Published in Trends Genet on August 24, 2017
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol (2007) 15.30
Coordinated transcription of key pathways in the mouse by the circadian clock. Cell (2002) 14.07
Obesity and metabolic syndrome in circadian Clock mutant mice. Science (2005) 12.66
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature (2009) 10.59
The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell (2002) 9.92
Resetting central and peripheral circadian oscillators in transgenic rats. Science (2000) 8.63
BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis. PLoS Biol (2004) 6.72
Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci U S A (2009) 6.67
The mammalian circadian timing system: organization and coordination of central and peripheral clocks. Annu Rev Physiol (2010) 6.63
The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell (2008) 6.44
Physiological significance of a peripheral tissue circadian clock. Proc Natl Acad Sci U S A (2008) 5.94
A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science (2011) 5.91
SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell (2008) 5.68
Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. Science (2009) 5.35
Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors. Science (2001) 5.03
Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock. Genes Dev (2006) 4.90
AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science (2009) 4.72
Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations. Cell (2016) 3.54
Circadian clocks in human red blood cells. Nature (2011) 3.39
Homeostasis in intestinal epithelium is orchestrated by the circadian clock and microbiota cues transduced by TLRs. Cell (2013) 3.34
Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis. Cell (2014) 3.33
The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification. Cell Metab (2006) 3.00
Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression. Proc Natl Acad Sci U S A (2009) 2.98
REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis. PLoS Biol (2009) 2.76
Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock. Cell (2001) 2.59
Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice. Science (2013) 2.49
The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors. Genes Dev (2010) 2.42
Effects of aging on central and peripheral mammalian clocks. Proc Natl Acad Sci U S A (2002) 2.38
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor. Nature (2011) 2.34
Bile acid is a host factor that regulates the composition of the cecal microbiota in rats. Gastroenterology (2011) 2.27
Coordination of the transcriptome and metabolome by the circadian clock. Proc Natl Acad Sci U S A (2012) 2.22
Obesity in mice with adipocyte-specific deletion of clock component Arntl. Nat Med (2012) 2.13
Epidemiology of autoimmune diseases in Denmark. J Autoimmun (2007) 2.05
Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism. Cell Host Microbe (2015) 2.05
The human circadian metabolome. Proc Natl Acad Sci U S A (2012) 2.04
PER2 controls lipid metabolism by direct regulation of PPARγ. Cell Metab (2010) 1.91
The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation. Cell (2015) 1.83
Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion. Science (2015) 1.82
Post-translational modifications in circadian rhythms. Trends Biochem Sci (2009) 1.80
SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging. Cell (2013) 1.71
An intrinsic circadian clock of the pancreas is required for normal insulin release and glucose homeostasis in mice. Diabetologia (2010) 1.69
Circadian disruption leads to insulin resistance and obesity. Curr Biol (2013) 1.66
Circadian rhythmicity restored by neural transplant. Immunocytochemical characterization of the graft and its integration with the host brain. J Neurosci (1987) 1.58
Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. J Clin Invest (2013) 1.57
Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges. Cell Metab (2014) 1.56
Bioinformatic analysis of circadian gene oscillation in mouse aorta. Circulation (2005) 1.40
Age-related decline in circadian output. J Neurosci (2011) 1.38
Activation of 5'-AMP-activated kinase with diabetes drug metformin induces casein kinase Iepsilon (CKIepsilon)-dependent degradation of clock protein mPer2. J Biol Chem (2007) 1.35
