. J Clin Endocrinol Metab (1982) 1.57
Urocortin-1 and -2 double-deficient mice show robust anxiolytic phenotype and modified serotonergic activity in anxiety circuits. Mol Psychiatry (2009) 1.57
Intraventricular corticotropin-releasing factor enhances behavioral effects of novelty. Life Sci (1982) 1.57
Primary structure of the ovine hypothalamic luteinizing hormone-releasing factor (LRF) (LH-hypothalamus-LRF-gas chromatography-mass spectrometry-decapeptide-Edman degradation). Proc Natl Acad Sci U S A (1972) 1.57
Reversible inhibition of testicular steroidogenesis and spermatogenesis by a potent gonadotropin-releasing hormone agonist in normal men: an approach toward the development of a male contraceptive. N Engl J Med (1981) 1.57
Gonadotropin-releasing hormone analog design. Structure-function studies toward the development of agonists and antagonists: rationale and perspective. Endocr Rev (1986) 1.56
Corticotropin releasing factor produces increases in brain excitability and convulsive seizures in rats. Brain Res (1983) 1.55
Identification and structure of the gene encoding gpII, a major glycoprotein of varicella-zoster virus. Virology (1986) 1.55
Rat liver preproalbumin: in vitro synthesis and partial amino acid sequence. Proc Natl Acad Sci U S A (1977) 1.54
Assay of corticotropin releasing factor. Methods Enzymol (1983) 1.53
Strain and substrain differences in context- and tone-dependent fear conditioning of inbred mice. Behav Brain Res (1999) 1.53
Potent and long-acting corticotropin releasing factor (CRF) receptor 2 selective peptide competitive antagonists. J Med Chem (2002) 1.53
The functional neuroanatomy of corticotropin-releasing factor. Ciba Found Symp (1993) 1.52
Relationship between fos production and classical fear conditioning: effects of novelty, latent inhibition, and unconditioned stimulus preexposure. J Neurosci (1998) 1.49
Rat liver pre-proalbumin: complete amino acid sequence of the pre-piece. Analysis of the direct translation product of albumin messenger RNA. J Biol Chem (1977) 1.48
Regulation of transforming growth factor beta- and activin-induced transcription by mammalian Mad proteins. Proc Natl Acad Sci U S A (1996) 1.46
Production of an epidermal growth factor receptor-related protein. Science (1984) 1.46
Effect of ethanol on the hypothalamic-pituitary-adrenal axis in the rat: role of corticotropin-releasing factor (CRF). J Pharmacol Exp Ther (1984) 1.46
Corticotropin-releasing factor antagonist attenuates the "anxiogenic-like" effect in the defensive burying paradigm but not in the elevated plus-maze following chronic cocaine in rats. Psychopharmacology (Berl) (1999) 1.46
Potent, structurally constrained agonists and competitive antagonists of corticotropin-releasing factor. Proc Natl Acad Sci U S A (1995) 1.45
Physiologic testosterone levels in normal men suppress high-density lipoprotein cholesterol levels. Ann Intern Med (1992) 1.43
Rat liver glutathione S-transferases. DNA sequence analysis of a Yb2 cDNA clone and regulation of the Yb1 and Yb2 mRNAs by phenobarbital. J Biol Chem (1986) 1.42
The effect of somatostatin analogs on secretion of growth, pancreatic, and gastrointestinal hormones in man. J Clin Endocrinol Metab (1981) 1.42
CRF2 receptor activation prevents colorectal distension induced visceral pain and spinal ERK1/2 phosphorylation in rats. Gut (2005) 1.41
Gonadal and extragonadal expression of inhibin alpha, beta A, and beta B subunits in various tissues predicts diverse functions. Proc Natl Acad Sci U S A (1988) 1.40
Detection and purification of inhibin using antisera generated against synthetic peptide fragments. Methods Enzymol (1989) 1.38
Effects of somatostatin on the secretion of thyrotropin and prolactin. Endocrinology (1974) 1.38
Interaction of corticotropin-releasing factor and arginine vasopressin on adrenocorticotropin secretion in vivo. Endocrinology (1983) 1.38
Phosphorylated cAMP response element binding protein in the mouse brain after fear conditioning: relationship to Fos production. Brain Res Mol Brain Res (2001) 1.37
Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides. Proc Natl Acad Sci U S A (1987) 1.37
Characterization of ovine hypothalamic hypophysiotropic TSH-releasing factor. Nature (1970) 1.36
Chemical synthesis and enzymatic activity of a 99-residue peptide with a sequence proposed for the human immunodeficiency virus protease. Proc Natl Acad Sci U S A (1988) 1.36
Steroid secretion in polycystic ovarian disease after ovarian suppression by a long-acting gonadotropin-releasing hormone agonist. J Clin Endocrinol Metab (1983) 1.36
Ontogeny of the stress response in the rat: role of the pituitary and the hypothalamus. Endocrinology (1986) 1.36
Isolation and sequence analysis of a somatostatin-like polypeptide from ovine hypothalamus. Biochemistry (1981) 1.35
Impaired growth hormone responses to growth hormone-releasing factor in obesity. A pituitary defect reversed with weight reduction. N Engl J Med (1984) 1.35
Smad8 mediates the signaling of the ALK-2 [corrected] receptor serine kinase. Proc Natl Acad Sci U S A (1997) 1.34
Development of Cushing's syndrome in corticotropin-releasing factor transgenic mice. Endocrinology (1992) 1.34
Production of the Fos protein after contextual fear conditioning of C57BL/6N mice. Brain Res (1998) 1.34
Mapping of glucocorticoid receptor immunoreactive neurons in the rat tel- and diencephalon using a monoclonal antibody against rat liver glucocorticoid receptor. Endocrinology (1985) 1.32
In vivo corticotropin-releasing factor-induced secretion of adrenocorticotropin, beta-endorphin, and corticosterone. Endocrinology (1982) 1.32
Stress-induced gastrointestinal secretory and motor responses in rats are mediated by endogenous corticotropin-releasing factor. Gastroenterology (1988) 1.32
Release of the predicted calcitonin gene-related peptide from cultured rat trigeminal ganglion cells. Nature (1984) 1.31