Diet and feeding pattern affect the diurnal dynamics of the gut microbiome. Cell Metab (2014) 1.34
Evidence for neuronal desynchrony in the aged suprachiasmatic nucleus clock. J Neurosci (2012) 1.31
The circadian clock protein BMAL1 is necessary for fertility and proper testosterone production in mice. J Biol Rhythms (2008) 1.30
The circadian clock gene period extends healthspan in aging Drosophila melanogaster. Aging (Albany NY) (2009) 1.29
Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism. Cell (2014) 1.26
Aging alters circadian and light-induced expression of clock genes in golden hamsters. J Biol Rhythms (2003) 1.23
Impact of aging on diurnal expression patterns of CLOCK and BMAL1 in the mouse brain. Brain Res (2010) 1.18
Phosphorylation Is a Central Mechanism for Circadian Control of Metabolism and Physiology. Cell Metab (2016) 1.15
Antioxidant N-acetyl-L-cysteine ameliorates symptoms of premature aging associated with the deficiency of the circadian protein BMAL1. Aging (Albany NY) (2009) 1.14
GENE REGULATION. Discrete functions of nuclear receptor Rev-erbα couple metabolism to the clock. Science (2015) 1.14
Loss of circadian clock accelerates aging in neurodegeneration-prone mutants. Neurobiol Dis (2011) 1.13
Old flies have a robust central oscillator but weaker behavioral rhythms that can be improved by genetic and environmental manipulations. Aging Cell (2012) 1.13
Circadian disorganization alters intestinal microbiota. PLoS One (2014) 1.12
Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening. Proc Natl Acad Sci U S A (2011) 1.10
Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock. Proc Natl Acad Sci U S A (2015) 1.09
Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans. Proc Natl Acad Sci U S A (2015) 1.08
Circadian dysregulation disrupts bile acid homeostasis. PLoS One (2009) 1.07
The microbiome and innate immunity. Nature (2016) 1.05
Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt. Proc Natl Acad Sci U S A (2015) 1.03
Short-term circadian disruption impairs bile acid and lipid homeostasis in mice. Cell Mol Gastroenterol Hepatol (2015) 1.01
Circadian rhythm of hyperoxidized peroxiredoxin II is determined by hemoglobin autoxidation and the 20S proteasome in red blood cells. Proc Natl Acad Sci U S A (2014) 0.98
The epigenetic language of circadian clocks. Handb Exp Pharmacol (2013) 0.95
Age-related changes in electrophysiological properties of the mouse suprachiasmatic nucleus in vitro. Brain Res Bull (2005) 0.95
Changes in vasopressin cells of the rat suprachiasmatic nucleus with aging. Brain Res (1987) 0.95
Hepatic Bmal1 Regulates Rhythmic Mitochondrial Dynamics and Promotes Metabolic Fitness. Cell Metab (2015) 0.94
Human Gut Bacteria Are Sensitive to Melatonin and Express Endogenous Circadian Rhythmicity. PLoS One (2016) 0.93
Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival. Sci Transl Med (2016) 0.92
Peripheral Circadian Clocks Mediate Dietary Restriction-Dependent Changes in Lifespan and Fat Metabolism in Drosophila. Cell Metab (2015) 0.91
Specificity in circadian clock feedback from targeted reconstitution of the NuRD corepressor. Mol Cell (2014) 0.89
The circadian clock maintains cardiac function by regulating mitochondrial metabolism in mice. PLoS One (2014) 0.87
Circadian rhythms of adenosine triphosphate contents in the suprachiasmatic nucleus, anterior hypothalamic area and caudate putamen of the rat--negative correlation with electrical activity. Brain Res (1994) 0.86
Circadian clocks, feeding time, and metabolic homeostasis. Front Pharmacol (2015) 0.85
Intestinal Microbiota Is Influenced by Gender and Body Mass Index. PLoS One (2016) 0.84
Sex differences and hormonal effects on gut microbiota composition in mice. Gut Microbes (2016) 0.83
Transcriptional architecture of the mammalian circadian clock. Nat Rev Genet (2016) 0.83
Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals. Sci Rep (2016) 0.82
A metabolomic study of adipose tissue in mice with a disruption of the circadian system. Mol Biosyst (2015) 0.78
Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism. Cell Metab (2017) 0.76
The Pentose Phosphate Pathway Regulates the Circadian Clock. Cell Metab (2016) 0.76
Mammalian Circadian Period, But Not Phase and Amplitude, Is Robust Against Redox and Metabolic Perturbations. Antioxid Redox Signal (2017) 0.76
Immunity around the clock. Science (2016) 0.75